Article
Biochemistry & Molecular Biology
Piotr Czarny, Sylwia Ziolkowska, Lukasz Kolodziej, Cezary Watala, Paulina Wigner-Jeziorska, Katarzyna Blizniewska-Kowalska, Katarzyna Wachowska, Malgorzata Galecka, Ewelina Synowiec, Piotr Galecki, Michal Bijak, Janusz Szemraj, Tomasz Sliwinski
Summary: This study explores the impact of SNPs in genes encoding enzymes involved in mtDNA replication, repair, or degradation on the occurrence, onset, severity, and treatment of MDD. The findings suggest that mtDNA damage and impairment in its metabolism play a crucial role in the development and treatment of depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Makedonka Atanasovska Velkovska, Katja Goricar, Tanja Blagus, Vita Dolzan, Barbara Cvenkel
Summary: The study found that GSTM1 gene deletion is associated with decreased risk of ocular hypertension, and genetic variability in IL1B and IL6 may be linked to glaucoma risk. Additionally, GPX and TNF genes may be associated with the glaucoma phenotype. This suggests potential new strategies and personalized treatment for glaucoma based on genetic factors.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Bensu Karahalil, Ece Miser Salihoglu, Aylin Elkama, Gurdal Orhan, Evrim Saygin, Sevgi Akaydin Yardim
Summary: Oxidative stress is important in the degeneration of dopaminergic neurons in Parkinson's disease. Individual susceptibility may be associated with the development of oxidative stress-based PD, and measuring oxidative stress-related biomarkers can help manage the detrimental effects of the disease.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mu-Rong Chao, Mark D. Evans, Chiung-Wen Hu, Yunhee Ji, Peter Moller, Pavel Rossner, Marcus S. Cooke
Summary: Research on oxidative damage to DNA has implications for understanding the pathogenesis of various diseases, with increasing interest in the effects of damage to RNA and nucleotide pools. LCMS/MS and comet assays are important methods for assessing oxidative stress, but have limitations in sample requirements and application scope. Urine is an ideal matrix for studying nucleic acid-derived biomarkers of oxidative stress, with progress being made in validating measurements, particularly through DNA adductomics approaches that offer insights into the role of oxidatively damaged nucleic acids in disease.
Article
Medicine, Research & Experimental
Yujie Zhang, Chunyang Ding, Wenkang Zhu, Xinyu Li, Techang Chen, Qingxi Liu, Sa Zhou, Tong-Cun Zhang, Wenjian Ma
Summary: This study reveals that bulky DNA damage inducing chemotherapeutic cancer drugs can stimulate persistent endogenous reactive oxygen species (ROS) production, which correlates with DNA double-strand breaks (DSBs) formation. The knockdown of key player BRCA1 in homologous recombination (HR) pathway enhances ROS accumulation, while inhibiting nonhomologous end-joining (NHEJ) repair pathway and restoring HR can partially suppress ROS levels. Knockdown of DNA repair regulator PP2A can also reduce ROS production.
Article
Oncology
Mingyao Zhang, Zhiguang Zhao, Sailing Chen, Zongwen Liang, Jiawei Zhu, Manman Zhao, Chaoyi Xu, Jing He, Ping Duan, Anqi Zhang
Summary: The study revealed that specific polymorphisms in the PARPI, hOGGI, and LIG3 genes may impact the risk of ovarian cancer, with certain variants of PARPI and hOGGI decreasing the risk, while a variant of LIG3 increasing the risk of developing ovarian cancer. Further research with larger and diverse populations is needed to confirm these findings.
Article
Oncology
Silvia Codenotti, Francesco Marampon, Luca Triggiani, Marco Lorenzo Bonu, Stefano Maria Magrini, Paola Ceccaroli, Michele Guescini, Stefano Gastaldello, Vincenzo Tombolini, Pietro Luigi Poliani, Michela Asperti, Maura Poli, Eugenio Monti, Alessandro Fanzani
Summary: The study investigated the role of Caveolin-1 (Cav-1) in radiation response in rhabdomyosarcoma (RMS), suggesting that Cav-1 may play a vital role in promoting radioresistance through mechanisms involving cell cycle regulation, apoptosis, oxidative stress and DNA repair pathways. The findings reveal that Cav-1, in conjunction with catalase, Src-kinase, and Akt pathways, may form a network of essential mechanisms that allow irradiated RMS cells to evade cell death induced by radiation.
Article
Environmental Sciences
Sonalin Rath, Surajit Das
Summary: Bacteria thriving in the mangrove ecosystem play a significant role in elemental cycles, but their performance is influenced by climate change and environmental stressors. This study investigates the genotoxic effect of such stressors on mangrove bacteria and their adaptation strategies. The results show cellular injuries and DNA damage in response to stressors, with different bacterial strains exhibiting varying levels of tolerance and adaptive mechanisms.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cell Biology
Wei Zhao, Zhongjie Liu, Jiaming Luo, Changqing Ma, Luying Lai, Zhengyuan Xia, Shiyuan Xu
Summary: The study indicates that PARP-1 plays a key role in repairing oxidative DNA damage induced by bupivacaine, with interactions with XPD protein contributing to DNA integrity maintenance.
Article
Oncology
Zhenjian Zhuo, Lei Miao, Wenfeng Hua, Huitong Chen, Zhonghua Yang, Yong Li, Jiao Zhang, Suhong Li, Jiwen Cheng, Li Li, Huimin Xia, Jing He
Summary: Through genotype analysis of Chinese children diagnosed with hepatoblastoma and controls, two SNPs in the XPC gene were found to be associated with increased or decreased risk of hepatoblastoma, suggesting XPC gene as a potential biomarker for hepatoblastoma risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Merle M. Nicolai, Ann-Kathrin Weishaupt, Jessica Baesler, Vanessa Brinkmann, Anna Wellenberg, Nicola Winkelbeiner, Anna Gremme, Michael Aschner, Gerhard Fritz, Tanja Schwerdtle, Julia Bornhorst
Summary: Although manganese is an essential trace element, overexposure can lead to toxicity and neurological dysfunction. This study investigated the mode of action of manganese toxicity on genomic integrity, focusing on DNA damage and repair mechanisms using Caenorhabditis elegans as a model organism. The results suggest that excessive manganese exposure can decrease genomic integrity and activate base excision repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
S. G. Chowdhury, S. Misra, Parimal Karmakar
Summary: Ageing is a multi-factorial phenomenon, and accumulation of DNA damage or mutations is a dominant theory which contributes largely to the development of ageing and age-related diseases. Obesity is a complex chronic disease that affects multiple organs and tissues, and it has been found to be associated with higher loads of DNA damage. The present review focuses on the involvement of DNA metabolism in the development of obesity and how it accelerates ageing in mammals.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Biochemistry & Molecular Biology
Dandan Sun, Shimei Chen, Shenping Li, Ning Wang, Shuchang Zhang, Li Xu, Shaopin Zhu, Huiming Li, Qing Gu, Xun Xu, Fang Wei
Summary: The accumulation of DNA damage induced by oxidative stress is a crucial pathogenic factor of endothelial loss in diabetic vascular complications. It is still unclear whether aberrant glucose metabolism leads to defective DNA repair and accounts for hyperglycemia-induced endothelial oxidative stress injury. Our study showed that Foxo1 knockdown alleviated diabetes-associated retinal DNA damage and vascular dysfunction by promoting DNA repair mediated by the MRN-ATM pathway and restoring glycolysis capacity. Our findings suggest that defective glycolysis-dependent DNA repair could be a novel therapeutic target for diabetic vascular complications.
Article
Oncology
Nicole M. Niehoff, Mary Beth Terry, Deborah B. Bookwalter, Joel D. Kaufman, Katie M. O'Brien, Dale P. Sandler, Alexandra J. White
Summary: This study suggests that there is an association between NO2 exposure and increased breast cancer risk in women with higher familial risk, while the association with PM2.5 did not vary. The impact of different pollutants on breast cancer risk may vary among individuals with different levels of familial risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Genetics & Heredity
Hossein Ghaderi-Zefrehi, Maryam Rezaei, Farzin Sadeghi, Mohammad Heiat
Summary: Hepatocellular carcinoma (HCC) is closely related to risk factors such as chronic hepatitis B or C infections and alcohol addiction. Defects in DNA repair systems can increase susceptibility to cancer, and genetic polymorphisms in DNA repair genes may affect DNA repair capacity and modulate cancer risk. Identifying these polymorphisms and their association with HCC risk can help improve prevention and treatment strategies.
Article
Biochemistry & Molecular Biology
Maria Pena-Chilet, Gema Roldan, Javier Perez-Florido, Francisco M. Ortuno, Rosario Carmona, Virginia Aquino, Daniel Lopez-Lopez, Carlos Loucera, Jose L. Fernandez-Rueda, Asuncion Gallego, Francisco Garcia-Garcia, Anna Gonzalez-Neira, Guillermo Pita, Rocio Nunez-Torres, Javier Santoyo-Lopez, Carmen Ayuso, Pablo Minguez, Almudena Avila-Fernandez, Marta Corton, Miguel Angel Moreno-Pelayo, Matias Morin, Alvaro Gallego-Martinez, Jose A. Lopez-Escamez, Salud Borrego, Guillermo Antinolo, Jorge Amigo, Josefa Salgado-Garrido, Sara Pasalodos-Sanchez, Beatriz Morte, Angel Carracedo, Angel Alonso, Joaquin Dopazo
Summary: The Collaborative Spanish Variability Server (CSVS) is a database containing genomes and exomes of unrelated Spanish individuals, generated through a crowdsourcing effort. It provides data support for studying disease variants and population genetic variations, with a web interface for querying and conducting pseudo-control studies for diseases.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Oncology
Marisol Huerta, Susana Rosello, Luis Sabater, Ana Ferrer, Noelia Tarazona, Desamparados Roda, Valentina Gambardella, Clara Alfaro-Cervello, Marina Garces-Albir, Andres Cervantes, Maider Ibarrola-Villava
Summary: Pancreatic cancer is a highly challenging and poor prognosis malignancy. Liquid biopsy using circulating tumor DNA (ctDNA) shows great potential as a non-invasive biomarker for early diagnosis, prognosis, and management of the disease, although its sensitivity remains limited and cannot be used as a screening or diagnostic tool.
Article
Oncology
Lara P. Fernandez, Maria Merino, Gonzalo Colmenarejo, Juan Moreno Rubio, Tais Gonzalez Pessolani, Guillermo Reglero, Enrique Casado, Maria Sereno, Ana Ramirez de Molina
Summary: Despite advancements in surgery and therapies, small cell lung cancer (SCLC) remains one of the deadliest types of cancer. A metabolic precision approach for SCLC patients is proposed for the first time, highlighting the importance of metabolic health and lipid gene expression in predicting SCLC survival. Two lipid metabolism genes, racemase and perilipin 1, along with a genetic risk score of both genes, are shown to be biomarkers of SCLC survival. Importantly, controlling metabolic health, lipid gene expression, and lifestyle-associated environmental factors is crucial for increased SCLC survival.
Article
Biochemistry & Molecular Biology
Macarena Lopez-Sanchez, Carlos Loucera, Maria Pena-Chilet, Joaquin Dopazo
Summary: Recent studies have shown the importance of host genetics in the prognosis of COVID-19. This study used a mathematical mechanistic model to identify potential interactions between rare disease genes and the COVID-19 infection process. Out of the analyzed disease genes, 254 genes directly affect the COVID-19 molecular disease mechanism and 207 genes have an indirect effect. These findings suggest the potential for preventive measures in some rare diseases based on the links between disease genes and COVID-19 hallmarks.
HUMAN MOLECULAR GENETICS
(2022)
Article
Multidisciplinary Sciences
Carlos S. Casimiro-Soriguer, Carlos Loucera, Maria Pena-Chilet, Joaquin Dopazo
Summary: The gut microbiome has gained attention for its association with diseases like colorectal cancer and its potential to predict diseases through non-intrusive biomarkers. A meta-analysis of fecal metagenomic samples revealed that an interpretable machine learning approach based on functional profiles showed greater accuracy in predicting colorectal cancer compared to previous proposals. This approach was also effective in identifying samples with adenoma, making it promising for detecting early stages of colorectal cancer and facilitating intervention. Functional profiles provide insights into the molecular mechanisms behind these conditions and have demonstrated superior accuracy compared to taxonomic profiles.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Fernando Pereira, Angel Serrano, Israel Manzanedo, Estibalitz Perez-Viejo, Santiago Gonzalez-Moreno, Luis Gonzalez-Bayon, Alvaro Arjona-Sanchez, Juan Torres, Isabel Ramos, Maria E. Barrios, Pedro Cascales, Rafael Morales, Enrique Boldo, Alfonso Garcia-Fadrique, Xabier Arteaga, Alberto Gutierrez-Calvo, Susana Sanchez-Garcia, Enrique Asensio, Cesar P. Ramirez, Manuel Artiles, Javier Vaque, Pedro A. Parra, Pedro Villarejo, Cristobal Munoz-Casares, Estrella Turienzo, Alicia Calero, Isabel Jaen Torrejimeno, Isabel Prieto, Julio Galindo, Vicente Borrego, Manuel E. Marcello, Cristina Rihuete, Joaquin Carrasco, Luis Gomez-Quiles
Summary: The French PRODIGE 7 trial raised doubts about the specific survival benefit of HIPEC with oxaliplatin for colorectal cancer peritoneal metastases. The GECOP-MMC trial aims to evaluate the effectiveness of HIPEC with high-dose mytomicin-C in preventing peritoneal recurrence in limited peritoneal metastasis from colon cancer. The primary endpoint is 3-year peritoneal recurrence-free survival.
Meeting Abstract
Clinical Neurology
Ana M. Perez-Gutierrez, Rosario Carmona, Luis Javier Martinez-Gonzalez, Elena Lopez-Isac, Joaquin Dopazo, Jorge A. Cervilla, Blanca Gutierrez, Esther Molina, Juan Antonio Zarza-Rebollo, Maria Pena-Chilet, Daniel Lopez-Lopez, Javier Perez-Florido, Margarita Rivera
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Oncology
Yasemin C. Cole, Yu-Zhi Zhang, Beatrice Gallo, Adam P. Januszewski, Anca Nastase, David J. Essex, Caroline M. H. Thaung, Victoria M. L. Cohen, Mandeep S. Sagoo, Anne M. Bowcock
Summary: A study on 100 uveal melanomas from the UK revealed that loss of nuclear BAP1 (nBAP1) predicts shorter overall survival. Tumors with BAP1 loss of function mutations frequently exhibited heterogeneous BAP1 staining, and tumors with >= 25% loss of nBAP1 were a more reliable prognostic indicator than chromosome 3 loss (LOH3) or chromosome 8q gain. Majority of BAP1 mutations result in loss of nBAP1 and aberrant expression of cBAP1.
Article
Biochemistry & Molecular Biology
Lorena Olivares-Gonzalez, Sheyla Velasco, Idoia Gallego, Marina Esteban-Medina, Gustavo Puras, Carlos Loucera, Alicia Martinez-Romero, Maria Pena-Chilet, Jose Luis Pedraz, Regina Rodrigo
Summary: This study evaluated the effect of an essential fatty acid (EFA) supplement containing specialized pro-resolving mediators (SPMs) on retinal degeneration and microglia activation in a mouse model of RP. The EFA supplement improved retinal function, reduced inflammation and microglia activation, and reduced oxidative stress markers. These findings suggest that oral supplementation with SPMs such as the EFA supplement could be a potential therapeutic approach for resolving inflammation in RP.
Article
Biochemistry & Molecular Biology
Cankut Cubuk, Carlos Loucera, Maria Pena-Chilet, Joaquin Dopazo
Summary: Reprogramming metabolism is a key feature of cancer, and recent research suggests that metabolites may play a crucial role in regulating signaling pathways. Mechanistic models were used to analyze the metabolic and signaling pathway activities of Breast invasive Carcinoma (BRCA), and Gaussian Processes combined with SHapley Additive exPlanations (SHAP) were employed to identify potential causal relationships between metabolite production and signaling pathway regulation. A total of 317 metabolites were found to significantly impact signaling circuits, revealing a complex crosstalk between signaling and metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Rocio Nunez-Torres, Guillermo Pita, Maria Pena-Chilet, Daniel Lopez-Lopez, Jorge Zamora, Gema Roldan, Belen Herraez, Nuria Alvarez, Maria Rosario Alonso, Joaquin Dopazo, Anna Gonzalez-Neira
Summary: The implementation of pharmacogenetics (PGx) is a significant milestone for achieving safer and more effective therapies in precision medicine. However, the adoption of PGx diagnostics is slow and unequal worldwide, partly due to the lack of ethnic-specific PGx information. Genetic data from 3006 Spanish individuals were analyzed, revealing allele frequencies and putative deleterious variants for main PGx genes. A comparison of high-throughput diagnostic techniques indicated that genotyping with the PGx HT array is the most suitable solution. The integrated information is made available through the Collaborative Spanish Variant Server for the scientific community.
Review
Biology
Alba Loras, Luis G. Gonzalez-Bonet, Julia L. Gutierrez-Arroyo, Conrado Martinez-Cadenas, Maria Angeles Marques-Torrejon
Summary: Glioblastoma multiforme (GBM) is an incurable and highly malignant brain tumor in adults. It contains a cell population called glioma stem cells (GSCs) that contribute to therapy resistance and tumor recurrence. Recent data suggest that neural stem cells (NSCs) in the subventricular zone (SVZ) may be the cells of origin for GBM and are also involved in disease progression and recurrence. Identifying the cellular origin of GBM is crucial for early detection techniques and the development of targeted therapies.
Article
Virology
Carlos Loucera, Rosario Carmona, Marina Esteban-Medina, Gerrit Bostelmann, Dolores Munoyerro-Muniz, Roman Villegas, Maria Pena-Chilet, Joaquin Dopazo
Summary: This study utilized data from the Andalusian Population Health Database to investigate the relationship between prior drug consumption and patient outcomes in COVID-19. It identified 21 drugs associated with better patient survival and effectively controlled covariates.
Article
Genetics & Heredity
Daniel Lopez-Lopez, Gema Roldan, Jose Fernandez-Rueda, Gerrit Bostelmann, Rosario Carmona, Virginia Aquino, Javier Perez-Florido, Francisco Ortuno, Guillermo Pita, Rocio Nunez-Torres, Anna Gonzalez-Neira, Maria Pena-Chilet, Joaquin Dopazo
Summary: SPACNACS is a collaborative database that collects copy number variation data from more than 400 genomes and exomes of unrelated Spanish individuals. It provides detailed information on the local genetic variability and can be used for disease gene discovery and pharmacogenomics research.
Article
Biotechnology & Applied Microbiology
Lara P. Fernandez, Nerea Deleyto-Seldas, Gonzalo Colmenarejo, Alba Sanz, Sonia Wagner, Ana Belen Plata-Gomez, Monica Gomez-Patino, Susana Molina, Isabel Espinosa-Salinas, Elena Aguilar-Aguilar, Sagrario Ortega, Osvaldo Grana-Castro, Viviana Loria-Kohen, Pablo J. Fernandez-Marcos, Alejo Efeyan, Ana Ramirez de Molina
Summary: This study identified a SNP, rs2291007, in the conserved region of the 3'UTR of the FNIP2 gene that is associated with multiple leanness parameters. The SNP affects FNIP2 mRNA levels and leads to decreased adiposity and increased leanness in both human volunteers and mice. FNIP2 expression is an important contributor to body mass index prediction.
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)