Zinc status and cognitive function of pregnant women in Southern Ethiopia

The relation between zinc status and cognitive function was examined in a cross-sectional study in the Sidama area of Southern Ethiopia. Pregnant women >24 weeks of gestation from three adjacent rural villages volunteered to participate. Mean (s.d.) plasma zinc of 99 women was 6.97 (1.07) mu mol/l (below the cutoff of 7.6 mu mol/l indicative of zinc deficiency at this stage of gestation). The Raven's Coloured Progressive Matrices (CPM) test was administered individually. Scores for the Raven's scale A, which is the simplest scale, ranged from 4 to 10 of a possible 12. Women with plasma zinc <7.6 mu mol/l had significantly lower Raven's CPM scale A scores than women with plasma zinc concentrations >7.6 mu mol/l. Plasma zinc and maternal age and education predicted 17% of the variation in Raven's CPM scale A scores. We conclude that zinc deficiency is a major factor affecting cognition in these pregnant women. European Journal of Clinical Nutrition (2009) 63, 916-918; doi:10.1038/ejcn.2008.77; published online 4 February 2009