Article
Sport Sciences
Stephanie Hody, Blair E. Warren, Dominique-Marie Votion, Bernard Rogister, Helene Lemieux
Summary: This study investigates the impact of eccentric exercise on mitochondrial function. The results show that eccentric exercise leads to a decrease in muscle oxidative phosphorylation capacity and mainly affects the distal muscle portion. This study provides new perspectives on the mitochondrial adaptation associated with eccentric exercise.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Physiology
Aleksander S. Golub, Bjorn K. K. Song, William H. Nugent, Roland N. Pittman
Summary: This study investigated changes in interstitial PO2 and calculated VO2 during rest, muscle contraction, and recovery periods using a rat spinotrapezius muscle preparation. The findings showed that interstitial PO2 decreased and VO2 increased within the first 20 seconds of muscle contraction, with a lower PO2 and higher VO2 at higher stimulation frequencies. After stimulation cessation, PO2 exponentially increased towards baseline values, while VO2 had delayed and exponential decreases. Further analysis revealed two distinct responses based on PO2 levels, with different corresponding VO2 responses. In summary, local microscopic PO2 and VO2 were measured during resting and contracting muscle, with slower post-contraction transients compared to onset transients.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Engineering, Environmental
Xiangyu Wang, Hanjiang Zhao, Zhenchuan Liu, Yitong Wang, Dan Lin, Long Chen, Jiewen Dai, Kaili Lin, Steve G. Shen
Summary: PDA nanoparticles exhibit a dual antioxidative and anti-inflammatory mechanism, effectively treating temporomandibular joint osteoarthritis by improving mitochondrial respiration efficiency and reducing ROS production. This nanoplatform opens up a new avenue for osteoarthritis treatment and offers valuable insights into the design of biomaterials with multiple biomedical applications by regulating cellular energy metabolism.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Francisco Javier Martinez-Noguera, Pedro E. E. Alcaraz, Jorge Carlos-Vivas, Cristian Marin-Pagan
Summary: This study aimed to investigate the possible mechanisms underlying the improved performance after chronic supplementation with 2S-hesperidin. The results showed that 8 weeks of 2S-hesperidin ingestion significantly increased CO2 and tCO2 levels, while pO2 remained unchanged. This suggests that chronic supplementation with 2S-hesperidin prevents decreases in pO2 at submaximal intensities in amateur cyclists during the off-season.
Article
Chemistry, Physical
Klaasjan Maas, Chloe Wulles, Jose Manuel Caicedo Roque, Belen Ballesteros, Valentin Lafarge, Jose Santiso, Monica Burriel
Summary: Depositing LaNiO3/La2NiO4 bilayers under different pO(2) conditions can significantly affect the electrical behavior of Pt/LaNiO3/La2NiO4/Pt devices. The devices deposited at low pO(2) exhibit the largest memristance, which is attributed to the formation of a p-type Schottky contact between LaNiO3 and La2NiO4. The extent of carrier depletion width in the contact can be modulated by the electric-field induced drift of interstitial oxygen ions acting as mobile acceptor dopants in La2NiO4.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Biochemistry & Molecular Biology
Xianglai Ye, Yaojun Xie, Yu Shi, Bo Wang, Xinyu Han, Xiaoxuan Zhou, Kexin Pan, Maofeng Wang, Hezhi Fang
Summary: In this study, the organization and expression pattern of muscle-specific CIV isoforms in different mouse muscle tissues were profiled. The results showed the presence of extensive CIV-containing supramolecular organization in mature skeletal muscles, and a switch in expression from ubiquitous to muscle-specific isoforms of CIV was detected. Furthermore, the enzymatic activity of CIV containing the muscle-specific isoform COX6A2 was found to be higher than that with COX6A1, suggesting the indispensable role of switching the expression to muscle-specific CIV isoforms in optimized oxidative phosphorylation in mature skeletal muscles.
Article
Biochemistry & Molecular Biology
Heikki V. Sarin, Eija Pirinen, Kirsi H. Pietilainen, Ville Isola, Keijo Hakkinen, Markus Perola, Juha J. Hulmi
Summary: This study on 42 healthy athletic females revealed that prolonged energy deficit can lead to metabolic adaptations, including suppression of mitochondrial and ribosome biogenesis gene expression. These findings suggest that adaptation to energy deficit in humans is broader than previously believed.
Article
Biochemistry & Molecular Biology
Kerri Lynn Ackerly, Benjamin Negrete Jr, Angelina M. Dichiera, Andrew J. Esbaugh
Summary: Environmental hypoxia poses a significant threat to fishes, but some fishes show respiratory flexibility and exhibit increased mitochondrial efficiency, oxygen storage capacity, and oxidative capacity under hypoxia. This study found that red drum fish acclimated to hypoxia can more efficiently utilize oxygen, explaining their improved aerobic swimming performance despite no increase in maximum metabolic rate following hypoxia acclimation.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Keiko Namma-Motonaga, Emi Kondo, Takuya Osawa, Keisuke Shiose, Akiko Kamei, Motoko Taguchi, Hideyuki Takahashi
Summary: Daily muscle glycogen recovery is crucial for athletes. This study used C-13-MRS to investigate the impact of carbohydrate intake on muscle glycogen recovery for 24 hours after exercise. The findings suggest that a carbohydrate intake of 5 g/kg BM/d is insufficient for Japanese athletes to recover muscle glycogen stores within 24 hours.
Article
Biology
Margaret A. M. Nelson, Kelsey L. McLaughlin, James T. Hagen, Hannah S. Coalson, Cameron Schmidt, Miki Kassai, Kimberly A. Kew, Joseph M. McClung, P. Darrell Neufer, Patricia Brophy, Nasreen A. Vohra, Darla Liles, Myles C. Cabot, Kelsey H. Fisher-Wellman
Summary: This study focuses on targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer, particularly acute myeloid leukemia (AML). It reveals intrinsic bioenergetic vulnerabilities in cancerous mitochondria and highlights the limitations of OXPHOS in leukemic cells. Leukemic mitochondria show high ATP consumption and restoring oxidative ATP synthesis is cytotoxic to leukemic blasts, suggesting a potential therapeutic avenue for combating hematological malignancy and chemoresistance.
Article
Cell Biology
Catherine A. Bellissimo, Luca J. Delfinis, Meghan C. Hughes, Patrick C. Turnbull, Shivam Gandhi, Sara N. DiBenedetto, Fasih A. Rahman, Peyman Tadi, Christina A. Amaral, Ali Dehghani, James N. Cobley, Joe Quadrilatero, Uwe Schlattner, Christopher G. R. Perry
Summary: This study aimed to determine whether the prospective mitochondrial-enhancing compound Olesoxime can prevent early-stage mitochondrial stress in limb and respiratory muscle from D2.mdx mice. Results showed that Olesoxime selectively preserved or maintained muscle sensitivity to creatine, reduced creatine kinase release, and improved some indices of muscle quality.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Critical Care Medicine
Connie C. W. Hsia
Summary: This article provides an overview of the journey of inspired oxygen after its uptake across the alveolar-capillary interface, and the interplay among tissue perfusion, diffusion, and cellular respiration in the transport and utilization of oxygen. The critical interactions between oxygen and its facilitative carriers, as well as other respiratory and vasoactive molecules, are emphasized. The importance of well-matched gas exchange rates and the role of red blood cells in regulating tissue perfusion and gas exchange are highlighted.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Jinhyuk Choi, Tae Gyu Oh, Hee-Won Jung, Kun-Young Park, Hyemi Shin, Taehee Jo, Du-Seock Kang, Dipanjan Chanda, Sujung Hong, Jina Kim, Hayoung Hwang, Moongi Ji, Minkyo Jung, Takashi Shoji, Ayami Matsushima, Pilhan Kim, Ji Young Mun, Man-Jeong Paik, Sung Jin Cho, In-Kyu Lee, David C. Whitcomb, Phil Greer, Brandon Blobner, Mark O. Goodarzi, Stephen J. Pandol, Jerome Rotter, Weiwei Fan, Sagar P. Bapat, Ye Zheng, Chris Liddle, Ruth T. Yu, Annette R. Atkins, Michael Downes, Eiji Yoshihara, Ronald M. Evans, Jae Myoung Suh
Summary: The phosphorylation of zinc finger protein and embryonic tumor cell locomotion coupling protein can regulate the migration ability of breast cancer cells.
Article
Medicine, General & Internal
Martijn van Hooff, Jem Arnold, Eduard Meijer, Paul Schreuder, Marta Regis, Lin Xu, Marc Scheltinga, Hans Savelberg, Goof Schep
Summary: This study compared the diagnostic accuracy of NIRS-derived variables with ABI(Flexed) in diagnosing FLIA. The results showed that NIRS kinetic variables combined with ABI(Flexed) had a higher diagnostic accuracy, while ABI(Flexed) alone had worse test characteristics.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Miguel Perez-Rodriguez, Jesus R. Huertas, Jose M. Villalba, Rafael A. Casuso
Summary: This study conducted a meta-analysis to investigate the effects of calorie restriction and bariatric surgery on human skeletal muscle mitochondria. The results showed that calorie restriction leads to a decrease in maximal mitochondrial state 3 respiration, while bariatric surgery does not affect mitochondrial respiration and content.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)