期刊
EUROPEAN JOURNAL OF CANCER
卷 50, 期 7, 页码 1239-1246出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2014.02.001
关键词
Lung neoplasms; Non-small-cell lung; EML4-ALK fusion protein; Adenocarcinoma; Crizotinib; Survival analysis
类别
资金
- Legs Poix (Chancellerie des Universites, Paris, France)
- Fond de Dotation 'Recherche en Sante Respiratoire'
The aim of this study was to analyse the clinico-pathological characteristics and outcomes of a cohort of French patients who were prospectively screened for Anaplastic Lymphoma Kinase (ALK) rearrangement. One hundred and sixteen consecutive patients screened for ALK rearrangement to be recruited into a crizotinib registration trial were included from eight French centres. ALK rearrangement was detected by fluorescence in situ hybridization. Seventeen patients (14.6%) were positive for ALK. ALK+ patients were younger (p = 0.049) and more likely to be males (p = 0.032), non-or light-smokers (p = 0.048) and without underlying respiratory disease (p = 0.025) compared to ALK - patients. Thyroid-transcription factor-1 expression was present in all ALK+ tumours. ALK+ tumours tended to have lymph node and brain metastases. In multivariate analyses, gender, smoking history and N stage were independently associated with ALK status. Median overall survival (OS) was not reached for ALK+ patients and was significantly longer than for ALK - patients (hazard ratio for death for ALK - patients 2.98; 95% CI [1.29-6.90], p = 0.01). French ALK+ patients present a specific phenotype. ALK rearrangement should be determined to improve OS with an effective targeted therapy. (C) 2014 Elsevier Ltd. All rights reserved.
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