Article
Nutrition & Dietetics
M. Yusof Said, Angelica Rodriguez-Nino, Adrian Post, Joelle C. Schutten, Lyanne M. Kieneker, Antonio W. Gomes-Neto, Marco van Londen, Maryse C. J. Oste, Karin J. Borgonjen-van den Berg, Ilja M. Nolte, Else van den Berg, Pim de Blaauw, Jennifer van der Krogt, M. Rebecca Heiner-Fokkema, Gerjan Navis, Benito A. Yard, Stephan J. L. Bakker
Summary: This study found that urinary 1-methylhistidine is associated with white meat intake, while urinary 3-methylhistidine is associated with red meat intake. Additionally, high urinary concentrations of 3-methylhistidine are independently associated with a lower risk of mortality, and high urinary concentrations of both 1- and 3-methylhistidine are independently associated with a lower risk of graft failure in kidney transplant recipients.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Oncology
Kenechukwu Chudy-Onwugaje, Wen-Yi Huang, L. Joseph Su, Mark P. Purdue, Christine C. Johnson, Lingxiao Wang, Hormuzd A. Katki, Kathryn Hughes Barry, Sonja I. Berndt
Summary: In this study, a beneficial role for both aspirin and ibuprofen in preventing advanced adenoma and curbing progression to recurrence and cancer among older adults was observed during long-term follow-up.
Article
Multidisciplinary Sciences
Oxana Dmitrieva-Posocco, Andrea C. Wong, Patrick Lundgren, Aleksandra M. Golos, Helene C. Descamps, Lenka Dohnalova, Zvi Cramer, Yuhua Tian, Brian Yueh, Onur Eskiocak, Gabor Egervari, Yemin Lan, Jinping Liu, Jiaxin Fan, Jihee Kim, Bhoomi Madhu, Kai Markus Schneider, Svetlana Khoziainova, Natalia Andreeva, Qiaohong Wang, Ning Li, Emma E. Furth, Will Bailis, Judith R. Kelsen, Kathryn E. Hamilton, Klaus H. Kaestner, Shelley L. Berger, Jonathan A. Epstein, Rajan Jain, Mingyao Li, Semir Beyaz, Christopher J. Lengner, Bryson W. Katona, Sergei I. Grivennikov, Christoph A. Thaiss, Maayan Levy
Summary: The study identifies a metabolite signalling pathway that can be used as a strategy for preventing and treating colorectal cancer. Ketogenic diets and the ketone body BHB show a strong inhibitory effect on tumor growth by reducing cell proliferation. The findings suggest that BHB-triggered pathway could play a crucial role in regulating intestinal tumorigenesis.
Article
Gastroenterology & Hepatology
Hee-Kyung Joh, Dong Hoon Lee, Jinhee Hur, Katharina Nimptsch, Yoosoo Chang, Hyojee Joung, Xuehong Zhang, Leandro F. M. Rezende, Jung Eun Lee, Kimmie Ng, Chen Yuan, Fred K. Tabung, Jeffrey A. Meyerhardt, Andrew T. Chan, Tobias Pischon, Mingyang Song, Charles S. Fuchs, Walter C. Willett, Yin Cao, Shuji Ogino, Edward Giovannucci, Kana Wu
Summary: The study found that high intake of simple sugars and SSBs during adolescence was associated with an increased risk of conventional adenoma, especially rectal adenoma. However, sugar and SSB intake during adulthood was not linked to adenoma risk.
Article
Medicine, General & Internal
Hanju Hua, Yanhong Sun, Xinjue He, Yi Chen, Lisong Teng, Chao Lu
Summary: This study investigated the characteristics of intestinal microbiota in patients with colorectal adenoma and carcinoma and its correlations with clinical characteristics. The results showed that certain intestinal bacteria changed along the adenoma-carcinoma sequence and could be potential markers for the diagnosis and treatment of colorectal adenoma/carcinoma.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Tamotsu Sugai, Mitsumasa Osakabe, Takeshi Niinuma, Ryo Sugimoto, Makoto Eizuka, Yoshihito Tanaka, Naoki Yanagawa, Koki Otsuka, Akira Sasaki, Takayuki Matsumoto, Hiromu Suzuki
Summary: This study identified specific miRNA/mRNA networks that contribute to the progression of colorectal tumors, providing insights into the molecular tumorigenesis of these tumors.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Cesare Hassan, Marco Spadaccini, Yuichi Mori, Farid Foroutan, Antonio Facciorusso, Paraskevas Gkolfakis, Georgios Tziatzios, Konstantinos Triantafyllou, Giulio Antonelli, Kareem Khalaf, Tommy Rizkala, Per Olav Vandvik, Alessandro Fugazza, Emanuele Rondonotti, Jeremy R. Glissen-Brown, Shunsuke Kamba, Marcello Maida, Loredana Correale, Pradeep Bhandari, Rodrigo Jover, Prateek Sharma, Douglas K. Rex, Alessandro Repici
Summary: Artificial intelligence computer-aided detection (CADe) during colonoscopy can increase adenoma detection rates (ADRs) and reduce adenoma miss rates, but may also lead to overdiagnosis and overtreatment of nonneoplastic polyps.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jia Shen, Yin Li, Meihui Xu, Fei Wu, Yanjie Jiang, Xiaohui Liu, Yang Ao, Qianru Lin, Pan Zhuang, Jingjing Jiao, Weifang Zheng, Yu Zhang
Summary: This study aimed to assess the association between egg intake and colorectal polyp prevalence. Through a food frequency questionnaire and electronic colonoscopy, it was found that high egg consumption was significantly correlated with a higher prevalence of colorectal polyps among the Chinese population at a high risk of CRC. However, this association disappeared after further adjustment for dietary cholesterol. Replacing egg intake with total dairy products was associated with a decrease in colorectal polyp prevalence.
Article
Health Care Sciences & Services
Georg Semmler, Sarah Wernly, Bernhard Wernly, Behrooz Mamandipoor, Sebastian Bachmayer, Lorenz Semmler, Elmar Aigner, Christian Datz, Venet Osmani
Summary: This study evaluated the potential of machine learning methods to predict advanced adenomas in a screening program for colorectal cancer, showing that machine learning based on point-prevalence laboratory and clinical information does not accurately predict advanced adenomas.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tanja Gumpenberger, Stefanie Brezina, Pekka Keski-Rahkonen, Andreas Baierl, Nivonirina Robinot, Gernot Leeb, Nina Habermann, Dieuwertje E. G. Kok, Augustin Scalbert, Per-Magne Ueland, Cornelia M. Ulrich, Andrea Gsur
Summary: Sporadic colorectal cancer shows a multistep progression from normal tissue to precancerous adenomas to invasive cancer, with underlying molecular mechanisms not completely understood. Metabolomic analysis of plasma samples from colorectal cancer patients and adenoma patients identified significant differences in molecular features, including acylcarnitines, caffeine, amino acids, and bile acids. These findings provide insight into the metabolic distinctions between colorectal cancer and adenomas, potentially offering a biological interpretation of these differences.
Article
Gastroenterology & Hepatology
Sergei Vosko, Neal Shahidi, Mayenaaz Sidhu, W. Arnout van Hattem, Iddo Bar-Yishay, Scott Schoeman, David J. Tate, Luke F. Hourigan, Rajvinder Singh, Alan Moss, Karen Byth, Eric Y. T. Lee, Nicholas G. Burgess, Michael J. Bourke
Summary: This study found significant differences in optical evaluation performance between flat and nodular large nonpedunculated colorectal polyps. Flat lesions can be presumed benign and managed accordingly, while nodular lesions are more likely to be missed for submucosal invasive cancer.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Julia Tevini, Sebastian K. Eder, Ursula Huber-Schoenauer, David Niederseer, Georg Strebinger, Johanna M. Gostner, Elmar Aigner, Christian Datz, Thomas K. Felder
Summary: This study uses serum metabolomics to identify the metabolic differences between colorectal cancer patients, adenoma patients, and healthy controls. The perturbations in lipid metabolism and amino acid metabolism provide a foundation for further mechanistic studies and highlight the importance of lipid metabolites. Biomarkers related to these pathways could improve the sensitivity and specificity of diagnosis, as well as the monitoring of therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Erica K. Barnell, Elizabeth M. Wurtzler, Julie La Rocca, Thomas Fitzgerald, Jessica Petrone, Yansheng Hao, Yiming Kang, Faith L. Holmes, David A. Lieberman
Summary: This study evaluated the sensitivity and specificity of a noninvasive multitarget stool RNA test for colorectal cancer and precancerous lesions. The results showed that the test had a sensitivity of 94% for detecting colorectal cancer and 46% for detecting advanced adenomas, with a specificity of 88%.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Jesus Brezmes, Maria Llambrich, Raquel Cumeras, Josep Guma
Summary: Metabolomics is a crucial method for discovering novel biomarkers and their application in precision medicine. NMR-based metabolomics in urine can serve as a powerful clinical tool in precision oncology. This review provides a comprehensive evaluation of NMR metabolomics for the detection of colorectal cancer (CRC) in urine, identifying potential relevant compounds and metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Peng Pan, Jingnan Li, Bo Wang, Xiaoyan Tan, Hekun Yin, Yingmin Han, Haobin Wang, Xiaoli Shi, Xiaoshuang Li, Cuinan Xie, Longfei Chen, Lanyou Chen, Yu Bai, Zhaoshen Li, Geng Tian
Summary: This study collected DNA and RNA sequencing data from colorectal adenoma and colorectal cancer samples, and found different mutation frequencies and exclusive patterns in the mutation profiles between adenoma and cancer patients, as well as differentially expressed genes. Two random forest classification models were built based on mutation profiles and expression profiles, and achieved high accuracy in distinguishing adenoma and cancer samples, suggesting the potential of the 519-gene panel for monitoring adenoma patients in clinical practice.
FRONTIERS IN ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Kristin A. Guertin, Erikka Loftfield, Simina M. Boca, Joshua N. Sampson, Steven C. Moore, Qian Xiao, Wen-Yi Huang, Xiaoqin Xiong, Neal D. Freedman, Amanda J. Cross, Rashmi Sinha
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2015)
Article
Oncology
Erikka Loftfield, Neal D. Freedman, Barry I. Graubard, Albert R. Hollenbeck, Fatma M. Shebl, Susan T. Mayne, Rashmi Sinha
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2015)
Article
Oncology
Erikka Loftfield, Neal D. Freedman, Barry I. Graubard, Albert R. Hollenbeck, Fatma M. Shebl, Susan T. Mayne, Rashmi Sinha
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2015)
Article
Biotechnology & Applied Microbiology
Rashmi Sinha, Galeb Abu-Ali, Emily Vogtmann, Anthony A. Fodor, Boyu Ren, Amnon Amir, Emma Schwager, Jonathan Crabtree, Siyuan Ma, Christian C. Abnet, Rob Knight, Owen White, Curtis Huttenhower
NATURE BIOTECHNOLOGY
(2017)
Article
Oncology
Alison L. Van Dyke, Margaret S. Langhamer, Bin Zhu, Ruth M. Pfeiffer, Demetrius Albanes, Gabriella Andreotti, Laura E. Beane Freeman, Andrew T. Chan, Neal D. Freedman, Susan M. Gapstur, Graham G. Giles, Francine Grodstein, Linda M. Liao, Juhua Luo, Roger L. Milne, Kristine R. Monroe, Marian L. Neuhouser, Jenny N. Poynter, Mark P. Purdue, Kim Robien, Catherine Schairer, Rashmi Sinha, Stephanie Weinstein, Xuehong Zhang, Jessica L. Petrick, Katherine A. McGlynn, Peter T. Campbell, Jill Koshiol
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2018)
Article
Nutrition & Dietetics
Li Jiao, Rachael Stolzenberg-Solomon, Thea Palmer Zimmerman, Zhigang Duan, Liang Chen, Lisa Kahle, Adam Risch, Amy F. Subar, Amanda J. Cross, Albert Hollenbeck, Helen Vlassara, Gary Striker, Rashmi Sinha
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2015)
Article
Nutrition & Dietetics
Carrie R. Daniel, Kavita Kapur, Mary J. McAdams, Sujata Dixit-Joshi, Niveditha Devasenapathy, Hemali Shetty, Sriram Hariharan, Preethi S. George, Aleyamma Mathew, Rashmi Sinha
BRITISH JOURNAL OF NUTRITION
(2014)
Meeting Abstract
Oncology
Erikka Loftfield, Susan Mayne, Fatma Shebl, Neal Freedman, Barry Graubard, Rashmi Sinha
Meeting Abstract
Oncology
Christine Dominianni, Rashmi Sinha, James J. Goedert, Zhiheng Pei, Liying Yang, Richard B. Hayes, Jiyoung Ahn
Article
Oncology
Rick J. Jansen, Dennis P. Robinson, Ryan D. Frank, Kristin E. Anderson, William R. Bamlet, Ann L. Oberg, Kari G. Rabe, Janet E. Olson, Rashmi Sinha, Gloria M. Petersen, Rachael Z. Stolzenberg-Solomon
INTERNATIONAL JOURNAL OF CANCER
(2014)
Article
Multidisciplinary Sciences
Xuguang Guo, Yikyung Park, Neal D. Freedman, Rashmi Sinha, Albert R. Hollenbeck, Aaron Blair, Honglei Chen
Article
Microbiology
Rashmi Sinha, Habibul Ahsan, Martin Blaser, J. Gregory Caporaso, Joseph Russell Carmical, Andrew T. Chan, Anthony Fodor, Mitchell H. Gail, Curtis C. Harris, Kathy Helzlsouer, Curtis Huttenhower, Rob Knight, Heidi H. Kong, Gabriel Y. Lai, Diane Leigh Smith Hutchinson, Loic Le Marchand, Hongzhe Li, Michael J. Orlich, Jianxin Shi, Ann Truelove, Mukesh Verma, Emily Vogtmann, Owen White, Walter Willett, Wei Zheng, Somdat Mahabir, Christian Abnet
Article
Gastroenterology & Hepatology
Jessica L. Petrick, Andrea A. Florio, Xuehong Zhang, Anne Zeleniuch-Jacquotte, Jean Wactawski-Wende, Stephen K. Van den Eeden, Frank Z. Stanczyk, Tracey G. Simon, Rashmi Sinha, Howard D. Sesso, Catherine Schairer, Lynn Rosenberg, Thomas E. Rohan, Mark P. Purdue, Julie R. Palmer, Martha S. Linet, Linda M. Liao, I-Min Lee, Jill Koshiol, Cari M. Kitahara, Victoria A. Kirsh, Jonathan N. Hofmann, Chantal Guillemette, Barry Graubard, Edward Giovannucci, J. Michael Gaziano, Susan M. Gapster, Neal D. Freedman, Lawrence S. Engel, Dawn Q. Chong, Yu Chen, Andrew T. Chan, Patrick Caron, Julie E. Buring, Gary Bradwin, Laura E. Beane Freeman, Peter T. Campbell, Katherine A. McGlynn
Article
Biotechnology & Applied Microbiology
Rashmi Sinha, Christian C. Abnet, Owen White, Rob Knight, Curtis Huttenhower
Review
Oncology
Somdat Mahabir, Walter C. Willett, Christine M. Friedenreich, Gabriel Y. Lai, Carol J. Boushey, Charles E. Matthews, Rashmi Sinha, Graham A. Colditz, Joseph A. Rothwell, Jill Reedy, Alpa V. Patel, Michael F. Leitzmann, Gary E. Fraser, Sharon Ross, Stephen D. Hursting, Christian C. Abnet, Lawrence H. Kushi, Philip R. Taylor, Ross L. Prentice
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2018)