期刊
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
卷 110, 期 1, 页码 1-15出版社
SPRINGER
DOI: 10.1007/s00421-010-1480-0
关键词
Muscle fatigue; Human; Evoked force; Electromyography; Single muscle fibre; Ca2+ handling; Myofibrillar function
资金
- Swedish Research Council
- Swedish National Center for Sports Research
Prolonged dynamic exercise and sustained isometric contractions induce muscle fatigue, as manifested by decreased performance and a reduction in the maximum voluntary contraction force. Studies with non-invasive measurements in exercising humans show that mechanisms located beyond the sarcolemma are important in the fatigue process. In this review, we describe probable cellular mechanisms underlying fatigue-induced changes in excitation-contraction (E-C) coupling occurring in human muscle fibres during strenuous exercise. We use fatigue-induced changes observed in intact single muscle fibres, where force and cellular Ca2+ handling can be directly measured, to explain changes in E-C coupling observed in human muscle during exercise.
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