Article
Multidisciplinary Sciences
Keitaro Tachi, Taeko Fukuda, Makoto Tanaka
Summary: Olanzapine attenuated spatial cognitive dysfunction and microglial activity of the hippocampus induced by surgery and LPS injection in adult rats. These effects were unrelated to inflammatory cytokine concentrations.
Article
Geriatrics & Gerontology
Marta Balietti, Arianna Pugliese, Fiorenzo Conti
Summary: It has been demonstrated that cognitive stimulation in late life can prevent cognitive decline in still cognitively preserved animals and improve cognitive compromised animals. Future research should focus on individually tailored stimulation protocols to enhance their effectiveness.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Anesthesiology
Natsuko Yamamoto, Tetsu Kimura, Yukitoshi Niiyama
Summary: This study investigated the effects of different concentrations of sevoflurane on postoperative cognitive function in aged rats. The results showed that low concentrations of sevoflurane prolonged the swimming latency in the Morris water maze test and reduced the number of intact CA1 hippocampal neurons.
ANESTHESIA AND ANALGESIA
(2023)
Article
Biochemistry & Molecular Biology
Fang Lian, Cao Cao, Fumou Deng, Chunfang Liu, Zhidong Zhou
Summary: This study found that propofol reduced postoperative cognitive dysfunction (POCD) in aged rats by up-regulating miR-223-3p. Propofol anesthesia had less effect on spatial learning and memory in rats undergoing cardiac surgery, and it contributed to a reduction in activated microglia in the hippocampus and a decrease in inflammation.
Article
Geriatrics & Gerontology
Stephanie M. Muscat, Nicholas P. Deems, Heather D'Angelo, Meagan M. Kitt, Peter M. Grace, Nathan D. Andersen, Shaelyn N. Silverman, Kenner C. Rice, Linda R. Watkins, Steven F. Maier, Ruth M. Barrientos
Summary: Postoperative cognitive dysfunction (POCD) is a collection of cognitive impairments experienced by individuals following surgery, with persistent POCD most commonly affecting older individuals. In a study on aged rats, it was found that postsurgical treatment with morphine led to long-term memory impairments through a neuroinflammatory mechanism rather than pain modulation. Central blockade of IL-1b signaling completely prevented the memory impairment in rats, suggesting a potential target for future treatment discoveries.
NEUROBIOLOGY OF AGING
(2021)
Article
Food Science & Technology
Xiaohu Liang, Xiaoqun Luo, Danping Li, Lingqiong Kong
Summary: Ruscogenin exhibits anti-inflammatory effects in various human diseases and can ameliorate cognitive dysfunction and reduce neuronal damage and neuroinflammation induced by isoflurane in aged mice. Its neuroprotective effects may be mediated through blocking of the NLRP3 pathway.
QUALITY ASSURANCE AND SAFETY OF CROPS & FOODS
(2021)
Article
Agriculture, Multidisciplinary
Zuchen Wei, Yuanji Wang, Zhenxing Shi, Nong Zhou, Guixing Ren, Xiyu Hao, Liang Zou, Yang Yao
Summary: Early undernutrition is associated with neurodevelopmental deficits, but a mung bean protein diet (MBPD) has been shown to reverse these effects by modulating gut microbiota and improving central nervous system functions. MBPD supplementation upregulates key neurotrophic factors and synaptic proteins while downregulating inflammatory pathways, indicating its potential therapeutic value for cognitive dysfunction.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Immunology
Yile Zhou, Huihui Ju, Yan Hu, Tingting Li, Zhouyi Chen, Yuan Si, Xia Sun, Yi Shi, Hao Fang
Summary: This study aimed to investigate the involvement of regulatory T cells (Tregs) in the development of postoperative cognitive dysfunction (POCD). The findings from animal experiments demonstrated that POCD in aged mice was accompanied by elevated levels of inflammatory factors and increased circulating Tregs. Transfusion of Tregs from young mice partially restored the blood-brain barrier structure and alleviated POCD in aged mice, indicating a crucial role of aged Tregs in the occurrence of POCD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Neurosciences
Stephanie M. Muscat, Nicholas P. Deems, Michael J. Butler, Emmanuel A. Scaria, Menaz N. Bettes, Sean P. Cleary, Ross H. Bockbrader, Steven F. Maier, Ruth M. Barrientos
Summary: This study highlights the importance of addressing perioperative neurocognitive disorders (PNDs) and provides evidence that blocking toll-like receptor 4 (TLR4) activation can mitigate the cognitive impairment caused by morphine treatment. These findings offer a promising therapeutic target for preventing or treating PNDs.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Zhou-Liang Xu, GanLu Chen, XiangFei Liu, DaoFen Xie, Jie Zhang, YongGan Ying
Summary: The study found that ginsenosides can ameliorate memory impairment in rats caused by propofol anesthesia by increasing the expression levels of NGF and BDNF. Therefore, ginsenosides have the potential to serve as a novel therapeutic agent for postoperative cognitive dysfunction caused by propofol anesthesia.
Article
Medicine, General & Internal
Yiqiao Wang, Gaolin Qiu, Yuanhai Li
Summary: This study found that hepatic I/R injury has a negative impact on postoperative cognitive function in aged rats, leading to abnormal changes in the hippocampus. However, this cognitive deficit improves over time.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Behavioral Sciences
Ericks Sousa Soares, Felipe Vanz, Vagner Fagnani Linartevichi, Helena Cimarosti, Thereza Christina Monteiro de Lima
Summary: Memory is the ability to store, retrieve and use information, and it relies on a time-dependent consolidation process. The hippocampus plays a crucial role in processing all types of information, particularly spatial memory. This study investigates the involvement and recruitment of neuropeptide Y (NPY) receptors in the consolidation of spatial memory. The results demonstrate that NPY injection impairs memory consolidation, and previous stress enhances this effect. Additionally, selective antagonists for NPY receptors Y-1 and Y-2 show that both receptors are key players in spatial memory consolidation. The findings suggest that NPY modulates aversive and adaptive memory formation through receptor activation.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Geriatrics & Gerontology
Geeta Rao, Heekyung Lee, Michela Gallagher, James J. Knierim
Summary: This study analyzed head scanning behavior in different groups of rats, finding that impaired aged rats had lower head scanning rates compared to young rats, indicating decreased attention to spatial landmarks may contribute to spatial learning deficits in aged rats.
NEUROBIOLOGY OF AGING
(2021)
Article
Medicine, Research & Experimental
Bin Wang, Xu Lin, Jiahui Zhou, Chunhui Xie, Chuan Li, Rui Dong, Gaofeng Zhang, Xiaopeng Sun, Mingshan Wang, Yanlin Bi
Summary: The study assessed the therapeutic effects of IGF-1 on POCD in aged rats, showing that IGF-1 reduced Aβ-protein production and inhibited neuronal apoptosis in the hippocampus, subsequently alleviating the symptoms of POCD.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Neurosciences
Long Sun, Yue Yong, Pan Wei, Yongqiang Wang, He Li, Yalan Zhou, Wenqing Ruan, Xing Li, Jiangang Song
Summary: Electroacupuncture (EA) treatment significantly improves cognitive dysfunction in POCD mice by inhibiting neuroinflammation, protecting hippocampal neurons and tight junction proteins. Mechanistically, the effects of EA treatment depend on the inhibition of NLRP3 inflammasome and NF-kappa B pathway activation.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Behavioral Sciences
Briannah Miles, William Yang, Gabi Dezsi, Elysia Sokolenko, Flavia M. M. Gomes, Bianca Jupp, Rachel Hill, Matthew Hudson, Nigel C. Jones
Summary: The study found no evidence to suggest that chronic consumption of sucrose impairs cognition, including both spatial and non-spatial learning tasks. These findings suggest that not all aspects of spatial cognition are negatively impacted by high sugar diet in rodents, and that particular use of touchscreen technology may probe different aspects of cognition than traditional tasks.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Anna Harutyunyan, Debbie Chong, Rui Li, Anup D. Shah, Zahra Ali, Cheng Huang, Christopher K. Barlow, Piero Perucca, Terence J. O'Brien, Nigel C. Jones, Ralf B. Schittenhelm, Alison Anderson, Pablo M. Casillas-Espinosa
Summary: This study employed a multi-omic, network-based approach to characterize the molecular signature associated with absence epilepsy in a rat model. The findings revealed dysregulated pathways and central regulatory hubs in the seizure-associated module, suggesting their potential involvement in the etiology and maintenance of absence seizure activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Peravina Thergarajan, Matthew R. Hudson, Irena Carmichael, Jerome Classadonte, Stefanie Dedeurwaerdere, Terence J. O'Brien, Nigel C. Jones, Idrish Ali
Summary: Our study demonstrates that SSSE in C57BL/6J mice induces epileptic seizures consistent with those seen in patients with mTLE, along with cognitive and behavioral comorbidities. This suggests that the model has the potential to be used experimentally to uncover mechanisms to target against epileptogenesis, or to test novel treatment approaches.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Shobi Sivathamboo, Zining Liu, Fiona Sutherland, Erica Minato, Pablo Casillas-Espinosa, Nigel C. Jones, Marian Todaro, Udaya Seneviratne, Varduhi Cahill, Raju Yerra, Christopher French, John-Paul Nicolo, Piero Perucca, Patrick Kwan, Paul Sparks, Terence J. O'Brien
Summary: This study utilized implantable cardiac monitors to detect cardiac arrhythmias in patients with chronic drug-resistant epilepsy, revealing a high incidence of clinically significant arrhythmias. These findings may impact the risk of premature mortality, including SUDEP, in these patients.
Article
Genetics & Heredity
Anna Harutyunyan, Nigel C. Jones, Patrick Kwan, Alison Anderson
Summary: This study identified commonly dysregulated gene modules between Alzheimer's disease (AD) and temporal lobe epilepsy (TLE) using gene coexpression networks, indicating the important roles of these genes and signaling pathways in epileptogenesis in AD and TLE.
FRONTIERS IN GENETICS
(2022)
Review
Neurosciences
Matthew R. Hudson, Nigel C. Jones
Summary: Neural oscillatory activity in the gamma frequency range is important for sensory and cognitive processing. However, the interpretation and generalization of studies on gamma oscillations are limited by diverse and questionable methodologies. This article provides an overview of different measures of gamma oscillatory activity, discusses the limitations of current techniques, and makes recommendations for future studies to optimize analysis, presentation, and interpretation of gamma frequency oscillations.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Rayiky Rupasinghe, Gabi Dezsi, Ezgi Ozturk, Simone Carron, Matthew R. Hudson, Pablo M. Casillas-Espinosa, Nigel C. Jones
Summary: Early life stress significantly affects maternal care, accelerates epileptogenesis, and exacerbates disease severity in epilepsy. It also relates to depressive behaviors in epileptic rats. The effects on HPA axis functions are complex and contradictory, with implications for understanding the increased prevalence of psychiatric disorders in epilepsy.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Clinical Neurology
Rahel Feleke, Dana Jazayeri, Maya Abouzeid, Kim L. Powell, Prashant K. Srivastava, Terence J. O'Brien, Nigel C. Jones, Michael R. Johnson
Summary: Prenatal exposure to sodium valproate can increase the risk of adverse postnatal neurodevelopmental outcomes. By studying gene expression and genetic risk data, this study reveals the molecular mechanisms behind this increased risk, including abnormalities in neurodevelopment and synaptic function pathways.
Article
Clinical Neurology
Juliana C. Silva, Yu Shen, Jianxiong Chan, Patrick Kwan, Nigel C. Jones
Summary: In the Tg2576 mouse model, treatment with brivaracetam exhibited significant anti-epileptic effects, including when treatment was ceased prior to initiating kindling. This study suggests that targeting SV2A may represent a potential strategy for preventing epilepsy in patients with Alzheimer's disease.
Article
Medicine, Research & Experimental
Xueying Li, Wanhua Qiu, Lu Deng, Jingjing Lin, Wenting Huang, Yuchen Xu, Mulan Zhang, Nigel C. Jones, Runxuan Lin, Huiqin Xu, Li Lin, Peijun Li, Xinshi Wang
Summary: 11 beta-HSD1 participates in the pathogenesis of epilepsy and associated cognitive impairment by elevating neuronal excitability and contributing to apoptosis and hippocampal neuronal damage. Inhibition of 11 beta-HSD1 represents a promising strategy to treat epilepsy and cognitive comorbidity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Neurosciences
Matthew R. Hudson, Joshua Foreman, Gil Rind, Elizabeth E. Manning, Nigel C. Jones, Maarten van den Buuse
Summary: Chronic METH treatment does not affect the regulation of high-frequency neuronal oscillations in the brain, despite causing behavioral sensitization.
Review
Clinical Neurology
Zining Liu, Peravina Thergarajan, Ana Antonic-Baker, Zhibin Chen, Paul B. Sparks, Natasha A. Lannin, Patrick Kwan, Nigel C. Jones, Pablo M. Casillas-Espinosa, Piero Perucca, Terence J. O'Brien, Shobi Sivathamboo
Summary: This study examined the alterations in cardiac structure and function in patients with epilepsy through a systematic review and meta-analysis. The results showed that compared with healthy controls, patients with epilepsy had decreased left ventricular ejection fraction and increased A-wave velocity, E/e' ratio, and isovolumic relaxation time. Additionally, the prevalence of cardiac hypertrophy and fibrosis in sudden unexpected death in epilepsy (SUDEP) cases was not higher than in epilepsy controls. These findings suggest changes in diastolic and systolic echocardiogram parameters in epilepsy and highlight the importance of longitudinal studies to determine the prognostic significance of these changes. Echocardiography may be a useful noninvasive diagnostic test for the epilepsy population.
Article
Cardiac & Cardiovascular Systems
Justin Ren, Colin Royse, David H. Tian, Aashray Gupta, Alistair Royse
Summary: The study compared the survival rates of diabetic and non-diabetic patients undergoing coronary artery bypass grafting with multi-arterial grafting and single-arterial grafting. The results showed that both diabetic and non-diabetic patients had significantly higher long-term survival rates after multi-arterial grafting than single-arterial grafting. The study suggests that multi-arterial grafting improves survival rates for both diabetic and non-diabetic patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Review
Anesthesiology
Jared Ou-Young, Stuart Boggett, Doa El Ansary, Sandy Clarke-Errey, Colin F. Royse, Andrea J. Bowyer
Summary: Traditional risk factors for predicting poor postoperative recovery have focused on complications, symptoms, length of stay, and patient quality of life. However, these factors may not fully capture the multidimensional nature of patient recovery. This review aimed to identify risk factors for multidimensional patient recovery and found that few studies have assessed preoperative risk factors for poor recovery. Higher quality studies with a consistent definition of recovery are needed.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Review
Biochemistry & Molecular Biology
Chitra Vinnakota, Matthew R. R. Hudson, Nigel C. C. Jones, Suresh Sundram, Rachel A. A. Hill
Summary: Glutamate N-methyl-D-aspartate receptor (NMDAR) hypofunction is believed to be responsible for schizophrenia symptoms. Among the NMDAR subunits, the GluN2D subunit is implicated in schizophrenia-related phenotypes, and further research into this subunit may lead to novel therapeutic targets for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
