Losmapimod concentration–QT relationship in healthy volunteers: meta-analysis of data from six clinical trials

Assessing the Probability of Drug-Induced QTc-Interval Prolongation During Clinical Drug Development

(2011) A S Y Chain et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

An Oral Inhibitor of p38 MAP Kinase Reduces Plasma Fibrinogen in Patients With Chronic Obstructive Pulmonary Disease

(2011) David A. Lomas et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Comparison of QTc Data Analysis Methods Recommended by the ICH E14 Guidance and Exposure–Response Analysis: Case Study of a Thorough QT Study of Asenapine

(2010) S Chapel et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance

(2009) B Darpo   BRITISH JOURNAL OF PHARMACOLOGY

Update on the evaluation of a new drug for effects on cardiac repolarization in humans: issues in early drug development

(2009) Vaibhav Salvi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comparison of Manual and Automated Measurements of the QT Interval in Healthy Volunteers: An Analysis of Five Thorough QT Studies

(2009) C Fosser et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Is a Thorough QTc Study Necessary? The Role of Modeling and Simulation in Evaluating the QTc Prolongation Potential of Drugs

(2009) Shashank Rohatagi et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Performance Characteristics for Some Typical QT Study Designs Under the ICH E-14 Guidance

(2008) Matthew M. Hutmacher et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A Perspective on the Use of Concentration-QT Modeling in Drug Development

(2007) Tanya Russell et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Concentration-QT Relationships Play a Key Role in the Evaluation of Proarrhythmic Risk During Regulatory Review

(2007) Christin E. Garnett et al.   JOURNAL OF CLINICAL PHARMACOLOGY