Article
Oncology
Teruaki Mizobuchi, Akihiro Nomoto, Hironobu Wada, Naoyoshi Yamamoto, Mio Nakajima, Takehiko Fujisawa, Hidemi Suzuki, Ichiro Yoshino
Summary: This study compares the outcomes of patients with GGO-dominant NSCLC treated with CIRT and segmentectomy. The results show that patients in the CIRT group are older, more likely to be male, and have lower forced vital capacity compared to the segmentectomy group. There is a significant difference in the 5-year overall survival rate, but not in the 5-year disease-specific survival rate.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Wongi Woo, Jimin Lee, Dae Hyun Jin, Jihoon Kim, Duk Hwan Moon, Sungsoo Lee
Summary: Segmentectomy for early-stage lung cancer has benefits for survival and parenchymal preservation. This study reviewed the quality of segmentectomies and their clinical impact. Anatomical segmentectomy resulted in better survival and a lower incidence of thick lung plication, even in ground-glass opacity-dominant tumors.
Article
Biochemistry & Molecular Biology
Ching-Feng Wu, Jui-Ying Fu, Ying-Sheng Li, Chi-Tsung Wen, Yung-Liang Wan, Yun-Hen Liu, Ming-Ju Hsieh, Ching-Yang Wu
Summary: This study aimed to compare treatment outcomes between anatomic and wedge resection for non-small cell lung cancer patients with small ground glass opacity (GGO) predominant lesions. Results showed that wedge resection resulted in less staple usage and blood loss during surgery, with fewer intrapulmonary lymph nodes dissected. However, there were no statistical differences in disease-free and overall survival between the two groups.
BIOMEDICAL JOURNAL
(2021)
Article
Oncology
Yaodong Zhou, Tao Yu, Yixin Zhang, Liqiang Qian, Qing Xia
Summary: The study compared operative and postoperative outcomes of simple segmentectomy and wedge resection in NSCLC patients with GGO diameter between 2 cm and 3 cm. The results showed that simple segmentectomy group had more complications, longer operative time, and slower postoperative pulmonary function recovery compared to wedge resection group, but there was no difference in recurrence free survival and overall survival between the two groups.
Review
Oncology
Yoshinori Handa, Yasuhiro Tsutani, Morihito Okada
Summary: With advancements in medical technology, the number of early-stage lung adenocarcinoma cases with GGO has been increasing. Studies have shown that HRCT findings can predict tumor invasiveness and prognosis in lung cancer patients, guiding appropriate treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Aritoshi Hattori, Takeshi Matsunaga, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki, Hisashi Saji, Shun-ichi Watanabe
Summary: The study validated the prognostic importance of ground-glass opacity component in clinical stage IA lung cancer and recommended considering it as an important parameter in the next clinical T classification.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Yukio Watanabe, Aritoshi Hattori, Shuko Nojiri, Takeshi Matsunaga, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki
Summary: This study demonstrates that a small ground-glass opacity component has a significant impact on the prognosis of patients with solid-dominant c-stage IA non-small cell lung cancer.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Oncology
Sikai Wu, Zimin Wang, Jiajing Sun, Han Wu, Zixian Jin, Sijia Ren, Bingyu Hu, William C. Cho, Chengchu Zhu, Tianxiang Chen, Jianfei Shen
Summary: The study aimed to investigate whether sublobectomy is comparable to lobectomy in elderly patients with peripheral solid-dominant NSCLC. Results showed that sublobectomy was associated with shorter operation time, but 5-year overall survival and disease-free survival did not significantly differ between the two groups. Cox regression analyses indicated that consolidation tumor ratio, visceral pleural infiltration, and smoking were independent risk factors for worse overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Sikai Wu, Zimin Wang, Jiajing Sun, Han Wu, Zixian Jin, Sijia Ren, Bingyu Hu, William C. Cho, Chengchu Zhu, Tianxiang Chen, Jianfei Shen
Summary: This study investigated whether sublobectomy was comparable to lobectomy in elderly patients (>= 75 years old) with peripheral solid-dominant and diameter <= 2 cm non-small cell lung cancer (NSCLC). The results showed that sublobectomy was associated with a shorter operation time and had equivalent survival outcomes compared to lobectomy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Hanyue Li, Yiyang Wang, Yang Chen, Chenxi Zhong, Wentao Fang
Summary: This study aims to compare the surgical outcomes and treatment results of minimally invasive segmentectomy and lobectomy for early-stage lung adenocarcinoma patients. A total of 1024 patients will be randomly assigned to either the segmentectomy or lobectomy group, collected from 19 hospitals in China. The results of this study will help determine the optimal surgical approach.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Hisashi Saji, Morihito Okada, Masahiro Tsuboi, Ryu Nakajima, Kenji Suzuki, Keiju Aokage, Tadashi Aoki, Jiro Okami, Ichiro Yoshino, Hiroyuki Ito, Norihito Okumura, Masafumi Yamaguchi, Norihiko Ikeda, Masashi Wakabayashi, Kenichi Nakamura, Haruhiko Fukuda, Shinichiro Nakamura, Tetsuya Mitsudomi, Shun-Ichi Watanabe, Hisao Asamura
Summary: This study demonstrated the benefits of segmentectomy over lobectomy in overall survival of patients with small peripheral NSCLC, suggesting that segmentectomy should be the standard surgical procedure for this population of patients.
Article
Biotechnology & Applied Microbiology
Zhigang Wu, Jie Tang, Runzhou Zhuang, Di Meng, Lichen Zhang, Chen Gu, Xiao Teng, Ziyue Zhu, Jiacong Liu, Jinghua Pang, Jian Hu, Xiayi Lv
Summary: This study reveals significant differences in the lower respiratory tract and lung microbiome between GGO and the non-malignant control group through the analysis of bronchoalveolar lavage fluid (BALF) and lung tissues. Furthermore, potential bacterial biomarkers show good performance in predicting GGO.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Haoxuan Wu, Yang Zhang, Hong Hu, Yuan Li, Xuxia Shen, Quan Liu, Shengping Wang, Haiquan Chen
Summary: Ground glass opacity (GGO) nodules may indicate early-stage lung adenocarcinoma in teenagers. A screening strategy with long intervals based on a baseline CT scan and a treatment strategy for diagnosed teenage patients are proposed.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Critical Care Medicine
Kezhong Chen, Jing Bai, Alexandre Reuben, Heng Zhao, Guannan Kang, Chunliu Zhang, Qingyi Qi, Yaping Xu, Shawna Hubert, Lianpeng Chang, Yanfang Guan, Lin Feng, Kai Zhang, Kaitai Zhang, Xin Yi, Xuefeng Xia, Shujun Cheng, Fan Yang, Jianjun Zhang, Jun Wang
Summary: Through studying the molecular and immune characteristics of GGO-associated lung nodules, it was found that compared to solid nodules, GGO-associated lung cancers have a lower tumor mutation burden, less active immune environment, lower T-cell expansion, and less frequent HLA loss of heterozygosity, which may explain their indolent clinical course.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Oncology
Jinsong Bai, Chaoqiang Deng, Fangqiu Fu, Di Li, Zelin Ma, Xiangyi Ma, Yang Zhang, Haiquan Chen
Summary: This study investigated the impact of pregnancy on ground-glass opacities (GGO) suspected for lung adenocarcinoma. The results showed that pregnancy had little influence on GGOs. Therefore, pregnancy can be safely planned during the follow-up of GGOs.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)