Article
Medicine, General & Internal
Afrose Liaquat, Ameerdad Khan, Saeed Ullah Shah, Hania Iqbal, Safa Iqbal, Atif Iqbal Rana, Habib Ur Rahman
Summary: This study investigates the use of coronary artery calcium scoring (CACS) as a tool for coronary artery disease (CAD) risk stratification and its association with conventional cardiovascular risk factors. The results demonstrate a strong positive correlation between CACS and coronary artery stenosis, indicating the potential of CACS as a useful tool for CAD risk assessment.
Article
Medicine, General & Internal
Kristin Kvakkestad, Jon Michael Gran, Sigrun Halvorsen
Summary: This study compares the survival rate of patients with ST-elevation myocardial infarction (STEMI) treated with a pharmacoinvasive (PI) strategy or primary percutaneous coronary intervention (pPCI) strategy. The results show that using a PI strategy can improve the survival rate of STEMI patients when pPCI cannot be performed within 120 minutes.
Review
Engineering, Biomedical
Junsong Guo, Hao Wang, Ying Li, Shuang Zhu, Houxiang Hu, Zhanjun Gua
Summary: Coronary heart disease (CHD) is a leading cause of death and disability worldwide, particularly in low-income and middle-income countries and among older populations. Conventional diagnostic and therapeutic approaches have limitations, but nanotechnology offers promising alternatives for the diagnosis and treatment of CHD by utilizing the unique properties of nanomaterials. Nanomaterials can enhance early detection of CHD, facilitate targeted drug delivery and tissue engineering, and modulate inflammation and oxidative stress, addressing multiple aspects of CHD pathophysiology.
ACTA BIOMATERIALIA
(2023)
Review
Medicine, General & Internal
Ziwei Xi, Hong Qiu, Tingting Guo, Yong Wang, Jianan Li, Yang Li, Jianfeng Zheng, R. Gao
Summary: This study assessed the impact of sex differences on short-term and long-term mortality in patients with ST-segment elevation myocardial infarction (STEMI). The analysis of 15 studies involving 128,585 patients showed that female patients had a higher short-term mortality rate but similar long-term mortality rate compared to male patients. These findings indicate the need for improved management in female STEMI patients.
Article
Medicine, General & Internal
Tatendashe Bernadette Dondo, Theresa Munyombwe, Marlous Hall, Ben Hurdus, Anzhela Soloveva, Gerard Oliver, Suleman Aktaa, Robert M. West, Alistair S. Hall, Chris P. Gale
Summary: This study investigates sex-based differences in health-related quality of life (HRQoL) in myocardial infarction (MI) survivors. It finds that women have lower HRQoL compared with men after MI, and this difference persists during the 12-month follow-up.
Review
Medicine, General & Internal
Arnav Katira, Ravish Katira
Summary: Colchicine may play a key role in the prevention of cardiovascular events in patients with stable and unstable coronary artery disease, as it is associated with a reduction in the rate of myocardial infarction and other major cardiovascular outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Wen Su, Jie-Gao Zhu, Xue-Qiao Zhao, Hui Chen, Wei-Ping Li, Hong-Wei Li
Summary: This study showed that there is a U-shaped relationship between serum calcium levels and all-cause mortality in patients with acute coronary syndrome, with maintaining serum calcium around 2.35 mmol/L associated with reduced mortality risk.
Review
Medicine, General & Internal
Jose Alexandre Barbosa Almeida, Rencio Bento Florencio, Darllane Azevedo Lemos, Jessica Costa Leite, Karolinne Souza Monteiro, Lucien Peroni Gualdi
Summary: This study aims to assess the measurement properties, methodological quality, and content of outcome measures of cardiac self-efficacy instruments for individuals with coronary artery disease (CAD).
Article
Medicine, General & Internal
Quan L. Huynh, Son Nghiem, Joshua Byrnes, Paul A. Scuffham, Thomas Marwick
Summary: This study found that high-risk patients with coronary heart disease (CHD) benefit more from intensive disease management, with significantly greater improvement in days alive and out of hospital (DAOH) compared to low-risk patients. Medication and interventional therapies were found to have significantly greater effects in high-risk patients, indicating a greater benefit in terms of readmission and death.
Article
Medicine, General & Internal
Nurliyana Juhan, Yong Zulina Zubairi, Ahmad Syadi Mahmood Zuhdi, Zarina Mohd Khalid
Summary: This study identifies the significant predictors and interprets the dependence structure between predictors and health outcomes in ST-elevation myocardial infarction (STEMI) male patients in the Malaysian setting. It establishes a Bayesian network model with good predictive performance.
Article
Medicine, General & Internal
Henrik Wilander, Christos Pagonis, Dimitrios Venetsanos, Eva Swahn, Christian Dworeck, Nina Johnston, Lena Jonasson, Thomas Kellerth, Per Tornvall, Troels Yndigegn, Sofia Sederholm Lawesson
Summary: This nationwide study in Sweden aimed to describe the incidence, management, and outcome of spontaneous coronary artery dissection (SCAD) patients. The study found a low incidence of SCAD, with a higher proportion of male patients compared to previous studies. SCAD patients were younger with lower cardiovascular risk burden, but still had higher mortality and morbidity rates and more frequent acute coronary reangiography.
Article
Medicine, General & Internal
Zhuoshan Huang, Xiaodong Zhuang, Shaozhao Zhang, Yiquan Huang, Lianxiong Yuan, Aiwen Lin, Leile Tang, Zhenyu Xiong, Odong Christopher, Yang Chen, Bingyuan Wu, Yesheng Ling, Suhua Li, Qiang Jie, Longgen Xiong, Xiaoxian Qian, Xinxue Liao, Jinlai Liu
Summary: This is a multicenter randomized controlled trial aiming to determine whether alirocumab could reduce the incidence of type 4a MI or major periprocedural myocardial injury in patients with CHD undergoing elective PCI. The study will randomly assign 422 non-AMI CHD patients to receive standard pharmacotherapy or additional use of alirocumab. The primary outcome is the elevation of high-sensitivity cardiac troponin above the upper reference limit within 48 hours after PCI.
Review
Medicine, General & Internal
Audrey Wise, Deepika Mannem, Wade Arthur, Ryan Ottwell, Benjamin Greiner, Derek Srouji, Daniel Wildes, Micah Hartwell, Drew N. Wright, Jam Khojasteh, Matthew Vassar
Summary: This study aims to investigate the prevalence of spin in systematic reviews. By analyzing 185 systematic reviews, it was found that 31.9% of the abstracts contained some form of spin. Seven forms of spin were identified among the nine most severe types. The study did not find statistically significant associations between spin and the evaluated study characteristics or methodological quality.
Article
Medicine, General & Internal
Xiaoxing Li, Fangkun Yan, Xinhui Liu, Mingzhuo Li, Jiangbing Li, Yuguo Chen, Chuanbao Li
Summary: This research aimed to develop a simple and effective ACS screening model by conducting a case-control study and statistical analysis. Two random forest models were established, and it was found that the model with 27 clinical features performed better in predicting ACS.
Article
Multidisciplinary Sciences
Kyuwoong Kim, Hyeyun Jung, Edvige Di Giovanna, Tae Joon Jun, Young-Hak Kim
Summary: GGT levels are associated with an increased risk of ischemic stroke in adult cancer survivors, independent of sex, insurance premium, and alcohol consumption.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Fabrizio Ricci, Behzad Banihashemi, Mirnabi Pirouzifard, Jan Sundquist, Kristina Sundquist, Richard Sutton, Artur Fedorowski, Bengt Zoller
Summary: This study found a high familial incidence of dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), which is associated with genetic resemblance. The strongest aggregation was observed in relatives of affected females with HCM, while the association was attenuated for DCM.
Article
Medicine, General & Internal
Deqiang Zheng, Ning Li, Rui Hou, Xiaoyu Zhang, Lijuan Wu, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: By combining observational and mendelian randomization studies, this research found that the use of GLP-1 RAs significantly decreases the risk of diabetic retinopathy in patients with type 2 diabetes.
Editorial Material
Oncology
Bengt Zoller, Eric Manderstedt, Christina Lind-Hallden, Christer Hallden
LEUKEMIA RESEARCH REPORTS
(2023)
Article
Medicine, General & Internal
Yishan Liu, Jan Sundquist, Kristina Sundquist, Deqiang Zheng, Jianguang Ji
Summary: This study examined the long-term impact of childhood cancer on parental mental health, with a focus on potential sex differences between mothers and fathers. The results showed that the mental health of both parents was continuously affected by the diagnosis, but the impact was more severe for mothers. Therefore, tailored psychological services or interventions are necessary to support parents of children with cancer.
Article
Cardiac & Cardiovascular Systems
Ning Li, Xiaoyu Zhang, Meng Zhang, Lijuan Wu, Changwei Li, Yuesong Pan, Wei Wang, Jianguang Ji, Deqiang Zheng
Summary: This study used Mendelian randomization analysis to investigate the association between dyslipidemia and diabetic retinopathy (DR). The findings suggest a negative association between high-density lipoprotein cholesterol (HDL-C) levels and the development of DR, while CETP inhibitors were not found to be associated with DR. These results indicate a potential protective role of HDL-C in preventing DR.
Article
Oncology
Shan Huang, Nai-Qi Zhang, Chun-Jie Xu, Wu-Qing Huang, Dong-Xue Li, Jun Li, Lin-Li Yao, Kristina Sundquist, Jan Sundquist, Shu-Heng Jiang, Xin Xing, Li-Peng Hu, Zhi-Gang Zhang, Jianguang Ji, Xue-Li Zhang
Summary: Combined administration of dipyridamole and aspirin enhances the anti-cancer effect of aspirin against colorectal cancer by inducing endoplasmic reticulum stress and apoptosis.
Article
Cardiac & Cardiovascular Systems
Annie Brink, Johan Elf, Peter J. J. Svensson, Gunnar Engstrom, Olle Melander, Bengt Zoller
Summary: This study aimed to investigate whether there are sex-specific differences in risk factors for noncancer-related DVT and PE in middle-aged and older individuals. The results showed that anthropometric obesity measures were more strongly associated with DVT and PE in women than in men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Artur Fedorowski, Per Rosengren, Mirnabi Pirouzifard, Jan Sundquist, Kristina Sundquist, Richard Sutton, Bengt Zoller
Summary: This nationwide study aimed to determine the occurrence of complete atrioventricular block (CAVB) in different degrees of relatives (full siblings, half-siblings, and cousins). The results showed that the risk of CAVB is highest in young siblings, and the degree of familial relationship is associated with the risk of disease, indicating the presence of genetic components in the cause of CAVB.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2023)
Letter
Urology & Nephrology
Kari Hemminki, Jianguang Ji, Jan Sundquist
Letter
Endocrinology & Metabolism
Bengt Zoller, Eric Manderstedt, Christina Lind-Hallden, Christer Hallden
JOURNAL OF DIABETES
(2023)
Letter
Cardiac & Cardiovascular Systems
Bengt Zoller, Eric Manderstedt, Christina Lind-Hallden, Christer Hallden
Letter
Cardiac & Cardiovascular Systems
Bengt Zoller, Eric Manderstedt, Christina Lind-Hallden, Christer Hallden
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Public, Environmental & Occupational Health
Yuying Wang, Yujie Zhang, Meng Zhang, Xiaoyu Zhang, Haibin Li, Youxin Wang, Wei Wang, Jianguang Ji, Lijuan Wu, Deqiang Zheng
Summary: This study aimed to explore the prevalence of adverse reactions to COVID-19 vaccination and provide direct evidence of vaccine safety for the elderly and those with underlying medical conditions. The prevalence of adverse reactions in these populations was found to be similar to that of the general population, suggesting that vaccination is safe for them.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Letter
Peripheral Vascular Disease
Bengt Zoller, Eric Manderstedt, Christina Lind-Hallden, Christer Hallden
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Medicine, General & Internal
Naiqi Zhang, Yanni Li, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This study identified eight druggable target genes for breast cancer and suggested that raloxifene is an effective chemoprevention against breast cancer, using Mendelian randomization analysis and population-based validation.
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)
