Article
Endocrinology & Metabolism
Wenjin Liu, Zhensen Chen, Dakota Ortega, Xuebing Liu, Xiaoqin Huang, Lulu Wang, Li Chen, Jie Sun, Thomas S. Hatsukami, Chun Yuan, Haige Li, Junwei Yang
Summary: In older hypertensive males, arterial stiffness and endothelial dysfunction are associated with reduced brain perfusion and overall cerebral vascular injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Ioana Mozos, Corina Flangea, Daliborca C. Vlad, Cristina Gug, Costin Mozos, Dana Stoian, Constantin T. Luca, Jaroslaw O. Horbanczuk, Olaf K. Horbanczuk, Atanas G. Atanasov
Summary: Cardiovascular disorders are a major cause of mortality worldwide, and a diet rich in fruits and vegetables, particularly containing anthocyanins, can have beneficial effects on vascular health. Anthocyanins have been shown to improve endothelial function, reduce oxidative stress, and exhibit various anti-atherogenic, antihypertensive, and anti-inflammatory properties, among others.
Article
Hematology
Darae Ko, Sarah R. Preis, Andrew D. Johnson, Ramachandran S. Vasan, Emelia J. Benjamin, Naomi M. Hamburg, Gary F. Mitchell
Summary: The study did not find any significant association between arterial vascular function measures and the risk of VTE after multivariable adjustment in a comprehensive examination.
THROMBOSIS RESEARCH
(2021)
Review
Peripheral Vascular Disease
Hirofumi Tomiyama
Summary: The arterial system is responsible for delivering blood to organs and maintaining vascular homeostasis. Dysfunction in the endothelial and medial layers can lead to development of cardiovascular diseases and hypertension. Flow-mediated vasodilatation and pulse wave velocity are markers of endothelial and medial layer function, respectively. Vascular dysfunction is involved in a vicious cycle with abnormal blood pressure variability and further research is needed to improve vascular dysfunction in hypertension.
HYPERTENSION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Diego A. A. Rodriguez-Chiaradia, Karys Khilzi, Isabel Blanco, Anna Rodo-Pin, Clara Martin-Ontiyuelo, Anna Herranz Blasco, Jessica Garcia-Lucio, Lluis Molina, Ester Marco, Esther Barreiro, Lucilla Piccari, Victor I. I. Peinado, Agustin R. Garcia, Olga Tura-Ceide, Joan Albert Barbera
Summary: In stable patients with pulmonary arterial hypertension, pulmonary rehabilitation is an effective non-pharmacological treatment. This study aimed to explore the effects of endurance exercise training on vascular function in these patients. The results showed that training promoted mechanisms of damage/repair in favor of repair, leading to potential improvements in hemodynamics and clinical response.
Review
Endocrinology & Metabolism
Ran Wei, Weihao Wang, Qi Pan, Lixin Guo
Summary: This systematic review and meta-analysis evaluated the effects of SGLT-2 inhibitors on endothelial function and arteriosclerosis in diabetic patients. The results showed that SGLT-2 inhibitors significantly improved endothelial function, but had no significant effect on arteriosclerosis levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Sport Sciences
Lijing Gong, Yujia Liu
Summary: Exercise training has positive effects on arterial stiffness in overweight or obese individuals, improving endothelial function and reducing arterial stiffness. The improvements are more pronounced in children, adolescents, and individuals with a BMI smaller than 30 kg/m².
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2022)
Review
Food Science & Technology
Banafsheh Jafari Azad, Javad Heshmati, Elnaz Daneshzad, Andriko Palmowski
Summary: Through a systematic review and meta-analysis of multiple studies, it was found that coffee intake has a beneficial short-term effect on endothelial function, while it may have an unfavorable impact on arterial stiffness. The long-term effects of coffee intake on endothelial function and arterial stiffness remain controversial.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Nutrition & Dietetics
Monica Volino-Souza, Gustavo Vieira de Oliveira, Carlos Adam Conte-Junior, Arturo Figueroa, Thiago Silveira Alvares
Summary: L-arginine is crucial for nitric oxide synthesis and supplementation with its precursor L-citrulline, found in watermelon, can improve vascular function. However, there are differing findings on the effect of watermelon supplementation, possibly due to varying L-citrulline doses. Food technology can be applied to concentrate L-citrulline content and reduce volume for convenient ingestion. Watermelon-derived L-citrulline appears to be an effective supplementation for improving vascular health.
Article
Geriatrics & Gerontology
Rogerio N. Soares, Francisco Ramirez-Perez, Francisco J. Cabral-Amador, Mariana Morales-Quinones, Christopher A. Foote, Thaysa Ghiarone, Neekun Sharma, Gavin Power, James A. Smith, R. Scott Rector, Luis A. Martinez-Lemus, Jaume Padilla, Camila Manrique-Acevedo
Summary: The study demonstrates that SGLT2 inhibition with Empa improves endothelial function and reduces arterial stiffness in an aging preclinical model, offering a potential therapeutic alternative for reducing the progression of cardiovascular disease in older individuals.
Review
Peripheral Vascular Disease
Tatsuya Maruhashi, Yukihito Higashi
Summary: Vascular function assessment plays an important role in evaluating the severity of atherosclerosis and understanding the link between vascular dysfunction and cardiometabolic disorders. Despite the global challenge of COVID-19, numerous articles on vascular function have been published, highlighting its relevance in cardiovascular risk assessment and the impact of lifestyle modifications. This review aims to provide helpful insights for the management of hypertension and cardiovascular diseases in clinical practice.
HYPERTENSION RESEARCH
(2023)
Article
Cell Biology
Sophia A. Mahoney, Ravinandan Venkatasubramanian, Mary A. Darrah, Katelyn R. Ludwig, Nicholas S. Vandongen, Nathan T. Greenberg, Abigail G. Longtine, David A. Hutton, Vienna E. Brunt, Judith Campisi, Simon Melov, Douglas R. Seals, Matthew J. Rossman, Zachary S. Clayton
Summary: This study found that fisetin can improve arterial function and reduce arterial stiffness by reducing vascular cell senescence and inflammation. Fisetin enhances endothelial function by increasing the bioavailability of nitric oxide and reducing oxidative stress.
Article
Cardiac & Cardiovascular Systems
Philipp Jud, Harald H. Kessler, Marianne Brodmann
Summary: A 24-year-old woman with Covid-19 infection exhibited reduced vascular reactivity upon diagnosis, but showed improvement after 6 weeks, suggesting a potential impact of Covid-19 infection on endothelial function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Sport Sciences
Amelie Debray, Carina Enea, Nicholas Ravanelli, Georgia Kate Chaseling, Hugo Gravel, Laurent Bosquet, Louis Bherer, Daniel Gagnon
Summary: There are no differences in blood pressure and markers of vascular function between physically active late pre- and early postmenopausal females.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Nutrition & Dietetics
Yejin Kang, Katherine N. Dillon, Mauricio A. Martinez, Arun Maharaj, Stephen M. Fischer, Arturo Figueroa
Summary: Hypertension is common in postmenopausal women. Endothelial dysfunction and reduced muscle mass and strength contribute to hypertension. L-citrulline supplementation and slow velocity low-intensity resistance training have shown improvements in vascular function, but their effects on muscle mass were unclear. This study found that combining L-citrulline supplementation and slow velocity low-intensity resistance training had additional benefits on leg endothelial function, lean mass, and strength in hypertensive postmenopausal women.
Article
Rehabilitation
Takanobu Okamoto, Ryota Kobayashi, Yuto Hashimoto, Naoki Kikuchi, Shigehiko Ogoh
Summary: Individual day-to-day variations in maximal aerobic performance are associated with variations in arterial stiffness, as lower arterial stiffness is linked to higher cardiorespiratory fitness levels.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2021)
Article
Sport Sciences
Naoki Kikuchi, Yukina Mochizuki, Ayumu Kozuma, Takamichi Inoguchi, Mika Saito, Minoru Deguchi, Hiroki Homma, Madoka Ogawa, Yuto Hashimoto, Koichi Nakazato, Takanobu Okamoto
Summary: The study found that online exercise using Zoom and exercises supervised directly had similar training effects on strength, muscle mass, blood pressure, and arterial stiffness. However, the control group showed greater improvements in chair-stand and sit-and-reach test results compared to the online group.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2022)
Article
Sport Sciences
Mika Saito, Michal Ginszt, Ekaterina A. Semenova, Myosotis Massidda, Kinga Huminska-Lisowska, Monika Michalowska-Sawczyn, Hiroki Homma, Pawel Cieszczyk, Takanobu Okamoto, Andrey K. Larin, Edward Generozov, Piotr Majcher, Koichi Nakazato, Ildus I. Ahmetov, Naoki Kikuchi
Summary: The study found no significant differences in the distribution of ACTN3 R577X and ACE I/D gene polymorphisms between climbers and controls in different ethnic groups, but the specific allele frequencies of CKM and TRHR genes were higher among climbers in the Russian cohort. Meta-analysis results indicated that the genotype of the ACTN3 R577X polymorphism was significantly higher in climbers than controls.
Article
Sport Sciences
Naoki Kikuchi, Takafumi Tajima, Yuki Tamura, Yoshiaki Yamanaka, Kunitaka Menuki, Takanobu Okamoto, Mikako Sakamaki-Sunaga, Akinori Sakai, Kenji Hiranuma, Koichi Nakazato
Summary: This study found an association between the ALDH2 rs671 polymorphism and muscle phenotypes and athletic capacity in the Japanese population. The AA genotype and A allele were associated with reduced muscle strength and poorer athletic performance.
Article
Genetics & Heredity
Naoki Kikuchi, Ethan A. Moreland, Hiroki Homma, Ekaterina A. K. Semenova, Mika Saito, Andrey K. A. Larin, Naoyuki Kobatake, Rinat A. Yusupov, Takanobu G. Okamoto, Koichi V. Nakazato, Alun G. I. Williams, Edward V. Generozov, Ildus I. Ahmetov
Summary: A recent case-control study identified 28 DNA polymorphisms associated with strength athlete status. This study investigated the association of these genetic markers with weightlifting performance in Russian and Japanese athletes, finding four common gene polymorphisms associated with weightlifting performance.
Article
Genetics & Heredity
Mika Saito, Michal Ginszt, Ekaterina A. Semenova, Myosotis Massidda, Kinga Huminska-Lisowska, Monika Michalowska-Sawczyn, Hiroki Homma, Pawel Cieszczyk, Takanobu Okamoto, Andrey K. Larin, Edward Generozov, Piotr Majcher, Koichi Nakazato, Ildus I. Ahmetov, Naoki Kikuchi
Summary: The study compared the frequency of COL1A1 rs1107946 polymorphism between sport climbers and controls from three ethnic groups and investigated its effect on the age-related decrease in flexibility. Results showed a higher frequency of the AC genotype in climbers and an association between sit-and-reach and the COL1A1 rs1107946 polymorphism in the Japanese population. Additionally, a higher negative correlation between sit-and-reach and age was observed in the AA + CC genotype compared to the AC genotype.
Article
Environmental Sciences
Takanobu Okamoto, Yuto Hashimoto
Summary: This study aimed to investigate whether isometric handgrip (IHG) training can improve cognitive function in older adults by reducing arterial stiffness and wave reflection. The results showed that after 8 weeks of IHG training, arterial stiffness and wave reflection decreased significantly, and cognitive function improved. This suggests that IHG training may be beneficial for improving cognitive function in older adults.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Genetics & Heredity
Aoto Saito, Mika Saito, Kathleen Y. de Almeida, Hiroki Homma, Minoru Deguchi, Ayumu Kozuma, Naoyuki Kobatake, Takanobu Okamoto, Koichi Nakazato, Naoki Kikuchi
Summary: The study found that the ALDH2 rs671 polymorphism is associated with strength performance in powerlifters, but not in weightlifters.
Article
Genetics & Heredity
Hiroki Homma, Mika Saito, Aoto Saito, Ayumu Kozuma, Ryutaro Matsumoto, Shingo Matsumoto, Naoyuki Kobatake, Takanobu Okamoto, Koichi Nakazato, Tetsunari Nishiyama, Naoki Kikuchi
Summary: This study investigated the relationship between power-oriented genetic polymorphisms and weightlifting performance. The study created a genotype scoring model and found that weightlifters had higher scores than controls. However, the scoring model was not associated with weightlifting performance and could not be applied to other power-oriented athletes.
Article
Physiology
Kathleen Yasmin De Almeida, Mika Saito, Hiroki Homma, Yukina Mochizuki, Aoto Saito, Minoru Deguchi, Ayumu Kozuma, Takanobu Okamoto, Koichi Nakazato, Naoki Kikuchi
Summary: This study aimed to investigate the impact of ALDH2 rs671 on the loss of muscle strength with aging and replicate previous findings in non-athletes. The results showed that individuals with the AA genotype had lower grip strength and experienced a higher age-related loss of muscle strength compared to those with the GG + GA genotypes.
JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
(2022)
Article
Physiology
Madoka Ogawa, Yuto Hashimoto, Yukina Mochizuki, Takamichi Inoguchi, Ayumu Kouzuma, Minoru Deguchi, Mika Saito, Hiroki Homma, Naoki Kikuchi, Takanobu Okamoto
Summary: The central question of this study is how free weight resistance training and body mass-based resistance training compare in terms of isometric muscular strength, muscle size, and intramuscular fat content in the quadriceps femoris. The main finding is that both types of resistance training can lead to muscle hypertrophy, but only body mass-based resistance training resulted in decreased intramuscular fat content.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Hiroki Homma, Mika Saito, Yukina Mochizuki, Maho Shinogi, Naoyuki Kobatake, Takanobu Okamoto, Tetsunari Nishiyama, Koichi Nakazato, Naoki Kikuchi
Summary: This study compared the allele frequency of the MCT1 T1470A polymorphism between Japanese power-oriented athletes and controls, and investigated the effect of this polymorphism on weightlifting and powerlifting performance. The results showed that the frequency of the T allele was significantly higher in weightlifters compared to controls, but there was no association between the MCT1 T1470A polymorphism and weightlifting and powerlifting performance.
GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
(2023)
Article
Public, Environmental & Occupational Health
Takahisa Ohta, Madoka Ogawa, Naoki Kikuchi, Hiroyuki Sasai, Takanobu Okamoto
Summary: This study aimed to clarify the association between physical activity, sedentary behavior, sleep, adherence to 24-h movement guidelines, and depressive status during the COVID-19 pandemic. The results showed that meeting the 24-h movement guidelines was associated with a lower prevalence of depressive status. It is recommended that adults adhere to these guidelines to maintain their mental health during future quarantine life.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Madoka Ogawa, Yuto Hashimoto, Naoki Kikuchi, Takanobu Okamoto
Summary: Muscle atrophy and increased body fat percentage may affect age-specific changes in vascular structure and function among normal-weight men in their 60s.
INTERNATIONAL JOURNAL OF GERONTOLOGY
(2022)
Article
Sport Sciences
Mika Saito, Michal Ginszt, Myosotis Massidda, Pawel Cieszczyk, Takanobu Okamoto, Piotr Majcher, Koichi Nakazato, Naoki Kikuchi
Summary: The T allele frequency in the MCT1 T1470A polymorphism is over-represented in Polish climbers but not in Japanese climbers. Additionally, the frequency of the T allele and TT genotype in Polish lead climbers is higher than that in controls.
