期刊
EUROPEAN JOURNAL OF CANCER
卷 47, 期 2, 页码 175-182出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2010.08.012
关键词
Alpha-feto-protein; BEP; Endodermal sinus tumour; Fertility; Malignant ovarian germ cell tumour
类别
Background: Ovarian yolk sac tumour (OYST) is a very rare malignancy arising in young women. Our study aimed to evaluate long-term outcomes and to identify prognostic parameters likely to help make appropriate risk-based decisions about therapy in this disease. Methods: This retrospective study is based on prospectively recorded OYST cases at the Institut Gustave-Roussy. A univariate analysis using the logrank test evaluated possible associations between survival and patient or disease covariates. The multivariate analysis was performed using the Cox proportional hazard regression method. Results: Between 1976 and 2006, 84 patients were registered. Since 1991, most of the patients have undergone fertility-sparing surgery. With a median follow-up of 71 months, the overall 5-year and event-free survival rates are 84% and 79%, respectively. In the multivariate model only the absence of ascites and a favourable serum AFP decline rate were significantly associated with better overall survival. Conclusions: Patients with a poor prognosis factor such as an unfavourable serum AFP decline may be considered for aggressive treatment whereas those with good prognostic factors could be given less courses of chemotherapy. (C) 2010 Elsevier Ltd. All rights reserved.
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