Article
Biochemistry & Molecular Biology
Martin Alcala, Victoria E. Bolado, Isabel Sanchez-Vera, Sonia Clapes, Francisco Dasi, Guillermo Saez, Esther Carrera, Fabiola Alvarez-Gallego, Mary R. Loeken, Marta Viana
Summary: Studies on rats and cell cultures have shown that obesity depletes maternal glutathione, reducing the antioxidant capacity in embryos, which can lead to malformations. Vitamin E supplementation can prevent this process and protect against birth defects.
Article
Nutrition & Dietetics
Virginia Boccardi, Giulia Poli, Roberta Cecchetti, Patrizia Bastiani, Michela Scamosci, Marta Febo, Emanuela Mazzon, Stefano Bruscoli, Stefano Brancorsini, Patrizia Mecocci
Summary: Alzheimer's disease (AD) is the leading cause of dementia globally and is a major contributor to disability in older individuals. Vitamin E levels are lower in AD patients, and inflammation and microRNAs also play significant roles in the development of AD. MiR-122 may be a modulating factor, correlating with alpha-tocopherol and inflammation molecules.
Article
Medicine, Research & Experimental
Fatemeh Mehvari, Fatemeh Imanparast, Pegah Mohaghegh, Abbas Alimoradian, Nafiseh Khansari, Behnoosh Ansari Asl, Ali Khosrowbeygi
Summary: This study investigated the relationship between serum vitamin E and selenium, paraoxonase-1 (PON1) activity, total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA), and oxidative stress index (OSI) values with the susceptibility of low density lipoprotein (LDL) to oxidative modification and the risk of coronary artery disease (CAD) in diabetic patients. The results showed that oxidative stress may be an important factor in making some diabetics more susceptible to CAD.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Francesco Violi, Cristina Nocella, Lorenzo Loffredo, Roberto Carnevale, Pasquale Pignatelli
Summary: Vitamin E possesses antioxidant and anti-inflammatory properties that have an impact on atherosclerosis and thrombus formation, but intervention trials have yielded negative results.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Alexander Vladimirovich Ivanov, Mikhail Aleksandrovich Popov, Arkady Andreevich Metelkin, Valery Vasil'evich Aleksandrin, Evgeniy Gennad'evich Agafonov, Maria Petrovna Kruglova, Ekaterina Vladimirovna Silina, Victor Aleksandrovich Stupin, Ruslan Andreevich Maslennikov, Aslan Amirkhanovich Kubatiev
Summary: Coronary artery disease (CAD) and coronary artery bypass graft (CABG) are associated with a decrease in blood glutathione (bGSH) level. This study aimed to examine the associations of bGSH with glucose and plasma aminothiols in CAD patients before CABG and in the early postoperative period. The results showed that bGSH and its redox status were lower in CAD patients at admission, and CABG had no significant effect on these parameters except for an increase in the bGSH/hemoglobin ratio. Additionally, an association was found between an increase in oxidized GSH in the blood after surgery and fasting glucose levels.
Article
Biochemistry & Molecular Biology
Rimil Guha Roy, Pravat K. Mandal, Joseph C. Maroon
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder with unknown pathogenesis, characterized by amyloid beta deposition and tau hyperphosphorylation. The presence of neurofibrillary tangles and toxic Aβ deposition in the brain confirms the diagnosis of AD. Oxidative stress is gaining attention as a potential early event that leads to Aβ deposition and tau hyperphosphorylation. This hypothesis suggests the use of antioxidants, such as glutathione enrichment, as a novel therapeutic approach.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Medicine, Research & Experimental
Aman B. Upaganlawar, Nitu L. Wankhede, Mayur B. Kale, Mohit D. Umare, Aayush Sehgal, Sukhbir Singh, Saurabh Bhatia, Ahmed Al-Harrasi, Agnieszka Najda, Renata Nurzynska-Wierdak, Simona Bungau, Tapan Behl
Summary: Epilepsy, affecting nearly 50 million people worldwide, can be caused by genetic predisposition or acquired acute insult leading to alteration of cellular and molecular mechanisms. The imbalanced state of enhanced excitatory glutamatergic and reduced inhibitory GABAergic signaling is considered to be accountable for seizures associated damage. Neurodegeneration contributing to epileptogenesis has become increasingly appreciated, with potential intervention through vitamin E therapy in managing epilepsy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Aybike Sena Ozuynuk, Aycan Fahri Erkan, Neslihan Coban, Nihan Unaltuna
Summary: This study found that genes related to oxidative stress and ferroptosis are associated with CAD risk factors in CAD patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Nutrition & Dietetics
Mina Darand, Amin Salehi-Abargouei, Mohammad Yahya Vahidi Mehrjardi, Awat Feizi, Seyed Mustafa Seyedhossaini, Gholamreza Askari
Summary: This study investigated the interaction between PON1 rs662 polymorphism and vitamin C/E intake on CAD severity and lipid profile. The results showed that R allele carriers had lower HDL-C levels and higher LDL-C levels when they had lower vitamin C intake. Vitamin C intake was also associated with the risk of high total cholesterol and low-density lipoprotein cholesterol.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Jing Zhang, Yuecheng Sun, Wentao Song, Anshan Shan
Summary: This study found that exposure to phoxim at low levels can cause bioaccumulation with neurotoxicity, oxidative stress, tissue damage, and abnormal nutrient metabolism. Vitamin E was found to alleviate phoxim-induced nephrotoxicity by inhibiting mitochondrial apoptosis.
Article
Neurosciences
Vivian Feng, Shankar Tumati, Ruoding Wang, Kritleen K. Bawa, Damien Gallagher, Nathan Herrmann, Susan Marzolini, Paul Oh, Ana Andreazza, Krista L. Lanctot
Summary: This study found that markers of late-stage lipid peroxidation are elevated in coronary artery disease patients with poor sleep and are associated with daily disturbances. However, this association is not related to other factors or with sleep quality and its factors after exercise intervention.
Article
Health Care Sciences & Services
Viktoriya S. Shramko, Eugeniia V. Striukova, Yana V. Polonskaya, Ekaterina M. Stakhneva, Marina V. Volkova, Alexey V. Kurguzov, Elena V. Kashtanova, Yuliya I. Ragino
Summary: The study identified associations of fatty acids and antioxidant enzymes in the blood of men with coronary atherosclerosis and ischemic heart disease. Changes in levels of these enzymes and a disbalance of the fatty acids profile may indicate active oxidative processes and atherosclerotic changes in the vessels.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Wei Wang, Jinyang Zheng, Hao Zhou, Qiang Liu, Li Jia, Xiuming Zhang, Dongtao Ge, Wei Shi, Yanan Sun
Summary: Overproduction of ROS and cumulative oxidative stress contribute to the degeneration of dopaminergic neurons in PD patients. Polydopamine (PDA), with its redox property, has been studied for its antioxidant enzyme mimetic activities. By co-synthesizing PDA with selenocystine, a nanocomposite (PDASeCys) with GPx-like activity was prepared. The PDASeCys nanocomposite showed better free radical scavenging efficiency and additional GPx enzymatic activity compared to PDA. In vitro and in vivo experiments demonstrated the protective effect of PDASeCys on neuronal cells and its ability to inhibit Parkinson-related symptoms in mice.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xinhao Yan, Wenjie Lin, Huan Liu, Wendan Pu, Junhong Li, Peng Wu, Jun Ding, Gaoxing Luo, Jianxiang Zhang
Summary: The OVE-based nanoprobes can effectively detect inflammation and oxidative stress, offering a highly sensitive imaging method. By combining with different fluorophores, OVE can generate luminescence systems with emission wavelengths ranging from blue to near-infrared light, providing guidance for the progression of various diseases.
Article
Biochemistry & Molecular Biology
Zahra Nadimi Shahraki, Hanie Azimi, Nasrin Ilchi, Mina Rohani Borj, Hossein Pourghadamyari, Saeedeh Mosallanejad, Kazem Abbaszadeh-Goudarzi, Amirhossein Sahebkar
Summary: CAD is a major cause of death globally, and its association with inflammation is known. Recent research shows that CTRP12 has strong anti-inflammatory effects, and this study aimed to assess its levels in relation to CAD severity.
Article
Cardiac & Cardiovascular Systems
Jose Pablo Werba, Alice Bonomi, Monica Giroli, Manuela Amato, Lorenzo Vigo, Marco Agrifoglio, Francesco Alamanni, Laura Cavallotti, Samer Kassem, Moreno Naliato, Alessandro Parolari, Eleonora Penza, Gianluca Polvani, Giulio Pompilio, Massimo Porqueddu, Maurizio Roberto, Stefano Salis, Marco Zanobini, Mauro Amato, Damiano Baldassarre, Fabrizio Veglia, Elena Tremoli
Summary: This retrospective case-control study aimed to assess the efficacy of a secondary prevention programme in reducing long-term coronary event recurrences after coronary artery bypass surgery (CABG) in a real-world setting. The study found that participating in a structured longstanding secondary prevention programme significantly lowers the risk of coronary recurrences.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alessandra Gorini, Mattia Giuliani, Camilla L'Acqua, Simone Barbieri, Erminio Sisillo, Fabrizio Veglia, Elena Tremoli
Summary: This study examines the effects of preoperative symptoms of anxiety and depression on the length of hospital stay and postoperative health-related quality of life (HRQoL) in surgical patients. The results show that anxiety symptoms predict longer hospital stays, and both anxiety and depression symptoms predict poorer HRQoL three months after surgery.
JOURNAL OF CARDIOVASCULAR NURSING
(2022)
Article
Biochemistry & Molecular Biology
Massimo R. Mannarino, Vanessa Bianconi, Bruna Gigante, Rona J. Strawbridge, Kai Savonen, Sudhir Kurl, Philippe Giral, Andries Smit, Per Eriksson, Elena Tremoli, Fabrizio Veglia, Damiano Baldassarre, Matteo Pirro
Summary: Inflammation is closely related to the risk of atherosclerotic cardiovascular disease, with the neutrophil to lymphocyte ratio (NLR) being a potential indicator. However, the study found that NLR was positively associated with cross-sectional measures of carotid intima-media thickness but not with its progression, and no significant association was found between NLR and incident vascular events.
Article
Medicine, Research & Experimental
Leonardo Sandrini, Patrizia Amadio, Alessandro Ieraci, Alessandro Malara, Jose P. Werba, Paolo M. Soprano, Alessandra Balduini, Marta Zara, Alice Bonomi, Fabrizio Veglia, Gualtiero Colombo, Maurizio Popoli, Francis S. Lee, Elena Tremoli, Silvia S. Barbieri
Summary: Depression is associated with thrombotic risk and arterial events, and its management is recommended in coronary artery disease patients. The BDNF Val66Met polymorphism, related to depression, is associated with arterial thrombosis in mice and acute myocardial infarction in humans. Finding show desipramine rescues behavioral impairments and reduces arterial thrombosis risk by normalizing norepinephrine levels in BDNFMet/Met mice, suggesting the potential use of alpha(2A)-ADR inhibitors in treating depression-associated thrombotic conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Jose P. Werba, Monica G. Giroli, Niccolo Simonelli, Lorenzo Vigo, Alessandra Gorini, Alice Bonomi, Fabrizio Veglia, Elena Tremoli
Summary: This study assessed the uptake and effectiveness of a primary cardiovascular prevention program for disadvantaged and ethnic minority communities. The program achieved positive outcomes in terms of cardiovascular risk improvement, smoking cessation, and favorable changes in diet quality, anxiety, depression, and physical activity. However, increasing global uptake requires further sensitization and awareness actions.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Chiara Pavanello, Alice Ossoli, Arianna Strazzella, Patrizia Rise, Fabrizio Veglia, Marie Lhomme, Paolo Parini, Laura Calabresi
Summary: Mutations in the LCAT gene lead to familial LCAT deficiency, resulting in reduced CE plasma levels. Carriers of two mutant LCAT alleles show significant reduction in CE plasma levels, with enrichment of saturated fatty acids observed. This study highlights the origin of CEs in apoB-containing lipoproteins in the absence of LCAT-derived CEs.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Maura Brioschi, Erica Gianazza, Daniele Andreini, Saima Mushtaq, Laura Cavallotti, Fabrizio Veglia, Calogero C. Tedesco, Gualtiero Colombo, Mauro Pepi, Gianluca Polvani, Elena Tremoli, Alessandro Parolari, Cristina Banfi
Summary: Coronary artery bypass graft (CABG) surgery is the preferred treatment for patients with complex multivessel coronary artery disease, but graft occlusion still occurs in a significant proportion. This study found that the preoperative level of mercaptoalbumin (HSA-SH) is independently associated with graft occlusion within 5 years after CABG.
Article
Cardiac & Cardiovascular Systems
Daniela Trabattoni, Marta Brambilla, Paola Canzano, Alessia Becchetti, Giovanni Teruzzi, Benedetta Porro, Susanna Fiorelli, Manuela Muratori, Calogero C. Tedesco, Fabrizio Veglia, Piero Montorsi, Antonio L. Bartorelli, Elena Tremoli, Marina Camera
Summary: This study investigates platelet activation, prothrombotic phenotype, and oxidative stress status of migraineurs with patent foramen ovale (PFO) before and after PFO closure. The results show that migraineurs with PFO display an increased prothrombotic phenotype and altered oxidative stress status. This phenotype is more controlled by P2Y(12) blockade and can be reversed after PFO closure.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, General & Internal
Oreste Lanza, Nicola Cosentino, Claudia Lucci, Marta Resta, Mara Rubino, Valentina Milazzo, Monica De Metrio, Filippo Trombara, Jeness Campodonico, Jose Pablo Werba, Alice Bonomi, Giancarlo Marenzi
Summary: Prior statin therapy is associated with a better in-hospital clinical outcome in patients with STEMI undergoing primary PCI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Marta Brambilla, Paola Canzano, Patrizia Della Valle, Alessia Becchetti, Maria Conti, Mariangela Alberti, Arianna Galotta, Maria Luisa Biondi, Paola Adele Lonati, Fabrizio Veglia, Alice Bonomi, Nicola Cosentino, Pier Luigi Meroni, Gian Vincenzo Zuccotti, Armando D'Angelo, Marina Camera
Summary: This study evaluated the impact of four COVID-19 vaccines on platelet activation, coagulation, and inflammation. It found that vaccination did not induce platelet activation and microvesicle release. Although there were minor changes in clotting activation and endothelial function, these could potentially explain the rare venous thromboembolic complications of COVID-19 vaccination at a population level.
THROMBOSIS RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Lena Tschiderer, Lisa Seekircher, Raffaele Izzo, Costantino V. Mancusi, Maria Manzi, Damiano Baldassarre, Mauro Amato, Elena Tremoli, Fabrizio Veglia, Tomi-Pekka Tuomainen, Jussi Kauhanen, Ari Voutilainen, Bernhard Iglseder, Lars Lind, Tatjana Rundek, Moise Desvarieux, Akihiko Kato, Eric de Groot, Guelay Asci, Ercan Ok, Stefan Agewall, Joline W. J. D. Beulens, Christopher C. Byrne, Philip C. Calder, Hertzel Gerstein, Paolo Gresele, Gerhard Klingenschmid, Michiaki H. Nagai, Michael Olsen, Grace S. Parraga, Maya Safarova, Naveed Sattar, Michael Skilton, Coen D. A. Stehouwer, Heiko A. Uthoff, Michiel A. van Agtmael, Amber A. van der Heijden, Dorota Zozulinska-Ziolkiewicz, Hyun-Woong Park, Moo-Sik Lee, Jang-Ho Bae, Oscar F. Beloqui, Manuel Landecho, Matthieu Plichart, Pierre Ducimetiere, Jean Philippe Empana, Lena Bokemark, Goeran Bergstroem, Caroline Schmidt, Samuela Castelnuovo, Laura D. Calabresi, Giuseppe Norata, Liliana Grigore, Alberico Catapano, Dong Zhao, Miao Wang, Jing Liu, M. Arfan Ikram, Maryam L. Kavousi, Michiel J. Bots, Michael W. Sweeting, Matthias Lorenz, Peter Willeit
Summary: This study conducted a meta-analysis of individual participant data from 20 prospective studies and found that common carotid artery intima-media thickness (CCA-IMT) is associated with the risk of developing carotid plaque, independent of traditional cardiovascular risk factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Buamina Maitusong, Federica J. Laguzzi, Rona Strawbridge, Damiano Baldassarre, Fabrizio E. Veglia, Steve Humphries, Kai Savonen, Sudhir Kurl, Matteo J. Pirro, Andries Smit, Philippe Giral, Angela Silveira, Elena Tremoli, Anders Hamsten, Ulf de Faire, Bruna Gigante, Karin Leander, IMPROVE Study Grp
Summary: The study found that certain genetic variants may modify the effect of smoking on carotid intima-media thickness, increasing the risk of atherosclerosis.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Cecilia Vitali, Chiara Pavanello, Marta Turri, Sissel Lund-Katz, Michael C. Phillips, Alberico Luigi Catapano, Andrea Baragetti, Giuseppe Danilo Norata, Fabrizio Veglia, Laura Calabresi
Summary: The present study investigated the ability of different isoforms of apoE to promote LCAT-mediated cholesterol esterification, and found that apoE2 isoform is associated with a higher LCAT-mediated cholesterol esterification.
Article
Cardiac & Cardiovascular Systems
Nicola Cosentino, Giancarlo Marenzi, Manuela Muratori, Damiano Magri, Gaia Cattadori, Piergiuseppe Agostoni
Summary: Fluid retention is a significant factor in determining symptoms and prognosis in heart failure patients. Congestion is a critical target for therapeutic intervention, with diuretic optimization being the first strategy. If diuretic therapy fails, renal replacement therapy becomes the only alternative for fluid removal and restoring diuretic responsiveness. The complex pathophysiology of fluid balance involves the heart, kidney, and lung, emphasizing the importance of considering their interactions in targeting fluid overload in heart failure patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Giancarlo Marenzi, Nicola Cosentino, Marta Resta, Claudia Lucci, Alice Bonomi, Filippo Trombara, Michele Della Rocca, Paolo Poggio, Olivia Leoni, Francesco Bortolan, Stefano Savonitto, Piergiuseppe Agostoni
Summary: Through the investigation of hospitalized AMI patients, we found that the use of PCI is associated with lower in-hospital and 1-year mortality in patients aged 75 years and above.
JOURNAL OF CLINICAL MEDICINE
(2023)