Article
Physiology
Rafael de Almeida Azevedo, Daniel A. Keir, Jonas Forot, Danilo Iannetta, Guillaume Y. Millet, Juan M. Murias
Summary: This study investigates the relationship between the development of slow component of oxygen uptake and muscle fatigue, finding that they are correlated in a time- and intensity-dependent manner. The results suggest that the slow component of oxygen uptake may depend on muscle fatigue, even if the mechanisms of reduced contractile function differ among intensities.
Article
Pharmacology & Pharmacy
Hongkang Zhu, Ruoyong Wang, Hanyi Hua, Yuliang Cheng, Yahui Guo, He Qian, Peng Du
Summary: This study evaluated the anti-fatigue properties of N-benzyl-(9Z, 12Z)-octadecadienamide in mice and found that it increased their grip strength and exercise time. It also decreased pro-inflammatory factors and reactive oxygen species levels in mice, and attenuated liver damage. The study suggests that macamides have great potential as a natural drug for fatigue management, with high efficiency and low side effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Sport Sciences
Johannus Q. de Korte, Coen C. W. G. Bongers, Maria T. E. Hopman, Thijs M. H. Eijsvogels
Summary: Elite athletes experienced significant performance losses and increases in gastrointestinal temperature when exercising in simulated Tokyo conditions, with varying responses across different sport disciplines. This highlights the importance of individualized preparation to optimize safe and maximal exercise performance during the Tokyo Olympics.
Article
Pediatrics
Nicole Mueller, Ulrike Herberg, Thomas Jung, Johannes Breuer, Julian Alexander Haertel
Summary: This study investigated the effects of normobaric hypoxia on cardiopulmonary and metabolic parameters in Fontan-palliated patients and the benefits of daily physical activity on hypoxic exercise capacity. The results showed that short-term exercise during artificial altitude exposure seems to be safe for young Fontan patients, and higher levels of daily physical activity might improve physical capacity under altitude conditions.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Joris Mallard, Elyse Hucteau, Roland Schott, Philippe Trensz, Carole Pflumio, Michal Kalish-Weindling, Fabrice Favret, Xavier Pivot, Thomas J. J. Hureau, Allan F. F. Pagano
Summary: This study found that skeletal muscle deconditioning and reduced exercise capacity occur early during chemotherapy for breast cancer. These changes occur within the first 8 weeks of treatment and do not further decrease after chemotherapy. The study also showed that cancer-related fatigue and quality of life are impaired after the start of chemotherapy, while physical activity level remains stable.
Article
Cardiac & Cardiovascular Systems
J. C. Weavil, T. S. Thurston, T. J. Hureau, J. R. Gifford, P. A. Kithas, R. M. Broxterman, A. D. Bledsoe, J. N. Nativi, R. S. Richardson, M. Amann
Summary: HFpEF patients show similar central and peripheral fatigue development as healthy controls during exercise not limited by cardiac output at the same relative intensity. However, HFpEF patients exhibit a greater susceptibility to neuromuscular fatigue during exercise at a given absolute intensity, which impairs functional capacity. The compromised leg blood flow response likely contributes to the attenuated fatigue resistance in HFpEF patients.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Neurosciences
Donguk Jo, Miriam Goubran, Martin Bilodeau
Summary: The aim of this study was to determine sex differences in central and peripheral fatigue produced by sustained isometric exercise of ankle plantar flexors in healthy young adults. The study found that there were no significant differences in performance fatigability markers between males and females, but there were some minor differences in variables reflecting central and peripheral fatigue mechanisms.
JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY
(2022)
Article
Medicine, General & Internal
Michael Heinz, George D. Price, Franklin Ruan, Robert J. Klein, Matthew Nemesure, Aliza Lopez, Nicholas C. Jacobson
Summary: This study examines the differences in physical movement among individuals treated with SSRIs compared with control participants and identifies the unique features of movement in patients treated with SSRIs. The results suggest a moderate association between passive movement and SSRI use, supporting the use of passive sensors for exploring and characterizing adverse effects of psychotropic medication.
Review
Physiology
Julien D. Periard, Thijs M. H. Eijsvogels, Hein A. M. Daanen
Summary: This review comprehensively discusses the body’s response to exercise in heat stress and the measures that can be taken to enhance aerobic performance in such conditions, covering fundamental concepts, physiological processes, and strategies to mitigate the effects of hyperthermia and hypohydration on exercise performance. It also examines the impact of heat stress on human performance and hydration status, as well as the underlying physiological mechanisms and adjustments that contribute to fatigue development.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Biophysics
Reinhard Puehringer, Hannes Gatterer, Martin Berger, Michael Said, Martin Faulhaber, Martin Burtscher
Summary: The study suggests that well-acclimatized mountain guides may have better preservation of VO(2)max at moderate altitude, especially for those with lower initial VO(2)max levels. Physiological responses, such as heart rate and blood lactate levels, remained stable or slightly decreased at submaximal exercise intensity in both groups at moderate altitude.
HIGH ALTITUDE MEDICINE & BIOLOGY
(2022)
Review
Physiology
Luca Ruggiero, Scott W. D. Harrison, Charles L. Rice, Chris J. McNeil
Summary: High altitude exposure affects neuromuscular fatigability, with acute exposure increasing fatigue compared to sea level and chronic exposure leading to partial restoration of supraspinal fatigue. Native highlanders show superior performance and lesser neuromuscular fatigability compared to acclimatized lowlanders at altitude.
Article
Food Science & Technology
Ruixue Zhang, Jiangtao Zhang, Yan Liu, Lei Fang, Ying Wei, Ruizeng Gu, Min Lin, Liang Chen, Zhengfu Zhou
Summary: Supplementation of FWPH improves anti-fatigue ability, enhances exercise performance, and alters intestinal flora composition.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Urology & Nephrology
Stefania S. Grigoriou, Christina Karatzaferi, Christoforos D. Giannaki, Gianna Patramani, Christina Vogiatzi, Georgia Mitrou, Ioannis Stefanidis, Giorgos K. Sakkas
Summary: A 9-month hybrid exercise training program during hemodialysis can improve motor and sensory nerve conduction in end-stage renal disease patients. This intervention also leads to improvements in fatigue and pain levels.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Review
Physiology
Katarzyna Kulej-Lyko, Piotr Niewinski, Stanislaw Tubek, Piotr Ponikowski
Summary: Dysfunctional peripheral chemoreceptors (PChRs) are associated with exercise intolerance in patients with heart failure (HF). Abnormal PChRs signaling may affect perceived dyspnea and muscle fatigue, leading to reduced exercise capacity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alessandro D. Heubel, Erika Z. Kabbach, Naiara T. Leonardi, Nathany S. Schafauser, Debora M. O. Kawakamia, Anna Claudia Sentanin, Valeria A. Pires Di Lorenzoa, Audrey Borghi Silva, John R. Hurst, Renata G. Mendes
Summary: Patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) may experience decreased exercise capacity, and this study found that respiratory and peripheral muscle strength can influence the recovery of exercise capacity. Specifically, quadriceps muscle strength was closely associated with the recovery of exercise capacity.
Article
Sport Sciences
K. Van Alsenoy, M. L. van der Linden, O. Girard, D. Santos
Summary: Wearing more comfortable footwear may improve running economy in recreational runners, but the quality of related studies is weak.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Myles C. Dennis, Paul S. R. Goods, Martyn J. Binnie, Olivier Girard, Karen E. Wallman, Brian Dawson, Francois Billaut, Peter Peeling
Summary: The present study investigated the effects of ambient air temperature manipulation on acute performance and physiological responses during repeated-sprint training in hypoxia. The study found that increasing the ambient temperature to 40 degrees Celsius did not have a detrimental effect on performance, while higher temperatures (>=35 degrees Celsius) resulted in greater changes in muscle oxygenation during exercise and recovery, suggesting that additional heat may increase the effectiveness of repeated-sprint training.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Nathan D. W. Smith, Olivier Girard, Brendan R. Scott, Jeremiah J. Peiffer
Summary: This study examined the effects of blood flow restriction on cardiovascular, perceptual, and neuromuscular fatigue during and after cycling intervals. The results showed that blood flow restriction reduced the mechanical and cardiovascular demands of the intervals, without affecting perception of fatigue or neuromuscular characteristics.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Thomas P. Walden, Olivier Girard, Brendan R. Scott, Andrew M. Jonson, Jeremiah J. Peiffer
Summary: This study investigated whether walking with blood flow restriction (BFR) can increase cardio-respiratory demands and serve as an alternative to jogging. The results showed that moderate-intensity BFR walking induced the highest cardio-respiratory and perceptual responses compared to other walking sessions. However, jogging elicited higher cardio-respiratory measures than moderate-intensity BFR walking, except for systolic blood pressure. Perceptual measures were higher during moderate-intensity BFR walking compared to jogging. Overall, BFR walking does not seem to provide an equivalent exercise modality for unrestricted jogging in physically active adults.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
N. Benjanuvatra, D. Bradbury, G. Landers, P. S. R. Goods, O. Girard
Summary: This study examined the effects of hypoxia on neuromuscular responses during multi-set, high-load resistance exercise. The results showed that hypoxia increased metabolic stress, but had only subtle effects on neuromuscular function.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Myles C. Dennis, Paul S. R. Goods, Martyn J. Binnie, Olivier Girard, Karen E. Wallman, Brian Dawson, Francois Billaut, Peter Peeling
Summary: The aim of this study was to investigate the acute performance and physiological responses to manipulating the exercise-to-rest ratio (E:R) during repeated-sprint hypoxic training (RSH) in hot conditions. The results showed that E:R-1:4 training increased mechanical power output and core temperature compared to E:R-1:2 training. Additionally, the two protocols had different effects on measures of muscle oxygenation. These findings provide a strong foundation for future mechanistic investigation into the effects of E:R manipulation during RSH in a hot environment.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Physiology
Nathan D. W. Smith, Chris R. Abbiss, Olivier Girard, Brendan R. Scott, Jeremiah J. Peiffer
Summary: This study investigated the influence of blood-flow restriction (BFR) on the distribution of pace, physiological demands, and perceptual responses during self-paced cycling. The results showed that trained cyclists adopted a more even distribution of pace when BFR was applied compared with a negative distribution without restriction. This study provides a useful tool to understand how the distribution of pace is self-regulated.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Sport Sciences
Matthew Lester, Peter Peeling, Olivier Girard, Alistair Murphy, Cameron Armstrong, Machar Reid
Summary: Understanding on-court movement in tennis is crucial for improving player readiness and performance. Thirteen elite tennis strength and conditioning coaches were interviewed, revealing that off-court training should be specific to the demands of the sport, and our understanding of the mechanical and physiological aspects of tennis movement needs improvement. The findings highlight the importance of enhancing knowledge about the mechanical demands of tennis and practical considerations from leading tennis conditioning experts.
JOURNAL OF SPORTS SCIENCE AND MEDICINE
(2023)
Article
Sport Sciences
Tze Chien Loh, Chris Chow Li Tee, Christopher Pok, Olivier Girard, Gary Brickley, Carl James
Summary: This study presents the physiological and performance profiles of a world-class tower runner during a 6-week period surrounding a successful Guinness World Record attempt, highlighting the efficacy of a specific field test for tower running.
JOURNAL OF SPORTS SCIENCES
(2023)
Article
Sport Sciences
Franck Brocherie, Sebastien Racinais, Scott Cocking, Nathan Townsend, Anthony Couderc, Julien Piscione, Olivier Girard
Summary: In world-class female rugby sevens players, four additional repeated-sprint sessions before competition can improve repeated-sprint ability and brachial endothelial function. However, adding severe hypoxic stress during sets of repeated sprints does not provide supplementary benefits.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Review
Neurosciences
Johannes Burtscher, Tom Citherlet, Alba Camacho-Cardenosa, Marta Camacho-Cardenosa, Antoine Raberin, Bastien Krumm, Erich Hohenauer, Margit Egg, Mona Lichtblau, Julian Mueller, Elena A. Rybnikova, Hannes Gatterer, Tadej Debevec, Sebastien Baillieul, Giorgio Manferdelli, Tom Behrendt, Lutz Schega, Hannelore Ehrenreich, Gregoire P. Millet, Max Gassmann, Christoph Schwarzer, Oleg Glazachev, Olivier Girard, Sophie Lalande, Michael Hamlin, Michele Samaja, Katharina Huefner, Martin Burtscher, Gino Panza, Robert T. Mallet
Summary: Intermittent hypoxia can have both positive and negative effects on health, depending on factors such as intensity, duration, and frequency of exposure. Adaptive responses to hypoxia can protect cells from future insults, improve resilience and function, and enhance mental and physical performance.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Sport Sciences
Siu Nam Li, Peter Peeling, Brendan R. Scott, Jeremiah J. Peiffer, Alex Shaykevich, Olivier Girard
Summary: This study investigated the acute effects of graded hypoxia on endurance cycling. The results showed that power output decreased stepwise with increasing hypoxia severity, while blood lactate and tissue saturation index were not significantly different between different hypoxia severities. Knee extensor torque decreased post-exercise, regardless of condition.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Editorial Material
Sport Sciences
Bing Yan, Olivier Girard
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Article
Sport Sciences
James R. Mckee, Olivier Girard, Jeremiah J. Peiffer, Brendan R. Scott
Summary: Team sport athletes commonly perform repeated short-duration sprints with brief recovery periods. The physiological limiters of repeated-sprint ability include decreased force production capacity, insufficient energy supply, and metabolite accumulation. Training with blood flow restriction may improve these limiting factors and enhance repeated-sprint ability.
STRENGTH AND CONDITIONING JOURNAL
(2023)
Review
Sport Sciences
Zhijian He, Lijun Qiang, Yusheng Liu, Wenfeng Gao, Tao Feng, Yang Li, Bing Yan, Olivier Girard
Summary: This meta-analysis suggests that hypoxia conditioning has significant effects on improving body composition in middle-aged and older adults, reducing body mass index and body fat. The improvement in lean mass is similar to normoxic interventions. Moderate hypoxia and exposure of at least 60 minutes per session have better effects on body mass index and body fat reductions.
SPORTS MEDICINE-OPEN
(2023)