Article
Hematology
Maurits R. Hollander, Matthijs F. Jansen, Stefan P. Schumacher, Wijnand J. Stuijfzand, Maarten A. H. van Leeuwen, Peter M. van de Ven, Anton J. Horrevoets, Alex Nap, Paul Knaapen, Niels van Royen
Summary: This study found a significant correlation between coronary and palmar collateral flow indexes, implying collateral coherence between vascular beds in humans. Coronary CFI was significantly correlated with palmar CFI and duration of angina pectoris, and inversely correlated with peripheral artery disease and systolic blood pressure.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cell Biology
Ryan M. McEnaney, Dylan D. McCreary, Nolan O. Skirtich, Elizabeth A. Andraska, Ulka Sachdev, Edith Tzeng
Summary: This study suggests that deconstruction of the extracellular matrix is crucial for the remodeling of smaller arteries into effective collaterals during arteriogenesis. The research also found that the development of collateral arteries involves the redistribution of existing elastic fibers rather than the formation of new ones.
Article
Medicine, General & Internal
Yasemin Dogan, Yucel Yilmaz, Saban Kelesoglu, Bekir Calapkorur, Salim Neselioglu, Ozcan Erel, Nihat Kalay
Summary: The aim of this study was to investigate the relationship between thiol, the main component of the antioxidant system, and coronary collateral circulation (CCC). The results showed that patients with stable coronary artery disease (sCAD) who developed poor CCC had lower levels of native thiol, total thiol, and disulfide compared to those with good CCC. Additionally, DM, total thiol, and disulfide were identified as independent predictors of poor CCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Feng Du, Wei Zhang, Hua Mao, Yanli Guo, Meiqin Guo, Yuming Lu, Min Chen, Zhongxin Sha
Summary: External counterpulsation combined with exercise therapy can reduce levels of moesin antibody, Angptl 2, Angptl 3, and miR-34a while increasing HIF-1 alpha levels, thereby promoting the establishment of occluded coronary collateral circulation.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Yahui Zhang, Ziqi Chen, Zhouming Mai, Wenjuan Zhou, Hui Wang, Xiaodong Zhang, Wenbin Wei, Jianhang Du, Guifu Wu
Summary: Enhanced external counterpulsation results in varied responses of vascular and blood flow characteristics in carotid and peripheral arteries, with more significant effects observed in the carotid arteries. Beneficial effects in terms of inner diameter, blood flow velocity, resistance index, and flow rate after 45 min-EECP were specifically shown in patients with CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Chunwei Liu, Fan Yang, Yuecheng Hu, Jingxia Zhang, Ximing Li, Zhigang Guo, Yin Liu, Hongliang Cong
Summary: The study identified ECG features associated with acute left main artery (LM) occlusion and explored their relationship with collateral circulation, providing guidance for the administration of early reperfusion. The combination of specific STE criteria showed high specificity and moderate sensitivity in predicting LM occlusion, with the addition of fascicular block criteria further improving specificity but reducing sensitivity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Marija T. Petrovic, Ana Djordjevic-Dikic, Vojislav Giga, Nikola Boskovic, Vladan Vukcevic, Vladimir Cvetic, Ana Mladenovic, Oliver Radmili, Zeljko Markovic, Milan Dobric, Srdjan Aleksandric, Milorad Tesic, Stefan Juricic, Biljana Nedeljkovic Beleslin, Sinisa Stojkovic, Miodrag C. Ostojic, Branko Beleslin, Eugenio Picano
Summary: The study on heparin plus exercise in patients with coronary artery disease found that this treatment method significantly improved angina symptoms, myocardial ischemia, and promoted collateral formation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Endocrinology & Metabolism
Xiaoyi Zou, Ming Chen, Limin Sun, Qiang Tan
Summary: This study aimed to explore the relationship between hyperinsulinemia and coronary collateral circulation in patients with chronic total coronary occlusion. The results showed that hyperinsulinemia is a valuable predictor of poor collateral formation in patients with chronic total coronary occlusion.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Cardiac & Cardiovascular Systems
Huongrui Yang, Lixue Song, Xiang Ning, Yanyan Ma, Aiying Xue, Hongbing Zhao, Yimeng Du, Qinghua Lu, Zhendong Liu, Juan Wang
Summary: The study findings suggest that EECP is an effective method for treating endothelial dysfunction and improving long-term exercise tolerance in patients with coronary heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Ying Shen, Xiao Qun Wang, Yang Dai, Yi Xuan Wang, Rui Yan Zhang, Lin Lu, Feng Hua Ding, Wei Feng Shen
Summary: Coronary collateralization is impaired in patients with type 2 diabetes and occlusive coronary artery disease, leading to worse prognosis. Dyslipidemia and glycoxidative modification of lipoprotein particles contribute to endothelial dysfunction and impaired collateral vessel growth. The effect of lipid-lowering treatments on collateral formation is also discussed in this review.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yating Wang, Danyan Xu
Summary: The study found that EECP therapy is beneficial for reducing platelet aggregation in patients with coronary heart disease, especially the arachidonic acid-induced platelet aggregation ratio.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Kangbo Li, Victoria Kratzmann, Mengjun Dai, Nora Gatzke, Petra Rocic, Peter Bramlage, Olaf Grisk, Lubomir T. Lubomirov, Meike Hoffmeister, Martin A. Lauxmann, Oliver Ritter, Eva Buschmann, Michael Bader, Anja Bondke Persson, Ivo Buschmann, Philipp Hillmeister
Summary: In this study, the pleiotropic effects of an ARNi on collateral-dependent myocardial perfusion were investigated in a rat model. The results showed that ARNis significantly improved coronary collateral perfusion and exerted pro-arteriogenic effects through activation of the bradykinin receptor signaling pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Anatomy & Morphology
Sheeja Balakrishnan, Senthil B. Kumar
Summary: Coronary collaterals act as alternative blood flow in coronary heart disease, and their development is influenced by cardiovascular risk factors and serum VEGF-A levels.
Article
Computer Science, Interdisciplinary Applications
Mingyan Chen, Bao Li, Youjun Liu, Ke Xu, BoYan Mao, Liyuan Zhang, Hao Sun, Chuanqi Wen, Xue Wang, Na Li
Summary: Currently, the optimal counterpulsation frequency for the treatment of coronary heart disease and cerebral ischemic stroke by enhanced external counterpulsation (EECP) devices is still unclear. This study investigated the effects of different frequencies of EECP on the hemodynamics of coronary and cerebral arteries and found that applying one counterpulsation per cardiac cycle may provide the optimal benefit.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Elizabeth Andraska, Nolan Skirtich, Dylan McCreary, Rohan Kulkarni, Edith Tzeng, Ryan McEnaney
Summary: During arteriogenesis, early elastin degradation is initiated and mediated by local upregulation of elastolytic genes. Elastolysis appears to be simultaneously balanced by production of elastic fiber components, potentially facilitating stabilization of the internal elastic lamina. Endothelial cells play a central role in initiating arteriogenesis and begin remodeling the extracellular matrix in response to altered shear stress.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Fabian Muehlberg, Markus Kornfeld, Leonora Zange, Saeed Ghani, Annette Reichardt, Peter Reichardt, Jeanette Schulz-Menger
Summary: This study aims to assess the subclinical changes in functional and morphologic myocardial MR parameters early in the course of high-dose anthracycline treatment. The results suggest that an early increase in myocardial T2 times 48 hours after the first anthracycline treatment may predict the subsequent development of anthracycline-induced cardiomyopathy. Additionally, a decrease in native T1 times was observed regardless of the development of cardiomyopathy in high-dose anthracycline therapy.
Review
Cardiac & Cardiovascular Systems
Lilia M. M. Sierra-Galan, Niti R. R. Aggarwal, Jadranka Stojanovska, Subha V. V. Raman, Yuchi Han, Vanessa M. M. Ferreira, Katharine Thomas, Nicole Seiberlich, Purvi Parwani, Chiara Bucciarelli-Ducci, Lauren A. A. Baldassarre, Sophie Mavrogeni, Karen Ordovas, Jeanette Schulz-Menger, W. Patricia Bandettini
Summary: Women's participation in medicine, particularly in cardiovascular imaging and cardiovascular MRI (CMR), has gradually increased over the past few decades. More and more women have joined the cardiovascular imaging community to contribute their expertise. This collaborative work summarizes the challenges women in cardiovascular imaging have overcome, the positive interventions implemented to support women in CMR, and the remaining obstacles, with a specific focus on women physicians.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Obstetrics & Gynecology
Dorota Sroka, Lisa-Antonia Lorenz-Meyer, Valerie Scherfeld, Julie Thoma, Andreas Busjahn, Wolfgang Henrich, Stefan Verlohren
Summary: A retrospective study found that integrating the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio with other markers in a multi-marker regression model had better predictive performance for adverse maternal and fetal outcomes related to preeclampsia in women beyond 34 weeks of gestation.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kirsten Miriam Kerkering, Jeanette Schulz-Menger, Tobias Schaeffter, Christoph Kolbitsch
Summary: In this study, a method was proposed to achieve T1 mapping of the myocardium within 2.3 s by utilizing both cardiac motion correction and model-based T1 reconstruction. The accuracy of cardiac motion estimation and T1 estimation was demonstrated through numerical simulations, phantom experiments, and in vivo scans in healthy volunteers. The proposed approach provided faster T1 mapping with improved precision.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Bobak Heydari, Yin Ge, Panagiotis Antiochos, Sabeeh Islam, Kevin Steel, Scott Bingham, Shuaib Abdullah, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Amit R. Patel, Sujata M. Shanbhag, Afshin Farzaneh-Far, John F. Heitner, Chetan Shenoy, Steve W. Leung, Jorge A. Gonzalez, Subha V. Raman, Victor A. Ferrari, Dipan J. Shah, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
Summary: This study investigated the impact of sex on the prognostic utility, invasive revascularization, and costs of stress perfusion CMR for suspected CVD. The findings showed that women with normal CMR had a lower rate of cardiovascular events compared to men, while women with abnormal CMR had a higher risk of cardiovascular events. Additionally, women had lower rates of invasive coronary angiography and associated costs following CMR.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Stephanie Wiesemann, Ralf Felix Trauzeddel, Ahmed Musa, Richard Hickstein, Thomas Mayr, Florian von Knobelsdorff-Brenkenhoff, Emilie Bollache, Michael Markl, Jeanette Schulz-Menger
Summary: Non-invasive assessment of aortic hemodynamics using 4D flow MRI provides new information on blood flow patterns and wall shear stress. This study investigates changes in aortic hemodynamics in patients with aortic valve stenosis and/or bicuspid aortic valves after aortic valve replacement.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Maximilian Fenski, Leo Dyke Krueger, Jeanette Schulz-Menger
Summary: Cardiovascular magnetic resonance (CMR) is not only valuable for diagnosis, but also increasingly important for therapeutic decision making and prevention of sudden cardiac death. This review discusses the role of CMR in ventricular arrhythmias, focusing on dilated, hypertrophic, and arrhythmogenic cardiomyopathy, as well as post-myocardial infarction patients in the chronic stage. It also presents relevant MRI techniques, protocols, expected study results, and knowledge gaps.
AKTUELLE KARDIOLOGIE
(2023)
Article
Computer Science, Interdisciplinary Applications
Thomas Hadler, Clemens Ammann, Jens Wetzl, Darian Viezzer, Jan Groeschel, Maximilian Fenski, Endri Abazi, Steffen Lange, Anja Hennemuth, Jeanette Schulz-Menger
Summary: This study developed software called Lazy Luna for the quantitative evaluation of cardiovascular magnetic resonance imaging. The software allows for comparing annotated images from artificial intelligence and clinicians, ensuring accurate metric calculations. It provides a graphical user interface for non-programmers and enables the tracing of differences in segmentation results among readers to identify the origins of these differences. The software can be extended to new application cases.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. Blaszczyk, S. Hellwig, H. Saad, R. Ganeshan, H. Stengl, C. H. Nolte, J. B. Fiebach, M. Endres, J. Kuhnt, J. Groeschel, J. Schulz-Menger, J. F. Scheitz
Summary: More than one-third of patients with acute ischemic stroke show evidence of focal myocardial fibrosis on CMR, accompanied by diffuse myocardial changes and reduced myocardial deformation. Further studies are needed to establish the impact of these findings on long-term prognosis after acute ischemic stroke.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Rolf, Ingo Eitel, Mirja Neizel-Wittke, Ulf K. Radunski, Peter Bernhardt, Florian von Knobelsdorff, Florian Andre, Eike Nagel, Jeanette Schulz-Menger, Sebastian Kelle
Summary: The aim of this curriculum is to provide further education for cardiologists in the field of cardiac magnetic resonance imaging (C-MRI) in order to achieve expert certification. It covers the necessary knowledge and skills for cardiologists to accurately assess, perform, and interpret C-MRI examinations in a wide range of cardiovascular diseases. The curriculum also includes the management of C-MRI laboratories and the ability to conduct scientific C-MRI examinations at a high level. The certification process follows the recommendations of reputable European societies for harmonizing education and facilitating exchange in Europe.
Review
Cardiac & Cardiovascular Systems
Florian von Knobelsdorff-Brenkenhoff, Jeanette Schulz-Menger
Summary: This study summarizes the current evidence and role of cardiovascular magnetic resonance (CMR) in the guidelines of the European Society of Cardiology (ESC). It found that 70.4% of the guidelines contain relevant text passages regarding CMR, with 92 specific recommendations regarding its use. Most of the recommendations have level C evidence and cover various aspects of CMR applications.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Bobby Heydari, Yin Ge, Panagiotis Antiochos, Sabeeh Islam, Kevin E. Steel, Scott E. Bingham, Shuaib Abdullah, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Amit R. Patel, Sujata Madhukar Shanbhag, Afshin Farzaneh-Far, John Heitner, Chetan Shenoy, Steven Leung, Jorge A. Gonzalez, Subha V. Raman, Victor A. Ferrari, Dipan J. Shah, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Sabeeh Islam, Bobby Heydari, Yin Ge, Panagiotis Antiochos, Kevin E. Steel, Scott E. Bingham, Shuaib Abdullah, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Amit R. Patel, Sujata Madhukar Shanbhag, Afshin Farzaneh-Far, John Heitner, Chetan Shenoy, Steve Leung, Jorge A. Gonzalez, Subha V. Raman, Victor A. Ferrari, Jeanette Schulz-Menger, Orlando P. Simonetti, Matthias Stuber, Raymond Y. Kwong
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Saadia Qazi, Yin Ge, Krishna Patel, Panagiotis Antiochos, Sabeeh Islam, Ryan B. Longmore, Bobby Heydari, Scott E. Bingham, J. Ronald Mikolich, Andrew E. Arai, W. Patricia Bandettini, Sujata Madhukar Shanbhag, Amit R. Patel, Afshin Farzaneh-Far, John Heitner, Chetan Shenoy, Steve Leung, Jorge A. Gonzalez, Dipan J. Shah, Subha V. Raman, Victor A. Ferrari, Jeanette Schulz-Menger, Matthias Stuber, Orlando P. Simonetti, Raymond Y. Kwong
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Vanessa M. Ferreira, Sven Plein, Timothy C. Wong, Qian Tao, Zahra Raisi-Estabragh, Supriya S. Jain, Yuchi Han, Vineeta Ojha, David A. Bluemke, Kate Hanneman, Jonathan Weinsaft, Mahesh K. Vidula, Ntobeko A. B. Ntusi, Jeanette Schulz-Menger, Jiwon Kim
Summary: Coronavirus disease 2019 (COVID-19) is a global pandemic that has affected nearly 600 million people worldwide. While primarily a respiratory illness, COVID-19 can also cause cardiac injury. Cardiovascular magnetic resonance (CMR) imaging can provide insights into the pattern and degree of cardiac injury. The reported prevalence of myocardial involvement among COVID-19 patients evaluated with CMR ranges from 26% to 60%. Standardized methodologies in imaging and reporting would likely improve consistency between studies. The Society for Cardiovascular Magnetic Resonance (SCMR) provides recommendations for standardized CMR imaging and reporting in COVID-19 patients.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2023)