Article
Ecology
Jose Julio Costa Sidrim, Gerlane Luziana de Maria, Manoel de Araujo Neto Paiva, Gessica dos Santos Araujo, Renan Vasconcelos da Graca-Filho, Jonathas Sales de Oliveira, Jamille Alencar Sales, Waldemiro Aquino Pereira-Neto, Glaucia Morgana de Melo Guedes, Debora de Souza Collares Maia Castelo-Branco, Rossana de Aguiar Cordeiro, Raimunda Samia Nogueira Brilhante, Marcos Fabio Gadelha Rocha
Summary: This study revealed that non-wild type and azole-resilient biofilm-producing Candida species can colonize agricultural soils treated with azole fungicides. These species exhibit strong biofilm-forming abilities.
Review
Microbiology
Zuzana Malinovska, Eva Conkova, Peter Vaczi
Summary: The widespread prevalence of biofilm-forming fungal pathogens poses a significant threat, especially to immunocompromised patients with long-term inserted medical devices. Medically important Candida species, such as C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, C. krusei, and C. auris, are associated with high mortality due to candidemia. Understanding the key mechanisms of biofilm formation is crucial for the treatment of invasive Candida infections.
Article
Public, Environmental & Occupational Health
Tahereh Alikhani, Roshanak Daie Ghazvini, Mehdi Mirzaii, Seyed Jamal Hashemi, Mozhgan Fazli, Zahra Rafat, Davoud Roostaei, Pegah Ardi, Hasti Kamali Sarvestani, Mahdi Zareei
Summary: This study identified the Candida species responsible for vulvovaginal candidiasis (VVC), specifically Candida albicans and Candida glabratia. It was found that these strains had a high biofilm-forming ability. Sensitivity testing to commonly used antifungal drugs showed that the isolates were susceptible to miconazole but displayed some resistance to fluconazole and clotrimazole.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Puteri Elysa Alia Mohd Badri, Nurul Alia Risma Rismayuddin, Norzaiti Mohd Kenali, Deny Susanti Darnis, Mohd Hafiz Arzmi
Summary: The study determined the effect of deer velvet antler (DVA) compounds on the formation of Candida species biofilm. It was found that DVA extract inhibits biofilm formation in most Candida strains, except for C. glabrata, C. krusei, and C. parapsilosis.
Review
Pharmacology & Pharmacy
Gina P. Rodriguez-Castano, Frank Rosenau, Ludger Staendker, Carolina Firacative
Summary: Expanding the antifungal drug arsenal is crucial for treating Candida infections, which are increasing in prevalence and often resistant to existing treatments. This review provides a comprehensive summary of antimicrobial peptides (AMPs) with anti-Candida activity that have undergone successful preclinical or clinical trials. The source, mode of action, and animal model of infection or clinical trial for these AMPs are presented. The advantages of combination therapy using AMPs and other drugs to fight Candida infections are also discussed.
Article
Dentistry, Oral Surgery & Medicine
Jiantao Yu, Fan Wang, Yan Shen, Fangzheng Yu, Lili Qiu, Lingjun Zhang, Yanhan Chen, Qing Yuan, Huan Zhang, Yan Sun, Keke Zhang
Summary: In this study, the effect of ficin, a protease, on Candida albicans biofilm was investigated. The results showed that ficin significantly reduced the biomass of both forming and pre-formed biofilms. However, it did not significantly affect fungal activity. Ficin also influenced fungal polymorphism and biofilm-associated gene expression, especially in groups with strong antibiofilm effects.
Article
Biochemistry & Molecular Biology
Bettina Szerencses, Attila Gacser, Gabriella Endre, Ildiko Domonkos, Hilda Tiricz, Csaba Vagvolgyi, Janos Szolomajer, Dian H. O. Howan, Gabor K. Toth, Ilona Pfeiffer, Eva Kondorosi
Summary: This study demonstrates the anticandidal activity of NCR335 and NCR169 peptide derivatives against five Candida species, showing the ability to inhibit biofilm formation and yeast-hypha transformation. Combined treatment with fluconazole revealed synergistic interactions and reduced minimal inhibitory concentrations of C. auris. Shortening NCR peptides can enhance and broaden their anticandidal activity and therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Fernanda Cristina Possamai Rossatto, Nagendran Tharmalingam, Iliana E. Escobar, Pedro Alves D'Azevedo, Karine Rigon Zimmer, Eleftherios Mylonakis
Summary: The study showed that plant polyphenols ellagic acid (EA) and caffeic acid phenethyl ester (CAPE) demonstrated promising antifungal and antivirulence effects against Candida auris, indicating their potential as novel antifungal agents against drug-resistant infections.
Article
Pharmacology & Pharmacy
Rawny G. Gouveia, Nayana R. Oliveira, Victor T. Gomes, Daiana K. F. Silva, Cassio I. S. Medeiros, Ulrich Vasconcelos, Abrahao A. Oliveira-Filho, Edeltrudes. O. Lima
Summary: This study investigated the inhibitory effect of (R) and (S)-citronellal enantiomers on biofilm formation and their interaction with fluconazole and voriconazole in Candida albicans strains causing onychomycosis. The results showed that (R)-CIT and (S)-CIT can inhibit biofilm formation and exhibit synergistic effects when combined with antifungal drugs. These findings suggest that (R) and (S)-citronellal enantiomers could be potential treatments for fungal nail infections.
LATIN AMERICAN JOURNAL OF PHARMACY
(2023)
Article
Biotechnology & Applied Microbiology
Dusan Usjak, Katarina Novovic, Branka Ivkovic, Branko Tomic, Valentina Dordevic, Marina T. Milenkovic
Summary: Biofilm production is important for microbial colonization in wounds and catheters. Acinetobacter baumannii and Candida albicans are both strong biofilm producers. The study found that 2'-hydroxychalcones have potential to inhibit the dual-species biofilm production of A. baumannii and Candida spp., and the trifluoromethyl-substituted derivative (p-CF3) was particularly effective in reducing biofilm biomass.
Review
Biochemistry & Molecular Biology
Panxin Li, Rui Yin, Juanli Cheng, Jinshui Lin
Summary: Bacterial biofilms can cause widespread infections and have strong resistance to antibiotics. This article summarizes the formation processes, resistance mechanisms, and main characteristics of clinically persistent infections caused by biofilms. Additionally, two main methods for preventing and treating biofilm-related infections on biomaterials are introduced: antibacterial coatings and surface modification of biomaterials. The advantages of each strategy in terms of antibacterial effect, biocompatibility, limitations, and application prospects are analyzed, providing ideas and research directions for the development of novel biofilm infection strategies related to therapeutic materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Anelise Maria Costa Vasconcelos Alves, Beatriz Oliveira Lopes, Ana Caroline Rocha de Melo Leite, Gabriela Silva Cruz, erika Helena Salles de Brito, Laritza Ferreira de Lima, Lucia Cernakova, Nuno Filipe Azevedo, Celia Fortuna Rodrigues
Summary: This study characterized mature biofilms of various Candida species obtained from the oral mucosa of children, adults, and elders. It was found that children were more likely to be infected by non-Candida albicans Candida species (NCACs) and these NCACs formed biofilms richer in matrix components. This finding is clinically important, especially in pediatric care, due to the association of stronger biofilms with antimicrobial resistance, recurrent infections, and higher therapeutic failure.
Review
Immunology
Gordon Ramage, Elisa Borghi, Celia Fortuna Rodrigues, Ryan Kean, Craig Williams, Jose Lopez-Ribot
Summary: Clinically we have long been aware of the concept of Candida biofilms, which have the ability to colonize surfaces and form tenacious structures. These infections, found in various body sites, are highly resistant to antifungal therapies. This review provides a comprehensive overview of current clinical understanding, as well as existing and emerging antifungal therapies and strategies.
Article
Infectious Diseases
Ibrahim Alfarrayeh, Edit Pollak, Arpad Czeh, Andras Vida, Sourav Das, Gabor Papp
Summary: The study revealed a strain- and dose-dependent effect of CAPE on various Candida species, inhibiting planktonic growth, biofilm formation ability, and inducing cell death responses.
Article
Pharmacology & Pharmacy
Annarita Falanga, Angela Maione, Alessandra La Pietra, Elisabetta de Alteriis, Stefania Vitale, Rosa Bellavita, Rosa Carotenuto, David Turra, Stefania Galdiero, Emilia Galdiero, Marco Guida
Summary: This study investigates the interaction between C. albicans and F. oxysporum dual-species biofilm and the effectiveness of combination treatment using WMR peptide and fluconazole (FLC). The results show that the combination treatment significantly reduces the biomass and viability of both species in the mixed biofilm.
Article
Microbiology
Jaime A. Bibian-Garcia, Jorge A. Ortiz-Ramirez, Lilia M. Almanza-Villegas, R. Aguayo-Ortiz, C. Cano-Canchola, Mayra Cuellar-Cruz, Everardo Lopez-Romero
Summary: Candida albicans is a common fungal pathogen in humans, particularly in immunocompromised patients. This study investigates the mechanisms of glycoprotein assembly in the organism and identifies a bifunctional nucleotidase that plays a role in maintaining the balance of sugar donors during the glycosylation process.
ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY
(2022)
Article
Microbiology
Dulce O. Saucedo-Campa, Ana L. Martinez-Rocha, Emmanuel Rios-Castro, Carlos A. Alba-Fierro, Miguel A. Escobedo-Bretado, Mayra Cuellar-Cruz, Estela Ruiz-Baca
Summary: Sporothrix schenckii modulates the expression of its cell wall proteins in response to reactive oxygen species, allowing it to evade the immune system. In this study, the proteomic analysis showed that several cell wall proteins and antioxidant enzymes were differentially expressed after exposure to an oxidizing agent. RT-qPCR assays confirmed that the transcription of these genes is regulated in response to oxidative stress. The findings suggest that S. schenckii utilizes cell wall proteins, including moonlighting proteins, to protect against oxidative stress and infect host cells.
Article
Chemistry, Multidisciplinary
Nancy A. Vazquez-Lopez, Gustavo Cruz-Jimenez, Armando Obregon-Herrera, Estela Ruiz-Baca, Mario Pedraza-Reyes, Everardo Lopez-Romero, Mayra Cuellar-Cruz
Summary: Invasive fungal infections caused by Candida species have become a significant public health problem in the last three decades. The difficulty in diagnosing and treating candidiasis has led to the development of drug resistance and toxicity in patients. This study investigates the antifungal activity of plants used in traditional Mexican herbal medicine against Candida species and identifies several active compounds that could serve as alternative treatments.
JOURNAL OF CHEMISTRY
(2022)
Article
Crystallography
Cesia D. Perez-Aguilar, Selene R. Islas, Abel Moreno, Mayra Cuellar-Cruz
Summary: The synthesis of nucleic acids in the Precambrian era marked the start of life, with DNA being the molecule in which the genetic information has been conserved ever since. After studying the DNA of different organisms, researchers have found that DNA concentration and environmental conditions influence cell size and cellular differentiation. This research aims to evaluate the influence of DNA concentration on the morphology of biomorphs under different synthesis conditions.
Article
Chemistry, Multidisciplinary
Mayra Cuellar-Cruz, Selene R. Islas, Norma Ramirez-Ramirez, Mario Pedraza-Reyes, Abel Moreno
Summary: The origin of life on Earth is associated with the Precambrian era, and this study explores the possibility of calcium, barium, and strontium biomorphs protecting and preserving biomolecules in a simulated atmosphere of the Precambrian era. Results showed for the first time the formation of the kerogen signal and the internalization of DNA into the structure of biomorphs.
Review
Infectious Diseases
Fatima Tornero-Gutierrez, Jorge A. Ortiz-Ramirez, Everardo Lopez-Romero, Mayra Cuellar-Cruz
Summary: This review discusses the diversity of materials developed to reduce and prevent Candida infections, focusing on several common strains of the Candida genus. The performance of each material in reducing Candida adhesion needs to be evaluated.
Article
Chemistry, Medicinal
Nancy A. A. Vazquez-Lopez, Rodrigo Aguayo-Ortiz, Mayra Cuellar-Cruz
Summary: The phosphoglycerate kinase and fructose-bisphosphate aldolase of Candida species play significant roles in their pathogenicity. Theoretical models of their interaction with potential drugs can be obtained through modeling and molecular dynamics.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Article
Polymer Science
Jose Arturo de la Cruz Bosques, Jose de Jesus Ibarra Sanchez, Birzabith Mendoza-Novelo, Juan Gabriel Segovia-Hernandez, Carlos Eduardo Molina-Guerrero
Summary: This report presents an economic analysis of large-scale production of chemically cross-linked collagen scaffold (CCLCS) using waste from the meat industry. The study demonstrates that producing CCLCS can be cost-effective and profitable in the Mexican market. This has the potential to stimulate the circular bioeconomy.
Article
Crystallography
Ulises Galindo-Garcia, Maria Vanegas-Reza, Roberto Arreguin-Espinosa, Karina Sandra Perez, Ricardo Perez-Solis, Maria Eugenia Mendoza, Karla Yadira Cervantes-Quintero, Selene R. Islas, Mayra Cuellar-Cruz, Abel Moreno
Summary: This article provides an overview of the role of different light-signaling proteins in biochemical processes, especially in plants, and their applications in optogenetics as a new research field. Case studies are presented, demonstrating the use of fluorescent proteins and phototropins in the synthesis of biomorphs. The article also analyzes the influence of these proteins on the shape and structure of silico-carbonates, serving as optical sensors for the detection of biomolecules.
Article
Chemistry, Multidisciplinary
Mayra Cuellar-Cruz
Summary: There are many theories about the origin of life, but currently it is believed that life has a single origin, although the starting point has not been determined. In order to understand the mechanism of life origin on Earth, it is necessary to unify the different theories. This study proposes a hypothesis based on biomorphs, which are silica-carbonates of alkaline earth metals, to unify the various theories on the origin of life.
Review
Microbiology
Jorge A. Ortiz-Ramirez, Mayra Cuellar-Cruz, Julio C. Villagomez-Castro, Everardo Lopez-Romero
Summary: This article reviews the importance of fungal glycosidases in biological processes, with a particular focus on two human pathogens, Sporothrix species and C. albicans. The classification, substrates, mechanism of action, recent research advances, and potential biotechnological applications of glycosidases are discussed.
Article
Nanoscience & Nanotechnology
Pedro U. Munoz-Gonzalez, J. M. Flores-Moreno, Irais A. Quintero-Ortega, Diego Mantovani, Birzabith Mendoza-Novelo, Gerardo Gonzalez-Garcia
Summary: This study reports a simple method for synthesizing silicon nanoparticles (SiNps) dispersed in water. The SiNps exhibit small size, good structure, and fluorescence, making them suitable as cell fluorescent trackers. Furthermore, the SiNps show cytocompatibility and exert an anti-inflammatory effect on macrophages, suggesting their potential as immunomodulatory biomaterials.
ACS APPLIED NANO MATERIALS
(2023)
Review
Crystallography
Marcelino Antonio Zuniga-Estrada, Erick Alfredo Zuniga-Estrada, Mayra Cuellar-Cruz
Summary: Under alkaline conditions, self-assembled mineral compounds similar to ancient biominerals can form from silica. This review explores a geochemical scenario in the early history of Earth that could have led to the production of organic compounds important for prebiotic chemistry. The scenario involves a high concentration of silica, high pH, a source of simple carbon molecules, and the formation of self-organized silica-metal mineral compounds that catalyzed the condensation of single molecules in a methane-rich atmosphere. The plausibility of this scenario and its transition towards a slightly alkaline to Neutral Ocean are discussed.
PROGRESS IN CRYSTAL GROWTH AND CHARACTERIZATION OF MATERIALS
(2023)
Meeting Abstract
Cell & Tissue Engineering
Pedro Ulises Munoz-Gonzalez, Birzabith Mendoza-Novelo, Gerardo Gonzalez-Garcia
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Pedro Ulises Munoz-Gonzalez, Maria Cruz Lona-Ramos, Gerardo Gonzalez-Garcia, Jorge Delgado, Laura Castellano, Birzabith Mendoza-Novelo
TISSUE ENGINEERING PART A
(2022)
