Article
Cell Biology
Huzi Xu, Meng Wang, Yinzheng Li, Mengxia Shi, Zheng Wang, Chujin Cao, Yu Hong, Bin Hu, Han Zhu, Zhi Zhao, Xiaoxin Chu, Fan Zhu, Xuan Deng, Jianliang Wu, Fenfei Zhao, Jing Guo, Yuxi Wang, Guangchang Pei, Fengming Zhu, Xiaoyan Wang, Juan Yang, Ying Yao, Rui Zeng
Summary: This study explores the role of connexin 43 (Cx43) in renal fibrosis and the release of ATP from injured renal tubular epithelial cells (TECs). The findings demonstrate that Cx43 is upregulated in TECs and its depletion reduces inflammation and fibrosis in obstructive nephropathy. The release of ATP induces macrophage pyroptosis, leading to the activation of fibroblasts and acceleration of renal fibrosis.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Avigail Ehrlich, Filippo Molica, Aurelie Hautefort, Brenda R. Kwak
Summary: This review provides an overview of the expression and function of connexins and pannexins in the lymphatic vasculature, focusing on their roles in healthy lymphatic system functions and pathological conditions. The discussion highlights their impact on intercellular communication, immune cell trafficking, and nutrient absorption, as well as their implications in lymphatic disorders and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Naina Garewal, Neetu Goyal, Shivalika Pathania, Jagdeep Kaur, Kashmir Singh
Summary: Pseudogenes, previously considered as junk or discarded genes, have been found to play important roles in gene regulation, especially in plants. However, their exact roles in gene regulation remain unresolved and require further research in order to better understand their functions.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pia C. Burboa, Mariela Puebla, Pablo S. Gaete, Walter N. Duran, Mauricio A. Lillo
Summary: Microcirculation homeostasis depends on channels permeable to ions and small molecules, and the Connexin and Pannexin large-pore channel proteins play a vital role in regulating vascular tone and intercellular communication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Christian Giaume, Christian C. Naus, Juan C. Saez, Luc Leybaert
Summary: Over the past few decades, research has shown that glial cells interact dynamically with neurons, impacting their activity and survival. Connexins and pannexins play a key role in these interactions, and understanding their function can provide insights into neuronal behavior and aid in the development of therapeutic strategies for brain diseases.
PHYSIOLOGICAL REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Daniela Baracaldo-Santamaria, Maria Gabriela Corrales-Hernandez, Maria Camila Ortiz-Vergara, Valeria Cormane-Alfaro, Ricardo-Miguel Luque-Bernal, Carlos-Alberto Calderon-Ospina, Juan-Fernando Cediel-Becerra
Summary: Cell-to-cell communication is crucial for embryonic development and dysfunction of connexins (Cxs) and pannexins (Panxs) can lead to diseases. Cxs play a pivotal role in embryogenesis and have been linked to both congenital and adult neurodegenerative diseases. Panxs, despite being structurally similar to Cxs, predominantly form channels connecting the cytoplasm to the extracellular space. Both Cxs and Panxs are involved in various stages of neuronal development in the nervous system.
Article
Biology
Giuseppe Sirago, Julian Candia, Martino V. Franchi, Fabio Sarto, Elena Monti, Luana Toniolo, Carlo Reggiani, Emiliana Giacomello, Sandra Zampieri, Lisa M. Hartnell, Giuseppe De Vito, Marco Sandri, Luigi Ferrucci, Marco V. Narici
Summary: Chronic inactivity of skeletal muscles leads to neuromuscular instability and muscle atrophy, and blocking the appearance of specific molecules can reduce the severity of muscle loss. Studies on humans and mice have shown that muscle inactivity causes changes in biomarkers and reveals potential mechanisms associated with neuromuscular disruption.
Article
Biochemistry & Molecular Biology
Egor A. Turovsky, Elena G. Varlamova, Maria Turovskaya
Summary: The study investigated the mechanisms of Ca2+ oscillation generation and regulation of the lipolysis/lipogenesis balance in white adipocytes in response to a decrease in extracellular calcium concentration. It was found that activation of connexin-43 led to ATP release from adipocytes, causing changes in gene expression related to lipolysis and a decrease in lipid droplet accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Manuel A. Riquelme, Sumin Gu, Rui Hua, Jean X. Jiang
Summary: Mechanical loading activates integrin alpha 5 and alpha V, leading to the opening of connexin 43 (Cx43) hemichannels (HCs) and release of bone anabolic factors. Inhibition of integrin alpha V affects HCs opening and disrupts PI3K/AKT signaling pathway, while integrin alpha 5 activation is dependent on PI3K/AKT activation. Dendritic alpha V is a more sensitive mechanosensor than alpha 5 in activating HCs at low fluid shear stress levels.
Article
Obstetrics & Gynecology
S. G. Sun, J. J. Guo, X. Y. Qu, X. Y. Tang, Y. Y. Lin, K. Q. Hua, J. J. Qiu
Summary: EV-LGMNP1, abundant in Ecto-ESCs and serum from ovarian EMs patients, can induce M2 macrophage polarization by upregulating LGMN expression, making it a promising biomarker for predicting ovarian EMs recurrence.
HUMAN REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Martin C. Frith
Summary: Protein fossils in genomes provide valuable insights into the ancient evolution of TEs and genomes. A recent study discovered ancient fossils in the human genome, which exhibit extreme sequence conservation and may have gene-regulatory functions.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Oncology
Mengjun Guo, Xiling Zhang
Summary: This study revealed that lncRNA MSTO2P promotes colorectal cancer progression through epigenetically silencing CDKN1A mediated by EZH2.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Cell Biology
Katia Suarez-Berumen, Henry Collins-Hooper, Anastasia Gromova, Robyn Meech, Alessandra Sacco, Phil R. Dash, Robert Mitchell, Valery Shestopalov, Thomas E. Woolley, Sakthivel Vaiyapuri, Ketan Patel, Helen P. Makarenkova
Summary: Pannexin1 plays a crucial role in skeletal muscle development and regeneration by coordinating myoblast activities. Lack of Panx1 results in impaired muscle regeneration after injury, highlighting the importance of lipid-based signaling pathways in regulating myoblast migration and fusion for tissue repair. These findings provide new insights into the mechanisms of skeletal muscle regeneration and the potential therapeutic targets for muscle injuries.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaowen Feng, Heng Li
Summary: The study introduced a more sensitive and accurate method to identify processed pseudogenes, pinpointing 40 processed pseudogenes not present in the human reference genome GRCh38 from 22 human individuals. Additionally, an overview of lineage-specific retrocopies in chimpanzee, gorilla, and orangutan genomes was provided.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Wei T. Chang, Naveena Poudyal, Daniel A. Verdugo, Francisca Pena, Jimmy Stehberg, Mauricio A. Retamal
Summary: This study aimed to test the effects of certain molecules derived from aminoglycosides on mammalian cells. It was found that KI04 is an effective inhibitor of Cx46 hemichannels, which could help in the development of future selective Cx46 inhibitors.
Article
Cell Biology
Kavya Reddy, Corey L. Cusack, Israel C. Nnah, Khoosheh Khayati, Chaitali Saqcena, Tuong B. Huynh, Scott A. Noggle, Andrea Ballabio, Radek Dobrowolski
Article
Biochemistry & Molecular Biology
Khoosheh Khayati, Henri Antikainen, Edward M. Bonder, Gregory F. Weber, Warren D. Kruger, Hieronim Jakubowski, Radek Dobrowolski
Article
Neurosciences
Jiong Zhang, Stephanie Griemsmann, Zhou Wu, Radoslaw Dobrowolski, Klaus Willecke, Martin Theis, Christian Steinhaeuser, Peter Bedner
BRAIN RESEARCH BULLETIN
(2018)
Article
Cell Biology
Israel C. Nnah, Biao Wang, Chaitali Saqcena, Gregory F. Weber, Edward M. Bonder, Dustin Bagley, Rossella De Cegli, Gennaro Napolitano, Diego L. Medina, Andrea Ballabio, Radek Dobrowolski
Article
Multidisciplinary Sciences
Benedicte Danis, Marijke van Rikxoort, Anita Kretschmann, Jiong Zhang, Patrice Godard, Lidija Andonovic, Franziska Siegel, Pitt Niehusmann, Etienne Hanon, Daniel Delev, Marec von Lehe, Rafal M. Kaminski, Alexander Pfeifer, Patrik Foerch
SCIENTIFIC REPORTS
(2016)
Article
Biology
Karina Kaczmarek-Hajek, Jiong Zhang, Robin Kopp, Antje Grosche, Bjoern Rissiek, Anika Saul, Santina Bruzzone, Tobias Engel, Tina Jooss, Anna Krautloher, Stefanie Schuster, Tim Magnus, Christine Stadelmann, Swetlana Sirko, Friedrich Koch-Nolte, Volker Eulenburg, Annette Nicke
Article
Neurosciences
Nolan B. Skop, Sweta Singh, Henri Antikainen, Chaitali Saqcena, Frances Calderon, Deborah E. Rothbard, Cheul H. Cho, Chirag D. Gandhi, Steven W. Levison, Radek Dobrowolski
Article
Neurosciences
Jihyun Kim, Alexandra A. Adams, Pradeepa Gokina, Brayan Zambrano, Jeyanthan Jayakumaran, Radek Dobrowolski, Patrice Maurel, Bryan J. Pfister, Haesun A. Kim
Article
Cell Biology
Richard A. Mariani, Shalaka Paranjpe, Radek Dobrowolski, Gregory F. Weber
MOLECULAR BIOLOGY OF THE CELL
(2020)
Article
Cell Biology
Rebekah Mahoney, Elizabeth Ochoa Thomas, Paulino Ramirez, Henry E. Miller, Adrian Beckmann, Gabrielle Zuniga, Radek Dobrowolski, Bess Frost
Review
Cell Biology
Pawel Mozolewski, Maciej Jeziorek, Christoph M. Schuster, Hilmar Bading, Bess Frost, Radek Dobrowolski
Summary: Nuclear Ca2+ signaling plays a crucial role in regulating gene expression and brain function, with deficits in this signaling pathway potentially contributing to neurodegenerative disorders and impairing neuronal autophagy. This review discusses the importance of nuclear Ca2+ signaling in neuroadaptation and neuroprotection, highlighting its potential implications for understanding and treating neurological diseases in the future.
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Brian H. Kim, Maciej Jeziorek, Hur Dolunay Kanal, Viorica Raluca Contu, Radek Dobrowolski, Steven W. Levison
Summary: Inhibiting ALK5 can reduce cell death and improve neurological function, potentially through increasing levels of autophagy markers.
Review
Cell Biology
Henri Antikainen, Monica Driscoll, Gal Haspel, Radek Dobrowolski
Article
Developmental Biology
Brian H. Kim, Mariano Guardia Clausi, Michelle J. Frondelli, Israel C. Nnah, Chaitali Saqcena, Radek Dobrowolski, Steven W. Levison
DEVELOPMENTAL NEUROSCIENCE
(2017)
Article
Cell Biology
Mohamed Kodiha, Nabila Azad, Siwei Chu, Noah Crampton, Ursula Stochaj
Summary: This study reveals that oxidative stress induces the nuclear accumulation of RanBP1 and the signaling pathways mediated by EGFR and PKA play a role in regulating RanBP1 localization during stress. RanBP1 acts as a downstream effector of these signaling routes, positioning it at the intersection of important cellular signaling circuits.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2024)