Review
Immunology
Jianli Zhou, Qiao Zhang, Yuzhen Zhao, Yuchen Song, Yanan Leng, Moxian Chen, Shaoming Zhou, Zhaoxia Wang
Summary: Inflammatory bowel disease (IBD) is a group of chronic diseases including Crohn's disease and ulcerative colitis, which have a global impact on both children and adults. The burden of IBD is increasing worldwide, and the costs associated with it are high. The pathogenesis of IBD is still unclear, but is believed to be related to environmental factors, gut microbiota, immune imbalance, and genetic susceptibility. This article reviews the research progress on alternative splicing events, splicing factors, and splicing mutations associated with IBD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Peter Bossuyt, Valerie Pittet, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Naila Arebi, Krisztina Gecse
Summary: This study aimed to develop a core outcome set for real-world studies in adult patients with inflammatory bowel disease (IBD). Candidate outcomes and outcome measures were identified through a systematic review and a modified Delphi consensus process. The international panel agreed on the final core outcome set, which will facilitate the synthesis and generation of real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2023)
Editorial Material
Gastroenterology & Hepatology
Catherine Le Berre, Laurent Peyrin-Biroulet
Summary: The SPIRIT consensus group has agreed that the ultimate therapeutic goal in both CD and UC is to prevent disease impact on patients' lives, including health-related quality of life, disability, and fecal incontinence, as well as prevent complications in the short and long term, such as bowel damage, surgeries, disease extension, extraintestinal manifestations, and dysplasia or cancer. These recommendations will need to be validated in clinical studies before being implemented in disease-modification trials.
Article
Multidisciplinary Sciences
Ryan W. Gan, Diana Sun, Amanda R. Tatro, Shirley Cohen-Mekelburg, Wyndy L. Wiitala, Ji Zhu, Akbar K. Waljee
Summary: This study replicated a machine-learning model's ability to predict acute exacerbations of inflammatory bowel disease (IBD) in a nationally representative cohort, with the random forest model outperforming the logistic regression model.
Review
Medicine, General & Internal
Elisabetta Antonelli, Gabrio Bassotti, Marta Tramontana, Katharina Hansel, Luca Stingeni, Sandro Ardizzone, Giovanni Genovese, Angelo Valerio Marzano, Giovanni Maconi
Summary: This review summarizes the dermatologic manifestations occurring in patients with inflammatory bowel diseases, including specific manifestations, cutaneous disorders associated with IBDs, reactive mucocutaneous manifestations of IBDs, mucocutaneous conditions secondary to treatment, and manifestations due to nutritional malabsorption. An accurate dermatological examination is crucial in all IBD patients, especially in candidates to biologic therapies where drug-induced cutaneous reactions may be clinically relevant.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Anastasia Katsoula, Georgios Axiaris, Afroditi Mpitouli, Maria Palatianou, Angeliki Christidou, Nikolaos Dimitriadis, Andreas Nakos, Ploutarchos Pastras, Panagiotis Kourkoulis, Pantelis Karatzas, Miltiadis Moutzoukis, Charalampos Zlatinoudis, Athanasios Philippidis, Anastasia Kourikou, Georgios Kokkotis, Antonios Gklavas, Angeliki Machaira, Aikaterini Mantaka, Persefoni Talimtzi, Evaggelia Anagnostopoulou, Ioannis E. Koutroubakis, Ioannis Papaconstantinou, Georgios Bamias, Spilios Manolakopoulos, Nicoletta Mathou, Konstantina Paraskeva, Andreas Protopappas, Eftychia Tsironi, Konstantinos H. H. Katsanos, Dimitrios K. K. Christodoulou, Georgios Papatheodoridis, Georgios Michalopoulos, Georgios Theocharis, Christos Triantos, Ioannis Pachiadakis, Konstantinos Soufleris, Nikolaos Viazis, Gerassimos J. Mantzaris, Georgios Tribonias, Maria Tzouvala, Angeliki Theodoropoulou, Konstantinos Karmiris, Evanthia Zampeli, Spyridon Michopoulos, Anna-Bettina Haidich, Olga Giouleme
Summary: The aim of this study was to validate the content of IBD-Disk in a Greek cohort of IBD patients. The results showed good correlation and consistency between the scores of IBD-Disk and IBD-DI at baseline and follow-up. Female gender and extraintestinal manifestations were significantly associated with a higher IBD-Disk total score. Therefore, the Greek version of IBD-Disk was proven to be a reliable and valid tool for assessing IBD-related disability.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Jee Hyun Kim, Chang-Myung Oh, Jun Hwan Yoo
Summary: Obesity is common in patients with inflammatory bowel disease (IBD), especially in newly developed countries. It has been suggested that 15%-40% of IBD patients are obese, and obesity may play a role in the development of IBD. Dysfunction of mesenteric fat can worsen the inflammation in Crohn's disease and lead to the formation of strictures or fistulas. Additionally, obesity can affect the course of the disease and the response to treatment in IBD. As a result, obesity control is being proposed as a novel management approach for IBD, and this review aims to discuss the impact of obesity on IBD treatment outcomes and the current status of pharmacologic or surgical anti-obesity treatments in IBD patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Vu Q. Nguyen, Fabiano Celio, Maithili Chitnavis, Mohammad Shakhatreh, Jeffry Katz, Fabio Cominelli, Amitabh Chak, Paul Yeaton
Summary: This study examined the role of EUS in distinguishing between Crohn's disease and ulcerative colitis, finding that it can be used to diagnose active and inactive disease by measuring colon wall layer thickness and assessing transmural disease activity.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Rheumatology
Javier Martinez-Lopez, Martin Kerick, Lourdes Ortiz-Fernandez, Marialbert Acosta-Herrera, Ana Marquez, Javier Martin
Summary: This study reports the association between rs76428106-C of the FLT3 gene and systemic sclerosis (SSc). The findings suggest that this low frequency polymorphism may play a role in the susceptibility to SSc and its different subphenotypes.
Article
Mathematical & Computational Biology
Alexei C. Ionan, Miya Paterniti, Devan Mehrotra, John Scott, Bohdana Ratitch, Sylva Collins, Shanti Gomatam, Lei Nie, Kaspar Rufibach, Frank Bretz
Summary: This article discusses the experience of implementing the estimand framework, including its use, impact on drug/biologic development, common challenges and ways to address them, as well as keys to productive interdisciplinary collaboration.
STATISTICS IN BIOPHARMACEUTICAL RESEARCH
(2023)
Article
Rheumatology
David Gonzalez-Serna, Chenfu Shi, Martin Kerick, Jenny Hankinson, James Ding, Amanda McGovern, Mauro Tutino, Gonzalo Villanueva-Martin, Norberto Ortego-Centeno, Jose Luis Callejas, Javier Martin, Gisela Orozco
Summary: This study used functional genomics to understand the genetic basis and disease mechanisms of systemic sclerosis (SSc). By analyzing gene expression and interactions in immune cells from SSc patients and healthy controls, 39 new potential target genes and 7 known SSc-associated genes were identified. The study also found cell type-specific interactions and potential drug targets for SSc treatment.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Genetics & Heredity
Jacqueline Moltzau Anderson, Tim Lachnit, Simone Lipinski, Maren Falk-Paulsen, Philip Rosenstiel
Summary: Viruses and bacteriophages have an impact on intestinal barrier function and bacterial communities. Changes in the fecal viral communities may be involved in human diseases such as inflammatory bowel disease. Antibiotics significantly affect the fecal viral communities. The composition of viral and bacterial communities are highly correlated, which may contribute to prolonged dysregulation of the bacterial composition.
G3-GENES GENOMES GENETICS
(2023)
Article
Pharmacology & Pharmacy
Cornelia Dunger-Baldauf, Rob Hemmings, Frank Bretz, Byron Jones, Anja Schiel, Chris Holmes
Summary: To support informed decision making, a new class of study designs called FACTIVE is proposed, which enables flexible augmentation of confirmatory randomized controlled trials with concurrent and close-to-real-world elements. These designs facilitate estimation of specific treatment effects in the confirmatory part and complementary treatment effects in a real-world part, generating high-quality data for decision making.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Mathematical & Computational Biology
Frank Bretz, Joel B. Greenhouse
Summary: The development of new drugs has undergone significant changes in the past decade, with advances in technology enabling scientists to generate large amounts of complex data at a faster pace. This has created a demand for innovative quantitative solutions and tools, making the role of statistical scientists in collaborative research more important than ever.
STATISTICS IN BIOPHARMACEUTICAL RESEARCH
(2023)
Article
Cell & Tissue Engineering
Sabine Kobold, Nils Bultjer, Glyn Stacey, Sabine C. Mueller, Andreas Kurtz, Nancy Mah
Summary: The Human Pluripotent Stem Cell Registry has created a database of clinical studies utilizing human pluripotent stem cells (PSCs) for cell therapies. A shift towards using human induced pluripotent stem cells (iPSCs) over human embryonic stem cells has been observed since 2018. However, allogeneic approaches are dominating over personalized medicines when it comes to utilizing iPSCs. Most treatments focus on ophthalmopathies, with genetically modified iPSCs used to produce tailored cells. One key observation is the lack of standardization and transparency in regards to the PSC lines used, characterization of the PSC-derived cells, and the preclinical models and assays employed to demonstrate efficacy and safety.
Article
Biology
Willi Maurer, Frank Bretz, Xiaolei Xun
Summary: This article discusses the problem of testing multiple null hypotheses in a real-life context where different losses may occur due to incorrect decisions. The authors argue that traditional methods for controlling Type I error rate may be too restrictive and suggest using loss functions and decision-theoretic approach to control familywise expected loss instead. They illustrate their methods using the problem of establishing efficacy of a new medicinal treatment in non-overlapping subgroups of patients.
Editorial Material
Biology
Willi Maurer, Frank Bretz, Xiaolei Xun
Article
Ecology
Svenja Starke, Danielle M. M. Harris, Johannes Zimmermann, Sven Schuchardt, Mhmd Oumari, Derk Frank, Corinna Bang, Philip Rosenstiel, Stefan Schreiber, Norbert Frey, Andre Franke, Konrad Aden, Silvio Waschina
Summary: Amino acid auxotrophies are prevalent in the human gut microbiome, with tryptophan auxotrophy being the most common. Auxotrophy frequencies are higher for amino acids essential to the human host. The presence of auxotrophies is related to microbiome diversity and stability.
Article
Multidisciplinary Sciences
Emily Wood, Hinrich Schulenburg, Philip Rosenstiel, Tobias Bergmiller, Dyan Ankrett, Ivana Gudelj, Robert Beardmore
Summary: The mechanism by which antibiotics regulate population decline in bacteria during periods of low nutrient availability is poorly understood. The study finds that ribosome-binding antibiotics can prolong the lifespan of bacteria, while resistance mechanisms that increase growth rates can be detrimental during nutrient stresses. Ribosomal protection acts as a Trojan horse, providing protection from antibiotics but promoting bacterial demise during nutrient stresses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Camille Chauvin, Katarina Radulovic, Olivier Boulard, Myriam Delacre, Nadine Waldschmitt, Paul Regnier, Gauthier Legris, Clement Bouchez, Mohamed-Yassine Sleimi, Philip Rosenstiel, Guillaume Darrasse-Jeze, Mathias Chamaillard, Lionel F. Poulin
Summary: The study indicates that loss of Nod2 signaling in myeloid cells aids in tissue repair of the inflamed large intestine through lysozyme secretion, which may lead to new therapeutics to limit the inflammatory and tumorigenic functions of NOD2.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Geriatrics & Gerontology
Roxana M. Pfefferkorn, Benedikt M. Mortzfeld, Christine Fink, Jakob von Frieling, Judith Bossen, Daniela Esser, Christoph Kaleta, Philip Rosenstiel, Holger Heine, Thomas Roeder
Summary: Severe protein restriction has effects on tumor growth and lifespan in a Drosophila model. Alternating periods of severe protein restriction with complete feeding can reduce tumor mass, restore gut functionality, and increase longevity. This diet also reduces chemotherapy-induced stem cell activity associated with tumor recurrence.
Meeting Abstract
Gastroenterology & Hepatology
Florian Tran, Raphael Brard, Klaus R. Flechsenhar, Konrad Aden, Philip Rosenstiel, Inoncent Agueusop, Stefan Schreiber
Meeting Abstract
Gastroenterology & Hepatology
Miriam Ecker, Olivia Coleman, Sandra Bierwirth, Adam Sorbie, Philipp Weber, Nikolai Kohler, Tim Kacprowski, Miriam Wimmer, Andreas Dunkel, Josch Pauling, Josef Ecker, Karin Kleigrewe, Jan Baumbach, Philip Rosenstiel, Katja Steiger, Moritz Jesinghaus, Klaus-Peter Janssen, Dirk Haller
