Article
Clinical Neurology
K. Massicotte-Tisluck, D. Vanderweyen, J-F Vendrell, D. Fortin, G. Gahide
Summary: The study evaluated agreement among different measurement techniques for primary central nervous system lymphoma lesions. Results showed excellent correlations between longest 1D and 2D measurements with 3D measurements, suggesting longest 1D could be used for follow-up. For defining response categorization, 20% and 30% cutoffs should be used for unidimensional techniques.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Oncology
Hubert Beaumont, Antoine Iannessi
Summary: The study retrospectively analyzed inter-reader discrepancies in five BICR clinical trials for lung cancer patients on immunotherapy or targeted therapy. It identified different rates of discrepancies, risk factors, and explored the potential of machine learning in predicting inter-reader discrepancies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Amy Junghyun Lee, Kyung Won Kim, Youngbin Shin, Jiwoo Lee, Hyo Jung Park, Young Chul Cho, Yousun Ko, Yu Sub Sung, Byung Sun Yoon
Summary: To address major issues in imaging data management, a CDISC-compliant CTIMS was developed with automatic verification and transformation modules to ensure data consistency and high quality by transforming data into SDTM format.
JOURNAL OF BIOMEDICAL INFORMATICS
(2021)
Article
Gastroenterology & Hepatology
Jordi Bruix
Summary: Clinical trials rely on strict definitions and criteria, but real-world clinical practice may not follow the same guidelines, leading to discrepancies in patient selection, disease assessment, and treatment decisions. Understanding these differences is crucial in refining criteria for drug activity, toxicity, and treatment failure in order to achieve evidence-based clinical practice and precision oncology.
JOURNAL OF HEPATOLOGY
(2021)
Review
Oncology
Ching-Chung Ko, Lee-Ren Yeh, Yu-Ting Kuo, Jeon-Hor Chen
Summary: RECIST criteria may not be sufficient to evaluate treatment response for new anticancer drugs, especially in the presence of molecular-targeted therapies and immunotherapies. Emerging imaging biomarkers, such as dynamic contrast-enhanced CT or MRI, DWI, MRS, and FDG-PET, show promise in assessing early tumor response beyond traditional RECIST criteria.
BIOMARKER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Firas S. Ahmed, Laurent Dercle, Gregory V. Goldmacher, Hao Yang, Dana Connors, Ying Tang, Sanja Karovic, Binsheng Zhao, Richard D. Carvajal, Caroline Robert, Michael L. Maitland, Geoffrey R. Oxnard, Lawrence H. Schwartz
Summary: The study compared tumor response assessment using RECIST 1.1 and iRECIST in melanoma patients treated with pembrolizumab. It found that iRECIST was more appropriate in detecting pseudoprogression, leading to longer overall survival for patients with pseudoprogression compared to those with uncontrolled disease.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, Research & Experimental
Fang-Shu Ou, Jun Tang, Ming-Wen An, Sumithra J. Mandrekar
Summary: Two modeling approaches, joint modeling (JM) and two-stage modeling, were used to predict overall survival (OS) with better accuracy compared to RECIST in analyzing longitudinal tumor measurements (TM) in solid tumor cancer clinical trials.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Laura Masuelli, Monica Benvenuto, Chiara Focaccetti, Sara Ciuffa, Sara Fazi, Arianna Bei, Martino Tony Miele, Lucia Piredda, Vittorio Manzari, Andrea Modesti, Roberto Bei
Summary: Immune effector cells play a critical role in determining tumor growth outcomes in the tissue microenvironment during neoplastic progression. Nutraceuticals, identified as natural compounds that may impact health and disease statuses, show potential benefits as immunomodulators in cancer treatment with subtle cell-specific effects.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Oncology
Hongsen Li, Jiaying Shen, Jiawei Shou, Weidong Han, Liu Gong, Yiming Xu, Peng Chen, Kaixin Wang, Shuangfeng Zhang, Chao Sun, Jie Zhang, Zhongfeng Niu, Hongming Pan, Wenli Cai, Yong Fang
Summary: This study investigated the reliability and reproducibility of a computer-aided contouring tool in tumor measurements for evaluating tumor response. Results showed that the tool reduced interobserver variability in measuring tumors and improved agreement in assessing tumor response on imaging.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Yi Yang, Xiaolin Jiang, Yun Liu, Huan Huang, Yanli Xiong, He Xiao, Kan Gong, Xuemei Li, Xunjie Kuang, Xueqin Yang
Summary: The study aimed to explore the role of the response evaluation criteria in solid tumors based on tumor markers (RecistTM) in compensating for the deficiencies of the immune-related response evaluation criteria in solid tumors (irRECIST). The results showed that RecistTM criteria could more accurately evaluate the treatment response to immunotherapy, especially in assessing whether patients can achieve deep or complete response.
Article
Clinical Neurology
Raquel D. Thalheimer, Vanessa L. Merker, K. Ina Ly, Amanda Champlain, Jennifer Sawaya, Naomi L. Askenazi, Hamilton P. Herr, Jennifer L. W. Da, Justin T. Jordan, Alona Muzikansky, Elizabeth Morehouse Pearce, Fernanda H. Sakamoto, Jaishri O. Blakeley, R. Rox Anderson, Scott R. Plotkin, REiNS Int Collaboration
Summary: The study evaluated the reliability and variability of digital calipers, 3D photography, and high-frequency ultrasound for measuring cutaneous neurofibromas in patients with neurofibromatosis type 1. HFUS and 3D photography showed excellent reliability, while digital calipers displayed good to excellent reliability in measuring cNF.
Article
Public, Environmental & Occupational Health
Michael Abouyannis, Hanif Esmail, Mainga Hamaluba, Mwanajuma Ngama, Hope Mwangudzah, Noni Mumba, Betty K. Yeri, Salim Mwalukore, Hassan J. Alphan, Dinesh Aggarwal, Gabriel Alcoba, Nick Cammack, Jean-Philippe Chippaux, Matthew E. Coldiron, Jose M. Gutierrez, Abdulrazaq G. Habib, Robert A. Harrison, Geoffrey K. Isbister, Eric J. Lavonas, Diogo Martins, Isabela Ribeiro, James A. Watson, David J. Williams, Nicholas R. Casewell, Sarah A. Walker, David G. Lalloo
Summary: Snakebite clinical trials have lacked standardised outcome measures, but a globally representative group has come together to reach consensus on a globally relevant set of core outcome measurements. Through literature search, systematic review, questionnaires, discussions, and voting, they identified five universal core outcome measures and additional syndrome-specific measures for snakebite clinical trials. This core outcome measurement set provides global standardisation, supports patient and clinician priorities, enables meta-analysis, and is suitable for low-income and middle-income settings.
LANCET GLOBAL HEALTH
(2023)
Article
Medicine, Research & Experimental
Xinran Ma, Lawrence Bellomo, Kelly Magee, Caroline S. Bennette, Olga Tymejczyk, Meghna Samant, Melisa Tucker, Nathan Nussbaum, Bryan E. Bowser, Joshua S. Kraut, Ariel Bulua Bourla
Summary: This study developed a real-world response variable for solid tumors using EHR data from a large patient cohort, demonstrating its clinical relevance and meaningfulness. Through quantifying the feasibility and reliability of data capture, and investigating the correlation between real-world and clinical trial response rates, the study provided an effective method for assessing treatment effectiveness in real-world settings.
ADVANCES IN THERAPY
(2021)
Review
Oncology
Vasileios Tsagkalidis, Maryjka B. Blaszczyk, Haejin In
Summary: The tumor response grade (TRG) is used to quantify therapeutic response in gastric cancer after neoadjuvant therapy. However, there are multiple grading systems with different cut-off values and variable reproducibility, leading to inconsistent results in prognostication. Radiographic and endoscopic responses have also been evaluated, but their use in gastric cancer remains challenging due to inability to accurately identify and measure the tumor. This review summarizes the literature on TRG in gastric cancer and discusses the interpretation of radiographic and endoscopic responses, as well as future directions for a widely accepted TRG system.
Article
Cardiac & Cardiovascular Systems
Nicolas Zhou, Cynthia S. Bell, Hope A. Feldman, Cara L. Haymaker, Wayne L. Hofstetter, Anne S. Tsao, Reza J. Mehran, David C. Rice, Boris Sepesi, Mesothelioma Immune Genomic Grp
Summary: This study aimed to evaluate tumor thickness as a predictor and prognostic marker in neoadjuvant therapy for resectable malignant pleural mesothelioma. The results showed that baseline tumor thickness was associated with different tumor response and survival rates. Further studies are needed to validate the value of tumor thickness as a prognostic and predictive biomarker.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Oncology
Diego de Miguel-Perez, Edward M. Pickering, Umberto Malapelle, William Grier, Francesco Pepe, Pasquale Pisapia, Gianluca Russo, Joseph A. Pinto, Alessandro Russo, Giancarlo Troncone, Melissa J. Culligan, Katherine A. Scilla, Ranee Mehra, Pranshu Mohindra, Oscar Arrieta, Andres F. Cardona, Marzia Del Re, Ashutosh Sachdeva, Fred R. Hirsch, Andrea Wolf, Joseph S. Friedberg, Christian Rolfo
Summary: In this study, genetic alterations in resectable pleural mesothelioma tissues and blood samples were analyzed, and it was found that high tissue tumor mutational burden, tissue median minor allele frequency, blood tumor mutational burden, and specific mutations were correlated with outcomes in patients with resected PM. These findings suggest that molecular profiling could help identify longer survivors in patients with resected PM.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Davide Melisi, Camilla Zecchetto, Valeria Merz, Giuseppe Malleo, Luca Landoni, Alberto Quinzii, Simona Casalino, Federica Fazzini, Marina Gaule, Camilla Pesoni, Luca Casetti, Alessandro Esposito, Giovanni Marchegiani, Cristiana Piazzola, Mirko D'Onofrio, Riccardo de Robertis, Armando Gabbrielli, Laura Bernardoni, Stefano F. Crino, Silvia Pietrobono, Claudio Luchini, Camillo Aliberti, Guido Martignoni, Stefano Milleri, Giovanni Butturini, Aldo Scarpa, Roberto Salvia, Claudio Bassi
Summary: This study evaluated the safety and activity of liposomal irinotecan in the perioperative treatment of resectable pancreatic ductal adenocarcinoma (rPDAC) patients. The results showed that NALIRIFOX has manageable and active outcomes, and should be further investigated in randomized trials comparing it to standard upfront surgery followed by adjuvant therapy.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Eric Jonasch, Todd M. Bauer, Kyriakos P. Papadopoulos, Elizabeth R. Plimack, Jaime R. Merchan, David F. Mcdermott, M. Dror Michaelson, Leonard J. Appleman, Ananya Roy, Rodolfo F. Perini, Yanfang Liu, Toni K. Choueiri
Summary: After a median follow-up of 41.2 months, belzutifan monotherapy demonstrated durable antitumor activity in patients with advanced ccRCC and acceptable safety.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Patricia A. H. Hamers, Geraldine R. Vink, Marloes A. G. Elferink, Leon M. G. Moons, Cornelis J. A. Punt, Anne M. May, Miriam Koopman
Summary: Screen-detection of the primary tumor is associated with longer overall survival after metachronous metastasis.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Camilla Nero, Nicolo Bizzarri, Stefano Di Berardino, Francesca Sillano, Giuseppe Vizzielli, Francesco Cosentino, Virginia Vargiu, Pierandrea De Iaco, Anna Myriam Perrone, Enrico Vizza, Benito Chiofalo, Stefano Uccella, Fabio Ghezzi, Luigi Carlo Turco, Giacomo Corrado, Diana Giannarelli, Tina Pasciuto, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia
Summary: This study evaluates the sensitivity and specificity of sentinel-lymph-node mapping compared to systematic lymphadenectomy in detecting lymph node metastasis in early stage ovarian cancer. The results show that sentinel-lymph-node mapping did not reach the expected sensitivity, but ultra-staging protocol improved the accuracy of diagnosis for patients.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Adriana Hepner, Judith M. Versluis, Roslyn Wallace, Clara Allayous, Lauren Julia Brown, Claudia Trojanielloh, Camille Lea Gerardi, Yanina J. L. Jansenj, Prachi Bhave, Bart Neyns, Andrew Haydon, Olivier Michielin, Joanna Manganan Oliver Klein, Alexander N. Shoushtari, Allison Betof Warner, Paolo Antonio Ascierto, Jennifer Leigh McQuade, Matteo S. Carlino, Lisa Zimmer, Celeste Lebbe, Douglas B. Johnson, Shahneen Sandhu, Victoria Atkinson, Christian U. Blank, Serigne N. Lo, Georgina V. Long, Alexander M. Menzies
Summary: Acquired resistance to PD-1 therapy in melanoma is mainly oligometastatic, and patients may have a favorable survival outcome following salvage treatment.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Savannah Roy, Stephanie Lakritz, Anna R. Schreiber, Elizabeth Molina Kuna, Cathy J. Bradley, Lavanya Kondapalli, Jennifer R. Diamond
Summary: This study evaluates major adverse cardiovascular events (MACE) in older women with TNBC treated with anthracycline and taxane-based chemotherapy (ATAX) compared to taxane-based chemotherapy (TAX). The results show that ATAX does not increase the risk of MACE and there is no difference in survival between patients who received TAX and ATAX.
EUROPEAN JOURNAL OF CANCER
(2024)
Letter
Oncology
Pei-Chun Weng, Yau-Li Huang, Chun-Yu Cheng
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Philipp Jansen, Jean Le 'Clerc Arrastia, Daniel Otero Baguer, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Michael Emberger, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Klaus Georg Griewank
Summary: This study highlights the enormous potential of artificial intelligence in pathology, showing that it can aid in the identification of rare cutaneous adnexal tumors and potentially become a standard tool in routine diagnostics.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Casper W. F. van Eijck, Gaby Strijk, Eveline E. Vietscha, Fleur van der Sijde, Maaike Verheij, Dana A. M. Mustafa, Madelief Vinkc, Joachim G. J. V. Aerts, Casper H. J. van Eijck, Marcella Willemsen
Summary: The study reveals that FOLFIRINOX has immunomodulatory effects, suggesting its potential in immune-based combination therapies for pancreatic cancer. Additionally, certain plasma proteins hold promise as circulating predictive biomarkers for early prediction of FOLFIRINOX response in patients with pancreatic cancer.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Marwan Fakih, Chongkai Wang, Jaideep Sandhu, Jian Ye, Colt Egelston, Xiaochen Li
Summary: This study explores the impact of metastatic sites on treatment outcomes for chemotherapy-refractory colorectal cancer patients. It found that patients with liver or peritoneal metastases had poor treatment outcomes, while those with lung-only metastases showed significant response. The presence of concurrent lymph node or other extrahepatic metastatic disease diminished treatment response in patients with lung metastases. Future checkpoint inhibitor trials should stratify patients based on metastatic locations.
EUROPEAN JOURNAL OF CANCER
(2024)
Article
Oncology
Georgios Christos Tsiatsianis, Candace S. Y. Chan, Ioannis Mouratidis, Nikol Chantzi, Anna Maria Tsiatsiani, Nelson S. Yee, Apostolos Zaravinos, Verena Kantere, Ilias Georgakopoulos-Soares
Summary: The study reveals that nullpeptides can serve as biomarkers for cancer detection and treatment, particularly in highly recurrent cancer patients. These nullpeptides primarily occur in highly expressed genes, particularly in specific loci of oncogenes and tumor suppressors. Recurrent nullpeptides are more likely to be found in neoantigens, which play a significant role in immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2024)