期刊
EUROPEAN JOURNAL OF CANCER
卷 45, 期 18, 页码 3271-3281出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2009.06.011
关键词
Vitamin D; Breslow thickness; Heredity; Body mass index
类别
资金
- Cancer Research UK [C8216/A6129, C588/A4994]
- NIH [R01 CA83115]
- Frenchay Hospital, Bristol [BS16 1LE]
- UK Department of Health
- Health and Safety Executive
- Cancer Research UK [10589] Funding Source: researchfish
We have carried out melanoma case-control comparisons for six vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) and serum 25-hydroxyvitamin D-3 levels in order to investigate the role of vitamin D in melanoma susceptibility. There was no significant evidence of an association between any VDR SNP and risk in 1028 population-ascertained cases and 402 controls from Leeds, UK. In a second Leeds case-control study (299 cases and S60 controls) the FokI T allele was associated with increased melanoma risk (odds ratio (OR) 1.42, 95% confidence interval (CI) 1.06-1.91, p = 0.02). In a meta-analysis in conjunction with published data from other smaller data sets (total 3769 cases and 3636 controls), the FokI T allele was associated with increased melanoma risk (OR 1.19, 95% CI 1.05-1.35), and the BsmI A allele was associated with a reduced risk (OR 0.81, 95% Cl 0.72-0.92), in each instance under a parsimonious dominant model. In the first Leeds case-control comparison cases were more likely to have a higher body mass index (BMI) than controls (p = 0.007 for linear trend). There was no evidence of a case-control difference in serum 25-hydroxyvitamin D-3 levels. In 1043 incident cases from the first Leeds case-control study, a single estimation of serum 25-hydroxyvitamin D-3 level taken at recruitment was inversely correlated with Breslow thickness (p = 0.03 for linear trend). These data provide evidence to support the view that vitamin D and VDR may have a small but potentially important role in melanoma susceptibility, and putatively a greater role in disease progression. (C) 2009 Elsevier Ltd. All rights reserved.
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