期刊
EUROPEAN HEART JOURNAL
卷 35, 期 36, 页码 2484-2491出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehu049
关键词
Cardiovascular diseases; Children; Epidemiology; Risk factors; Passive smoking
资金
- Commonwealth Departments of Sport, Recreation and Tourism, and Health
- National Heart Foundation
- Commonwealth Schools Commission
- National Health and Medical Research Council
- Heart Foundation
- Tasmanian Community Fund
- Veolia Environmental Services
- National Heart Foundation of Australia post-doctoral fellowship
- National Health and Medical Research Council Early Career Fellowship
- National Health and Medical Research Council Career Development Fellowship
- Academy of Finland [134309, 126925, 121584, 124282, 129378, 117787, 41071]
- Social Insurance Institution of Finland, Kuopio
- Tampere and Turku University Hospital Medical Funds
- Juho Vainio Foundation
- Paavo Nurmi Foundation
- Finnish Foundation of Cardiovascular Research
- Finnish Cultural Foundation
- Tampere Tuberculosis Foundation
- Emil Aaltonen Foundation
- Academy of Finland (AKA) [134309] Funding Source: Academy of Finland (AKA)
Aim Recent evidence suggests that the exposure of children to their parents' smoking adversely effects endothelial function in adulthood. We investigated whether the association was also present with carotid intima-media thickness (IMT) up to 25 years later. Methods and results The study comprised participants from the Cardiovascular Risk in Young Finns Study (YFS, n = 2401) and the Childhood Determinants of Adult Health (CDAH, n = 1375) study. Exposure to parental smoking (none, one, or both) was assessed at baseline by questionnaire. B-mode ultrasound of the carotid artery determined IMT in adulthood. Linear regression on a pooled dataset accounting for the hierarchical data and potential confounders including age, sex, parental education, participant smoking, education, and adult cardiovascular risk factors was conducted. Carotid IMT in adulthood was greater in those exposed to both parents smoking than in those whose parents did not smoke [adjusted marginal means: 0.647 mm +/- 0.022 (mean +/- SE) vs. 0.632 mm +/- 0.021, P = 0.004]. Having both parents smoke was associated with vascular age 3.3 years greater at follow-up than having neither parent smoke. The effect was independent of participant smoking at baseline and follow-up and other confounders and was uniform across categories of age, sex, adult smoking status, and cohort. Conclusions These results show the pervasive effect of exposure to parental smoking on children's vascular health up to 25 years later. There must be continued efforts to reduce smoking among adults to protect young people and to reduce the burden of cardiovascular disease across the population.
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