Article
Oncology
Xinchen Wang, Qing Liu, Oskar O. Halfdanarson, Helga Zoega, Omid Sadr-Azodi, Lars Engstrand, Katja Fall, Nele Brusselaers
Summary: The study found that PPI use after CRC diagnosis was associated with increased all-cause and CRC-specific mortality, particularly among male patients, cancer stage 0-I, rectal cancer, and patients receiving CRC surgery. Additionally, the association between PPI use and all-cause mortality was more pronounced in new users compared to non-users. Risk estimates for CRC-specific mortality comparing PPI users to nonusers were similar to those for all-cause mortality.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Qing Shen, Arvid Sjolander, Erica K. Sloan, Adam K. Walker, Katja Fall, Unnur Valdimarsdottir, Par Sparen, Karin E. Smedby, Fang Fang
Summary: Intake of low-dose aspirin after cancer diagnosis was associated with a lower risk of unnatural deaths among cancer patients.
Article
Oncology
Manon Cairat, Anton Pottegard, Morten Olesen, Laure Dossus, Agnes Fournier, Blanaid Hicks
Summary: The use of antiplatelet drugs, including low-dose aspirin, clopidogrel, and dipyridamole, does not appear to be associated with a reduced risk of breast cancer. However, there may be a potential inverse association between dipyridamole use and breast cancer risk in women under 55 years old.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Oluwafunke R. Kolawole, Khosrow Kashfi
Summary: Acute inflammation is an adaptive host defense mechanism, but unresolved or chronic inflammation can lead to various maladies, including cancer. Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin have been shown to reduce the risk and mortality of many cancers. Besides targeting cyclooxygenase-2 (COX-2), NSAIDs also affect other important targets, and specialized pro-resolving mediators (SPMs) promote the resolution of inflammation and tissue healing, showing potential in inhibiting cancer growth and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Lauren E. Barber, Kimberly A. Bertrand, Shanshan Sheehy, Laura F. White, Hemant K. Roy, Lynn Rosenberg, Julie R. Palmer, Jessica L. Petrick
Summary: Evidence suggests that aspirin use reduces the occurrence of colorectal neoplasia. This study specifically examined the association between aspirin use and colorectal adenoma among Black women, a group disproportionately affected by the disease.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Ronald McDowell, Sarah Perrott, Peter Murchie, Christopher Cardwell, Carmel Hughes, Leslie Samuel
Summary: The study found that antibiotics may be associated with colon tumor formation across all age groups, while they were not associated with rectal cancer.
BRITISH JOURNAL OF CANCER
(2022)
Review
Pharmacology & Pharmacy
Patrizia Ballerini, Annalisa Contursi, Annalisa Bruno, Matteo Mucci, Stefania Tacconelli, Paola Patrignani
Summary: Colorectal and hepatocellular carcinoma are associated with chronic inflammation, and there is a need for sensitive and specific noninvasive biomarkers for monitoring. Platelets play a role in intestinal and liver inflammation, and antiplatelet agents like Aspirin can reduce the incidence and mortality of these cancers. Platelet-mediated drug delivery systems could improve the efficacy and reduce the toxicity of anti-inflammatory agents.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Suzanna Shermon, Kimberly M. Fazio, Richard Shim, Alaa Abd-Elsayed, Chong H. Kim
Summary: The objective of this study was to evaluate discrepancies in prescription trends for analgesic medications in complex regional pain syndrome (CRPS) patients based on recommendations in the literature. The study design was a retrospective case-control study, with 2510 CRPS patients and 2510 demographic-matched controls participating. The results showed a divergence between some published recommendations and actual practice.
Article
Oncology
Shuo-Han Yin, Shiu-Dong Chung, Shih-Han Hung, Tsai-Ching Liu, Herng-Ching Lin
Summary: This study found a significant association between prostate cancer and HPV infections, with individuals who had a history of HPV infections having an increased risk of developing prostate cancer, even after adjusting for other factors.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Lusine Yaghjyan, A. Heather Eliassen, Graham Colditz, Bernard Rosner, Pepper Schedin, Akemi Wijayabahu, Rulla M. Tamimi
Summary: The associations of aspirin and other NSAIDs with breast cancer risk are not influenced by COX2 expression status.
BREAST CANCER RESEARCH
(2022)
Article
Oncology
Wei Tang, Jay H. Fowke, Lauren M. Hurwitz, Mark Steinwandel, William J. Blot, Stefan Ambs
Summary: The study found that aspirin use was not associated with prostate cancer risk among African-American men in the Southern Community Cohort Study (SCCS), but may be suggestively associated with reduced prostate cancer mortality. Prospective SCCS data suggest that aspirin use may help prevent lethal prostate cancer among this high-risk group of men.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Malene Outzen, Anne Tjonneland, David J. Hughes, Mazda Jenab, Kirsten Frederiksen, Lutz Schomburg, Steve Morris, Kim Overvad, Anja Olsen
Summary: The study did not find any association between toenail selenium or plasma SELENOP concentrations with advanced, high-grade or advanced-stage prostate cancer. Additionally, variations in selenoprotein genes were not found to be associated with PC risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Heng-Jui Chang, Yuan-Hung Pong, Chen-Yen Chiang, Po-Chien Huang, Ming-Hua Wang, Yu-Jiun Chan, Tzuo-Yun Lan
Summary: The rising incidence rate of prostate cancer (PCa) worldwide is a concern. The association between human papillomavirus (HPV) and PCa has been widely investigated. This case-control study in Taiwan found a slightly significant association between HPV infection and PCa, but the focus should be on other risk factors such as dietary habits, personal lifestyle, and family history.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Yao Lin, Yaqi Li, Jingjing Ma, Aijie Li, Lin Shi, Yang Liu
Summary: The study found that aspirin-induced urticaria (AIU) in children with Kawasaki disease (KD) is not related to gender or aspirin dose, but those with AIU have more severe inflammation at admission. Aspirin should be withdrawn for AIU management, and baseline NT-proBNP may serve as a valuable biomarker to predict AIU.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Oncology
Bo Fan, Alradhi Mohammed, Yuanbin Huang, Hong Luo, Hongxian Zhang, Shenghua Tao, Weijiao Xu, Qian Liu, Tao He, Huidan Jin, Mengfan Sun, Man Sun, Zhifei Yun, Rui Zhao, Guoyu Wu, Xiancheng Li
Summary: Regular use of aspirin is not associated with a reduced incidence of bladder cancer, but it may lower the risk for male and current smokers. However, aspirin intake does not significantly influence the prognosis of bladder cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Ophthalmology
Sirpa Loukovaara, Anssi Auvinen, Jari Haukka
Summary: The study found that the use of amlodipine, felodipine, bicalutamide, estradiol, and atorvastatin may be associated with an increased risk for wet AMD development. However, patients using digoxin and ramipril had a lower incidence of wet AMD. Further studies are needed to clarify these associations.
ACTA OPHTHALMOLOGICA
(2022)
Article
Urology & Nephrology
Antti Rannikko, Mare Leht, Tuomas Mirtti, Anu Kenttamies, Teemu Tolonen, Irina Rinta-Kiikka, Tuomas P. Kilpelainen, Kari Natunen, Hans Lilja, Terho Lehtimaki, Jani Raitanen, Paula Kujala, Johanna Ronkainen, Mika Matikainen, Anssi Petas, Kimmo Taari, Teuvo Tammela, Anssi Auvinen
Summary: This study evaluated the feasibility of a population-based screening trial using PSA, a kallikrein panel, and MRI. The findings showed that the screening protocol was able to minimize overdiagnosis while retaining mortality benefit, and achieved a substantial detection rate for clinically significant prostate cancer. However, participation rate needs improvement.
Article
Public, Environmental & Occupational Health
Brigitte Schlehofer, Maria Blettner, Monika Moissonnier, Isabelle Deltour, Graham G. Giles, Bruce Armstrong, Jack Siemiatycki, Marie-Elise Parent, Daniel Krewski, Christoffer Johansen, Anssi Auvinen, Anna Lahkola, Martine Hours, Gabriele Berg-Beckhoff, Siegal Sadetzki, Susanna Lagorio, Toru Takebayashi, Naohito Yamaguchi, Alistair Woodward, Angus Cook, Tore Tynes, Lars Klaboe, Maria Feychting, Richard Feltbower, Anthony Swerdlow, Minouk Schoemaker, Elisabeth Cardis, Joachim Schuz
Summary: This case-control study found a negative association between allergic diseases and the risk of glioma, but no association with meningioma or acoustic neuroma. The previous diagnosis of epilepsy was associated with an increased risk of glioma and meningioma.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Oncology
Idris Olasunmbo Ola, Kirsi Talala, Teuvo Tammela, Kimmo Taari, Teemu Murtola, Paula Kujala, Jani Raitanen, Anssi Auvinen
Summary: PSA-based screening can reduce prostate cancer mortality, but may also lead to overdetection of low-risk disease. The incidence of prostate cancer is associated with PSA levels, with higher PSA values indicating an increased risk of aggressive disease. Risk stratification and appropriate rescreening intervals can help reduce overdetection.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Endocrinology & Metabolism
Lotta H. Nygard, Kirsi Talala, Kimmo Taari, Teuvo L. J. Tammela, Anssi Auvinen, Teemu J. Murtola
Summary: The use of antidiabetic medication, especially insulin, and untreated hyperglycemia are associated with an elevated risk of BPH surgery in diabetic men. These findings suggest that insulin use and high blood glucose levels may be risk factors for BPH.
Article
Public, Environmental & Occupational Health
Kaja Rahu, Mati Rahu, Hajo Zeeb, Anssi Auvinen, Evelyn Bromet, John D. D. Boice Jr
Summary: Mortality among Estonian cleanup workers in the Chernobyl area from 1986 to 2020 was studied. The all-cause standardized mortality ratio (SMR) was 1.04 and all-cancer mortality was elevated (SMR 1.16), with radiation-related cancers in excess (SMR 1.20). However, the excesses could be attributed to tobacco and alcohol consumption. Longer stays in the Chernobyl area, non-Estonian ethnicity, and lower education were associated with increased mortality risks. Suicide mortality was also increased, particularly among men with lower education.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biology
Olli Kurkela, Jaakko Nevalainen, Salla-Maaria Patsi, Katja Kojo, Olli Holmgren, Anssi Auvinen
Summary: This study estimated the number of lung cancer cases attributable to residential radon in Finland in 2017, considering factors such as age, sex, dwelling type, and smoking status. The results showed that at least 3% and at most 8% of all lung cancers were attributed to residential radon. Among smokers, the majority of radon-related cases were due to the joint effect of radon and smoking. Reducing radon exposure to specified action levels could significantly decrease the number of radon-attributable cases.
RADIATION AND ENVIRONMENTAL BIOPHYSICS
(2023)
Article
Public, Environmental & Occupational Health
Wafa Alimam, Atte Nikkila, Jani Raitanen, Kaija-Leena Kolho, Anssi Auvinen
Summary: The purpose of the study was to examine the association between residential mobility and childhood inflammatory bowel disease (IBD) risk. The findings suggest a slightly decreased risk of childhood IBD associated with residential mobility, especially when moving to rural areas and distances less than 50 km.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Urology & Nephrology
Sebastiaan Remmers, Chris H. Bangma, Rebecka A. Godtman, Sigrid. Carlsson, Anssi Auvinen, Teuvo L. J. Tammela, Louis J. Denis, Vera Nelen, Arnauld Villers, Xavier Rebillard, Maciej Kwiatkowski, Franz Recker, Stephen Wyler, Marco Zappa, Donella Puliti, Giuseppe Gorini, Alvaro Paez, Marcos Lujan, Daan Nieboer, Fritz H. Schroeder, Monique J. Roobol
Summary: Based on the guidelines of the European Association of Urology, a risk-based strategy for prostate cancer screening should be determined by the first prostate-specific antigen (PSA) level and age. In this study, the baseline PSA level was found to guide decisions on the repeat screening interval and had an impact on prostate cancer detection and specific mortality rates.
Article
Oncology
Kaja Rahu, Mati Rahu, Anssi Auvinen, Hajo Zeeb, John D. Boice Jr
Summary: From 1986 to 1991, 4831 men from Estonia were sent to clean up radioactively contaminated areas near Chernobyl. The study compared their cancer incidence rates to that of the male population of Estonia. It was found that there was an excess of radiation-related cancers combined, but not when smoking- and alcohol-related cancers were excluded. Less educated workers had a higher risk of all cancers and smoking-related cancers. An elevated risk of alcohol-related cancers was evident 15 to 24 years after return from the Chernobyl area.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Editorial Material
Medicine, General & Internal
Anssi Auvinen
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Review
Oncology
Julia Ventela, Anni Alanko, Anssi Auvinen, Olli Lohi, Atte Nikkila
Summary: This article conducted a systematic review to evaluate the association between childhood leukemia and autoimmune diseases. The study found a moderately increased risk of leukemia in children with autoimmune diseases. Further investigation is needed to explore the association for specific autoimmune diseases.
CANCER EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Anna-Maija Talvitie, Mika Helminen, Hanna Ojala, Teuvo Tammela, Anssi Auvinen, Ilkka Pietilae
Summary: Researchers found missing data issue in EPIC-26 scale, with 37% of patients leaving at least one question unanswered during follow-up. Factors associated with missingness include older age, lower education level, no relationship, more severe cancer, lower function scores in some EPIC domains, lower treatment satisfaction, or self-rated health. To improve validity, the hormonal section of the questionnaire needs additional explanation, and questions 8-10 should include a not-applicable option for sexually inactive patients.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2023)
Article
Clinical Neurology
Tuomas Natukka, Joonas Haapasalo, Tomi Kivioja, Linnea Rajala, Jani Raitanen, Jaakko Nevalainen, Sirpa-Liisa Lahtela, Kristiina Nordfors, Minna Rauhala, Arja Jukkola, Juhana Frosen, Pauli Helen, Anssi Auvinen, Hannu Haapasalo
Summary: The study aimed to analyze the impact of time interval from referral to surgery and from surgery to adjuvant treatment on survival of adult isocitrate dehydrogenase-wild-type (IDH-wt) glioblastomas. The results showed that the time interval from referral to surgery within 4-10 weeks was not associated with decreased survivals in IDH-wt glioblastomas, while a delay exceeding 30 days from surgery to adjuvant treatment may decrease long-term survival.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Aino Siltari, Teemu J. Murtola, Josefina Kausz, Kirsi Talala, Kimmo Taari, Teuvo L. J. Tammela, Anssi Auvinen
Summary: This study found that men using testosterone replacement therapy (TRT) were not at increased risk for prostate cancer (PCa) and did not experience increased mortality rate specifically from PCa or cardiovascular disease (CVD) compared to non-users. In fact, TRT users had a lower PCa mortality rate and slightly lower CVD and all-cause mortality.
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)
