Article
Veterinary Sciences
Daniel Salazar-Rodriguez, Yamile Aleaga-Santiesteban, Enrique Iglesias, Arturo Plascencia-Hernandez, Hector R. Perez-Gomez, Enrique J. Calderon, Jose A. Vazquez-Boland, Yaxsier de Armas
Summary: Rhodococcus equi is an animal pathogen and zoonotic human opportunistic pathogen associated with immunosuppressive conditions. Molecular characterization of R. equi isolates from HIV/AIDS patients in Cuba reveals the presence of virulence plasmids and provides insights into the zoonotic origin of infections and the potential dispensability of the virulence plasmid in immunosuppressed patients.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Food Science & Technology
Chenxu Sun, Chuanxi Zhu, Ying Tang, Dandan Ren, Yunfei Cai, Ganghan Zhou, Yiwen Wang, Ling Xu, Pinkuan Zhu
Summary: Calcium propionate (CP) can inhibit mycelial growth, infection cushion development, and reduce the virulence of Botrytis cinerea. Therefore, CP shows promise for practical management of gray mold in fruit crops and warrants further evaluation.
FOOD QUALITY AND SAFETY
(2021)
Article
Microbiology
Ad C. Fluit, Jumamurat R. Bayjanov, Maria Diez Aguilar, Rafael Canton, Stuart Elborn, Michael M. Tunney, Jelle Scharringa, Barry J. Benaissa-Trouw, Miquel B. Ekkelenkamp
Summary: This study investigated the taxonomic position, antibiotic resistance, and virulence factors of Stenotrophomonas maltophilia isolates from patients with chronic lung disease. The results revealed that potential novel Stenotrophomonas species identified as S. maltophilia differed from true S. maltophilia in resistance and virulence genes, possibly indicating different pathogenicity.
Article
Veterinary Sciences
Laura Huber, Steeve Giguere, Kelsey A. Hart, Nathan M. Slovis, Maggie E. Greiter, Cody A. Dailey, Noah D. Cohen
Summary: The study revealed that horse-breeding farms using TUS for screening and treating subclinical pneumonia selected for antimicrobial-resistant R equi strains. It is recommended to cautiously use antimicrobials for treating foals with subclinical pulmonary lesions attributed to R equi due to worse prognosis for foals infected with resistant strains.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2021)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Agronomy
Sabrine Dhaouadi, Amira Mougou Hamdane, Ali Rhouma
Summary: This study aimed to isolate and identify Rhodococcus spp. strains from almond and pistachio rootstocks and trees in Tunisia, using 16S rDNA and vicA gene amplification. Phylogenetic analysis revealed different groups within the strains, with some showing high pathogenicity on pea seedlings. This research sheds light on the presence of undocumented plant-associated Rhodococcus spp. on economically important crops in Tunisia.
Article
Veterinary Sciences
Anyaphat Srithanasuwan, Noppason Pangprasit, Witaya Suriyasathaporn
Summary: The objectives of this study were to compare the virulence patterns between transient and persistent intramammary infection (IMI) of Streptococcus uberis and determine the changes in virulence patterns after long-term transmission. The results showed that approximately 50% of field S. uberis IMI were spontaneously cured within 1 week, while 25% were not cured within 10 weeks. Regardless of transient or persistent IMI, a high similarity of the virulence pattern within a PFGE strain was found.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Microbiology
Jin-Lei Yang, Danyang Li, Xiao-Yong Zhan
Summary: Pathogenic species of Legionella can cause Legionellosis by infecting human alveolar macrophages through Legionella-containing aerosols. The disease has two forms, Pontiac fever and Legionnaires' disease. Legionella is an opportunistic pathogen that can be found in aquatic environments as a biofilm or protozoa parasite. The virulence factors of Legionella are better classified as survival factors, as they are associated with infections in protozoa and macrophages.
Article
Microbiology
Fuxiang Li, Pei Zhu, Zhanhong Li, Wenhua Zhao, Huafeng Gao, Qionghua Hong, Jianling Song, Shibiao Yang
Summary: A novel Gram-stain-negative bacteria, Moraxella nasovis sp. nov., was isolated from the nasal cavity of a sheep with respiratory disease in Yunnan Province, China. It showed similarity to other species in the genus Moraxella, but also formed a distinct clade. This study provides valuable taxonomic information on this newly discovered species.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jelena Konstantinovic, Andreas M. Kany, Alaa Alhayek, Ahmed S. Abdelsamie, Asfandyar Sikandar, Katrin Voos, Yiwen Yao, Anastasia Andreas, Roya Shafiei, Brigitta Loretz, Esther Schoenauer, Robert Bals, Hans Brandstetter, Rolf W. Hartmann, Christian Ducho, Claus-Michael Lehr, Christoph Beisswenger, Rolf Mueller, Katharina Rox, Joerg Haupenthal, Anna K. H. Hirsch
Summary: Targeting the main virulence factor elastase LasB of Pseudomonas aeruginosa, a nontraditional approach is discovered to combat the infections caused by this pathogen. The new chemical class of phosphonates shows promising in vitro and in vivo activity, and its mode of action is established through structural analysis.
ACS CENTRAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Zhaokun Xu, Xiujing Hao, Min Li, Haixia Luo
Summary: This study examines the properties of R. equi-derived extracellular vesicles (EVs) and their role in mediating inflammatory responses in macrophages. The results show that R. equi-EVs can induce macrophage cytotoxicity and increase the expression of inflammatory factors through the TLR2-NF-κB/MAPK pathway. The study also compares the differences in macrophage inflammatory responses mediated by EVs derived from virulent and avirulent strains of R. equi.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Essam Kotb, Baher A. El-Nogoumy, Haifa A. Alqahtani, Asmaa A. Ahmed, Hussah A. Al-shwyeh, Sakina M. Algarudi, Hanan Almahasheer
Summary: A putative virulence exoprotease UcB5 was purified from Salmonella typhimurium with high purity and recovery. It exhibited serine protease-type characteristics and had broad substrate specificity. UcB5 was found to cause subcellular proteolysis and liver necrosis, suggesting its potential role in microbial diseases. Future research should focus on combination therapy using external antiproteases and antimicrobial agents.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Yi Li, Fengli Zhu, Adhar C. Manna, Liang Chen, Jason Jiang, Jong-In Hong, Richard A. Proctor, Arnold S. Bayer, Ambrose L. Cheung, Yan Q. Q. Xiong
Summary: Persistent endovascular infections caused by MRSA strains susceptible to anti-MRSA antibiotics represent a unique variant of antibiotic resistance mechanisms and a significant therapeutic challenge. Prophage, a mobile genetic element carried by MRSA isolates, provides metabolic advantages and resistance mechanisms to bacterial hosts. This study demonstrates that the gp05 gene of the novel prophage & phi;SA169 significantly impacts MRSA virulence factors, host immune responses, and vancomycin treatment efficacy, leading to persistent outcomes in MRSA endovascular infection.
MICROBIOLOGY SPECTRUM
(2023)
Review
Chemistry, Multidisciplinary
Israel Diniz-Lima, Leonardo Marques da Fonseca, Elias Barbosa da Silva-Junior, Joyce Cristina Guimaraes-de-Oliveira, Leonardo Freire-de-Lima, Danielle Oliveira Nascimento, Alexandre Morrot, Jose Osvaldo Previato, Lucia Mendonca-Previato, Debora Decote-Ricardo, Celio Geraldo Freire-de-Lima
Summary: Cryptococcosis is caused by pathogenic fungi, including Cryptococcus neoformans and Cryptococcus gattii. The latter causes severe undiscriminating infections in immunocompetent individuals and is becoming more prevalent due to climatic factors. The immunopathology of cryptococcosis caused by C. gattii is still poorly understood, but research has helped to uncover its different variants.
APPLIED SCIENCES-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Emile Auria, Lise Hunault, Patrick England, Marc Monot, Juliana Pipoli Da Fonseca, Mariette Matondo, Magalie Duchateau, Yannick D. N. Tremblay, Bruno Dupuy
Summary: The ability of Clostridioides difficile to form biofilms during infection and its association with recurrence and persistence are discussed in this study. The researchers investigate the role of the lipoprotein CD1687 in biofilm formation induced by deoxycholate (DCA). They found that CD1687 is necessary for biofilm formation, and its overexpression alone can induce biofilm formation. Furthermore, CD1687 affects the expression of transporters and metabolic pathways and binds DNA in a non-specific manner, suggesting its involvement in mediating the interaction between cells and the biofilm matrix.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Biochemistry & Molecular Biology
Mehdi Fatahi-Bafghi, Masoumeh Rasouli-nasab, Somayeh Yasliani-Fard, Shadi Habibnia, Fatemeh Gharehbaghi, Seyyed Saeed Eshraghi, Kouroush Kabir, Parvin Heidarieh
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2019)
Letter
Rheumatology
Mehdi Fatahi-Bafghi
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2019)
Review
Infectious Diseases
Mehdi Fatahi-Bafghi
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2019)
Review
Microbiology
Mehdi Fatahi-Bafghi
Summary: Williamsia and Segniliparus, two genera of aerobic actinomycetes, consist of a total of 14 species that can cause infections in humans. This review examines their taxonomy, isolation, identification, and roles in human infections.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Biochemistry & Molecular Biology
Mohadeseh Majidzadeh, Parvin Heidarieh, Mehdi Fatahi-Bafghi, Mahmood Vakili
Summary: This study isolated 18 strains of Actinobacteria from soil in Yazd, Iran, with 7 strains exhibiting antimicrobial activity against ATCC strains. These isolates possess at least one type I or type II polyketide synthase or nonribosomal peptide synthetase gene. The results confirm the potential of soil Actinobacteria to produce antibacterial compounds against resistant and sensitive test organisms.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Infectious Diseases
Mehdi Fatahi-Bafghi
Summary: The genus Rothia are emerging as opportunistic pathogens associated with various infections in both immunocompromised and immunocompetent individuals. This review provides a comprehensive overview of the taxonomy, cell wall structure, pathogenesis, phenotypic and molecular characteristics, clinical diseases, treatment, as well as other related genera that may be misidentified as Rothia species.
INFECTION GENETICS AND EVOLUTION
(2021)
Review
Biotechnology & Applied Microbiology
Hanieh Sadat Riahi, Parvin Heidarieh, Mehdi Fatahi-Bafghi
Summary: Pseudonocardia, a genus of Actinomycetes, is important in biotechnology for its production of secondary metabolites with antibacterial, antifungal, and antitumor effects. Identification of Pseudonocardia involves phenotypic tests and molecular methods.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Mehdi Fatahi-Bafghi, Sara Naseri, Ali Alizehi
Summary: This study identified antibiotic resistance genes in a group of bacteria with probiotic properties through whole-genome sequence analysis, revealing that these genes can be transferred to other bacteria. The tet(W) tetracycline resistance gene was the most common among the antibiotic resistance genes found in probiotic bacteria, and most of the resistance genes were transferred through mobile genetic elements. The study suggests performing antibiotic susceptibility testing and genome sequence analysis before using a bacterium as a probiotic.
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Mansoureh Bakhshi, Hengameh Zandi, Mehdi Fatahi Bafghi, Akram Astani, Vahid Reza Ranjbar, Mahmood Vakili