Review
Pharmacology & Pharmacy
Thomas Kaufmann, Hans-Uwe Simon
Summary: Apoptosis is crucial for maintaining health, as it ensures proper development of immune cells and shutdown of immune reactions. Limiting the lifespan of granulocytes is important to prevent chronic inflammation and tissue damage. There are various methods, such as the use of anti-inflammatory drugs and targeted antibodies, to induce granulocyte apoptosis for therapeutic purposes in immune disorders and even cancer treatments.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Review
Immunology
Daniel Radtke, David Voehringer
Summary: Granulocytes provide a rapid response to pathogens and allergens through the release of inflammatory mediators and recruitment of different cell types. They play a role in both promoting and limiting tissue damage and are potential targets for therapeutic interventions in allergic disorders.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Fisheries
Kelsey A. Hauser, Christina N. Garvey, Milan Popovic, Leon Grayfer
Summary: Granulocyte-lineage cells are important innate immune effectors in all vertebrates, with conspicuous secretory granules. Different environmental and physiological pressures have shaped the biology of granulocytes in different vertebrate classes. For amphibians, their unique granulocyte biologies satisfy many antimicrobial needs due to their pathogen-rich aquatic environments.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Izabela Sieminska, Ewa Poljanska, Jarek Baran
Summary: Colorectal cancer is a common malignancy worldwide, with both genetic predispositions and environmental factors playing significant roles in its development. While surgery remains a basic treatment option, additional methods such as chemotherapy and targeted immunotherapy can improve survival rates. Understanding the interactions between tumor and different types of cells, including granulocytes, is crucial for enhancing treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jiram Torres-Ruiz, Beatriz Alcala-Carmona, Ricardo Alejandre-Aguilar, Diana Gomez-Martin
Summary: Skeletal muscle is responsible for movement and has a significant regeneration capacity due to the interaction between myoblasts and immune cells. Neutrophils play a crucial role in muscle damage and inflammation, but their overactivation can hinder muscle repair. In chronic muscle diseases like idiopathic inflammatory myopathies (IIM), neutrophils serve as biomarkers of disease activity and are associated with clinical features like interstitial lung disease (ILD) and cancer. Low density granulocytes (LDG) and neutrophil extracellular traps (NETs) are also involved in disease activity and clinical features of IIM.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Wenjie Luo, Wenhui Qu, Li Gan
Summary: Decoding cellular changes in Alzheimer's disease through large cohorts with defined clinical stages is critical for understanding the diverse trajectories of AD progression. In this issue of Cell, five studies have utilized single-nuclei RNA sequencing (snRNA-seq) and single-nuclei ATAC sequencing (snATAC-seq) at an unprecedented scale, shedding light on cell-type-specific mechanisms underlying the progression of AD pathogenesis.
Article
Rheumatology
Yudong Liu, Shulan Zhang, Chang-sheng Xia, Jiali Chen, Chunhong Fan
Summary: The study found that the levels of G-CSF are closely related to disease activity in AOSD patients, indicating its potential involvement in the pathogenesis of AOSD. Targeting G-CSF may have therapeutic potential for AOSD, and incorporating circulating G-CSF levels into the clinical assessment system could help monitor disease activity.
JOURNAL OF RHEUMATOLOGY
(2021)
Review
Immunology
Michele Fresneda Alarcon, Zoe McLaren, Helen Louise Wright
Summary: Dysregulated neutrophil activation plays a significant role in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, contributing to inflammation and autoantibody production in both autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Sergi Masgrau-Alsina, Lou Martha Wackerbarth, Dae-sik Lim, Markus Sperandio
Summary: This study identifies MST1 as a critical regulator of neutrophil homeostasis and mobilization from the bone marrow, shedding light on its complex role in regulating innate immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Marion Vanharen, Isabelle Durocher, Abdelaziz Saafane, Denis Girard
Summary: This study found that different nanoparticles can alter the apoptosis rates of neutrophils and eosinophils differently, with gender playing a role in the effects. Factors like PAMAM dendrimers and ZnO were found to influence neutrophil apoptosis, while ZnO, Pt, and Pd were influential in eosinophil apoptosis, with variations between men and women.
Review
Immunology
Gustaf Wigerblad, Mariana J. Kaplan
Summary: Systemic autoimmune diseases occur when the immune system fails to recognize self from non-self, resulting in significant morbidity and mortality. Neutrophils, especially the neutrophil extracellular traps they release, play a crucial role in the initiation and perpetuation of these diseases, leading to organ damage. Dysregulation of neutrophil cell death can alter autoantigens and trigger complex inflammatory responses. Studies have identified specific neutrophil subsets associated with systemic autoimmune disorders that contribute to vascular damage and oxidative stress. Advances in technology have enhanced our understanding of neutrophil biology and dysregulation. This review provides an overview of the roles of neutrophils in systemic autoimmune and autoinflammatory diseases and explores potential therapeutic targets.
NATURE REVIEWS IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maren M. Limberg, Tobias Weihrauch, Natalie Gray, Nancy Ernst, Karin Hartmann, Ulrike Raap
Summary: Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by circulating autoantibodies against BP180 and BP230 proteins. In addition to autoantibodies, effector cells and cell-mediated immunity play important roles in BP pathogenesis. This review aims to summarize the current understanding of eosinophils, basophils, and neutrophils in BP.
Article
Critical Care Medicine
Angelica Tiotiu, Yusef Badi, Nazanin Zounemat Kermani, Marek Sanak, Johan Kolmert, Craig E. Wheelock, Philip M. Hansbro, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Yike Guo, Sharon Mumby, Ian M. Adcock, Kian Fan Chung
Summary: By analyzing gene signatures of MC activation, we can identify phenotypes of severe asthma and indicate that MCs can have distinct transcriptional phenotypes associated with specific clinical phenotypes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Allergy
Yudong Liu, Mariana J. Kaplan
Summary: Neutrophils contribute to the initiation, promotion, and perpetuation of immune dysregulation in systemic rheumatic diseases, making them potential targets for therapeutic interventions to improve clinical outcomes.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Article
Immunology
Layla A. Al-Kharashi, Saleh A. Alqarni, Sheikh F. Ahmad, Naif O. Al-Harbi, Sary Alsanea, Khalid E. Ibrahim, Mohammad M. Algahtani, Khalid Alhazzani, Gamal A. Shazly, Mohammad M. Al-Harbi, Ahmed Nadeem
Summary: Asthma is a complex and heterogeneous disease influenced by various molecular mechanisms, including the presence of antioxidant and oxidant enzymes in immune cells. The interaction between epithelial cells and immune cells plays a crucial role in the pathogenesis of asthma. The oxidant-antioxidant balance is important in the chronic phase of the disease. Genetic variability in immune cells may affect the development of airway inflammation, and different mouse strains show different responses to allergens. This study found that C57BL/6 mice had a better antioxidant system and developed mostly eosinophilic airway inflammation, while BALB/c mice developed mixed granulocytic airway inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Petter Jaremo, Marie Eriksson-Franzen, Micha Milovanovic
JOURNAL OF TRANSLATIONAL MEDICINE
(2015)
Article
Medical Laboratory Technology
Micha Milovanovic, Kristoffer Eriksson, Bengt Winblad, Staffan Nilsson, Tomas L. Lindahl, Claes Post, Petter Jaremo
CLINICAL BIOCHEMISTRY
(2014)
Article
Medicine, General & Internal
P. Jaremo, O. Nilsson
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2008)
Letter
Cardiac & Cardiovascular Systems
M. Milovanovic, E. Fransson, C. Hallert, P. Jaremo
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2010)
Letter
Medicine, General & Internal
P. Jaremo, M. Milovanovic, S. Nilsson, C. Buller, C. Post, B. Winblad
JOURNAL OF INTERNAL MEDICINE
(2011)
Article
Cell Biology
P. Jaremo, M. Milovanovic, C. Buller, S. Nilsson, B. Winblad
Article
Cell Biology
P. Jaremo, M. Eriksson, T. L. Lindahl, S. Nilsson, M. Milovanovic
Article
Medicine, Research & Experimental
Petter Jaremo, Micha Milovanovic, Caroline Buller, Staffan Nilsson, Bengt Winblad
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2013)
Letter
Hematology
P. Jaremo, M. Milovanovic, T. L. Lindahl
THROMBOSIS RESEARCH
(2009)
Article
Cardiac & Cardiovascular Systems
P. Jaremo, M. Milovanovic, T. L. Lindahl, A. Richter
JOURNAL OF CARDIOVASCULAR MEDICINE
(2008)
Letter
Hematology
P. Jaremo, C. Starkhammar, A. Lundstrom, T. L. Lindahl, A. Richter
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2007)
Letter
Hematology
P Järemo, M Milovanovic, A Richter
THROMBOSIS AND HAEMOSTASIS
(2005)
Article
Cell Biology
M Milovanovic, SG Fransson, A Richter, P Järemo
Article
Medical Laboratory Technology
A Milovanovic, E Nilsson, P Järemo
CLINICA CHIMICA ACTA
(2004)