Article
Biochemistry & Molecular Biology
Franccesco P. P. Boeno, Jay Patel, Ryan N. N. Montalvo, Stephanie S. S. Lapierre-Nguyen, Claire M. M. Schreiber, Ashley J. J. Smuder
Summary: Doxorubicin (DOX) is an effective chemotherapy drug for cancer treatment, but its clinical use is limited due to off-target toxicity. DOX accumulation in the liver and kidneys causes inflammation and oxidative stress, leading to cytotoxicity. Endurance exercise preconditioning may help prevent liver and kidney damage caused by DOX treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Hossein Amiri, Fatemeh Shabkhiz, Parisa Pournemati, Amir Hossein Saffar Kohneh Quchan, Reza Zeighami Fard
Summary: This study investigated the effects of swimming exercise on oxidative stress and liver cell damage caused by electromagnetic radiation in rats. The results showed that swimming exercise attenuated the liver damage caused by electromagnetic radiation. In the electromagnetic radiation group, the activity of superoxide dismutase and catalase decreased significantly, and the concentration of malondialdehyde and liver enzymes increased significantly; while in the swimming exercise and electromagnetic radiation + swimming exercise groups, the activity of superoxide dismutase and catalase increased significantly, and the concentration of malondialdehyde and liver enzymes decreased significantly.
Article
Biochemistry & Molecular Biology
Emre Sahin, Cemal Orhan, Fusun Erten, Besir Er, Manutosh Acharya, Abhijeet A. Morde, Muralidhara Padigaru, Kazim Sahin
Summary: The new formulation of curcumin, NGUC, enhances exercise performance and reduces muscle damage by targeting antioxidant, anti-inflammatory, and muscle mass regulatory pathways.
Article
Biochemistry & Molecular Biology
Ioannis Stratos, Ingmar Rinas, Konrad Schroepfer, Katharina Hink, Philipp Herlyn, Mario Baeumler, Tina Histing, Sven Bruhn, Brigitte Mueller-Hilke, Michael D. Menger, Brigitte Vollmar, Thomas Mittlmeier
Summary: This study evaluates the potential of different training modalities in preventing muscle and bone loss in hypogonadal male rats. The findings suggest that running exercise can prevent bone loss in osteoporosis, with similar bone restoration effects observed across different training modalities.
Article
Nutrition & Dietetics
Tyler J. Titcomb, Fariba Fathi, Mikayla S. Kaeppler, Sofia Beatriz Sandoval Cates, Paulo Falco Cobra, John L. Markley, Jesse F. Gregory III, Sherry A. Tanumihardjo
Summary: This study evaluated the interaction between niacin and vitamin A metabolism. The results showed that an optimal intake of niacin is associated with lower liver vitamin A concentrations, as well as higher serum vitamin A and plasma pyridoxal-P concentrations.
JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Ke Liu, Lei Chai, Taotao Zhao, Shaosan Zhang, Jixiang Wang, Yanghuan Yu, Ruiyan Niu, Zilong Sun
Summary: Excessive fluoride exposure can cause hepatotoxicity and induce liver cell apoptosis. The effect of moderate exercise on F-induced liver apoptosis is unclear. This study found that treadmill exercise can alleviate F-induced liver cell apoptosis by affecting the TNFR1 signaling pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Physiology
Elena M. Yee, Carson T. Hauser, Jonathan J. Petrocelli, Naomi M. M. P. de Hart, Patrick J. Ferrara, Princess Bombyck, Zachary J. Fennel, Lisha van Onselen, Sohom Mookerjee, Katsuhiko Funai, J. David Symons, Micah J. Drummond
Summary: This study found that 12 weeks of treadmill training in old male mice improved endothelial function, physical performance, and overall body composition, but had limited impact on skeletal muscle remodeling at baseline or in response to recovery following disuse atrophy.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Physiology
Angela C. Greenman, Gary M. Diffee, Amelia S. Power, Gerard T. Wilkins, Olivia M. S. Gold, Jeffrey R. Erickson, James C. Baldi
Summary: The cardiovascular benefits of regular exercise are well-known, however, patients with type 2 diabetes often have reduced cardiac reserve, making them less responsive to exercise. This study investigated the effects of endurance training on the calcium sensitivity and phosphorylation of cardiac troponin I (cTnI) in diabetic and non-diabetic rat hearts. The results showed that training increased calcium sensitivity in both diabetic and non-diabetic hearts, but had no effect on phosphorylation or O-GIcNAcylation of myofilament proteins.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Food Science & Technology
Tiffany Antoine, Patrick Borel, Roland Govers, Laure Meiller, Philippe Guichard, Charlotte Halimi, Teresa Gonzalez, Marion Nowicki, Valerie Sauvinet, Michel Grino, Emmanuelle Reboul
Summary: This study investigated the effects of vitamin A deficiency on vitamin A and lipid postprandial metabolism in young rats, showing that vitamin A deficiency can modulate both vitamin A absorption rate and lipid postprandial metabolism, partially explaining the altered fasting lipid status observed in VAD diet-fed offspring.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Kai Aoki, Takuji Suzuki, Fang Hui, Takuro Nakano, Koki Yanazawa, Masato Yonamine, Shinichiro Fujita, Takehito Sugasawa, Yasuko Yoshida, Naomi Omi, Yasushi Kawakami, Kazuhiro Takekoshi
Summary: This study showed that acute low-intensity exercise affects the expression of molecules involved in intestinal carbohydrate digestion and absorption through GLP-2, leading to higher plasma GLP-2 levels and increased expression of GLP-2 receptor, SI, and GLUT2 in the jejunum in mice. These results suggest that exercise may be beneficial for small intestine function in individuals with intestinal frailty.
Article
Physiology
Haluk Kelestimur, Ozgur Bulmus, Ihsan Serhatlioglu, Zubeyde Ercan, Seyma Ozer Kaya, Ahmet Yardimci, Nazife Ulker, Emine Kacar, Sinan Canpolat
Summary: Exposure to chronic stress can have negative effects on reproductive function in male rats, while chronic treadmill exercise has been shown to increase ejaculation frequency and improve sperm motility.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maki Tsujita, Boris Vaisman, Liu Chengyu, Kasey C. Vickers, Kei-ichiro Okuhira, Sten Braesch-Andersen, Alan T. Remaley
Summary: The study suggests that apoA-I protein in CSF originates from the liver and small intestine, and its levels are highly correlated with plasma HDL levels.
Article
Neurosciences
Zohreh Zare, Sam Zarbakhsh, Mohsen Tehrani, Moslem Mohammadi
Summary: In this study, we investigated the detrimental effects of estrogen and insulin deficiencies on the hippocampus, specifically by examining apoptosis-induced neuronal damage and the cholinergic system in ovariectomized and/or diabetic rat hippocampus. We also explored the potential neuroprotective effects of treadmill exercise. Our findings suggest that both ovariectomy and diabetes lead to increased apoptosis-related protein levels and decreased survival of neurons in the hippocampus. Additionally, diabetic rats showed lower acetylcholinesterase (AChE) activity, indicating impairment in the cholinergic system. However, treadmill exercise attenuated apoptosis-induced neuropathology and restored AChE activity in diabetic rats. The neuroprotective effects of exercise were mediated by the inhibition of apoptosis. Notably, the exercise protocol used in this study did not have significant anti-apoptotic and neuroprotective effects in ovariectomized-diabetic rats.
Article
Medicine, Research & Experimental
Guoyuan Pan, Huimei Zhang, Anqi Zhu, Yao Lin, Lili Zhang, Bingyun Ye, Jingyan Cheng, Weimin Shen, Lingqin Jin, Chan Liu, Qingfeng Xie, Xiang Chen
Summary: Treadmill training increased caveolin-1 expression, improved neuroprotection, reduced neuronal loss and apoptosis, and protected mitochondrial integrity in rats with cerebral ischaemic injury.
Article
Engineering, Biomedical
Wei-Yi Li, Jia-Yi Li, Terry B. J. Kuo, Kuan-Liang Kuo, Tzu-Chun Wang, Cheryl C. H. Yang
Summary: The hippocampus is responsible for generating the theta rhythm (4-12 Hz) in the EEG signals recorded during locomotion. Holo-Hilbert spectral analysis (HHSA) was used to analyze hippocampal EEG signals recorded in rats. The results showed that the signals recorded before and after treadmill running were concentrated in the delta band with amplitude modulation (AM) at 0.5-1 Hz, while the signals during treadmill exercise were concentrated in the theta band with AM at 0.5-4 Hz. These findings suggest that the hippocampal theta signals can provide insights into functional brain connectivity.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Biochemical Research Methods
Saeed Ranjbar, Fatemeh Rahbarizadeh, Davoud Ahmadvand
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
(2019)
Article
Sport Sciences
A. Ghanbari-Niaki, A. Saeidi, L. Gharahcholo, K. Moradi-Dehbaghi, N. Zare-Kookandeh, M. Ahmadian, H. Zouhal, A. C. Hackney
Article
Chemistry, Physical
Ammar Taghavi, Fatemeh Rahbarizadeh, Sara Abbasian, Ahmad Moshaii
Review
Oncology
Mohadese Hashem Boroojerdi, Fatemeh Rahbarizadeh, Pouya Safarzadeh Kozani, Elahe Kamali, Pooria Safarzadeh Kozani
Article
Biotechnology & Applied Microbiology
Elahe Kamali, Fatemeh Rahbarizadeh, Zohreh Hojati, Morten Frodin
Summary: CRISPR/Cas9 technology holds great potential in cancer immunotherapy, but genetic knockout in human T cells remains challenging. Knockout through electroporation of CRISPR/Cas9 plasmids is technically feasible, albeit with low efficiency.
Article
Clinical Neurology
Fardin Soleimanipour, Ehsan Razmara, Fatemeh Rahbarizadeh, Elnaz Fallahi, Mehrnoosh Khodaeian, Ali Reza Tavasoli, Masoud Garshasbi
Summary: Progressive myoclonus epilepsies (PMEs) are a group of disorders characterized by myoclonus, seizures, and neurological dysfunctions. This study identified a novel homozygous missense variant in the LMNB2 gene as a likely disease-causing variant for a consanguineous Iranian family with autosomal recessive PME. It highlights the challenges in diagnosing PMEs due to genetic heterogeneity and underscores the potential of next-generation sequencing in genetic diagnosis of patients with neurologic diseases.
ACTA NEUROLOGICA BELGICA
(2022)
Review
Oncology
Pooria Safarzadeh Kozani, Pouya Safarzadeh Kozani, Fatemeh Rahbarizadeh, Shahryar Khoshtinat Nikkhoi
Summary: CAR T cell therapy has shown promise in treating hematologic malignancies, but faces challenges such as toxicities and tumor microenvironment suppressive effects. Addressing these issues is crucial to bridge the gap between successful clinical outcomes and the hope for them.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Pooria Safarzadeh Kozani, Pouya Safarzadeh Kozani, Fatemeh Rahbarizadeh
Summary: CAR-T therapy has shown reliable therapeutic effects in treating certain hematologic malignancies, but faces challenges in treating solid tumors. Recent advancements in bioinformatics and cell biology offer hope for discovering novel tumor antigens, with some new CAR-T therapies showing promising clinical achievements.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ali Delpisheh, Alireza Safarzade
Summary: The study found that high-intensity interval training (HIIT) has a reducing effect on weight gain and fat depots in rats, but does not affect the levels of circulating and fat depot vaspin.
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2022)
Article
Medicine, General & Internal
Yousef Moghaddasi Kouchaksaraei, Farshad Ghazalian, Saeid Abediankenari, Khosro Ebrahim, Hossein Abednatanzi
Summary: The study found that there is not a significant relationship between exercise training and CRP levels in type 1 diabetic patients, especially in the aerobic training group. Therefore, it can be concluded that there is no effective relationship between this biomarker and exercise training in type 1 diabetic patients.
CASPIAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cell Biology
Alireza Rajabzadeh, Fatemeh Rahbarizadeh, Davoud Ahmadvand, Maryam Kabir Salmani, Amir Ali Hamidieh
Summary: The study developed an anti-MUC1 CAR based on camelid heavy chain antibodies, showing enhanced effectiveness in T cell immunotherapy for cancer treatment. The novel VHH-based CAR demonstrated high CAR surface expression, increased Th1 cytokine secretion, and enhanced cytotoxic activity against MUC1-positive tumor cells, indicating potential clinical applications in cancer immunotherapy.
Article
Biochemistry & Molecular Biology
Alireza Safarzade, Hamid Alizadeh, Zainab Bastani
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2020)
Article
Cell Biology
Ommolbanin Asadpour, Fatemeh Rahbarizadeh
Article
Biochemistry & Molecular Biology
Hamid Alizadeh, Alireza Safarzade
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2019)
Article
Medicine, General & Internal
Hamid Alizadeh, Alireza Safarzade
MEDICINA DELLO SPORT
(2019)