Article
Immunology
Anna Strzepa, Cody J. Gurski, Landon J. Dittel, Marian Szczepanik, Kirkwood A. Pritchard, Bonnie N. Dittel
Summary: The study found that MPO plays a dual role in the pathogenesis of CHS. During the induction phase, MPO promotes IL-1 beta production in the skin, affecting migratory DC and effector T cells. In the elicitation phase, inhibiting MPO significantly reduces ear swelling and vascular permeability, indicating that MPO could potentially be a therapeutic target for ACD treatment in humans.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Physiology
Han Shi, Mary El Kazzi, Yuyang Liu, Antony Gao, Angie L. Schroder, Sally Vuong, Pamela A. Young, Benjamin S. Rayner, Caryn van Vreden, Nicholas J. C. King, Paul K. Witting
Summary: This study developed and applied an innovative spatial analysis workflow for multiplex imaging data in order to understand the mechanism of neutrophil-mediated damage post-myocardial infarction. The results showed that the expression of damage markers and the immunoreactivity of these markers decreased with increasing neutrophil density in different regions. Additionally, the immunoreactivity of the markers decreased linearly with increasing distance from the infarct. The study also confirmed the spatial dependence between neutrophils and markers of cardiac cellular damage.
Article
Medicine, General & Internal
Masumi Nakahama-Matsushima, Yoshi-ichiro Kamijyo, Yasunori Umemoto, Takamasa Hashizaki, Yukihide Nishimura, Kazunari Furusawa, Yohei Furotani, Fumihiro Tajima, Ken Kouda
Summary: Exercise increases the IL-6 level, which stimulates the production of inflammatory cytokine antagonists. This study compared the effects of wheelchair half marathon on the immune system of male athletes with CSCI and SCI, and found that the race increases IL-1ra level, possibly mediated through circulatory neutrophils.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Monica Gelzo, Sara Cacciapuoti, Biagio Pinchera, Annunziata De Rosa, Gustavo Cernera, Filippo Scialo, Mauro Mormile, Gabriella Fabbrocini, Roberto Parrella, Ivan Gentile, Giuseppe Castaldo
Summary: NLR can be used as a predictive marker of disease severity and mortality in COVID-19 patients. In the first wave, NLR increased significantly with disease severity due to a decrease in lymphocytes and increase in neutrophils. In the second wave, the use of steroids led to no significant differences in NLR among patients of different severity levels.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Sanna Tornblom, Sara Nisula, Suvi T. Vaara, Meri Poukkanen, Sture Andersson, Ville Pettila, Eero Pesonen
Summary: Elevation of neutrophil activation markers HBP and MPO is an early event in sepsis development, lasting beyond the subsidence of the pro-inflammatory cytokine reaction. IL-6 and IL-8 rise and decline rapidly close to the emergence of sepsis-associated organ dysfunction.
Article
Cell Biology
Kyle D. Timmer, Daniel J. Floyd, Allison K. Scherer, Arianne J. Crossen, Johnny Atallah, Adam L. Viens, David B. Sykes, Michael K. Mansour
Summary: We developed a high throughput flow cytometry-based assay to detect changes in four canonical neutrophil functions. The study showed that antifungal drugs and inflammatory cytokines can alter neutrophil function. In addition, small molecule inhibitors can suppress neutrophil function, but it can be restored with lipopolysaccharide co-stimulation.
Editorial Material
Endocrinology & Metabolism
Niklas Joisten, Sebastian Gehlert, Philipp Zimmer
Summary: High-intensity interval training (HIIT) is a common method used to improve athletic performance, aid in rehabilitation, and prevent diseases. However, research suggests that exceeding a certain limit of HIIT might have detrimental effects on metabolic health.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Priyam Singh, Khushtar Anwar Salman, Mohammad Shameem, Mohd Sharib Warsi
Summary: This study demonstrated the clinical efficacy of Withania somnifera (WS) root as an add-on therapy for COPD patients, significantly improving lung function, quality of life, exercise tolerance, and reducing inflammation. Withanolides found in WS root showed inhibitory activity against the SARS-CoV-2 receptor and proteins associated with inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Bruna Cunha Mendes, Candice Lais Knoner Copetti, Vilma Simoes Pereiea Panza, Lucas B. R. Orssatto, Julia Salvan da Rosa, Fernando Diefenthaeler, Eduardo Monguilhott Dalmarco, Patricia Faria Di Pietro, Debora Kurrle Rieger
Summary: The study found that consuming ju, cara fruit juice may help alleviate the inflammatory response to high-intensity intermittent exercise, possibly due to reducing muscle stress. Compared to water, the impact of ju, cara fruit juice on tumor necrosis factor-alpha and IL-10 was more pronounced. Additionally, individuals who consumed ju, cara fruit juice performed better during sprints.
Article
Biochemistry & Molecular Biology
Marcus V. L. Dos Santos Quaresma, Raquel Campos, Edgar Tavares-Silva, Camila Guazzelli Marques, Ronaldo Vagner Thomatieli-Santos
Summary: The study showed that caffeine supplementation can decrease fatigue and increase vigor perception post-exercise. Levels of IL-10 were higher in the caffeine group 1 hour after exercise, suggesting a potential association between IL-10 and reduced post-exercise fatigue perception.
Article
Geriatrics & Gerontology
Nicolas Vidal-Seguel, Camilo Cabrera, Luciano Ferrada, Macarena Artigas-Arias, Andrea Alegria-Molina, Sergio Sanhueza, Alejandra Flores, Nolberto Huard, Jorge Sapunar, Luis A. Salazar, Reuben McGregor, Estefania Nova-Lamperti, Gabriel Nasri Marzuca-Nassr
Summary: This study aimed to investigate the regulatory effect of high-intensity interval training (HIIT) on neutrophil extracellular trap formation (NETosis) in older individuals. The results showed that HIIT significantly reduced the induction of NETosis in older men. This suggests that HIIT is a feasible non-invasive training strategy for regulating the immune response in older individuals.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Physiology
Gabriella F. Bellissimo, Jeremy Ducharme, Zachary Mang, Desmond Millender, Jessica Smith, Matthew J. Stork, Johnathan P. Little, Michael R. Deyhle, Ann L. Gibson, Flavio de Castro Magalhaes, Fabiano Amorim
Summary: This study compared the acute physiological, perceptual, and enjoyment responses between bodyweight high-intensity interval exercise (BW-HIIE) and treadmill running high-intensity interval exercise (RUN-HIIE). The results showed that BW-HIIE elicited higher oxygen consumption, blood lactate, heart rate, and rating of perceived exertion compared to RUN-HIIE, while the physical activity enjoyment was similar between the two exercises.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Multidisciplinary Sciences
Jacob M. McDougle, Gerald T. Mangine, Jeremy R. Townsend, Adam R. Jajtner, Yuri Feito
Summary: A scoping review was conducted to investigate the acute physiological response to HIFT-based exercise. The review found that markers of intensity were consistently assessed, supporting the idea that HIFT workouts are performed at high-intensity. However, the inclusion of other measures has been inconsistent, limiting the ability to draw generalized conclusions.
Review
Neurosciences
Angelo Sabag, Johnathan P. Little, Nathan A. Johnson
Summary: Low-volume HIIT, involving short bouts of high-intensity exercise, has shown to provide similar, or even greater, health benefits compared to traditional aerobic exercises. The improvements seen in cardiorespiratory health, glucose control, and cardiac function may be attributed to enhanced mitochondrial function and insulin sensitivity. Additionally, low-volume HIIT is well-tolerated and safe for adults, with high exercise adherence rates and minimal adverse effects reported.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Immunology
Florian Javelle, Wilhelm Bloch, Andre Knoop, Gilles J. Guillemin, Philipp Zimmer
Summary: This study found that High Intensity Interval Training (HIIT) can shift the kynurenine pathway from its neurotoxic branch to its neuroprotective branch, leading to a decrease in impulsivity. Both emotion-related and -unrelated impulsivity were effectively decreased by interventions, with only the HIIT group showing a decrease in emotion-unrelated levels.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Medicine, General & Internal
Takashi Kato, Toshiaki Nakajima, Taira Fukuda, Ikuko Shibasaki, Takaaki Hasegawa, Koji Ogata, Hironaga Ogawa, Shotaro Hirota, Hirotaka Ohashi, Shunsuke Saito, Yusuke Takei, Masahiro Tezuka, Masahiro Seki, Toshiyuki Kuwata, Masashi Sakuma, Shichiro Abe, Shigeru Toyoda, Teruo Inoue, Hirotsugu Fukuda
Summary: This study aimed to investigate the relationships between preoperative serum levels of GDF-15 and ET-1 and short-term operative risks, such as AKI, for patients undergoing cardiovascular surgery. The findings showed correlations between GDF-15, ET-1 levels, and STS score, as well as associations with preoperative factors like eGFR, Alb, Hb, and perioperative data. Patients with AKI had longer CPB time, and male patients with AKI had higher ET-1 levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Haruhiko Madarame
Summary: This study investigated changes in shot distribution and accuracy in senior and under-17 international basketball tournaments in the 2010s. Analysis of 1055 games from 20 world-level tournaments revealed significant differences in two-point shot attempts between 2012 and 2016, as well as in three-point shot attempts between 2010, 2012, and 2016. Shot accuracy varied significantly between age categories, with under-17 games showing lower accuracy compared to senior games.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Ikuko Shibasaki, Toshiaki Nakajima, Taira Fukuda, Takaaki Hasegawa, Hironaga Ogawa, Go Tsuchiya, Yusuke Takei, Masahiro Tezuka, Takashi Kato, Yuta Kanazawa, Yasuyuki Kano, Toshiyuki Kuwata, Motoshi Ouchi, Shigeru Toyoda, Yoshimasa Aso, Hirotsugu Fukuda
Summary: Dipeptidyl peptidase 4 (DPP-4) and adiponectin levels were compared in different tissues and found that DPP-4 levels were higher in subcutaneous adipose tissue (SAT) compared to epicardial adipose tissue (EAT). The levels of DPP-4 in SAT and EAT were positively correlated. SAT DPP-4 levels were associated with atherosclerosis, diabetes mellitus, DPP-4 inhibitor use, and fasting blood glucose, while EAT DPP-4 levels were negatively correlated with eGFR and positively correlated with atrial fibrillation. The study suggests that DPP-4 inhibitors may suppress angiogenesis and adipose-tissue hypertrophy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Sport Sciences
Haruhiko Madarame
Summary: This study examined shot distribution and accuracy in international 3x3 basketball tournaments and compared them among different age and sex categories. The analysis of ninety-one games from the FIBA 3x3 World Cup 2019 and the FIBA 3x3 Under-18 World Cup 2019 showed that there were no sex differences in the success rates for two-point and mid-range shots. However, male teams attempted more two-point shots and fewer mid-range shots than female teams. Senior teams also attempted more two-point shots and fewer paint shots than under-18 teams in men's tournaments. Male teams had higher scoring efficiency than female teams.
MONTENEGRIN JOURNAL OF SPORTS SCIENCE AND MEDICINE
(2023)
Article
Sport Sciences
Haruhiko Madarame
Summary: This study compared the incidence and success rates of offensive plays in 3x3 basketball based on starting actions and age/sex categories. Offensive plays were classified into three types: check-ball offensive plays (CBOP), transition offensive plays (TOP), and offensive rebound offensive plays (OROP). The success rates of OROP were significantly higher than those of TOP and CBOP in all categories. Improving the success rate of TOP is crucial to increase the chance of winning a game, as it accounts for more than half of the total offensive plays. Acquiring offensive rebounds is also important in 3x3 basketball.
KINESIOLOGIA SLOVENICA
(2023)
Article
Cardiac & Cardiovascular Systems
Riichi Nishikawa, Taira Fukuda, Akiko Haruyama, Ikuko Shibasaki, Suomi Yamaguchi, Takuo Arikawa, Syotaro Obi, Hirohisa Amano, Hiroshi Yagi, Masashi Sakuma, Shichiro Abe, Hirotsugu Fukuda, Shigeru Toyoda, Toshiaki Nakajima
Summary: This study investigated the relationship between serum GDF-15, myostatin, and sarcopenia in patients receiving cardiovascular surgery. The results showed that GDF-15 and myostatin are associated with skeletal muscle volume, but in different ways. The sarcopenia index calculated from GDF-15 and myostatin levels may serve as a biomarker for sarcopenia.
IJC HEART & VASCULATURE
(2022)
Article
Cardiac & Cardiovascular Systems
Taira Fukuda, Toshiaki Nakajima, Hiroko Yazawa, Suguru Hirose, Jun Yokomachi, Takashi Kato, Riichi Nishikawa, Nobuo Koshiji, Michiaki Tokura, Takahisa Nasuno, Setsu Nishino, Syotaro Obi, Ikuko Shibasaki, Tomoaki Kanaya, Fumitaka Nakamura, Hirotsugu Fukuda, Shichiro Abe, Masashi Sakuma, Shigeru Toyoda
Summary: This study examined the relationship between serum GDF-15 concentration and muscle function in patients undergoing aortic valve replacement and healthy elderly subjects. The results showed that the preoperative serum GDF-15 concentration was higher in patients receiving aortic valve replacement than in healthy elderly subjects, suggesting it may be a serum marker of sarcopenia.
IJC HEART & VASCULATURE
(2022)
Article
Cardiac & Cardiovascular Systems
Ikuko Shibasaki, Taira Fukuda, Hironaga Ogawa, Go Tsuchiya, Yusuke Takei, Masahiro Seki, Takashi Kato, Yuta Kanazawa, Shunsuke Saito, Toshiyuki Kuwata, Yasuyuki Yamada, Yasuo Haruyama, Hirotsugu Fukuda
Summary: This study evaluated the outcomes of hemodialysis patients who underwent surgical aortic valve replacement with a bioprostheses for aortic stenosis and identified the risk factors for mortality. The study found that preoperative age, hyperlipidemia, left ventricular diastolic diameter, left ventricular systolic diameter, and Japan SCORE were independent predictors of 5-year mortality. Postoperative predictors included intensive care unit stay and albumin level.
IJC HEART & VASCULATURE
(2022)
Article
Cardiac & Cardiovascular Systems
Ikuko Shibasaki, Motoshi Ouchi, Taira Fukuda, Go Tsuchiya, Hironaga Ogawa, Yusuke Takei, Masahiro Tezuka, Yuta Kanazawa, Satoshi Katayanagi, Naohiro Nozawa, Takashi Mizushima, Shigeru Toyoda, Hirotsugu Fukuda, Toshiaki Nakajima
Summary: Sarcopenia is the most significant factor associated with prolonged hospital stay after cardiovascular surgery in older patients. Improving sarcopenia, nutritional status, and shortening cardiopulmonary bypass time appear to shorten the hospital stay in patients with sarcopenia.
IJC HEART & VASCULATURE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Takashi Kato, Toshiaki Nakajima, Taira Fukuda, Ikuko Shibasaki, Toshiyuki Kuwata, Shigeru Toyoda, Teruo Inoue, Hirotsugu Fukuda
Meeting Abstract
Cardiac & Cardiovascular Systems
Toshiaki Nakajima, Akiko Haruyama, Suguru Hirose, Hiroko Yazawa, Taira Fukuda, Hirohisa Amano, Shu Inami, Syotaro Obi, Takuo Arikawa, Ikuko Shibasaki, Masashi Sakuma, Shichiro Abe, Hirotsugu Fukuda, Teruo Inoue, Shigeru Toyoda
Meeting Abstract
Cardiac & Cardiovascular Systems
Taira Fukuda, Shigeru Toyoda, Shichiro Abe, Teruo Inoue, Toshiaki Nakajima
Article
Cardiac & Cardiovascular Systems
Hiroko Yazawa, Taira Fukuda, Hiroyuki Kaneda, Ryutaro Waku, Masashi Sakuma, Akihiro Matsumoto, Shigeru Toyoda, Shichiro Abe, Fumitaka Nakamura, Teruo Inoue, Toshiaki Nakajima
IJC HEART & VASCULATURE
(2020)
Article
Sport Sciences
Haruhiko Madarame
Article
Physiology
Haruhiko Madarame, Satoshi Nakada, Takahisa Ohta, Naokata Ishii
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2018)