Article
Surgery
Brendan T. Heiden, Daniel B. Eaton Jr, Su-Hsin Chang, Yan Yan, Martin W. Schoen, Li-Shiun Chen, Nina Smock, Mayank R. Patel, Daniel Kreisel, Ruben G. Nava, Bryan F. Meyers, Benjamin D. Kozower, Varun Puri
Summary: This study explores the relationship between the duration of smoking cessation and postoperative complications for lung cancer patients undergoing surgical treatment. The findings suggest that quitting smoking at least 3 weeks before surgery is associated with reduced mortality and complications.
Article
Cardiac & Cardiovascular Systems
Mikio Okazaki, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Kota Araki, Mototsugu Watanabe, Masanori Okada, Yuho Maki, Tsuyoshi Ueno, Shinji Otani, Ryujiro Sugimoto, Hitoshi Nishikawa, Riki Okita, Makio Hayama, Hiroyuki Tao, Toshiya Fujiwara, Hidetoshi Inokawa, Yuji Hirami, Yoshifumi Sano, Motohiro Yamashita, Osamu Kawamata, Motoki Matsuura, Shinichi Toyooka
Summary: We retrospectively examined the surgical outcome and prognosis of ipsilateral anatomical resection for lung cancer after pulmonary lobectomy using a multicentre database. The 5-year overall survival rate after anatomical resection followed by ipsilateral lobectomy is comparable to that in patients who underwent anatomical resection without prior pulmonary lobectomy, but with a higher frequency of intraoperative and postoperative complications.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Steven S. Fu, Alexander J. Rothman, David M. Vock, Bruce R. Lindgren, Daniel Almirall, Abbie Begnaud, Anne C. Melzer, Kelsey L. Schertz, Mariah Branson, David Haynes, Patrick Hammett, Anne M. Joseph
Summary: Adding a referral to prescription medication therapy management (MTM) to the tobacco longitudinal care (TLC) program showed positive effects among patients eligible for lung cancer screening (LCS) who did not respond to early treatment; however, decreasing the intensity of TLC among early treatment responders did not show significant improvement.
Article
Oncology
Haoyue Guo, Lishu Zhao, Junjie Zhu, Peixin Chen, Hao Wang, Minlin Jiang, Xiaogang Liu, Hui Sun, Wencheng Zhao, Zixuan Zheng, Wei Li, Bin Chen, Qiyu Fang, Menghang Yang, Yayi He, Yang Yang
Summary: This article emphasizes the importance of microbiota in lung cancer, highlighting the risk factors associated with certain microbiota imbalances and pathogen infections. Antibiotics may impair anti-cancer treatment efficacy, while probiotics and microbe-mediated drugs show potential in enhancing regular anti-tumor treatments.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Oncology
Mihaela Flavia Avram, Daniela Cornelia Lazar, Mihaela Ioana Maris, Sorin Olariu
Summary: A considerable amount of recent research has been conducted on the application of artificial intelligence (AI) in colorectal cancer (CRC). However, the use of AI in CRC surgery is not as advanced as in screening, diagnosis, and prognosis due to the complexity and variability in the surgical field and the lack of annotated video banks. This review summarizes the potential areas for AI application in CRC surgery, including phase and action recognition, navigation, endoscopy control, real-time analysis, biopsy, and imaging. The review also discusses the current progress in robotic treatment and the possibility of automated CRC robotic surgery. In order to widely utilize AI in CRC surgical treatment, the development of AI models that can replicate the skills of expert surgeons, the creation of large and complex datasets, and the standardization of surgical procedures are essential.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Aritoshi Hattori, Takeshi Matsunaga, Mariko Fukui, Kazuya Takamochi, Shiaki Oh, Kenji Suzuki
Summary: This study evaluated the operative techniques, clinicopathologic characteristics, and surgical outcomes of extended sleeve lobectomy (ESL) for centrally located non-small cell lung cancer (NSCLC), showing a better 3-year overall survival rate for ESL compared with pneumonectomy (PN).
ANNALS OF THORACIC SURGERY
(2022)
Article
Oncology
Eunji Choi, Sophia J. Luo, Jacqueline Aredo, Leah M. Backhus, Lynne R. Wilkens, Chloe C. Su, Joel W. Neal, Loic Le Marchand, Iona Cheng, Heather A. Wakelee, Summer S. Han
Summary: Survivors of lung cancer have a high risk of developing second primary lung cancer (SPLC), but the impact of SPLC diagnosis on survival remains unclear. This study found that compared to patients with a single primary lung cancer, those with SPLC had significantly reduced overall survival. The effect of SPLC on reduced survival was more pronounced among patients with early-stage lung cancer and those who actively smoked at the time of diagnosis.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Lohuwa Mamudu, Bonita Salmeron, Emmanuel A. Odame, Paul H. Atandoh, Joanne L. Reyes, Martin Whiteside, Joshua Yang, Hadii M. Mamudu, Faustine Williams
Summary: There are disparities in the receipt of surgical treatment among patients with localized malignant lung cancer in Tennessee. Factors such as time to treatment initiation, gender, race, marital status, residency, and insurance coverage are associated with the odds of receiving surgical treatment. Health policies should target reducing these disparities in order to improve the survival of these patients.
Article
Oncology
Sarah D. Hohl, Richard S. Matulewicz, Ramzi G. Salloum, Jamie S. Ostroff, Timothy B. Baker, Robert Schnoll, Graham Warren, Steven L. Bernstein, Mara Minion, Katie Lenhoff, Neely Dahl, Hee Soon Juon, Ursula Tsosie, Linda Fleisher, Heather D'Angelo, Alex T. Ramsey, Kimlin T. Ashing, Betsy Rolland, Margaret B. Nolan, Jennifer E. Bird, Claire V. T. Nguyen, Danielle Pauk, Robert T. Adsit, Hilary A. Tindle, Kimberly Shoenbill, Sophia Yeung, Cary A. Presant, Kara P. Wiseman, Kuang-Yi Wen, Lou-Anne Chichester, Li-Shiun Chen
Summary: The C3I program found that implementing comprehensive tobacco treatment programs and improving the staff-to-patient ratio can increase the reach of cessation treatment. Strengthening the tobacco treatment team and providing more resources can improve the effectiveness of smoking cessation.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Jacqueline V. Aredo, Sophia J. Luo, Rebecca M. Gardner, Nilotpal Sanyal, Eunji Choi, Thomas P. Hickey, Thomas L. Riley, Wen-Yi Huang, Allison W. Kurian, Ann N. Leung, Lynne R. Wilkens, Hilary A. Robbins, Elio Riboli, Rudolf Kaaks, Anne Tjonneland, Roel C. H. Vermeulen, Salvatore Panico, Loic Le Marchand, Christopher I. Amos, Rayjean J. Hung, Neal D. Freedman, Mattias Johansson, Iona Cheng, Heather A. Wakelee, Summer S. Han
Summary: The study revealed that smoking is a risk factor for second primary lung cancer (SPLC), and smoking cessation may reduce the risk of SPLC. Additionally, individuals who meet the U.S. Preventive Services Task Force's criteria at the diagnosis of initial primary lung cancer also have an increased risk of developing SPLC.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Review
Medicine, General & Internal
Scott J. Adams, Emily Stone, David R. Baldwin, Rozemarijn Vliegenthart, Pyng Lee, Florian J. Fintelmann
Summary: Randomised controlled trials have shown that low-dose CT lung cancer screening reduces mortality compared with chest radiography or no screening. However, uncertainties remain about optimizing clinical and cost effectiveness. This Review provides an international perspective on lung cancer screening, covering clinical trials, identification of individuals who benefit, management of screen-detected findings, smoking cessation interventions, cost-effectiveness, artificial intelligence and biomarkers, and challenges and opportunities in implementation.
Review
Biochemistry & Molecular Biology
Patrudu Makena, Tatiana Kikalova, Gaddamanugu L. L. Prasad, Sarah A. A. Baxter
Summary: Lung fibrosis is a progressive fatal disease caused by deregulated wound healing of lung epithelial cells. Chronic cigarette smoking and oxidative stress are major risk factors for lung fibrosis. This study aims to develop an adverse outcome pathway (AOP) to investigate the mechanisms of lung fibrosis due to lung injury caused by inhaled toxicants, including cigarette smoke. Cellular and tissue-level events lead to the development of lung fibrosis through proinflammatory and profibrotic mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Nadia Milad, Marie Pineault, Felix Tremblay, Joanie Routhier, Ariane Lechasseur, Marie-Josee Beaulieu, Sophie Aubin, Mathieu C. Morissette
Summary: This study compared the anti-inflammatory effects of IL-1 alpha signaling blockade during active cigarette smoke exposure and during the cessation period using a pre-clinical model. The results showed that blocking IL-1 alpha signaling during smoke exposure delayed the inflammatory response, while the same treatment during cessation accelerated the return to pulmonary inflammatory homeostasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Ryan H. Nguyen, Laura B. Vater, Lava R. Timsina, Gregory A. Durm, Katelin Rupp, Keylee Wright, Miranda H. Spitznagle, Brandy Paul, Shadia Jalal, Lisa Carter-Harris, Karen S. Hudmon, Nasser H. Hanna, Patrick J. Loehrer, DuyKhanh P. Ceppa
Summary: The study found that counties with stronger smoke-free air ordinances had lower smoking rates and fewer new lung cancer cases per year. Therefore, strengthening smoke-free air ordinances is crucial for reducing lung cancer incidence.
Review
Genetics & Heredity
Agnishwar Girigoswami, Koyeli Girigoswami
Summary: Lung cancer is typically treated using traditional methods like chemotherapy and radiation therapy, but they have limitations such as non-specific cell killing and drug solubility issues. Nanotechnology offers new solutions by utilizing nano-formulated drugs and particles to improve cancer cell killing and radiation sensitization. This review discusses conventional therapies for lung cancer inhibition and highlights the advancements made through the use of nanoparticles.
Editorial Material
Surgery
F. Mohamed, M. Kallioinen, M. Braun, S. Fenwick, M. Shackcloth, R. J. Davies
BRITISH JOURNAL OF SURGERY
(2020)
Article
Gastroenterology & Hepatology
M. Milosevic, J. Edwards, D. Tsang, J. Dunning, M. Shackcloth, T. Batchelor, A. Coonar, J. Hasan, B. Davidson, A. Marchbank, S. Grumett, N. R. Williams, F. Macbeth, V. Farewell, T. Treasure
COLORECTAL DISEASE
(2020)
Article
Medicine, General & Internal
Article
Cardiac & Cardiovascular Systems
Giordano Perin, Matthew Shaw, Caroline Toolan, Kenneth Palmer, Omar Al-Rawi, Paul Modi
Summary: The study found that there was no difference in overall hospital cost between MI and ST mitral valve surgery, with higher operative costs of MI surgery being offset by lower post-operative costs, and a 2-day shorter hospital stay.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Firas Aljanadi, Caroline Toolan, Thomas Theologou, Matthew Shaw, Kenneth Palmer, Paul Modi
Summary: In patients undergoing MIMVS, there is insufficient evidence to suggest that obesity affects short- or mid-term outcomes. Obesity should not be considered a contraindication to this technique for experienced teams.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Surgery
Amer Harky, Ahmed Othman, Matthew Shaw, Omar Nawaytou, Deborah Harrington, Manoj Kuduvalli, Johnathan Kendall, Francesco Torella, Mark Field
Summary: Open thoracoabdominal aortic surgery carries significant risk to life, which is related to age, extent of aortic replacement, timing of surgery, and left ventricular function. Morbidity is considerable. Understanding these risks is fundamental for patient selection and the consent process of potential candidates for surgery, particularly in the elderly.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Oncology
Marcus Taylor, Stuart W. Grant, Doug West, Michael Shackcloth, Steven Woolley, Babu Naidu, Rajesh Shah
Summary: Research suggests that 90-day mortality after lung resection may be twice that of 30-day mortality, indicating the need to adopt 90-day mortality as the standard measure of perioperative mortality after lung resection and investigate strategies to reduce mortality risk within 90 days of surgery.
CLINICAL LUNG CANCER
(2021)
Article
Cardiac & Cardiovascular Systems
Jennifer Whiteley, Caroline Toolan, Matthew Shaw, Giordano Perin, Kenneth Palmer, Omar Al-Rawi, Paul Modi
Summary: The study compared patient-reported outcome measures of minimally invasive (MI) to sternotomy (ST) mitral valve repair. Results showed that MI surgery had faster recovery time and less pain compared to ST surgery, while treatment satisfaction and safety profiles were similar.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Liam Mullen, Mohammed N. Meah, Ahmed Elamin, Suneil Aggarwal, Adeel Shahzad, Matthew Shaw, Jaroslav Hasara, Muhammad Rashid, Michael Fisher, Turab Ali, Billal Patel, Wern Y. Ding, Ruth Grainger, Thomas Heseltine, Bilal H. Kirmani, Mohammed Obeidat, Yande Kasolo, Jecko Thatchil, Aleem Khand
Summary: The study compares the use of clopidogrel and ticagrelor in patients with acute coronary syndrome, finding that ticagrelor leads to more frequent bleeding events in patients not undergoing coronary artery bypass graft surgery. There was no significant difference in the incidence of subsequent myocardial infarction between the two drugs. Although higher crude mortality was observed in the clopidogrel group, this difference disappeared after adjusting for covariates.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Anesthesiology
Marcus Taylor, Udo Abah, Tim Hayes, Thomas Eadington, Leah Argus, Michael Shackcloth, Felice Granato, Rajesh Shah, Richard Booton, Stuart W. Grant, Nils Cristopher North West Thoracic Surg Collaborative NWTSC
Summary: This study aimed to investigate the impact of preoperative anemia on outcomes after resection for primary lung cancer. The findings showed that preoperative anemia was independently associated with reduced overall survival for patients undergoing lung cancer resection, but not with 90-day mortality. Further research is needed to understand why anemia reduces long-term survival and to explore pathways for improving long-term outcomes.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Annemarie Brunswicker, Marcus Taylor, Stuart W. Grant, Udo Abah, Matthew Smith, Michael Shackcloth, Felice Granato, Rajesh Shah, Kandadai Rammohan
Summary: For lung cancer patients undergoing pneumonectomy, neoadjuvant therapy, patient Performance Status score, and advanced disease are key factors associated with adverse outcomes.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Health Care Sciences & Services
Eric Lim, Rosie A. Harris, Holly E. McKeon, Timothy J. P. Batchelor, Joel Dunning, Michael Shackcloth, Vladimir Anikin, Babu Naidu, Elizabeth Belcher, Mahmoud Loubani, Vipin Zamvar, Lucy Dabner, Timothy Brush, Elizabeth A. Stokes, Sarah Wordsworth, Sangeetha Paramasivan, Alba Realpe, Daisy Elliott, Jane Blazeby, Chris A. Rogers
Summary: This study compared the clinical effectiveness and cost-effectiveness of video-assisted thoracoscopic surgery lobectomy with open surgery for lung cancer. The results showed that video-assisted thoracoscopic surgery was associated with less pain, fewer complications, and better quality of life, without compromising oncologic outcomes.
HEALTH TECHNOLOGY ASSESSMENT
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ashwin Kerai, Paul Modi, Michael Shackcloth, Andrew G. Schache, Richard J. Shaw
Summary: This study reports a novel technique of robot-assisted harvesting of the internal mammary vessels for effective recipient vessels in a patient with bilateral vessel depleted neck. The technique was successfully used to reconstruct a mandibular defect, with excellent recipient arterial diameter and length and no significant complications.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2023)
Article
Surgery
Robert P. Jones, Ainhoa Mielgo, Michael Schmid, Danielle Bury, Timothy Andrews, Susanne Burdak-Rothkamm, Michael Shackcloth, Timothy J. S. Cross, Stephen Fenwick, Hassan Z. Malik, Rafa Diaz-Nieto, Christian Ottensmeier, Daniel H. Palmer, Dale Vimalachandran
BRITISH JOURNAL OF SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Amer Harky, Ahmed Othman, Carlos Nistal De Paz, Matthew Shaw, Omar Nawaytou, Deborah Harrington, Manoj Kuduvalli, Mark Field
Summary: The management of infected prosthetic aortic grafts in the ascending and root is complex and requires a patient-specific approach. Surgical intervention is often necessary for curative treatment, but comes with high operative mortality risk. Overall, the 1 year survival rate is reasonable with successful strategies.
JOURNAL OF CARDIAC SURGERY
(2021)