Article
Multidisciplinary Sciences
Cristian Cuadra, Steven Wolf, Mark Lyle
Summary: Excitatory feedback from muscle spindles and inhibitory feedback from Golgi tendon organs and recurrent inhibitory circuits are widely distributed within the spinal cord to modulate activity between human lower limb muscles. The unique effect of non-spindle heteronymous feedback is difficult to determine. This study compared excitatory and inhibitory effects from femoral nerve and quadriceps muscle belly stimulation onto soleus H-reflex size, as well as the heteronymous effects onto ongoing soleus EMG.
Article
Engineering, Biomedical
Johanna Flodin, Philip Wallenius, Li Guo, Nils-Krister Persson, Paul Ackermann
Summary: Neuromuscular electrical stimulation (NMES) of the quadriceps (Q) can increase venous blood flow and reduce the risk of venous thromboembolism. This study evaluated the use of Q-NMES pants to increase peak venous velocity (PVV) and minimize discomfort. The results showed that Q-NMES pants significantly increased PVV, with 36 Hz and 66 Hz frequencies, no ramp-up/-down time (RUD), and ML II intensity having the most significant effect.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Neurosciences
Vesna M. van Midden, Jure Demsar, Zvezdan Pirtosek, Maja Kojovic
Summary: This study investigates the effects of transcutaneous auricular vagal nerve stimulation (taVNS) and sham earlobe vagal nerve stimulation (sVNS) on cortical excitability. The results show that taVNS increases short-interval intracortical inhibition (SICI), while sVNS decreases SICI. Additionally, taVNS has no effect on short-latency afferent inhibition (SAI), while sVNS decreases SAI.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Jonathan Galvao Tenorio Cavalcante, Alvaro de Almeida Ventura, Leandro Gomes de Jesus Ferreira, Alessandra Martins Melo de Sousa, Ivo Vieira de Sousa Neto, Rita de Cassia Marqueti, Nicolas Babault, Joao Luiz Quagliotti Durigan
Summary: Neuromuscular electrical stimulation (NMES) is commonly used to increase muscle strength and physical function. This study aimed to investigate the effect of different muscle lengths on NMES-induced contraction fatigability of the quadriceps femoris muscle. The results showed that QF NMES-induced contraction fatigability was greater when the knee was flexed at 60 degrees compared to 20 degrees. Additionally, a supine position promoted earlier fatigue for a 60-degree knee flexion, but delayed fatigue onset for a 20-degree knee flexion compared to the seated position. These findings provide valuable insights for optimizing lower limb positioning during NMES training.
APPLIED BIONICS AND BIOMECHANICS
(2022)
Proceedings Paper
Engineering, Biomedical
Luis Vargas, John Baratta, Xiaogang Hu
Summary: Novel transcutaneous nerve stimulation techniques can delay muscle fatigue, and by adjusting stimulation parameters, it is possible to maximize muscle activation through the reflex pathway, thus delaying fatigue.
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)
(2021)
Article
Medicine, General & Internal
Wirawan Indra Priyantono, Damayanti Tinduh, Yudith Dian Prawitri, Putu Alit Pawana, Soenarnatalina Melaniani
Summary: The COVID-19 pandemic has led to decreased leg muscle strength due to inactivity. The hybrid training method uses electrical stimulation of antagonist muscles to strengthen agonist muscles. This study aimed to analyze the effects of modified hybrid resistance training on quadriceps and hamstring muscle strength.
BALI MEDICAL JOURNAL
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Awadh Alhawwash, M. Ryne Horn, Nathaniel Lazorchak, Ken Yoshida
Summary: Traditionally, electrical stimulation uses short duration charge balanced rectangular impulses. This study explores the use of low frequency alternating current (LFAC) stimulation using a pure tone continuous sinusoidal waveform. In-silico and in-vivo experiments were conducted to compare LFAC with standard rectangular pulse stimulation. Preliminary results indicate that LFAC evokes motor nerve activation with a normal physiological order of recruitment.
2023 11TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING, NER
(2023)
Article
Biophysics
Javier Rodriguez-Falces, Alberto Botter, Taian Vieira, Nicolas Place
Summary: The study found that the shoulder, a sharp deflection in M waves, was present in most monopolar recordings but rarely observed in bipolar recordings. It was a stationary feature with short duration and positive polarity along the muscle fibers. The latency of the shoulder was shorter than the estimated time for action potentials to reach the biceps tendon, suggesting a dipole source generating the shoulder.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Physiology
Javier Rodriguez-Falces, Nicolas Place
Summary: The study found that short-duration muscle contractions lead to a short-term increase in conduction velocity, while long-duration contractions result in a long-term decrease in conduction velocity.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Editorial Material
Physiology
Nicolas Place
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Cell Biology
Peiling Luan, Davide D'Amico, Penelope A. Andreux, Pirkka-Pekka Laurila, Martin Wohlwend, Hao Li, Tanes Imamura de Lima, Nicolas Place, Chris Rinsch, Nadege Zanou, Johan Auwerx
Summary: Research shows that decreased mitochondrial autophagy may contribute to mitochondrial dysfunction in Duchenne muscular dystrophy (DMD) patients and experimental models. However, administration of the mitophagy activator urolithin A can improve mitochondrial function and alleviate symptoms of DMD, suggesting potential therapeutic applications for muscular dystrophies.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Chris Donnelly, Jonathan Stegmuller, Anthony J. Blazevich, Fabienne Crettaz von Roten, Bengt Kayser, Daria Neyroud, Nicolas Place
Summary: The study shows that pre-treatment with TENS before WPHF NMES can modulate the torque generated, while anodal tsDCS intervention had no effect. This finding opens up new avenues for designing interventions to enhance WPHF NMES.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Johannes Burtscher, Gregoire P. Millet, Nicolas Place, Bengt Kayser, Nadege Zanou
Summary: Regular exercise has pronounced health benefits, with enhanced mitochondrial functions in skeletal muscle playing a central role in exercise-induced adaptations. Along with muscle, regular exercise also benefits the brain and is crucial in protecting against neurodegenerative diseases. Mitochondria seem to be central players in the communication routes from muscle to the brain induced by exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Nadege Zanou, Haikel Dridi, Steven Reiken, Tanes Imamura de Lima, Chris Donnelly, Umberto De Marchi, Manuele Ferrini, Jeremy Vidal, Leah Sittenfeld, Jerome N. Feige, Pablo M. Garcia-Roves, Isabel C. Lopez-Mejia, Andrew R. Marks, Johan Auwerx, Bengt Kayser, Nicolas Place
Summary: Exercise-induced transient calcium leak through RyR1 causes mitochondrial remodeling to improve respiration.
NATURE COMMUNICATIONS
(2021)
Article
Physiology
Javier Rodriguez-Falces, Nicolas Place
Summary: The study aimed to investigate sarcolemmal excitability during a sustained low-force contraction. The main findings were that conduction velocity remained unchanged, the M-wave first phase decreased initially and stabilized, while the second phase increased initially before stabilizing. Perceived effort increased significantly during the contraction, with a decrease in both maximal voluntary force and peak twitch force post-contraction. These results suggest that sarcolemmal excitability is preserved during sustained low-force contraction, and fatigue can develop without changes in membrane excitability.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Pirkka-Pekka Laurila, Peiling Luan, Martin Wohlwend, Nadege Zanou, Barbara Crisol, Tanes Imamura de Lima, Ludger J. E. Goeminne, Hector Gallart-Ayala, Minho Shong, Julijana Ivanisevic, Nicolas Place, Johan Auwerx
Summary: Inhibition of sphingolipid synthesis, targeting multiple pathogenic pathways, shows promise as a potential treatment for muscular dystrophies.
Editorial Material
Physiology
Ramona Ritzmann, Alessandro Del Vecchio, Stephane Baudry, Nicolas Place, Albert Gollhofer, Marco Narici, Christoph Centner
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biology
Chris Donnelly, Timothee Popesco, Julie Rosse, Bengt Kayser, Nicola A. Maffiuletti, Nicolas Place
Summary: This study compared contralateral facilitation of plantar flexor strength during rest and different types of NMES stimulation. The results showed that neither conventional nor wide-pulse high-frequency NMES induced any contralateral facilitation of maximal voluntary strength.
Article
Physiology
Javier Rodriguez-Falces, Armando Malanda, Javier Navallas, Nicolas Place
Summary: This study aimed to experimentally assess the changes in the compound muscle action potential (M-wave) caused by brief voluntary and stimulated isometric contractions. Two methods of inducing muscle shortening were used under isometric condition, and the amplitude and duration of the M-wave phases were measured. The results showed that muscle shortening led to a decrease in the amplitude of the first phase and an increase in the amplitude of the second phase of the M-wave.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Sport Sciences
Darias Holgado, Leo Jolidon, Guillermo Borragan, Daniel Sanabria, Nicolas Place
Summary: A study analyzing neurophysiological and physical responses found that individualized mental fatigue tasks do not adversely affect neuromuscular function or physical exercise.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Cell Biology
Pirkka-Pekka Laurila, Martin Wohlwend, Tanes Imamura de Lima, Peiling Luan, Sebastien Herzig, Nadege Zanou, Barbara Crisol, Maroun Bou-Sleiman, Eleonora Porcu, Hector Gallart-Ayala, Michal K. Handzlik, Qi Wang, Suresh Jain, Davide D'Amico, Minna Salonen, Christian M. Metallo, Zoltan Kutalik, Thomas O. Eichmann, Nicolas Place, Julijana Ivanisevic, Jari Lahti, Johan G. Eriksson, Johan Auwerx
Summary: Age-related muscle dysfunction and sarcopenia can be prevented by inhibiting sphingolipid synthesis, which enhances muscle mass, strength, and exercise capacity. Inhibition of sphingolipid synthesis promotes myogenic potential and protein synthesis.
Review
Sport Sciences
Marcus P. Hannon, Joelle Leonie Flueck, Vincent Gremeaux, Nicolas Place, Bengt Kayser, Chris Donnelly
Summary: There are currently no nutrition guidelines for youth winter sports athletes, as there is a lack of research on this specific population. It is important to carefully extrapolate from guidelines for adult athletes and consider the rapid biological growth and maturation of youth athletes when developing nutritional recommendations. Educating youth athletes, their parents, and coaches on best nutritional practices and the risks associated with dietary supplements is crucial for their long-term athletic development. Further research is urgently needed to inform nutritional guidelines for youth winter sports athletes across different stages of growth and maturation competing in a variety of sports.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2021)