Article
Oncology
Philip D. Poorvu, Shari I. Gelber, Yue Zheng, Kathryn J. Ruddy, Rulla M. Tamimi, Jeffrey Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Matteo Lambertini, Shoshana M. Rosenberg, Ann H. Partridge
Summary: Many young women with newly diagnosed breast cancer express interest in future pregnancies. Within 5 years of diagnosis, 36% reported interest in having children, with the majority successfully conceiving if they attempted to do so. Factors such as age at diagnosis and parity status were associated with likelihood of pregnancy, while endocrine therapy was inversely linked to pregnancy outcomes. Longitudinal fertility discussions are important for this population.
Article
Oncology
Chloe Leproux, Valerie Seegers, Anne Patsouris, Baptiste Sauterey
Summary: This study aimed to assess the rate of live births achieved through natural or assisted reproductive technology in breast cancer patients with pregnancy desire, with a live birth rate of 19.7% observed in the cohort.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Kimia Sorouri, Tal Sella, Shoshana M. Rosenberg, Maggie Loucks, Gregory Kirkner, Craig Snow, Kathryn J. Ruddy, Shari I. Gelber, Rulla M. Tamimi, Jeffrey M. Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Ellen Warner, Ann H. Partridge
Summary: This study investigated the postcancer conception and pregnancy experience of young BC survivors and found that most of them conceived naturally without negative impact from the history of BC. However, a higher rate of hypertensive disorders of pregnancy was observed, requiring further investigation.
Article
Oncology
M. Condorelli, M. Bruzzone, M. Ceppi, A. Ferrari, A. Grinshpun, A. S. Hamy, E. de Azambuja, E. Carrasco, F. A. Peccatori, A. Di Meglio, S. Paluch-Shimon, P. D. Poorvu, M. Venturelli, C. Rousset-Jablonski, C. Senechal, L. Livraghi, R. Ponzone, L. De Marchis, K. Pogoda, A. Sonnenblick, C. Villarreal-Garza, O. Cordoba, L. Teixeira, F. Clatot, K. Punie, R. Graffeo, M. Dieci, J. A. Perez-Fidalgo, F. P. Duhoux, F. Puglisi, A. R. Ferreira, E. Blondeaux, T. Peretz-Yablonski, O. Caron, C. Saule, L. Ameye, J. Balmana, A. H. Partridge, H. A. Azim, I Demeestere, M. Lambertini
Summary: In breast cancer survivors carrying germline BRCA1/2 pathogenic variants, assisted reproductive techniques (ART) may be a safe option when natural conception fails. Patients in the ART group were older and experienced more delivery complications, but there were no apparent differences in other obstetrical outcomes between the two groups.
Review
Oncology
Matteo Lambertini, Eva Blondeaux, Marco Bruzzone, Marta Perachino, Richard A. Anderson, Evandro de Azambuja, Philip D. Poorvu, Hee Jeong Kim, Cynthia Villarreal-Garza, Barbara Pistilli, Ines Vaz-Luis, Cristina Saura, Kathryn J. Ruddy, Maria Alice Franzoi, Chiara Sertoli, Marcello Ceppi, Hatem A. Azim, Frederic Amant, Isabelle Demeestere, Lucia Del Mastro, Ann H. Partridge, Olivia Pagani, Fedro A. Peccatori
Summary: This study found that breast cancer survivors are less likely to have a subsequent pregnancy compared to the general population, and they face higher risks during pregnancy, especially among those who have received chemotherapy. However, compared to breast cancer patients without subsequent pregnancy, those who become pregnant have better disease-free survival and overall survival rates.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Review
Nutrition & Dietetics
Jose Luis Mansur, Beatriz Oliveri, Evangelina Giacoia, David Fusaro, Pablo Rene Costanzo
Summary: Vitamin D deficiency in pregnancy and infants may lead to health issues such as rickets, preeclampsia, and fetal growth restriction; supplementation with Vitamin D can reduce the risk of complications for pregnant women, fetuses, and newborns.
Article
Medicine, General & Internal
Ann H. Partridge, Samuel M. Niman, Monica Ruggeri, Fedro A. Peccatori, Hatem A. Azim, Marco Colleoni, Cristina Saura, Chikako Shimizu, Anna B. Saetersdal, Judith R. Kroep, Audrey Mailliez, Ellen Warner, Virginia F. Borges, Frederic Amant, Andrea Gombos, Akemi Kataoka, Christine Rousset-Jablonski, Simona Borstnar, Junko Takei, Jeong E. Lee, Janice M. Walshe, Manuel Ruiz-Borrego, Halle C. F. Moore, Christobel Saunders, Vesna Bjelic-Radisic, Snezana Susnjar, Fatima Cardoso, Karen L. Smith, Teresa Ferreiro, Karin Ribi, Kathryn Ruddy, Roswitha Kammler, Sarra El-Abed, Giuseppe Viale, Martine Piccart, Larissa A. Korde, Aron Goldhirsch, Richard D. Gelber, Olivia Pagani
Summary: This study evaluated the risk of breast cancer recurrence among young breast cancer patients who temporarily discontinued hormone therapy to attempt pregnancy. The results showed that this interruption in therapy did not increase the risk of breast cancer events.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Obstetrics & Gynecology
Kirsten Jorgensen, Roni Nitecki, Hazel B. Nichols, Shuangshuang Fu, Chi-Fang Wu, Alexander Melamed, Paula Brady, Mariana Chavez Mac Gregor, Mark A. Clapp, Sharon Giordano, J. Alejandro Rauh-Hain
Summary: The study evaluated obstetric and neonatal outcomes of the first live birth conceived 1 or more years after breast cancer diagnosis, and found that there was no strong association between breast cancer diagnosed 1 or more years before fertilization and obstetric and neonatal complications.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Genetics & Heredity
Mary Kathryn Abel, Kaitlyn Wald, Nikita Sinha, Joseph M. Letourneau, Rhodel Simbulan, Evelyn Mok-Lin, Marcelle I. Cedars, Mitchell P. Rosen
Summary: Half of breast cancer patients with return of ovarian function after chemotherapy were able to conceive through intercourse alone; to maximize reproductive potential, providers should offer natural conception as an option prior to the use of cryopreserved tissue; the use of pre-treatment cryopreserved eggs or embryos had a high likelihood of success for those who did not attempt to conceive on their own.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Oncology
Tal Sella, Philip D. Poorvu, Kathryn J. Ruddy, Shari I. Gelber, Rulla M. Tamimi, Jeffrey M. Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Ann H. Partridge, Shoshana M. Rosenberg
Summary: The study found that one-third of young women with breast cancer were affected by fertility concerns when making decisions about endocrine therapy, with parity at diagnosis being the main factor associated with these concerns. Women with fertility-related concerns were more likely to be nonpersistent in their endocrine therapy use compared to those without fertility concerns.
Review
Oncology
Santiago Moragon, Raimondo Di Liello, Begona Bermej, Cristina Hernando, Ernesto Olcina, Isabel Chirivella, Ana Lluch, Juan Miguel Cejalvo, Maria Teresa Martinez
Summary: Fertility preservation is crucial for breast cancer patients undergoing oncological treatment. Cryopreservation of mature oocytes is the standard procedure, while other options like ovarian tissue preservation or gonadal protection during chemotherapy are still experimental but effective. Timely referral to a fertility unit is highly recommended to ensure quality care.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Obstetrics & Gynecology
Manon Mangiardi-Veltin, Clara Sebbag, Christine Rousset-Jablonski, Isabelle Ray-Coquard, Clementine Berkach, Lucie Laot, Yuting Wang, Ines Abdennebi, Julie Labrosse, Camille Sautter, Aullene Toussaint, Laura Sablone, Enora Laas, Sarah Khallouch, Florence Coussy, Pietro Santulli, Charles Chapron, Angelique Bobrie, William Jacot, Nadir Sella, Elise Dumas, Claire Senechal-Davin, Marc Espie, Sylvie Giacchetti, Lorraine Maitrot, Genevieve Plu-Bureau, Charles Coutant, Julien Guerin, Bernard Asselain, Pierre Fumoleau, Manuel Rodrigues, Christine Decanter, Audrey Mailliez, Lidia Delrieu, Amelie Lemoine, Christelle Jouannaud, Doriane Houdre, Fabien Reyal, Anne-Sophie Hamy, Seintinelles Research Network Seintinelles Res Network
Summary: This study examined the oncofertility practices in young women diagnosed with breast cancer. The majority of patients did not receive proper specialized oncofertility counseling at the time of diagnosis, resulting in a higher rate of naturally conceived pregnancies compared to pregnancies resulting from the use of cryopreserved gametes. Adequate contraceptive counseling is as important as information about fertility and can prevent unplanned pregnancies.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Oncology
Serena Girardelli, Giorgia Mangili, Stefania Cosio, Emanuela Rabaiotti, Antonio Fanucchi, Luca Valsecchi, Massimo Candiani, Angiolo Gadducci
Summary: The paper aims to review the impact of pregnancy on survivors of common childhood cancers and provide guidance for clinicians to counsel patients in delicate moments. A multidisciplinary team is crucial in supporting patients and their loved ones when facing pregnancy after a previous cancer diagnosis.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Daniel J. Corsi, Malia S. Q. Murphy
Summary: Research on the effects of opioid use on female fertility, pregnancy, and infant health is primarily focused on pregnancy and neonatal outcomes, with limited exploration of fertility effects. Limited studies with small sample sizes and methodological challenges exist, hindering a comprehensive understanding of the impacts of opioid use on reproductive health.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Review
Oncology
Marta Perachino, Francesca Poggio, Luca Arecco, Eva Blondeaux, Stefano Spinaci, Camilla Marrocco, Alessia Levaggi, Matteo Lambertini
Summary: Survivorship is crucial in breast cancer care, and conceiving after anticancer treatments should not be discouraged. Oncofertility counseling should be provided at diagnosis to inform patients about potential fertility issues and preservation strategies. This article focuses on pregnancy in patients with hormone receptor-positive disease and BRCA carriers.
Review
Oncology
Adelina Petrone, Marta Carlesimo, Maria Caterina Fortuna, Fedro Alessandro Peccatori, Giovanni Codacci-Pisanelli, Raffaele Barbara, Sara Cruciani, Pier Andrea Serra, Laura Maioli, Margherita Maioli, Gloria Trocchi
Summary: The prevalence of cancer is increasing due to rising incidence of tumors and more effective treatments. Many oncological treatments are associated with cutaneous toxicity, which may become chronic or permanent. Collaboration between specialists in different branches can help prevent and manage cutaneous toxicity in cancer patients.
Review
Oncology
Konstantinos Venetis, Elham Sajjadi, Fedro A. Peccatori, Elena Guerini-Rocco, Nicola Fusco
Summary: Pregnancy-associated breast cancer is a rare tumor that requires complex management. The coexistence of cancer and pregnancy involves shared proliferative, invasive, and immune tolerance mechanisms. The understanding of these mechanisms could lead to the identification of novel biomarkers and improved clinical management for patients with pregnancy-associated breast cancer.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Review
Oncology
Maria Cristina Pirosa, Fedro Alessandro Peccatori
Summary: Lymphoma in pregnancy is a rare condition that requires a multidisciplinary approach for management. The choice of treatment depends on the type of lymphoma and gestational age. ABVD is safe for Hodgkin lymphoma after the thirteenth week of pregnancy, while a watchful waiting approach is reasonable for indolent non-Hodgkin lymphomas. Termination of pregnancy may be considered for aggressive NHLs in early gestational weeks, while R-CHOP regimen is safe after the thirteenth week. More data on the safety of new anti-lymphoma drugs in pregnant patients is needed to facilitate clinical decision making.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Oncology
David Cibula, Maria Rosaria Raspollini, Francois Planchamp, Carlos Centeno, Cyrus Chargari, Ana Felix, Daniela Fischerova, Daniela Jahnn-Kuch, Florence Joly, Christhardt Kohler, Sigurd Lax, Domenica Lorusso, Umesh Mahantshetty, Patrice Mathevet, Raj Naik, Remi A. Nout, Ana Oaknin, Fedro Peccatori, Jan Persson, Denis Querleu, Sandra Rubio Bernabe, Maximilian P. Schmid, Artem Stepanyan, Valentyn Svintsitskyi, Karl Tamussino, Ignacio Zapardiel, Jacob Lindegaard
Summary: In 2018, ESGO, ESTRO, and ESP jointly published evidence-based guidelines for the management of patients with cervical cancer. The update includes new topics to provide comprehensive guidelines on all relevant issues of diagnosis and treatment.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Nursing
Martina Smorti, Lucia Ponti, Chiara Cassani, Giuseppe Nastasi, Nicola Giuntini, Gabriella Pravettoni, Fedro A. Peccatori, Giulia Mauri, Giovanni Danesi, Francesca Pozza, Valentina Sarchi, Lucia Bonassi
Summary: This study explored the differences in pregnancy and infant feeding experiences between pregnant women with a cancer history and those without. The results showed that women with a cancer history had a higher perception of negative judgment and moral choice about breastfeeding. However, they had a more positive childbirth experience and higher levels of satisfaction and pleasure in infant feeding.
JOURNAL OF HUMAN LACTATION
(2023)
Editorial Material
Geriatrics & Gerontology
Riccardo Audisio, Lodovico Balducci, Silvio Monfardini, Fedro A. Peccatori, Siri Rostoft, Barbara van Leeuwen
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Medicine, General & Internal
Ann H. Partridge, Samuel M. Niman, Monica Ruggeri, Fedro A. Peccatori, Hatem A. Azim, Marco Colleoni, Cristina Saura, Chikako Shimizu, Anna B. Saetersdal, Judith R. Kroep, Audrey Mailliez, Ellen Warner, Virginia F. Borges, Frederic Amant, Andrea Gombos, Akemi Kataoka, Christine Rousset-Jablonski, Simona Borstnar, Junko Takei, Jeong E. Lee, Janice M. Walshe, Manuel Ruiz-Borrego, Halle C. F. Moore, Christobel Saunders, Vesna Bjelic-Radisic, Snezana Susnjar, Fatima Cardoso, Karen L. Smith, Teresa Ferreiro, Karin Ribi, Kathryn Ruddy, Roswitha Kammler, Sarra El-Abed, Giuseppe Viale, Martine Piccart, Larissa A. Korde, Aron Goldhirsch, Richard D. Gelber, Olivia Pagani
Summary: This study evaluated the risk of breast cancer recurrence among young breast cancer patients who temporarily discontinued hormone therapy to attempt pregnancy. The results showed that this interruption in therapy did not increase the risk of breast cancer events.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Paola Quarello, Angela Toss, Paola Berchialla, Maurizio Mascarin, Matteo Lambertini, Marta Canesi, Giuseppe Maria Milano, Lorena Incorvaia, Giuseppe Luigi Banna, Fedro Peccatori, Andrea Ferrari
Summary: This study aims to explore the attitude of Italian healthcare professionals towards sexual health communication with AYA patients. The findings reveal that lack of preparation and embarrassment are barriers to communication, and less than 5% of clinicians received specific training on sexual health issues in AYA patients.
Editorial Material
Oncology
Daniele Carrieri, Fedro Alessandro Peccatori, Giovanni Boniolo
Summary: 'Oncohumanities' is a new field that combines humanities and oncology to address the real needs and priorities of patients. A training program is proposed to integrate conceptual knowledge of oncology with person-centered care, patient empowerment, and respect for diversity. Oncohumanities differs from traditional medical humanities training as it is integrated with and driven by the needs of daily oncology practice. It is hoped that this program and approach will guide future efforts to strengthen the partnership between humanities and oncology.
Article
Pathology
David Cibula, Maria Rosaria Raspollini, Francois Planchamp, Carlos Centeno, Cyrus Chargari, Ana Felix, Daniela Fischerova, Daniela Jahnn-Kuch, Florence Joly, Christhardt Kohler, Sigurd Lax, Domenica Lorusso, Umesh Mahantshetty, Patrice Mathevet, Raj Naik, Remi A. Nout, Ana Oaknin, Fedro Peccatori, Jan Persson, Denis Querleu, Sandra Rubio Bernabe, Maximilian P. Schmid, Artem Stepanyan, Valentyn Svintsitskyi, Karl Tamussino, Ignacio Zapardiel, Jacob Lindegaard
Summary: In 2018, the European Society of Gynecological Oncology (ESGO) collaborated with the European Society for Radiotherapy and Oncology (ESTRO) and the European Society of Pathology (ESP) to publish evidence-based guidelines for the management of cervical cancer. These updated guidelines cover all relevant issues of diagnosis and treatment, and were developed by a panel of 27 experts from across Europe.
Review
Oncology
Konstantinos Venetis, Elham Sajjadi, Mariia Ivanova, Fedro Alessandro Peccatori, Nicola Fusco, Elena Guerini-Rocco
Summary: Pregnancy-associated breast cancer (PrBC) affects a small number of women and has unique immune characteristics. Understanding the immune environment of PrBC can provide insights for better clinical management, but current research on this topic is limited.
Article
Oncology
Daniela Pierannunzio, Alice Maraschini, Tania Lopez, Serena Donati, Rosalba Amodio, Fortunato Bianconi, Rossella Bruni, Marine Castaing, Claudia Cirilli, Giovanna Fantaci, Linda Guarda, Silvia Iacovacci, Lucia Mangone, Guido Mazzoleni, Walter Mazzucco, Anna Melcarne, Elisabetta Merlo, Fabio Parazzini, Fedro Alessandro Peccatori, Massimo Rugge, Giuseppe Sampietro, Giovanni Scambia, Giovanna Scarfone, Ausilia Sferrazza, Fabrizio Stracci, Antonina Torrisi, Maria Francesca Vitale, Silvia Francisci
Summary: Concurrence of pregnancy and cancer diagnosis is becoming more common due to the trend of postponing childbearing. This study aims to describe the frequency and trend of pregnancy-associated cancer (PAC) in Italy. The study found that PAC has been increasing from 2003 to 2015, with breast cancer being the most frequent type. The findings provide guidance for clinicians in managing PAC.
Meeting Abstract
Oncology
Ann Partridge, Olivia Pagani, Samuel M. Niman, Monica Ruggeri, Fedro Alessandro A. Peccatori, Hatem A. Azim, Marco Colleoni, Cristina Saura, Chikako Shimizu, Anna Saetersdal, Judith Kroep, Audrey Mailliez, Ellen Warner, Virginia F. Borges, Frederic Amant, Andrea Gombos, Akemi Kataoka, Christine Rousset-Jablonski, Simona Borstnar, Junko Takei, Jeong Eon Lee, Janice Walshe, Manuel Ruiz Borrego, Halle Moore, Christobel Saunders, Vesna Bjelic-Radisic, Snezana Susnjar, Fatima Cardoso, Karen L. Smith, Teresa Ferreiro Vilarino, Karin Ribi, Kathryn Ruddy, Sarra El-Abed, Martine Piccart, Larissa A. Korde, Aron Goldhirsch, Richard D. Gelber
Meeting Abstract
Oncology
Elham Sajjadi, Konstantinos Venetis, Mariia Ivanova, Marianna Noale, Concetta Blundo, Giovanna Scarfone, Eugenia Di Loreto, Stefano Ferrero, Stefania Maggi, Paolo Veronesi, Viviana Enrica Galimbreti, Giuseppe Viale, Fedro Alessandro A. Peccatori, Elena Guerini-Rocco, Nicola Fusco
Article
Law
Alma Linkeviciute, Giuseppe Curigliano, Fedro Alessandro Peccatori, Paulius Pakutinskas
Summary: This article critically analyzes how the proposed Artificial Intelligence Act (AIA) will support the rights, safety, dignity, and well-being of clinical research participants and ensure the availability of reliable and robust data. The focus is on the impact of the proposed regulation on clinical research within the European Union and how it aligns with the core principles of the Clinical Trials Regulation.
BIOLAW JOURNAL-RIVISTA DI BIODIRITTO
(2022)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)