Article
Gastroenterology & Hepatology
Xin Zhang, Yu-Jing Fang, Xiao-Li Feng, Alinuer Abulimiti, Chu-Yi Huang, Hong Luo, Cai-Xia Zhang
Summary: This study found a significant reduction in colorectal cancer risk associated with higher intakes of dietary vitamin D and calcium, as well as a significant interaction between dietary vitamin D intake and Apa I polymorphisms. However, no significant associations were found between Fok I, Bsm I, and Taq I and colorectal cancer risk.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Oncology
Dorottya Muehl, Magdolna Herold, Zoltan Herold, Lilla Hornyak, Attila Marcell Szasz, Magdolna Dank
Summary: Vitamin D-3 and homocysteine level abnormalities are closely related to the etiology of colorectal cancer. This study explored the longitudinal changes in these parameters in CRC patients and found a swoosh-shaped trend in homocysteine levels. The study also observed that vitamin D-3 levels remained constant or increased in patients without metastasis, but the disease-worsening effect of metastases cancelled out the positive effects of vitamin D-3 in metastatic patients. Right-sided tumors, male sex, and pathological values of serum lipids, albumin, total protein, and inflammatory markers were associated with lower vitamin D-3 and higher homocysteine levels.
Review
Nutrition & Dietetics
Stephanie Marie Cruz-Pierard, Teresa Nestares, Francisco J. Amaro-Gahete
Summary: Vitamin D supplementation has a protective effect in the prevention and treatment of CRC, while calcium intake shows contradictory effects and further studies are needed to understand its relevance in patients with CRC.
Article
Oncology
Jian Zhou, Xianxiu Ge, Xikang Fan, Jiayu Wang, Lin Miao, Dong Hang
Summary: Research from UK Biobank showed that higher concentrations of serum 25(OH)D are associated with decreased incidence and improved survival of colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Yali Ling, Feng Xu, Xuedi Xia, Dexing Dai, An Xiong, Ruoman Sun, Lei Qiu, Zhongjian Xie
Summary: The combination of vitamin D and calcium has a beneficial effect in preventing falls among elderly individuals, particularly those with 25(OH)D levels lower than 50 nmol/L. Vitamin D supplementation alone does not reduce the risk of falls in elderly individuals with 25(OH)D levels higher than 50 nmol/L.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Jacklyn N. Hellwege, Xiangzhu Zhu, Xiang Huang, Martha J. Shrubsole, Lei Fan, Bingshan Li, Reid Ness, Douglas L. Seidner, Edward L. Giovannucci, Todd L. Edwards, Qi Dai
Summary: Optimal 25(OH)D levels are associated with a significantly reduced risk of colorectal cancer, particularly among women. Individuals with BPRVID are at higher risks of incident adenoma and colorectal cancer compared to those with HPRVID, especially among women. Treatment strategies should be tailored based on individuals' different response types.
CLINICAL NUTRITION
(2021)
Article
Oncology
Jeeyoo Lee, Aesun Shin, Ji-Yeob Choi, Daehee Kang, Jong-Koo Lee
Summary: This study found that Korean women who consumed more than the recommended calcium intake had a significantly reduced risk of colorectal cancer compared to those who consumed less than the recommended amount. However, no significant association was observed between dietary calcium intake and colorectal cancer risk among men.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Yazhou He, Xiaomeng Zhang, Maria Timofeeva, Susan M. Farrington, Xue Li, Wei Xu, Harry Campbell, Richard S. Houlston, Ian P. Tomlinson, Evropi Theodoratou, Malcolm G. Dunlop
Summary: A bidirectional Mendelian randomization study found no significant causal effect of vitamin D on colorectal cancer risk, nor any reverse causal association between genetically increased CRC risk and vitamin D levels; this suggests that associations reported in observational studies may be primarily driven by unidentified confounders.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Carolina Morgado-Aguila, Guadalupe Gil-Fernandez, Orlando Rafael Davila-Villalobos, Jesus Perez-Rey, Purificacion Rey-Sanchez, Francisco Jose Rodriguez-Velasco
Summary: This study investigated the association between serum vitamin D levels and non-melanoma skin cancers. Despite all subjects having normal or low levels of vitamin D, it was found that higher vitamin D levels may increase the risk of non-melanoma skin cancer. Further research is needed to fully understand the relationship between vitamin D and skin cancer risk.
Article
Nutrition & Dietetics
Yanhui Ma, Lin Deng, Yuchan Huangfu, Yunlan Zhou, Ping Wang, Lisong Shen
Summary: This study aims to evaluate the association between serum vitamin D level and the risk of non-hereditary colorectal cancer (CRC). The results showed that an adequate level of vitamin D was associated with a reduced risk of CRC, especially in the elderly. The use of statins may affect the protective effect of vitamin D and could be an important confounding factor for the inverse association between serum 25(OH)D and colorectal cancer.
FRONTIERS IN NUTRITION
(2023)
Article
Oncology
Nicholas Lucchesi, Jenna M. Ally, Matthew J. Reilley
Summary: The standard of care for stage III colorectal cancer is curative resection with adjuvant chemotherapy. Circulating tumor DNA has been proven to be an effective method for early detection of disease relapse and risk stratification. However, there is currently no established protocol for using ctDNA to assess response to adjuvant chemotherapy and alter therapy in real time.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Giovanni Fuca, Francesca Corti, Margherita Ambrosini, Rossana Intini, Massimiliano Salati, Elisabetta Fenocchio, Paolo Manca, Chiara Manai, Francesca Daniel, Alessandra Raimondi, Federica Morano, Salvatore Corallo, Michele Prisciandaro, Andrea Spallanzani, Virginia Quara, Carmen Belli, Marta Vaiani, Giuseppe Curigliano, Chiara Cremolini, Filippo De Braud, Maria Di Bartolomeo, Vittorina Zagonel, Sara Lonardi, Filippo Pietrantonio
Summary: This study found that early tumor shrinkage (ETS) and depth of response (DoR) were significantly associated with survival outcomes in patients with MSI-H/dMMR mCRC treated with immune checkpoint inhibitors (ICIs), suggesting that they may serve as important prognostic factors for designing treatment strategies. Prospective validation of these findings is recommended.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Ryoko Katagiri, Atsushi Goto, Shiori Nakano, Masahiro Nakatochi, Yuriko N. Koyanagi, Masao Iwagami, Akiko Hanyuda, Taiki Yamaji, Norie Sawada, Yohko Nakamura, Sho Nakamura, Kiyonori Kuriki, Sadao Suzuki, Issei Imoto, Yukihide Momozawa, Isao Oze, Hidemi Ito, Shoichiro Tsugane, Kenji Wakai, Keitaro Matsuo, Motoki Iwasaki
Summary: The association between vitamin D and total and colorectal cancer risk was inconclusive in observational studies. The researchers used a Mendelian randomization approach to reduce confounding factors. They selected 110 single nucleotide polymorphisms associated with vitamin D concentrations and found no significant association between genetically predicted vitamin D levels and total or colorectal cancer risk.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Lei Wen, Zhigang Chen, Xiaomeng Ji, William Pat Fong, Qiong Shao, Chao Ren, Yanyu Cai, Binkui Li, Yunfei Yuan, Deshen Wang, Yuhong Li
Summary: CRLM patients with POLE EDM exhibit distinct clinical characteristics and extremely high TMB, and show significant clinical response to ICI-based combination therapy. Complete sequencing of POLE exonuclease domains is recommended in CRLM patients clinically.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Nutrition & Dietetics
Davide Serrano, Chiara Pozzi, Silvia Guglietta, Bruno Fosso, Mariano Suppa, Patrizia Gnagnarella, Federica Corso, Federica Bellerba, Debora Macis, Valentina Aristarco, Paolo Manghi, Nicola Segata, Cristina Trovato, Maria Giulia Zampino, Marinella Marzano, Bernardo Bonanni, Maria Rescigno, Sara Gandini
Summary: This study suggests that microbiome mediates the diet effect on CRC risk, with high levels of Bifidobacteria/Escherichia genera ratio playing a significant role in reducing the risk of CRC. Other factors to consider include vitamin D, markers of inflammation, and adipokines in order to better understand the carcinogenic process as a whole.
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)