期刊
EUROPEAN JOURNAL OF CELL BIOLOGY
卷 93, 期 7, 页码 267-277出版社
ELSEVIER GMBH
DOI: 10.1016/j.ejcb.2014.05.002
关键词
Vps1; Dynamin-like protein; Tubulation; Scission; Vacuole; Peroxisome; Endocytosis; Intracellular trafficking
类别
资金
- National Scientific Foundation [0923024]
- Missouri State University
Dynamin is a GTPase mechanoenzyme most noted for its role in vesicle scission during endocytosis, and belongs to the dynamin family proteins. The dynamin family consists of classical dynamins and dynamin-like proteins (DLPs). Due to structural and functional similarities DLPs are thought to carry out membrane tubulation and scission in a similar manner to dynamin. Here, we discuss the newly emerging roles for DLPs, which include vacuole fission and fusion, peroxisome maintenance, endocytosis and intracellular trafficking. Specific focus is given to the role of DLPs in the budding yeast Saccharomyces cerevisiae because the diverse function of DLPs has been well characterized in this organism. Recent insights into DLPs may provide a better understanding of mammalian dynamin and its associated diseases. (C) 2014 Elsevier GmbH. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据