Article
Pediatrics
Ines Carloni, Silvia Ricci, Chiara Rubino, Giovanni Cobellis, Giampaolo Rinaldelli, Chiara Azzari, Fernando M. de Benedictis
Summary: The hospitalization rate for NP in children decreased a few years after the implementation of PCV13 immunization in Italy. However, an increased trend in admissions was found thereafter. S. pneumoniae was the most frequent causal agent in both pre- and post-PCV13 periods, with Pneumococcal serotypes mainly represented by serotype 3.
PEDIATRIC PULMONOLOGY
(2021)
Article
Immunology
Jason E. Lang, Christoph P. Hornik, Carrie Elliott, Adam Silverstein, Chi Hornik, Amira Al-Uzri, Miroslava Bosheva, John S. Bradley, Charissa Fay Corazon Borja-Tabora, David Di John, Ana Mendez Echevarria, Jessica E. Ericson, David Friedel, Ferenc Gonczi, Marie Grace Dawn Isidro, Laura P. James, Krisztina Kalocsai, Ioannis Koutroulis, Istvan Laki, Anna Lisa T. Ong-Lim, Marta Nad, Gabor Simon, Salma Syed, Eva Szabo, Daniel K. Benjamin, Michael Cohen-Wolkowiez
Summary: This study evaluated the safety and effectiveness of Solithromycin in pediatric community-acquired bacterial pneumonia. The results showed a higher incidence of adverse events in the Solithromycin group, but the drug was generally well-tolerated and associated with clinical improvement.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Medicine, General & Internal
Amani Alnimr
Summary: This study investigated the serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae in infected individuals, and found that the fitness cost and dissemination patterns of resistant strains are associated with different antimicrobial resistances.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Pediatrics
Jian-Te Lee, Jou-Wei Lin, Ho-Min Chen, Chen-Yu Wang, Chun-Yi Lu, Luan-Yin Chang, Li-Min Huang
Summary: This study found that the national PCV13 vaccination program in Taiwan reduced the incidence rates of pneumococcal parapneumonic diseases and lobar/pneumococcal pneumonia, as well as the intensity of pneumonia care and mortality across all age groups.
PEDIATRIC RESEARCH
(2022)
Article
Immunology
Ching-Fen Shen, Ju-Ling Chen, Chien-Chou Su, Wen-Liang Lin, Min-Ling Hsieh, Ching-Chun Liu, Ching-Lan Cheng
Summary: The implementation of PCV13 in Taiwan has significantly reduced hospitalizations for P-CAP, especially in children and adults, and has markedly decreased ICU rates and severe pneumonia cases.
Article
Immunology
Matteo Astengo, Chiara Paganino, Daniela Amicizia, Laura Sticchi, Andrea Orsi, Giancarlo Icardi, Maria Francesca Piazza, Salini Mohanty, Francesca Senese, Gian Marco Prandi, Filippo Ansaldi
Summary: The introduction of pneumococcal conjugate vaccines (PCVs) in Liguria, Italy has led to a significant decrease in hospitalizations for pneumococcal pneumonia in children, but an increase in hospitalizations for all-cause pneumonia in adults. The hospitalization rate for pneumococcal-related pneumonia increased in the age group over 65, indicating a higher risk in this age group. Despite vaccination, there is still a substantial burden of pneumococcal disease (PD) in children and adults in Liguria.
Article
Pediatrics
I-Fan Chang, Wei-Liang Shih, Yun-Chung Liu, Te-Wei Ho, Ting-Yu Yen, Hsiu-Hao Chang, Luan-Yin Chang, Chi-Tai Fang, Feipei Lai
Summary: Anemia is associated with poor outcomes in pediatric CAP, with iron-deficiency anemia and normocytic anemia being particularly concerning. Patients with these types of anemia should be carefully monitored and managed due to their higher disease severity risks.
PEDIATRIC PULMONOLOGY
(2022)
Article
Immunology
Sara de Miguel, Mirian Domenech, Fernando Gonzalez-Camacho, Julio Sempere, Dolores Vicioso, Juan Carlos Sanz, Luis Garcia Comas, Carmen Ardanuy, Asuncion Fenoll, Jose Yuste
Summary: The study analyzed the invasive pneumococcal disease cases in children and adults from 2009 to 2019, as well as the impact of different vaccine strategies. It found that PCV13 reduced disease burden in both children and adults, but an increase in serotype 8 in adults was observed.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Olivia J. J. Carr, Keoudomphone Vilivong, Laddaphone Bounvilay, Eileen M. Dunne, Jana Y. R. Lai, Jocelyn Chan, Malisa Vongsakid, Anisone Changthongthip, C. Siladeth, Belinda Ortika, Cattram Nguyen, Mayfong Mayxay, Paul N. Newton, Kim Mulholland, Lien A. H. Do, Audrey Dubot-Peres, Catherine Satzke, David A. B. Dance, Fiona M. Russell
Summary: This study in Laos explored the association between pneumococcal nasopharyngeal density and severe pneumonia, finding a positive correlation between pneumococcal carriage density and severe pneumonia among children carrying acute respiratory infections and pneumococcal.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Milou J. Serbee, Elisabeth A. Dulfer, Kirsten K. T. Dirkx, Ron Bosboom, Bas Robberts, Heiman F. L. Wertheim, Bert Mulder, Marien de Jonge, Carel F. Schaars, Caroline M. A. Swanink, Amelieke J. H. Cremers
Summary: This study investigated the use of CRP at admission to exclude complicated disease manifestations of pneumococcal disease. Results showed that low CRP levels could reliably exclude the development of pulmonary empyema, but in cases with pleural fluid, elevated CRP levels made it challenging to rule out empyema suspicion.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Sana S. Ahmed, Fernanda C. Lessa, Hilma Coradin, Jacqueline Sanchez, Maria da G. Carvalho, Elizabeth Soda, Chabela Pena, Josefina Fernandez, Doraliza Cedano, Cynthia G. Whitney, Jesus Feris-Iglesias
Summary: The introduction of PCV13 had an impact on the serotypes causing pneumococcal pneumonia with pleural effusion, with no significant difference in the prevalence of pneumococcus before and after PCV13 introduction, but changes in the proportion of cases caused by different serotypes. The PCV13 uptake rate decreased in 2015 compared to 2014, highlighting the need for higher vaccination coverage.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Public, Environmental & Occupational Health
Rita Reyburn, Anthea Tsatsaronis, Claire von Mollendorf, Kim Mulholland, Fiona M. Russell
Summary: A systematic review revealed that the pneumococcal conjugate vaccines effectively reduce the hospitalization rates of pneumonia in children aged <5 years, supporting the continued use of PCV10 and PCV13.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Microbiology
Bryndis Bjornsdottir, Ubaldo Benitez Hernandez, Asgeir Haraldsson, Valtyr Thors
Summary: This prospective study describes a cohort of children presenting to a single-centre pediatric emergency department (ED) with suspected invasive bacterial infection, and explores the relationships between nasopharyngeal microbes and outcomes. It found that the presence of respiratory viruses and the carriage of Streptococcus pneumoniae and Haemophilus influenzae were associated with a higher risk of pneumonia in children.
Article
Clinical Neurology
Shao-rui Hao, Zhe Zhang, Yuan-yue Zhou, Xue Zhang, Wen-jun Sun, Zi Yang, Jian-hua Zhao, Hai-yin Jiang
Summary: The gut mycobiome is altered in children and adolescents with depression, with certain fungi being enriched and others showing decreased abundance. Furthermore, the interkingdom network between gut bacteria and fungi is significantly altered in individuals with depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
Annika Eklundh, Samuel Rhedin, Malin Ryd-Rinder, Maria Andersson, Jesper Gantelius, Giulia Gaudenzi, Magnus Lindh, Ville Peltola, Matti Waris, Pontus Naucler, Andreas Martensson, Tobias Alfven
Summary: Immunization with pneumococcal conjugate vaccines has reduced the burden of community-acquired pneumonia in children and potentially changed the etiology of CAP. The majority of clinical CAP episodes in children were classified as viral etiology, with bacterial etiology being uncommon.
Article
Obstetrics & Gynecology
M. Girona-Alarcon, A. Cuaresma-Gonzalez, J. Rodriguez-Fanjul, S. Bobillo-Perez, E. Inarejos, J. Sánchez-de-Toledo, I. Jordan, M. Balaguer
Summary: Cardiopulmonary bypass during cardiac surgery generates a systemic capillary leak syndrome with pulmonary edema. In this prospective study performed in the Pediatric Intensive Care Unit, lung ultrasound detected pulmonary edema better than X-ray, with greater sensitivity and negative predictive value. LUCAS score was useful to predict more inotropic support and longer mechanical ventilation.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Immunology
Carlota Dobano, Selena Alonso, Marta Vidal, Alfons Jimenez, Rocio Rubio, Rebeca Santano, Diana Barrios, Gemma Pons Tomas, Maria Mele Casas, Maria Hernandez Garcia, Monica Girona-Alarcon, Laura Puyol, Barbara Baro, Pere Millat-Martinez, Sara Ajanovic, Nuria Balanza, Sara Arias, Natalia Rodrigo Melero, Carlo Carolis, Aleix Garcia-Miquel, Elisenda Bonet-Carne, Joana Claverol, Marta Cubells, Claudia Fortuny, Victoria Fumado, Anna Codina, Quique Bassat, Carmen Munoz-Almagro, Mariona Fernandez de Sevilla, Eduard Gratacos, Luis Izquierdo, Juan Jose Garcia-Garcia, Ruth Aguilar, Iolanda Jordan, Gemma Moncunill
Summary: COVID-19 has a lesser impact on children compared to adults, but they can still get infected and transmit the virus. A study evaluated the use of high-throughput Luminex assays to measure SARS-CoV-2 antibodies in saliva and compared them to serum/plasma samples in infected children and adults. The results showed a correlation between saliva and serum/plasma antibody levels, and infected children had higher antibody levels, suggesting stronger clinical immunity. Therefore, measuring saliva antibodies could be a useful tool to determine COVID-19 prevalence and transmission in pediatric populations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Anna Sole-Ribalta, Cristian Launes, Aida Felipe-Villalobos, Monica Balaguer, Carles Luaces, Roser Garrido, Sara Bobillo-Perez, Monica Girona-Alarcon, Ana Valls, Francisco Jose Cambra, Elisabeth Esteban, Iolanda Jordan
Summary: This study aimed to develop a quantitative predictive scoring model for early recognition and assessment of pediatric sepsis. The model showed excellent predictive performance, with an AUC of 0.886 and high sensitivity and specificity. This model has great clinical significance in detecting and predicting the severity of pediatric sepsis. However, external validation is still needed.
Article
Pediatrics
Maria L. Rossi, Stephanie M. Hadley, Paula C. Randanne, Maria C. Escobar-Diaz, Marta C. Camprubi, Iolanda Jordan, Joan Sanchez-de-Toledo
Summary: The study aimed to investigate the presence of cardiac dysfunction in severe bronchiolitis cases, revealing that children requiring positive pressure respiratory support exhibited worse cardiac function, including decreased right ventricle systolic function and parameters indicative of global diastolic dysfunction. NT-proBNP levels at admission showed strong discriminatory power in predicting outcomes.
PEDIATRIC PULMONOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Lucia Rossi, Maria Clara Escobar-Diaz, Stephanie Marie Hadley, Paula Cecilia Randanne, Joan Sanchez-de-Toledo, Iolanda Jordan
Summary: This study evaluated pulmonary artery pressure in patients with bronchiolitis and analyzed their correlation with clinical outcomes. The results showed that the presence of pulmonary hypertension did not lead to worse clinical outcomes compared to normal pulmonary artery pressure group. Patients with severe bronchiolitis had higher values of NT-proBNP, but interestingly, there was no clear association with pulmonary hypertension.
PEDIATRIC CARDIOLOGY
(2023)
Article
Immunology
Ana Garcia-Garcia, Claudia Fortuny, Victoria Fumado, Iolanda Jordan, Laura Ruiz-Lopez, Europa Azucena Gonzalez-Navarro, Natalia Egri, Ana Esteve-Sole, Yiyi Luo, Alexandru Vlagea, Manel Monsonis Cabedo, Cristian Launes, Aleix Soler, Anna Codina, Manel Juan, Mariona Pascal, Angela Deya-Martinez, Laia Alsina
Summary: This study compared the infection outcomes and immune responses to SARS-CoV-2 in unvaccinated individuals with inborn errors of immunity (IEI) and healthy individuals. The results showed that IEI patients had weaker immune responses in the acute phase of infection and lower immune responses at 6 months after infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Jeppe S. A. Nielsen, Rachel Agbeko, Jessica Bate, Iolanda Jordan, Christian Dohna-Schwake, Jenny Potratz, Andrea Moscatelli, Gabriella Bottari, John Pappachan, Volker Witt, Roman Crazzolara, Angela Amigoni, Agniezka Mizia-Malarz, Maria Sanchez Martin, Jef Willems, Marry M. van den Heuvel-Eibrink, Luregn J. Schlapbach, Roelie M. Wosten-van Asperen
Summary: This study describes the organizational characteristics and processes of care for pediatric oncology patients in PICUs across Europe. Most PICUs have similar organizational characteristics, but oncology-specific practices are less common. Providing multidisciplinary care for these vulnerable and challenging patients remains complex and challenging.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Daniel Penela-Sanchez, Muntsa Rocafort, Desiree Henares, Iolanda Jordan, Pedro Brotons, Maria Cabrerizo, Cristian Launes, Carmen Munoz-Almagro
Summary: This study reveals a close relationship between nasopharyngeal microbiota and different clinical presentations of RV/EV infection in children.
PEDIATRIC PULMONOLOGY
(2023)
Review
Pediatrics
Sergi Huerta-Calpe, Ignacio Del Castillo-Velilla, Aida Felipe-Villalobos, Iolanda Jordan, Lluisa Hernandez-Platero
Summary: Juvenile-onset systemic lupus erythematosus (jSLE) is a multisystemic disease diagnosed in young patients based on clinical criteria. It is more aggressive than lupus diagnosed during adulthood (aSLE). Management involves supportive care and immunosuppressive drugs to reduce disease activity and prevent exacerbation. This paper presents three recent jSLE cases requiring admission to the Pediatric Intensive Care Unit (PICU) due to life-threatening complications such as diffuse alveolar hemorrhage, cerebral vasculitis, and antiphospholipid syndrome, emphasizing the need for early and aggressive treatment for favorable prognosis.
Article
Immunology
Conchita Izquierdo, Pilar Ciruela, Nuria Soldevila, Juan-Jose Garcia-Garcia, Sebastia Gonzalez-Peris, Alvaro Diaz-Conradi, Belen Vinado, Mariona F. de Sevilla, Fernando Moraga-Llop, Carmen Munoz-Almagro, Angela Dominguez, Barcino Working Grp
Summary: The incidence of invasive pneumococcal disease (IPD) and healthcare demand decreased in children in Catalonia in 2021 compared to the pre-pandemic period and the early pandemic period. Emergency room (ER) visits declined by 21% in 2021, with the greatest decrease in the first quarter. IPD incidence overall decreased by 58% in 2021, especially in the first quarter.
Article
Pediatrics
Maria Hernandez-Garcia, Claudia Solito, Alba Pavon Ortiz, Noelia Arguedas Casamayor, Maria Mele-Casas, Gemma Pons-Tomas, Mariona F. de Sevilla, Rosa Pino, Cristian Launes, Carmina Guitart, Monica Girona-Alarcon, Iolanda Jordan, Juan Jose Garcia-Garcia
Summary: SARS-CoV-2 pneumonia in children has a lower incidence and severity compared to adults. Risk factors associated with severity in children include prematurity and comorbidities. Our study found that pediatric patients with prematurity, anemia, lymphopenia, elevated procalcitonin, elevated lactate dehydrogenase (LDH) levels, hypoalbuminemia, and low HDL-cholesterol levels may require hospitalization and present more severe forms. No significant differences in severity were observed between different periods of SARS-CoV-2 variants.
Article
Pediatrics
Maria Hernandez-Garcia, Quique Bassat, Victoria Fumado, Gil Rodas, Ramon Pi, Maite Miranda-Garcia, Monica Girona-Alarcon, Marti Catala, Sergio Alonso, Enrique Alvarez-Lacalle, Daniel Lopez, Maria Mele-Casas, Gemma Pons-Tomas, Mariona F. de Sevilla, Elisenda Bonet-Carne, Claudia Fortuny, Aleix Garcia-Miquel, Cristina Jou, Cristina Adroher, Joana Claverol, Marta Cubells, Anna Codina, Daniel Cuadras, Eduard Gratacos, Pedro Brotons, Carmen Munoz-Almagro, Clara Prats, Juan Jose Garcia-Garcia, Iolanda Jordan
Summary: Studies show that engaging in physical activities in stable sports teams is not associated with an increased risk of SARS-CoV-2 transmission, whereas indoor sports and closed living settings can increase the risk. Fulfillment of preventive measures is essential.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Anna Sole-Ribalta, Monica Balaguer, Sara Bobillo-Perez, Monica Girona-Alarcon, Carmina Guitart, Elisabeth Esteban, Iolanda Jordan-Garcia
Summary: The aim of this study was to quantify a qualitative screening tool for the early recognition of sepsis in febrile children either visiting the emergency department or already admitted to hospital. A prospective observational study was conducted, including febrile patients under 18 years of age, with sepsis diagnosis as the main outcome. A multivariable analysis was performed, and four clinical variables were identified as independent predictors of sepsis.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Microbiology
Desiree Henares, Stephanie W. Lo, Amaresh Perez-Arguello, Alba Redin, Pilar Ciruela, Juan Jose Garcia-Garcia, Pedro Brotons, Jose Yuste, Raquel Sa-Leao, Carmen Munoz-Almagro
Summary: This study compared serological typing and whole genome sequencing (WGS) for determining the capsular types of pneumococci causing invasive disease. Different bioinformatics pipelines were used for short-read and long-read data from WGS. The results showed high concordance between serological typing and WGS-based pipelines, with some discrepancies observed at the serotype level within serogroups.
JOURNAL OF CLINICAL MICROBIOLOGY
(2023)
Article
Pediatrics
Maria Hernandez-Garcia, Elies Roldan-Berengue, Carmina Guitart, Monica Girona-Alarcon, Guillermo Arguello, Rosa Pino, Mariona F. de Sevilla, Juan Jose Garcia-Garcia, Iolanda Jordan
Summary: Distinguishing between Multisystem Inflammatory Syndrome in Children (MIS-C) and sepsis is complex. This study compared demographic, clinical, diagnostic, and therapeutic data to identify differences between pediatric patients with MIS-C and sepsis, and developed a scoring system to distinguish between the two. The MISSEP score, based on five criteria, showed high sensitivity and specificity in discriminating MIS-C from sepsis.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)