Review
Biochemistry & Molecular Biology
Robert T. Mallet, Johannes Burtscher, Vincent Pialoux, Qadar Pasha, Yasmin Ahmad, Gregoire P. Millet, Martin Burtscher
Summary: High-altitude illnesses result from acute exposure to high altitude/hypoxia. Understanding molecular mechanisms is essential for optimizing hypoxic acclimatization for efficient prophylaxis and treatment of these illnesses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lorena Duca, Sara Ottolenghi, Silvia Coppola, Rocco Rinaldo, Michele Dei Cas, Federico Maria Rubino, Rita Paroni, Michele Samaja, Davide Alberto Chiumello, Irene Motta
Summary: In patients with ARDS, COPD, and COVID-19, hypoxia negatively affects the hematopoietic response, leading to potential complications like anemia. Research indicates that redox state and antioxidant barrier markers are overexpressed, potentially inducing increased inflammatory responses and anemia, particularly in ARDS patients.
Article
Biochemistry & Molecular Biology
Richa Rathor, Geetha Suryakumar, Som Nath Singh
Summary: Exposure to high altitude leads to compromised physical performance and weight loss, with hypobaric hypoxia being a major stressor that disrupts redox homeostasis. Altered redox balance is considered the main culprit of high altitude-related skeletal muscle atrophy.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
Anamika Gangwar, Subhojit Paul, Aditya Arya, Yasmin Ahmad, Kalpana Bhargava
Summary: This study investigated redox post-translational modifications (PTMs), nitrosylation and carbonylation, in the context of extended environmental hypoxia exposure. The findings revealed the interplay between nitrosylation and carbonylation in coagulation and inflammation networks, and their role in hypoxia signaling and tolerance.
Review
Immunology
Yubo Li, Chengming Li, Tao Luo, Tian Yue, Wenjing Xiao, Ling Yang, Zaiyuan Zhang, Fei Han, Pan Long, Yonghe Hu
Summary: With the increasing participation of low-altitude individuals in high-altitude activities, the study of high altitude cerebral edema (HACE) has regained attention. HACE is a severe acute mountain sickness that occurs due to hypobaric hypoxia at high altitudes and is characterized by consciousness disturbance and ataxia. Previous research has suggested that the pathogenesis of HACE may involve cerebral blood flow disorders, blood-brain barrier disruption, and brain parenchymal cell injury caused by inflammatory factors. Recent studies have also shown that the imbalance of REDOX homeostasis is involved in HACE, resulting in abnormal activation of microglia and disruption of tight junctions in vascular endothelial cells through excessive production of mitochondrial-related reactive oxygen species. Therefore, this review focuses on the role of REDOX homeostasis and its potential in HACE treatment, which is of great importance for expanding the understanding of HACE pathogenesis and exploring possible therapeutic approaches targeting REDOX homeostasis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Vittore Verratti, Simona Mrakic-Sposta, Jonathan Fusi, Iva Sabovic, Ferdinando Franzoni, Tiziana Pietrangelo, Danilo Bondi, Stefano Dall'Acqua, Simona Daniele, Giorgia Scarfo, Camillo Di Giulio, Andrea Garolla
Summary: This study evaluated the effects of high-altitude exposure on sperm parameters and health status in travellers. The results showed that high-altitude trekking led to a decrease in sperm concentration and seminal volume, and an increase in oxidative stress. The study also suggested that uncontrolled ROS production may be the cause of impaired sperm quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Sport Sciences
Manuel Mateo-March, Xabier Muriel, Pedro L. Valenzuela, Alexis Gandia-Soriano, Mikel Zabala, David Barranco-Gil, Jesus G. Pallares, Alejandro Lucia
Summary: Acute altitude exposure affects real-world cycling performance differently in lowlanders and altitude natives, giving altitude natives a competitive advantage in races at altitudes above 1500 meters.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Biochemistry & Molecular Biology
Jay F. Storz
Summary: Population genomic analyses have identified candidate genes for hypoxia adaptation in high-altitude humans and other vertebrates, with subsequent studies revealing associations between genotypes and hypoxia-responsive phenotypes. However, deciphering causal mechanisms is complicated by potential second-order consequences of selection-mediated changes in other traits, and manipulative experiments are critical for identifying causal relationships underlying genotype-phenotype associations.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Biochemistry & Molecular Biology
Kelsey Jorgensen, Daisheng Song, Julien Weinstein, Obed A. Garcia, Laurel N. Pearson, Maria Inclan, Maria Rivera-Chira, Fabiola Leon-Velarde, Melisa Kiyamu, Tom D. Brutsaert, Abigail W. Bigham, Frank S. Lee
Summary: For over 10,000 years, Andeans have been living at high altitudes where the limited oxygen poses a challenge to human survival. Recent studies have discovered evidence of positive selection acting on the HIF2A locus in Andeans, which is associated with the hypoxia-inducible factor pathway. However, the specific mechanism by which this allele leads to altitude adaptation remains unknown. By analyzing the genomes of 46 Peruvian Andeans, researchers confirmed the presence of positive selection on HIF2A and identified a unique variation pattern surrounding the Andean-specific single nucleotide variant (SNV) rs570553380. This variant is associated with increased nitric oxide biosynthesis, as shown in a Peruvian Andean population living at high altitude.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Review
Physiology
Kathy Pham, Keval Parikh, Erica C. Heinrich
Summary: The article discusses the key regulators of transcriptional response to hypoxia and inflammation, as well as their evolutionary conservation and significant crosstalk. Inflammation can induce activity of hypoxia pathway genes, while hypoxia may modulate inflammatory signaling, showing mutual influence. The physiological consequences of maladaptive hypoxia-induced inflammation are not well established.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Marine & Freshwater Biology
Abraao Tiago Batista Guimaraes, Fernanda Neves Estrela, Aline Sueli de Lima Rodrigues, Rafael Henrique Nobrega, Ives Charlie-Silva, Guilherme Malafaia
Summary: CNFs induced nutritional deficit, oxidative stress, cell apoptosis, and neurotoxicity in aquatic vertebrates. This study represents the first report on the toxic effects of CNFs on amphibians, expanding our understanding of the ecological risks associated with their dispersion in freshwater ecosystems.
AQUATIC TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Bindu D. Paul, Marian D. Lemle, Anthony L. Komaroff, Solomon H. Snyder
Summary: The review summarizes evidence of biological abnormalities in patients with acute COVID-19 and ME/CFS, including redox imbalance, systemic inflammation, neuroinflammation, impaired ATP generation, and general hypometabolism. Although these phenomena have not been extensively studied in individuals with long COVID-19, understanding these abnormalities may lead to the development of novel therapeutics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Christoph Siebenmann, Johanna Roche, Maja Schlittler, Lydia L. Simpson, Mike Stembridge
Summary: Lowlanders staying at high altitude experience changes in plasma and red cell volumes, primarily driven by fluid redistribution and accelerated erythropoietic activity. Native highlanders from the Tibetan and Ethiopian plateaus show a different response, with normal or mildly elevated hemoglobin concentrations. Genetic adaptations and larger plasma volumes have been proposed as explanations for these differences.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemistry & Molecular Biology
Ana Beatriz Farias de Souza, Natalia Alves de Matos, Thalles de Freitas Castro, Guilherme de Paula Costa, Laser Antonio Machado Oliveira, Katiane de Oliveira Pinto Coelho Nogueira, Iara Mariana Lellis Ribeiro, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Hesperidin can protect the lungs of mice submitted to mechanical ventilation by reducing the inflammatory response and oxidative damage, and may act to prevent mechanical ventilation-induced injuries.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Junmin Zhou, Ruifeng He, Zhuozhi Shen, Yan Zhang, Xufang Gao, Dejiquzong, Xiong Xiao, Tao Zhang, Dan Yang, Yufei Wang, Huan Song, Yuming Guo, Shanshan Li, Gongbo Chen, Jianzhong Yin, Xing Zhao
Summary: This study evaluated the correlation between altitude and metabolic syndrome in Chinese residents, as well as the mediation effects of diet and physical activity. The results showed that living at middle and high altitudes was associated with a lower risk of metabolic syndrome compared to low altitude, with middle altitude having the lowest risk. Diet and physical activity played a mediating role in this association.
JOURNAL OF GLOBAL HEALTH
(2023)
Review
Nutrition & Dietetics
Dustin W. Davis, James W. Navalta, Graham R. McGinnis, Reimund Serafica, Kenneth Izuora, Arpita Basu
Article
Hospitality, Leisure, Sport & Tourism
Hannah J. Blazer, Cassidy L. Jordan, Joseph A. Pederson, Rebecca R. Rogers, Tyler D. Williams, Mallory R. Marshall, Christopher G. Ballmann
Summary: Regardless of training preference, barbell velocity was higher in the evening trial compared to the morning trial. However, training preference did not significantly influence resistance-exercise performance, with higher motivation and lower rate of perceived exertion during preferred training times.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2021)
Article
Environmental Sciences
Mallory Marshall, McKenzie McClanahan, Sarah McArthur Warren, Rebecca Rogers, Christopher Ballmann
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Environmental Sciences
Amanda M. Dumar, Anna F. Huntington, Rebecca R. Rogers, Thomas J. Kopec, Tyler D. Williams, Christopher G. Ballmann
Summary: The study found that trained sprinters experience decreased anaerobic performance in the morning compared to afternoon, but ingestion of BRJ can prevent these performance decrements.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Mallory Marshall, Beth Birchfield, Rebecca Rogers, Joyeuse Senga, McKenna Persch, Madison Currie, Daphne Schmid, Christopher Ballmann
Summary: The study found that pregnant women have a similar walking cadence equivalent to 3 METs as non-pregnant populations, indicating that the traditional 3 MET cutoff for moderate-intensity activity is appropriate for pregnant women. There was a moderate and significant relationship between METs and cadence, suggesting that exercise prescription in pregnant populations can be based on established metabolic thresholds.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Tyler D. Williams, Haley N. Langley, Caleb C. Roberson, Rebecca R. Rogers, Christopher G. Ballmann
Summary: The study found that short-term Golden Root Extract supplementation can increase mean bench press velocity but decrease bench press repetition volume. Additionally, Golden Root Extract resulted in higher norepinephrine levels and blood lactate following exercise.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Courteney L. Benjamin, Elliot P. Norton, Benjamin M. Shirley, Rebecca R. Rogers, Tyler D. Williams, Mallory R. Marshall, Christopher G. Ballmann
Summary: This study assessed the effect of two fluid intake protocols on alertness and reaction time. The results showed that participants had significantly improved reaction time and alertness after following the prescribed fluid intake protocol. In contrast, participants who followed the fluid restricted protocol displayed poorer reaction time and alertness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Megan E. Barnes, Camryn R. Cowan, Lauren E. Boag, Julianne G. Hill, Morgan L. Jones, Kylie M. Nixon, Mckenzie G. Parker, Shelby K. Parker, Mary V. Raymond, Lillie H. Sternenberg, Shelby L. Tidwell, Taylor M. Yount, Tyler D. Williams, Rebecca R. Rogers, Christopher G. Ballmann
Summary: The purpose of this study was to investigate the effects of a single acute dose of yohimbine hydrochloride on repeated anaerobic sprint ability. The results showed that yohimbine hydrochloride supplementation increased power, total work, and heart rate, while decreasing fatigue index and post-exercise lactate levels. These findings suggest that yohimbine hydrochloride may improve sprint performance.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Rebecca R. Rogers, Kalee G. Beardsley, Peighton E. Cumbie, Christopher G. Ballmann
Summary: This study aimed to examine the effects of NH3 on psychophysiological responses and performance during repeated high-intensity exercise. The results showed that NH3 significantly increased mean power and peak power during the exercise, as well as subjective alertness and psyched-up energy.
RESEARCH QUARTERLY FOR EXERCISE AND SPORT
(2022)
Article
Environmental Sciences
Courteney L. Benjamin, Luke W. Dobbins, Shealyn G. Sullivan, Rebecca R. Rogers, Tyler D. Williams, Mallory R. Marshall, Christopher G. Ballmann
Summary: This study aimed to determine if ad libitum (AL) versus periodic (PER) fluid intake affects fluid consumption and gastrointestinal distress during exercise in trained athletes. The findings suggest that increased fluid availability allows for higher fluid intake without experiencing gastrointestinal discomfort.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Psychology, Experimental
Ibrahim Ouergui, Eya Jebabli, Slaheddine Delleli, Hamdi Messaoudi, Craig Alan Bridge, Hamdi Chtourou, Emerson Franchini, Christopher Garrett Ballmann, Luca Paolo Ardigo
Summary: This study aimed to investigate the effects of warm-up music preference and loudness on physical performance, perceived exertion, and enjoyment in young taekwondo athletes. The results showed that listening to preferred music with a higher volume resulted in better performance and lower perceived exertion during taekwondo tasks. These findings have important implications for enhancing taekwondo training and performance.
PERCEPTUAL AND MOTOR SKILLS
(2023)
Article
Sport Sciences
Rebecca R. Rogers, Tyler D. Williams, Emma B. Nester, Grace M. Owens, Christopher G. Ballmann
Summary: The study found that listening to preferred music can enhance isometric strength, increase motivation, and feelings of being psyched up.
JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY
(2023)
Article
Psychology, Experimental
Christopher G. Ballmann, Mason L. Favre, Matthew T. Phillips, Rebecca R. Rogers, Joseph A. Pederson, Tyler D. Williams
Summary: Listening to pre-exercise music before bench press exercise can increase muscle power output, velocity, repetitions to failure, and exercise motivation.
PERCEPTUAL AND MOTOR SKILLS
(2021)
Article
Psychology, Experimental
Sarah C. Duckworth, Carrie S. Higginbotham, Joseph A. Pederson, Rebecca R. Rogers, Mallory R. Marshall, Tyler D. Williams, Christopher G. Ballmann
Summary: This study found that cognitive performance was preserved regardless of the amount of muscle mass activated during dual task rowing, but physical performance suffered more during full-body rowing than upper-extremity rowing under the dual task condition.
PERCEPTUAL AND MOTOR SKILLS
(2021)
Article
Psychology, Experimental
Morgan C. Karow, Rebecca R. Rogers, Joseph A. Pederson, Tyler D. Williams, Mallory R. Marshall, Christopher G. Ballmann
PERCEPTUAL AND MOTOR SKILLS
(2020)