期刊
EUROPEAN JOURNAL OF CANCER
卷 44, 期 1, 页码 100-109出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2007.10.015
关键词
smoking; smoking cessation; cancer; mortality; population attributable risk; Chinese; Singapore
类别
资金
- NCI NIH HHS [R35 CA053890, R01 CA055069, R01 CA80205, R01 CA080205-01, R01 CA080205] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA080205, R35CA053890, R01CA055069] Funding Source: NIH RePORTER
Objectives: We examined the association among cigarette smoking, smoking cessation and a broad range of cancer incidence and all cause and cause-specific mortality in a population-based cohort of adults of Chinese ethnicity in Singapore. Methods: Subjects were 61,320 participants of the Singapore Chinese Health Study (44.5% men, aged 45-74 years, recruitment from 1993-1998) who were free of cancer at the base-line examination. Main outcomes-of-interest included cancer incidence, all cause and cause-specific mortality as of December 31, 2005. Results: Cigarette smoking was positively associated with overall cancer incidence, including cancers at the following specific sites: head and neck region, upper gastrointestinal tract, hepatobiliary and pancreas cancer, lung, and bladder/renal pelvis cancer. compared to never smokers, the relative risk (RR) (95% confidence interval [CI]) of cancer incidence (all cancer sites) among current smokers smoking >22 cigarettes/day was 1.9 (1.7-2.1), p-trend < 0.0001. Similarly, cigarette smoking was associated with all cause and cause-specific mortality, including deaths due to cancer, ischemic heart disease, other heart diseases, and chronic obstructive pulmonary disease. Compared to never smokers, RR (95%CI) of all cause mortality among current smokers smoking >22 cigarettes/day was 1.8 (1.6-2.0), p-trend < 0.0001. Also, relative to current smokers, ex-smokers experienced reduced cancer incidence and total mortality. The population attributable risk of smoking in men for cancer incidence as well as all-cause mortality was 23%, whereas in women it ranged from 4-5%. Conclusions: Cigarette smoking is an important risk factor for cancer incidence and major causes of mortality in Chinese men and women of Singapore. (c) 2007 Elsevier Ltd. All rights reserved.
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