Article
Physiology
Killian Salzmann, Anthony M. J. Sanchez, Fabio Borrani
Summary: This study found that applying different levels of blood flow restriction (BFR) during heavy cycling exercise can slow down the main phase time of VO2, increase the amplitude of the slow component, and accelerate the phase 3 amplitude of O-2 extraction kinetics. This suggests that using BFR in heavy exercise may shift the muscles to a more oxygen-dependent situation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
J. Carter Luck, Christopher T. Sica, Cheryl Blaha, Aimee Cauffman, Jeffrey Vesek, John Eckenrode, Jon Stavres
Summary: The study aimed to determine the level of agreement between PIVOT, Doppler ultrasound, and NIRS assessments of skeletal muscle perfusion and oxygenation. The results showed that the PIVOT technique has a moderate level of agreement with other assessment methods and is subject to significant proportional bias. These differences may be due to variations in vascular compartments, sampling volumes, and evaluated parameters.
MAGNETIC RESONANCE IMAGING
(2023)
Article
Nutrition & Dietetics
Colleen S. Deane, Ushnah S. U. Din, Tanvir S. Sian, Ken Smith, Amanda Gates, Jonathan N. Lund, John P. Williams, Ricardo Rueda, Suzette L. Pereira, Philip J. Atherton, Bethan E. Phillips
Summary: Acute curcumin supplementation enhances the effect of oral nutritional supplement on microvascular blood flow in healthy older adults, without affecting muscle glucose uptake, vascular function, or blood flow.
Article
Medicine, General & Internal
Rodrigo Polaquini Simoes, Cassia da Luz Goulart, Flavia Rossi Caruso, Adriana S. Garcia de Araujo, Silvia Cristina Garcia de Moura, Aparecida Maria Catai, Polliana Batista dos Santos, Patricia de Faria Camargo, Renan Shida Marinho, Renata Goncalves Mendes, Audrey Borghi-Silva
Summary: This study aimed to investigate the effects of non-invasive positive pressure ventilation (NIPPV) combined with high-intensity exercise on heart rate (HR) and oxygen uptake (V?O-2) recovery kinetics in patients with coexistence of chronic obstructive pulmonary disease (COPD) and heart failure (HF). The results showed that NIPPV significantly improved V?O(2) and HR kinetics during high-intensity constant workload protocol compared to Sham ventilation. Additionally, NIPPV also improved oxygenation and reduced deoxygenation in the peripheral and respiratory muscles. These findings suggest that NIPPV can effectively enhance exercise tolerance and improve respiratory and peripheral muscle oxygenation in COPD-HF patients.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Tanvir S. Sian, Ushnah S. U. Din, Colleen S. Deane, Ken Smith, Amanda Gates, Jonathan N. Lund, John P. Williams, Ricardo Rueda, Suzette L. Pereira, Bethan E. Phillips, Philip J. Atherton
Summary: The study found that acute cocoa flavanol supplementation can increase postprandial muscle microvascular blood volume in older adults, but does not enhance muscle glucose uptake.
Article
Clinical Neurology
Ronit Aviram, Inbar Kima, Yisrael Parmet, Haim Bassan, Thierry Willigenburg, Raziel Riemer, Simona Bar-Haim
Summary: This study evaluated muscle haemodynamics and oxygen metabolism in adults with cerebral palsy (CP) at rest and during exercise. The results showed that participants with CP had lower muscle blood flow at rest and low load, but increased blood flow at high load. Compared to typically developing individuals, participants with CP had higher muscle saturation, suggesting inefficient oxygen utilization.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Cassia da Luz Goulart, Flavia Rossi Caruso, Adriana Sanches Garcia de Araujo, Silvia Cristina Garcia de Moura, Aparecida Maria Catai, Piergiuseppe Agostoni, Renata Goncalves Mendes, Ross Arena, Audrey Borghi-Silva
Summary: Non-invasive positive pressure ventilation (NIPPV) can improve exercise tolerance and oxygen consumption in patients with coexisting COPD and HF during high-intensity exercise. It also enhances cerebral, respiratory, and peripheral muscle oxygenation and reduces muscle fatigue.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Edward Z. Pelka, B. Ryan Davis, Patrick M. Tomko, John McDaniel
Summary: This study compared differences in skeletal muscle oxygen consumption and mitochondrial recovery between voluntary and electrically stimulated contractions. The results showed that electrically stimulated contractions resulted in higher oxygen consumption rates compared to voluntary contractions, but the mitochondrial recovery rates were similar. These findings may help explain the increased rate of fatigue observed during electrically stimulated exercise in individuals with muscle paralysis.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Robert Arnar Karlsson, Olof Birna Olafsdottir, Vedis Helgadottir, Soumaya Belhadj, Thorunn Scheving Eliasdottir, Einar Stefansson, Sveinn Hakon Hardarson
Summary: Automated measurements of retinal oximetry values are more repeatable compared to measurements where vessels are selected manually, with higher ICC values for the automated version than the semiautomatic version.
Article
Geosciences, Multidisciplinary
Haichao Guo, Iris Kriest, Andreas Oschlies, Wolfgang Koeve
Summary: This study investigates the use of oxygen utilization rate (OUR) to track the temporal change of true respiration (R-true). The results show that in the North Atlantic Subtropical Gyre and the mesopelagic Tropical South Atlantic, both OUR and R-true decrease with global warming. However, in the mesopelagic Tropical South Atlantic, OUR increases while R-true decreases. Ocean mixing could be a possible reason for the diverging OUR and R-true.
GEOPHYSICAL RESEARCH LETTERS
(2023)
Article
Nutrition & Dietetics
Ushnah S. U. Din, Tanvir S. Sian, Colleen S. Deane, Ken Smith, Amanda Gates, Jonathan N. Lund, John P. Williams, Ricardo Rueda, Suzette L. Pereira, Philip J. Atherton, Bethan E. Phillips
Summary: The study showed that acute green tea extract supplementation increased microvascular blood volume in leg muscles, but did not affect muscle glucose uptake. There were no significant differences in other vascular and metabolic responses between the two conditions.
Article
Endocrinology & Metabolism
Haitham Abdulla, Bethan Phillips, Daniel Wilkinson, Amanda Gates, Marie Limb, Tereza Jandova, Joseph Bass, Johnathan Lewis, John Williams, Kenneth Smith, Iskandar Idris, Philip Atherton
Summary: The study indicates that GLP-1 significantly increases skeletal muscle microvascular blood flow and whole-body glucose uptake, showing its benefits on overall glycemic control. Therefore, GLP-1 may serve as a therapeutic target, further enhancing the insulin effects on whole-body glucose uptake in older men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Physiology
Rafael de Almeida Azevedo, Jonas Forot, Guillaume Y. Millet, Juan M. Murias
Summary: This study investigated the relationship between pulmonary oxygen uptake and muscle oxygen uptake in females and males during cycling exercise at different intensities. The results showed a correlation between the two variables regardless of exercise intensity and sex of the participants.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Clinical Neurology
Jacqueline Montes, Ashley M. Goodwin, Michael P. McDermott, David Uher, Feliz Marie Hernandez, Kayla Coutts, Julia Cocchi, Margarethe Hauschildt, Kayla M. Cornett, Ashwini K. Rao, Umrao R. Monani, Carol Ewing Garber, Darryl C. De Vivo
Summary: This study reveals reduced muscle oxygen uptake and increased fatigue during exercise in individuals with spinal muscular atrophy (SMA) compared to healthy controls, with significant correlations between muscle oxygen uptake and aerobic capacity, workload, and body composition in SMA patients. Understanding the mechanisms underlying these changes may lead to identifying new therapeutic targets for alleviating symptoms and reducing disease burden in SMA patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Physiology
Jiri Balas, Jan Gajdosik, David Giles, Simon Fryer, Dominika Krupkova, Tomas Brtnik, Andri Feldmann
Summary: The study aimed to investigate systemic and local muscle oxygen responses during sport climbing. The results showed that both systemic and muscle oxygen kinetics determine climbing-specific endurance, and exhaustive climbing and isolated finger flexion endurance tests are interrelated and suitable for assessing climbing-specific endurance. An exhaustive climbing test with progressive wall angle allows determination of the muscle oxygenation breakpoint.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Letter
Nutrition & Dietetics
Sebastiaan Dalle, Jolan Dupont, Evelien Gielen, Katrien Koppo
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Geriatrics & Gerontology
Sebastiaan Dalle, Jolan Dupont, Lenore Dedeyne, Sabine Verschueren, Jos Tournoy, Evelien Gielen, Katrien Koppo
Summary: This study compared the protein expression profiles between older adults with preserved and low muscle strength, and found differences in catabolic, mitochondrial, stress-related, and myogenic pathways. The increased stress factors in the low muscle strength group may reflect the deterioration of tissue homeostasis, while the upregulation of myogenic markers in this group may be an attempt to compensate for the gradual loss in muscle quantity and quality.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Cell Biology
Sebastiaan Dalle, Moniek Schouten, Gitte Meeus, Lotte Slagmolen, Katrien Koppo
Summary: The cannabinoid system plays a crucial role in neural and immunity processes, as well as in whole body and tissue metabolism. It is regulated by receptor-independent and -dependent mechanisms, impacting skeletal muscle plasticity and physiology. Further research is needed to explore how targeting the cannabinoid system can improve muscle quantity and quality in various conditions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Physiology
Sophie van Doorslaer de ten Ryen, Sebastiaan Dalle, Romano Terrasi, Katrien Koppo, Giulio G. Muccioli, Louise Deldicque
Summary: This study aimed to investigate the regulation of the endocannabinoid system by different exercise paradigms in human skeletal muscle. The findings showed that resistance and endurance exercise have opposite effects on the levels of endocannabinoid ligands and CB1 expression. This has important implications for understanding the physiological impact of exercise on endocannabinoid ligands in skeletal muscle.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Physiology
Charlotte Hiroux, Moniek Schouten, Isabelle de Glisezinski, Chantal Simon, Francois Crampes, Peter Hespel, Katrien Koppo
Summary: Increased protein intake effectively prevents muscle wasting and maintains exercise capacity during a period of caloric restriction in female recreational athletes. Exogenous ketosis does not affect body composition, but shows its potential in weight management by preserving a drop in exercise capacity and resting energy expenditure (REE) and by improving overall stress parameters during a period of caloric restriction.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Sport Sciences
Chiel Poffe, Katrien Koppo, Arne Jaspers, Filip Boen, Werner F. Helsen, Evelien Van Roie
Summary: This study evaluated the effects of a 10-week recreational football training in adults aged 55 to 70 years. The study found that the training led to improvements in leg-extensor velocity production, functional capacity, exercise tolerance, and body fat percentage. The participants also perceived the training sessions as enjoyable and feasible. Overall, this short-term recreational football training can provide comprehensive health benefits in older adults with only 2 hours of training per week.
JOURNAL OF SPORTS SCIENCE AND MEDICINE
(2023)
Article
Cell Biology
Sebastiaan Dalle, Moniek Schouten, Monique Ramaekers, Katrien Koppo
Summary: This study investigated whether the CB1 antagonist AM6545 can promote muscle synthesis in vivo, and found that it can activate protein synthesis in muscles, protecting mice from muscle loss caused by dexamethasone. However, further research is needed to uncover the signaling pathways through which AM6545 enhances muscle synthesis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Jolan Dupont, Eva Wauters, Lenore Dedeyne, Laura Vercauteren, Nadjia Amini, Laurence Lapauw, Christophe Matthys, Sabine Verschueren, Jos Tournoy, Katrien Koppo, Evelien Gielen
Summary: This study aims to explore the relationship between dietary polyunsaturated fatty acids (PUFAs) intake, nutritional PUFAs status and sarcopenia outcomes in sarcopenic older adults. The results showed no correlation between dietary PUFAs intake and status. However, some markers of PUFAs intake and status were positively associated with sarcopenia outcomes.
Article
Geriatrics & Gerontology
Jolan Dupont, Laura Vercauteren, Nadjia Amini, Laurence Lapauw, Maxim De Schaepdryver, Koen Poesen, Lenore Dedeyne, Sabine Verschueren, Jos Tournoy, Katrien Koppo, Evelien Gielen
Summary: This study aimed to explore the relationship between inflammatory markers and sarcopenia-related traits. Analysis of baseline data from 40 sarcopenic patients revealed correlations between inflammatory markers and sarcopenia-defining parameters, physical activity, and quality of life. Gender differences played an important role in this relationship.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Geriatrics & Gerontology
Lien Meulemans, Julian Alcazar, Luis M. Alegre, Sebastiaan Dalle, Katrien Koppo, Jan Seghers, Christophe Delecluse, Evelien Van Roie
Summary: This study investigated the influence of age, functional limitations, and sex on the movement strategy and power production during sit-to-stand tests, and compared the estimation of power using a simple equation versus a sensor. The results showed that age and functional limitations affected the movement strategy, and the power estimated using the equation was slightly higher than that estimated using the sensor.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Sport Sciences
Chiel Poffe, Katrien Koppo, Arne Jaspers, Filip Boen, Werner F. Helsen, Evelien Van Roie
Summary: This study found that 10 weeks of recreational football training can improve leg-extensor velocity production and functional capacity in 55- to 70-year-old adults. It also improves exercise tolerance and reduces body fat percentage. Short-term recreational football training has broad-spectrum health benefits for middle-aged and older adults.
JOURNAL OF SPORTS SCIENCE AND MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Moniek Schouten, Sebastiaan Dalle, Katrien Koppo
Summary: CBD has the potential to improve muscle recovery as a supplement. However, research on CBD in relation to exercise is still in its early stages and further studies are needed to understand its molecular and functional effects.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Meeting Abstract
Geriatrics & Gerontology
J. Dupont, E. Wauters, L. Dedeyne, L. Vercauteren, N. Amini, L. Lapauw, C. Matthys, S. Verschueren, J. Tournoy, K. Koppo, E. Gielen
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Cell Biology
Mohammad Haroon, Heleen E. Boers, Astrid D. Bakker, Niek G. C. Bloks, Willem M. H. Hoogaars, Lorenzo Giordani, Rene J. P. Musters, Louise Deldicque, Katrien Koppo, Fabien Le Grand, Jenneke Klein-Nulend, Richard T. Jaspers
Summary: Aging-associated muscle wasting and impaired regeneration are caused by deficiencies in muscle stem cell (MuSC) number and function. Aged MuSCs exhibit intrinsic impairments in their responsiveness to mechanical cues and growth potential, accompanied by alterations in morphology, mechanical properties, and integrin expression.
Letter
Pharmacology & Pharmacy
Sebastiaan Dalle, Moniek Schouten, Katrien Koppo
CANNABIS AND CANNABINOID RESEARCH
(2022)