Article
Oncology
Alexandra Leary, Ana Oaknin, Jose Manuel Trigo, Victor Moreno, Jean-Pierre Delord, Valentina Boni, Irene Brana, Cristian Fernandez, Carmen Kahatt, Antonio Nieto, Martin Cullell-Young, Ali Zeaiter, Vivek Subbiah
Summary: Lurbinectedin is an approved drug for the treatment of metastatic small cell lung cancer. This study analyzes safety data from various solid tumors treated with Lurbinectedin, and confirms its manageable safety profile in patients with advanced solid tumors.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Chemistry, Physical
Luan N. M. Nguyen, Zachary P. Lin, Shrey Sindhwani, Presley MacMillan, Stefan M. Mladjenovic, Benjamin Stordy, Wayne Ngo, Warren C. W. Chan
Summary: Nanoparticles can exit solid tumors through lymphatic vessels, either within or surrounding the tumor, depending on their size. This mechanism, called active transport and retention principle, allows nanoparticles to recirculate and interact with the tumor again. This finding provides a new framework for engineering nanomedicines for cancer treatment and detection, different from the current paradigm of enhanced permeability and retention effect.
Editorial Material
Nanoscience & Nanotechnology
Lutz Nuhn
Summary: AI analysis of individual blood vessels reveals heterogeneous vascular permeability in different tumor types, which is crucial for designing protein nanoparticle-based drug delivery systems to achieve active trans-endothelial permeability in tumors.
NATURE NANOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Zuzana Bielcikova, Jan Stursa, Ludmila Krizova, Lanfeng Dong, Jan Spacek, Stanislav Hlousek, Michal Vocka, Katerina Rohlenova, Olga Bartosova, Vladimir Cerny, Tomas Padrta, Michal Pesta, Pavel Michalek, Sona Stemberkova Hubackova, Katarina Kolostova, Eliska Pospisilova, Vladimir Bobek, Peter Klezl, Renata Zobalova, Berwini Endaya, Jakub Rohlena, Lubos Petruzelka, Lukas Werner, Jiri Neuzil
Summary: MitoTam, a mitochondria-targeted anti-cancer agent, was tested in a phase I/Ib trial with 75 metastatic cancer patients. The study found that MitoTam showed high efficacy against renal cell carcinoma.
Article
Medicine, General & Internal
Daniel D. Karp, D. Ross Camidge, Jeffery R. Infante, Tyler D. Ames, Matthew R. Price, Jose Jimeno, Alan H. Bryce
Summary: PT-112, the first pyrophosphate-platinum conjugate, shows immunogenic cell death and recruitment of tumour-infiltrating lymphocytes in experimental models. This study investigates the safety and efficacy of PT-112 monotherapy in heavily pre-treated patients with advanced solid tumours. PT-112 demonstrates prolonged responses in thymoma and lung cancer, and improves radiographic and serum marker outcomes in prostate cancer.
Article
Oncology
Patrick Schoeffski, Ahmad Awada, Anne-Marie de la Bigne, Zakia Felloussi, Mike Burbridge, Frederique Cantero, Riccardo Colombo, Sara Maruzzelli, Katia Ammattatelli, Maja de Jonge, Philippe Aftimos, Herlinde Dumez, Stefan Sleijfer
Summary: S81694 can be safely administered as a single agent in adults with solid tumors at a dose of up to 135 mg/m(2)/week on days 1,8,15 of a 28-day cycle, without reaching the MTD.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Francisco Martinez-Jimenez, Ali Movasati, Sascha Remy Brunner, Luan Nguyen, Peter Priestley, Edwin Cuppen, Arne Van Hoeck
Summary: This study characterizes the genomic differences between early-stage untreated primary tumors and late-stage treated metastatic tumors. Metastatic tumors have lower heterogeneity and a conserved karyotype, with only a modest increase in mutations. Most cancer types show either moderate or consistent genomic differences between early-stage and late-stage disease, except for breast, prostate, thyroid, kidney renal clear cell carcinomas, and pancreatic neuroendocrine tumors, which exhibit extensive genetic landscape transformation in advanced stages.
Review
Oncology
Flavia G. Ghiraldini, Dan Filipescu, Emily Bernstein
Summary: Cancer is a complex disease characterized by loss of cellular homeostasis due to genetic and epigenetic alterations. Histone variants play critical roles in processes like maintenance of genome integrity, nuclear architecture, and cell identity. Cancer cells hijack histone variants and their chaperones to disrupt homeostasis, which is emerging as a common strategy across various cancers, especially solid tumors.
NATURE REVIEWS CANCER
(2021)
Review
Immunology
Sangeeta Goswami, Swetha Anandhan, Deblina Raychaudhuri, Padmanee Sharma
Summary: This study describes current therapies that aim to modulate the functional activities of myeloid cell populations in the tumor microenvironment, impacting their recruitment, survival, and activity. Myeloid cells are the most abundant immune components in the tumor microenvironment and have diverse functions. The authors highlight key features of monocyte and macrophage biology as potential targets for cancer therapies and discuss the need for a deeper understanding of myeloid cells to improve clinical outcomes.
NATURE REVIEWS IMMUNOLOGY
(2023)
Review
Biochemical Research Methods
K. Paterson, S. Zanivan, R. Glasspool, S. B. Coffelt, M. Zagnoni
Summary: Immunotherapy is an effective cancer treatment that uses the body's immune system to target and eliminate cancer cells, showing success in treating hematological malignancies and melanoma. However, challenges arise in tackling solid tumors due to the immunosuppressive tumor microenvironment. Microfluidics and lab-on-a-chip technologies offer opportunities to study cancer-immune cell interactions and test immunotherapies in solid tumors with higher translational value.
Article
Chemistry, Physical
Yanlei Geng, Jianfu Li, Zhaobin Zhang, Yang Lv, Zhenzhen Xu, Yong Liu, Jianan Yuan, Qinglin Wang, Xiaoli Wang
Summary: This study employs first-principles calculations and the CALYPSO structure search technique to investigate the crystal structure stability of CsxIy compounds under high pressures. New phases with conventional and unconventional stoichiometries are predicted. Surprisingly, Cs-I compounds decompose into Cs and I elemental solids under pressure due to the weakening of electrostatic interactions. These findings provide insights into the decomposition mechanism and high-pressure properties of alkali metal halides, which may inspire new perspectives in geology and the study of alkali metal halides under extreme conditions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Oncology
Jian Zhang, Rujiao Liu, Shuiping Gao, Wenhua Li, Yang Chen, Yanchun Meng, Chang Liu, Wenyue Jin, Junyan Wu, Ying Wang, Yanrong Hao, Shuli Yi, Yan Qing, Junyou Ge, Xichun Hu
Summary: This phase I study evaluated the safety, pharmacokinetics, and antitumour activity of the HER2-targeted antibody-drug conjugate A166 in patients with HER2-expressing advanced solid tumours. The recommended phase II dose of A166 was determined to be 4.8 mg/kg Q3W, and it demonstrated manageable toxicity and promising antitumour activity in HER2-positive breast cancer patients.
Article
Biotechnology & Applied Microbiology
Cedrik M. Britten, Aiman Shalabi, Axel Hoos
Summary: Cell therapy is a rapidly growing field in the pharmaceutical industry with significant therapeutic potential, particularly in the treatment of blood cancers. Despite success in this area, challenges remain in treating solid tumors. To fully industrialize engineered T cell therapies as mainstream medicines, they need to provide unique clinical effects and be applicable in currently unaddressed disease contexts.
NATURE REVIEWS DRUG DISCOVERY
(2021)
Article
Nanoscience & Nanotechnology
Yifei Lu, Kristin Huntoon, DaeYong Lee, Yifan Wang, JongHoon Ha, Yaqing Qie, Xuefeng Li, Benjamin R. Schrank, Shiyan Dong, Thomas D. Gallup, Minjeong Kang, Hai Zhao, Yi An, Zhaogang Yang, Jing Li, Betty Y. S. Kim, Wen Jiang
Summary: Compared to hematological tumors, solid tumors have a lower response to immunotherapies. In this study, the authors propose a strategy to enhance the effectiveness of immunotherapies for solid tumors by decorating the cell membrane with a protein that promotes phagocytosis of cancer cells.
NATURE NANOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Caroline R. R. Bartman, Daniel R. R. Weilandt, Yihui Shen, Won Dong Lee, Yujiao Han, Tara TeSlaa, Connor S. R. Jankowski, Laith Samarah, Noel R. R. Park, Victoria da Silva-Diz, Maya Aleksandrova, Yetis Gultekin, Argit Marishta, Lin Wang, Lifeng Yang, Asael Roichman, Vrushank Bhatt, Taijin Lan, Zhixian Hu, Xi Xing, Wenyun Lu, Shawn Davidson, Martin Wuehr, Matthew G. G. Vander Heiden, Daniel Herranz, Jessie Yanxiang Guo, Yibin Kang, Joshua D. D. Rabinowitz
Summary: In this study, the rates of glycolysis and the tricarboxylic acid (TCA) cycle were measured in various mouse tissues and cancer models. The research found that TCA cycle flux was suppressed in solid tumors and increased in lung metastases of breast cancer. Although glycolysis was increased in tumors, it was not enough to compensate for the low TCA flux in terms of ATP production. This suggests that solid tumors generally produce ATP at a slower rate than normal.
Article
Oncology
Funda Meric-Bernstam, Randy F. Sweis, Stefan Kasper, Omid Hamid, Shailender Bhatia, Reinhard Dummer, Agostina Stradella, Georgina Long, Anna Spreafico, Toshio Shimizu, Neeltje Steeghs, Jason J. Luke, Sarah M. McWhirter, Thomas Mueller, Nitya Nair, Nancy Lewis, Xinhui Chen, Andrew Bean, Lisa Kattenhorn, Marc Pelletier, Shahneen Sandhu
Summary: This study assessed the safety and tolerability of the combination of MIW815 and spartalizumab in patients with advanced solid tumors or lymphomas. The results showed that the combination therapy had immune activation but limited antitumor activity.
CLINICAL CANCER RESEARCH
(2023)
Article
Biophysics
Rachel L. C. Barrett, Diana Cash, Camilla Simmons, Eugene Kim, Tobias C. Wood, Richard Stones, Anthony C. Vernon, Marco Catani, Flavio Dell'Acqua
Summary: In this study, an optimization strategy for ex vivo diffusion imaging was developed to improve image quality and signal-to-noise ratio (SNR). The strategy successfully enabled the acquisition of high-resolution diffusion data with improved SNR efficiency and allowed for faster acquisitions in preclinical experiments.
NMR IN BIOMEDICINE
(2023)
Article
Psychiatry
Dorothea L. Floris, Han Peng, Varun Warrier, Michael V. Lombardo, Charlotte M. Pretzsch, Clara Moreau, Alex Tsompanidis, Weikang Gong, Maarten Mennes, Alberto Llera, Daan van Rooij, Marianne Oldehinkel, Natalie J. Forde, Tony Charman, Julian Tillmann, Tobias Banaschewski, Carolin Moessnang, Sarah Durston, Rosemary J. Holt, Christine Ecker, Flavio Dell'Acqua, Eva Loth, Thomas Bourgeron, Declan G. M. Murphy, Andre F. Marquand, Meng-Chuan Lai, Jan K. Buitelaar, Simon Baron-Cohen, Christian F. Beckmann
Summary: Using deep learning on brain images, the authors found that both autistic males and females tend to have neuroanatomy more similar to males, as well as social cognitive features and gene expression patterns associated with male characteristics. These neurophenotypes provide important insights into the biological mechanisms underlying autism.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Oncology
John J. W. Lee, Vijay Kunaratnam, Christina J. H. Kim, Martha Pienkowski, Katrina Hueniken, Axel Sahovaler, Andrew C. L. Lam, Joel C. Davies, Catherine M. Brown, John R. De Almeida, Shao Hui Huang, John N. Waldron, Anna Spreafico, Rayjean J. Hung, Wei Xu, David P. Goldstein, Geoffrey Liu
Summary: Smoking cessation and long-term abstinence are associated with improved overall survival and HNSCC-specific survival in patients with HNSCC. Former smokers have a reduced risk of overall mortality compared with current smokers, especially those who quit smoking more than 10 years before diagnosis. Long-term abstinence is significantly associated with a decreased risk of HNSCC-specific death.
Review
Biochemistry & Molecular Biology
Pavlina Spiliopoulou, Olga Vornicova, Sofia Genta, Anna Spreafico
Summary: Recent advances in treating cutaneous melanoma have significantly improved patient survival rates by refining disease staging, accurately classifying patient risk, and introducing cancer immunotherapy. Immunotherapy, particularly in the form of immune checkpoint inhibition, has played a crucial role in managing both early and late-stage melanoma and has extended its benefits to other types of skin cancers as well. This review summarizes the current role of immunotherapy in melanoma and non-melanoma skin cancers, highlights important immunotherapy-related molecular biomarkers, and discusses future research directions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Acoustics
Anna Palmisano, Davide Vignale, Elisa Bruno, Giovanni Peretto, Giacomo De Luca, Corrado Campochiaro, Alessandro Tomelleri, Eustachio Agricola, Matteo Montorfano, Antonio Esposito
Summary: In this study, CMR findings in patients with myocarditis-like syndrome during the acute and post-acute phase of COVID-19 were reported. The majority of cases were confirmed as myocarditis by CMR, with mild extent of lesions. Additionally, some patients had myocardial infarction and cardiomyopathies. CMR can improve diagnostic accuracy and evaluate subclinical cardiomyopathies.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Cardiac & Cardiovascular Systems
Davide Vignale, Anna Palmisano, Chiara Gnasso, Davide Margonato, Davide Romagnolo, Simone Barbieri, Giacomo Ingallina, Stefano Stella, Marco Bruno Ancona, Matteo Montorfano, Francesco Maisano, Eustachio Agricola, Antonio Esposito
Summary: The prognostic value of the interstitial fibrosis marker ECV measured at planning CT before TAVI was assessed. The study found that ECV higher than 31.3% was associated with an increased risk of heart failure hospitalization or death.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Immunology
Eugene Kim, Ines Carreira Figueiredo, Camilla Simmons, Karen Randall, Loreto Rojo Gonzalez, Tobias Wood, Brigida Ranieri, Paula Sureda-Gibert, Oliver Howes, Carmine Pariante, N. I. M. A. NIMA Consortium, Ofer Pasternak, Flavio Dell'Acqua, Federico Turkheimer, Diana Cash
Summary: It has been found that neuroinflammation is crucial in various neurological and psychiatric disorders. Recent studies have shown that diffusion MRI (dMRI) can detect changes in microglial density and morphology related to neuroinflammation, but these studies were mostly conducted ex vivo or in extreme animal models. In this study, the utility of established dMRI methods to detect neuroinflammation in a clinically relevant animal model of sickness behavior was investigated. The results demonstrated that diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) indicated widespread increases in diffusivity in the brains of rats with a lipopolysaccharide challenge. These findings confirm the sensitivity of dMRI to neuroinflammatory processes and contribute to the development of a noninvasive indicator of neuroinflammation for early diagnosis and treatment monitoring in neurological and psychiatric diseases.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Oncology
Sofia Genta, Katherine Lajkosz, Noelle R. Yee, Pavlina Spiliopoulou, Alya Heirali, Aaron R. Hansen, Lillian L. Siu, Sam Saibil, Lee-Anne Stayner, Maryia Yanekina, Maxwell B. Sauder, Sareh Keshavarzi, Abdulazeez Salawu, Olga Vornicova, Marcus O. Butler, Philippe L. Bedard, Albiruni R. Abdul Razak, Robert Rottapel, Andrzej Chruscinski, Bryan Coburn, Anna Spreafico
Summary: This study used custom autoantigen microarrays to analyze autoantibodies related to immune-related adverse events in patients receiving immune checkpoint inhibitors. The results support the potential role of autoantibodies in the occurrence and development of immune-related adverse events.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Alberto Hernando-Calvo, Eoghan Malone, Daphne Day, Amy Prawira, Ilan Weinreb, S. Y. Cindy Yang, Horace Wong, Angela Rodriguez, Sarah Jennings, Anneli Eliason, Lisa Wang, Anna Spreafico, Lillian L. Siu, Aaron R. Hansen
Summary: This study aimed to evaluate the activity of selinexor in patients with recurrent or metastatic salivary gland tumors. The results showed limited anti-tumor activity of selinexor, although some tumor reduction was observed.
Article
Oncology
Maysa Vilbert, Erica C. Koch, April A. N. Rose, Rob C. Laister, Diana Gray, Valentin Sotov, Susanne Penny, Anna Spreafico, Devanand M. Pinto, Marcus O. Butler, Samuel D. Saibil
Summary: Cutaneous melanoma (CM) patients respond better to immune checkpoint inhibitors (ICI) than mucosal and uveal melanoma patients (MM/UM). Aiming to explore these differences and understand the distinct response to ICI, we evaluated the serum metabolome of advanced CM, MM, and UM patients. Our study revealed a distinct metabolomic profile between the most resistant melanoma subtypes, UM and MM, compared to CM. Alterations within the kynurenine pathway, polyamine metabolism, and sphingolipid metabolic pathway may contribute to the poor response to ICI.
Article
Oncology
Sabrina Gloria Giulia Testoni, Claudia Minici, Elisa Benetti, Francesca Clemente, Daniela Boselli, Clara Sciorati, Lucia De Monte, Maria Chiara Petrone, Markus Enderle, Walter Linzenbold, Maria Pia Protti, Angelo Manfredi, Francesco De Cobelli, Michele Reni, Massimo Falconi, Gabriele Capurso, Paolo Giorgio Arcidiacono, Emanuel Della-Torre
Summary: Thermal ablation under endoscopic ultrasound (EUS)-guidance has shown potential to enhance immune response in pancreatic ductal adenocarcinoma (PDAC). In a recent trial, EUS-guided ablation with HybridTherm Probe (HTP) in combination with chemotherapy improved disease progression compared to chemotherapy alone. This study explored the effects of EUS-HTP on systemic immune response in PDAC and found that it selectively affected immunological predictors of poor outcome.
Letter
Radiology, Nuclear Medicine & Medical Imaging
Davide Vignale, Anna Palmisano, Caterina Colantoni, Lisa Brunetti, Valeria Nicoletti, Chiara Gnasso, Antonio Esposito
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Palmisano, Corrado Campochiaro, Davide Vignale, Alessandro Tomelleri, Giacomo De Luca, Elisa Bruno, Caterina B. Monti, Giulio Cavalli, Lorenzo Dagna, Antonio Esposito
Summary: AV groove localization in ECD patients is associated with LV wall fibrosis in downstream coronary territories, while atrial pseudomass localization impacts atrial contractility and is associated with atrio-caval junction stenosis.
Review
Radiology, Nuclear Medicine & Medical Imaging
Antonio Esposito, Marco Gatti, Maria Giovanna Trivieri, Eustachio Agricola, Giovanni Peretto, Guglielmo Gallone, Federica Catapano, Silvia Pradella, Ana Devesa, Elisa Bruno, Giorgio Fiore, Marco Francone, Anna Palmisano
Summary: Mitral valve prolapse is the most common valve disease in the western world and has recently been associated with sudden cardiac death. Echocardiography plays a crucial role in diagnosis and assessment of MVP, while cardiac magnetic resonance provides comprehensive risk stratification.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)