Article
Medicine, General & Internal
T. K. Choueiri, T. Powles, M. Burotto, B. Escudier, M. T. Bourlon, B. Zurawski, V. M. Oyervides Juarez, J. J. Hsieh, U. Basso, A. Y. Shah, C. Suarez, A. Hamzaj, J. C. Goh, C. Barrios, M. Richardet, C. Porta, R. Kowalyszyn, J. P. Feregrino, J. Zolnierek, D. Pook, E. R. Kessler, Y. Tomita, R. Mizuno, J. Bedke, J. Zhang, M. A. Maurer, B. Simsek, F. Ejzykowicz, G. M. Schwab, A. B. Apolo, R. J. Motzer
Summary: The study demonstrates that nivolumab plus cabozantinib has significant advantages over sunitinib in the treatment of previously untreated advanced renal-cell carcinoma, including progression-free survival, overall survival, and likelihood of response.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Oncology
Yun Peng, Shiqiang Dong, Yuxuan Song, Dingkun Hou, Lili Wang, Bowen Li, Haitao Wang
Summary: This study identified key immune-related genes and hub genes associated with sunitinib and immune infiltration in clear cell RCC (ccRCC), providing insights into sunitinib resistance and potential biomarkers or drug targets for ccRCC.
Article
Urology & Nephrology
Kojiro Ohba, Yasuyoshi Miyata, Kensuke Mitsunari, Tsuyoshi Matsuda, Yuta Mukae, Yuichiro Nakamura, Tomohiro Matsuo, Hideki Sakai
Summary: The study demonstrated that every-other-day dosing of sunitinib has long-term efficacy and safety for mRCC patients, with significantly prolonged PFS and OS in the experimental group. After treatment with ICI drugs, sunitinib still showed efficacy in some patients.
UROLOGIA INTERNATIONALIS
(2022)
Review
Pharmacology & Pharmacy
Juan Jin, Yuhao Xie, Jin-Shi Zhang, Jing-Quan Wang, Shi-Jie Dai, Wen-fang He, Shou-Ye Li, Charles R. Ashby Jr, Zhe-Sheng Chen, Qiang He
Summary: Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer, and targeted therapy with Sunitinib has become the main treatment option due to the lack of efficacy in radiation therapy and chemotherapy. However, many patients develop resistance to Sunitinib within months of therapy. In this review, we discuss the molecular mechanisms of Sunitinib resistance, strategies to overcome it, and potential predictive biomarkers.
DRUG RESISTANCE UPDATES
(2023)
Article
Oncology
Zeshen Wu, Yulu Peng, Longbin Xiong, Jun Wang, Zhen Li, Kang Ning, Minhua Deng, Ning Wang, Wensu Wei, Zhiyong Li, Pei Dong, Chunping Yu, Fangjian Zhou, Zhiling Zhang
Summary: This study reveals that Sam68 protein impacts the sensitivity to the drug Sunitinib by mediating cell apoptosis. The expression level of Sam68 is higher in Sunitinib-sensitive tumor tissues, and downregulation of Sam68 inhibits Sunitinib-induced cell apoptosis. These findings suggest that Sam68 expression level may serve as a biomarker for predicting Sunitinib sensitivity in RCC patients.
Review
Pharmacology & Pharmacy
Yunxia Wang, Xiaolin Liu, Luyao Gong, Weihong Ding, Wenjing Hao, Yeheng Peng, Jun Zhang, Weimin Cai, Yuan Gao
Summary: This review summarizes the mechanisms of sunitinib resistance in renal cell carcinoma, including activation of bypass or alternative pathways, inadequate drug accumulation, tumor microenvironment, metabolic reprogramming, and epigenetic regulation. It also covers current and potential biomarkers as well as treatment strategies for overcoming sunitinib resistance.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Yangjun Zhang, Xiaoliang Wu, Jingzhen Li, Kui Sun, Heng Li, Libin Yan, Chen Duan, Haoran Liu, Ke Chen, Zhangqun Ye, Mugen Liu, Hua Xu
Summary: Irregular splicing in renal cell carcinoma (RCC) is associated with tumor formation and progression. Alternative splicing can be useful for subtype classification, while splicing inefficiency is linked to advanced conditions and unfavorable overall survival in patients with RCC. Factors such as splice site strength, nucleotide content, and exon length may disrupt splicing balance in RCC, affecting cancer-associated pathways and immune responses.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biochemistry & Molecular Biology
Tomonori Sato, Yoshihide Kawasaki, Masamitsu Maekawa, Shinya Takasaki, Kento Morozumi, Masahiko Sato, Shuichi Shimada, Naoki Kawamorita, Shinichi Yamashita, Koji Mitsuzuka, Nariyasu Mano, Akihiro Ito
Summary: Metabolomics analysis can identify potential therapeutic targets for treatment resistance in cancer, such as sunitinib resistance in renal cell carcinoma (RCC), through changes in metabolites. This study found that alterations in energy metabolism, glycolysis upregulation, and antioxidant activity are associated with sunitinib resistance in RCC cells.
Article
Biochemistry & Molecular Biology
Xiaoyi Du, Zhipeng Zhao, Xin Zhao, Hexi Wang, Li Jiang, Wei Tang
Summary: In this study, we analyzed the subtypes of ccRCC mediated by 8 TSGs contained in the 3p21.3 gene cluster and their effects on TME cell infiltration. A risk score model was established to predict prognosis and drug sensitivity. The hub gene NPRL2 was found to promote sunitinib sensitivity in ccRCC cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Xin Wang, Jiang-Hua Jia, Ming Zhang, Qing-Song Meng, Bo-Wen Yan, Zi-Yue Ma, Dong-Bin Wang
Summary: This study found that the upregulation of ADM enhanced the chemoresistance of sunitinib by inhibiting FDX1 expression through cuproptosis. Mechanistically, ADM activates the p38/MAPK signaling pathway to promote FOXO3 phosphorylation and its entry into the nucleus, resulting in the inhibition of FDX1 transcription and cell cuproptosis, ultimately promoting chemoresistance in ccRCC.
Article
Oncology
Kei Nagase, Takashi Akutagawa, Mihoko Rikitake-Yamamoto, Sayuri Morito, Maki Futamata, Shohei Tobu, Mitsuru Noguchi, Shuji Toda, Shigehisa Aoki
Summary: This study investigated the cellular and physical microenvironments of RCC, exploring their regulatory effects on RCC behavior. The results showed that adipose tissue, macrophages, and fluid flow influence the proliferative and invasive capacity of RCC cells, and these effects may be mediated through the extracellular signal-regulated kinase and p38 signaling pathways.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qi Wang, Su Gao, Yi Shou, Yujie Jia, Zhihao Wei, Yuenan Liu, Jian Shi, Daojia Miao, Qi Miao, Chuanyi Zhao, Chenchen Liu, Hongmei Yang, Tianbo Xu, Xiaoping Zhang
Summary: In this study, AIM2 was identified as a new biomarker of RCC and promoted RCC progression and sunitinib resistance through FOXO3a-ACSL4 axis-regulated ferroptosis. This finding provides new ideas and therapeutic targets for the diagnosis and treatment of RCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Chenchen Feng, Yuqing Li, Kunping Li, Yinfeng Lyu, Wenhui Zhu, Haowen Jiang, Hui Wen
Summary: PFKFB4 was found to be significantly overexpressed in tumors compared to normal kidney, associated with advanced tumor grade, stage and poor prognosis. PFKFB4 overexpression impaired cell proliferation, migration, and wound healing. Targeting PFKFB4 showed promise in overcoming resistance to Sunitinib.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Rausch, Adriano Rutz, Pierre-Marie Allard, Celine Delucinge-Vivier, Mylene Docquier, Olivier Dormond, Jean-Luc Wolfender, Patrycja Nowak-Sliwinska
Summary: Resistance against sunitinib in clear cell renal cell carcinoma (ccRCC) involves various molecular aberrations, leading to clinical complications. Understanding these aberrations and developing an optimized multidrug combination is crucial to surpassing resistance mechanisms and improving treatment outcomes. Research on resistance mechanisms revealed morphometric and molecular changes, as well as the presence of N-desethyl sunitinib and lysosomal sequestration of the drug, highlighting the importance of studying drug responses in laboratory settings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yan Sun, Liang Zhu, Pian Liu, Huan Zhang, Feng Guo, Xin Jin
Summary: In this study, researchers found that the upregulation of palmitoyl acyltransferase ZDHHC2 is associated with TKI resistance in ccRCC. ZDHHC2 mediates AGK S-palmitoylation to activate the PI3K-AKT-mTOR signaling pathway, which modulates sunitinib sensitivity. These findings suggest that targeting ZDHHC2 may improve the efficacy of sunitinib in treating ccRCC.
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)