Article
Medicine, General & Internal
Taishi Okuno, Caglayan Demirel, Daijiro Tomii, Gabor Erdoes, Dik Heg, Jonas Lanz, Fabien Praz, Rainer Zbinden, David Reineke, Lorenz Raber, Stefan Stortecky, Stephan Windecker, Thomas Pilgrim
Summary: This study aimed to evaluate the risk of noncardiac surgery after TAVI. The results suggest that noncardiac surgery can be performed early after successful TAVI, and device performance may impact the risk of adverse outcomes after surgery.
Article
Cardiac & Cardiovascular Systems
Jun Shi, Lai Wei, Yucheng Chen, Xu Wang, Jian Ye, Chaoyi Qin, Lulu Liu, Hong Qian, Chunsheng Wang, Yingqiang Guo
Summary: The study showed good midterm outcomes of transcatheter aortic valve implantation with the J-Valve system in treating patients with aortic stenosis or pure aortic insufficiency, suggesting it as a promising alternative therapy for high-risk patients.
ANNALS OF THORACIC SURGERY
(2021)
Review
Cardiac & Cardiovascular Systems
Waqas Ullah, Abdul-Rahman M. Suleiman, Heba Osman, Sairamya Bodempudi, Hamza Zahid Ullah Muhammadzai, Salman Zahid, Mohamed Zghouzi, Yasar Sattar, Salim S. Virani, David L. Fischman, M. Chadi Alraies
Summary: This study analyzed data from the Nationwide Readmissions Database and found that patients undergoing transcatheter aortic valve implantation (TAVI) for aortic insufficiency had higher rates of in-hospital clinical events, mortality, major bleeding, and valvular complications compared to those undergoing TAVI for aortic stenosis. However, there were no significant differences in these complications at 30-day and 180-day follow-up.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Article
Medicine, General & Internal
Xavier Freixa, Rami Gabani, Pedro Cepas-Guillen, Eduardo Flores-Umanzor, Rodrigo Estevez-Loureiro, Eustaquio Maria Onorato
Summary: Catheter-based closure is an effective and less invasive option for high-risk patients with symptomatic PVL regurgitation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yang Liu, Mengen Zhai, Yu Mao, Chennian Xu, Yanyan Ma, Lanlan Li, Ping Jin, Jian Yang
Summary: This study examines the early experience with transcatheter aortic valve replacement (TAVR) in patients with quadricuspid aortic valve (QAV). The results demonstrate that TAVR is a feasible treatment option for QAV patients with acceptable early outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Uri Landes, Aviram Hochstadt, Lisa Manevich, John G. Webb, Janarthanan Sathananthan, Horst Sievert, Kerstin Piayda, Martin B. Leon, Tamim M. Nazif, David Hildick-Smith, Chris Pavitt, Holger Thiele, Mohamed Abdel-Wahab, Nicolas M. Van Mieghem, Rik Adrichem, Lars Sondergaard, Ole De Backer, Raj R. Makkar, Ofir Koren, Thomas Pilgrim, Taishi Okuno, Ran Kornowski, Pablo Codner, Ariel Finkelstein, Itamar Loewenstein, Israel Barbash, Amir Sharon, Federico De Marco, Matteo Montorfano, Nicola Buzzatti, Azeem Latib, Andrea Scotti, Won-Keun Kim, Christian Hamm, Luis Nombela Franco, Antonio Mangieri, Wolfgang H. Schoels, Marco Barbanti, Matjaz Bunc, Myriama Akodad, Ronen Rubinshtein, Haim Danenberg
Summary: This study investigated the effect of transcatheter interventions to treat paravalvular regurgitation (PVR) after transcatheter aortic valve implantation (TAVI). The results showed that patients with successful reduction of PVR had better prognosis, but further investigation is needed to determine the selection of patients and the optimal treatment modality for PVR.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Daijiro Tomii, Taishi Okuno, Fabien Praz, Dik Heg, Mirjam Gauri Wild, Jonas Lanz, Stefan Stortecky, David Reineke, Stephan Windecker, Thomas Pilgrim
Summary: A significant proportion of patients were deemed potential candidates for TTVI after TAVR, with impaired prognosis and persistently impaired functional status at 1 year after the procedure.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Javier Lopez-Pais, Diego Lopez-Otero, Arturo Garcia-Touchard, Barbara Izquierdo Coronel, Pablo Jose Antunez Muinos, Xabier Cia Mendioroz, Marta Perez-Poza, Oscar Otero Garcia, Carlos Gustavo Martinez Peredo, Carlos Arellano Flores, Leyre Alvarez-Rodriguez, Fernando Gomez Pena, Maria Juskova, Juan Carlos Sanmartin Pena, Rodrigo Estevez-Loureiro, Ana Belen Cid Alvarez, Ramiro Trillo Nouche, Joaquin Jesus Alonso-Martin, Jose Ramon Gonzalez-Juanatey, Juan Francisco Oteo
Summary: This study aimed to assess the impact of significant paravalvular leak (SPL) after TAVI on anaemia and prognosis. The findings showed that SPL is an independent predictor of anaemia at 3 months after TAVI, and both SPL and anaemia were associated with long-term mortality. Further pathophysiological studies are needed to explain this association.
Article
Cardiac & Cardiovascular Systems
Maxim J. P. Rooijakkers, Niels A. Stens, Marleen H. van Wely, Kees van der Wulp, Laura Rodwell, Helmut Gehlmann, Leen A. F. M. van Garsse, Guillaume S. C. Geuzebroek, Michel W. A. Verkroost, Jesse Habets, Saloua El Messaoudi, Dick H. J. Thijssen, Robin Nijveldt, Niels van Royen
Summary: This study aimed to assess the accuracy of haemodynamic indices in predicting relevant paravalvular regurgitation (PVR) after transcatheter aortic valve replacement (TAVR). The diastolic delta (DD) measured during TAVR showed the best correlation with CMR-RF and the highest ability to predict PVR.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Morgan H. Randall, Thomas J. Lewandowski, Calvin Choi, Thomas M. Beaver
Summary: Advancements in the treatment of severe symptomatic aortic stenosis have improved patient outcomes, but management of multijet paravalvular regurgitation remains challenging. Both surgical and transcatheter options can successfully treat multijet PVR, but individualized treatment plans are necessary.
CLINICAL CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Review
Medicine, General & Internal
Victor Quentin, Jules Mesnier, Clemence Delhomme, Neila Sayah, Paul Guedeney, Olivier Barthelemy, Gaspard Suc, Jean-Philippe Collet
Summary: Transcatheter mitral valve replacement (TMVR) is an emerging field dedicated to addressing the therapeutic challenges posed by patients at high surgical risk with mitral valve disease. TMVR can be categorized into TMVR with transcatheter aortic valves (TAV) and TMVR with dedicated devices. This field is gradually surmounting technical challenges and numerous devices are currently undergoing clinical trials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Sandeep Bhushan, Xin Huang, Yuan Li, Songlin He, Long Mao, Wang Hong, Zongwei Xiao
Summary: Paravalvular leak (PVL) is a common complication after TAVI and can negatively affect the short- and long-term survival of patients. Factors such as AVC volume, annulus dimensions, and pre-TAVI transvalvular peak velocity have been associated with the occurrence and increased risk of PVL. Aortic root calcification volume, larger annulus dimensions, and pre-TAVI transvalvular peak velocity can predict the occurrence of PVL. Further research is needed to evaluate the association between different degrees of post-TAVI PVL and mortality.
CURRENT PROBLEMS IN CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Jules Mesnier, Vassili Panagides, Jorge Nuche, Josep Rodes-Cabau
Summary: This article summarizes the current indications for transcatheter aortic valve replacement (TAVR) and explores future directions for its expansion.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shinichi Fukuhara, Chan Tran N. Nguyen, Bo Yang, Steven F. Bolling, Matthew A. Romano, Karen M. Kim, Himanshu J. Patel, G. Michael Deeb
Summary: Despite the widespread adoption of transcatheter aortic valve replacement (TAVR), the frequency and clinical outcomes of reoperation after TAVR are not well-described. This study retrospectively reviewed 48 patients who underwent reoperation after TAVR and found that the clinical impact of post-TAVR reoperation remains substantial, highlighting the importance of considering lifetime management strategy during candidate selection.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Angela Lowenstern, Nicholas Ng, Hidenobu Takagi, Jennifer A. Rymer, Lynne M. Koweek, Pamela S. Douglas, Jessica M. Duran, Mark Rabbat, Gianluca Pontone, Timothy Fairbairn, Kavitha Chinnaiyan, Daniel S. Berman, Bernard De Bruyne, Jeroen J. Bax, Takashi Akasaka, Tetsuya Amano, Koen Nieman, Campbell Rogers, Hironori Kitabata, Niels P. R. Sand, Tomohiro Kawasaki, Sarah Mullen, Hitoshi Matsuo, Bjarne L. Norgaard, Manesh R. Patel, Jonathan Leipsic, Melissa A. Daubert
Summary: This study investigated the relationship between BMI, CAD, and clinical outcomes using the ADVANCE registry. The results showed that overweight and obese patients had a lower rate of anatomical stenosis, but had a similar burden of physiologically significant disease and rates of adverse events regardless of BMI.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Immunology
Emma M. Kileel, Carlos D. Malvestutto, Janet Lo, Kathleen Fitch, Carl J. Fichtenbaum, Judith A. Aberg, Markella Zanni, Esteban Martinez, Nwora Lance Okeke, Princy Kumar, Esau Joao, Sara H. Bares, Daniel Berrner, Marek Smieja, Jhoanna C. Roa, Sara McCallum, Pamela S. Douglas, Heather J. Ribaudo, Steven K. Grinspoon
Summary: Over a 2-year follow-up period, the use of integrase strand transfer inhibitors (INSTIs) was associated with weight gain among patients who had been using INSTIs for less than 2 years at the start of the study (+0.27 kg/m(2)/year; 95% CI, .22 to .33), but not among those who had been using INSTIs for more than 2 years. The difference in weight gain between the two groups was statistically significant (P = .01).
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Medicine, General & Internal
Pamela S. Douglas
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Nicholas Cauwenberghs, Francois Haddad, Melissa A. Daubert, Ranee Chatterjee, Michael Salerno, Jessica L. Mega, Paul Heidenreich, Adrian Hernandez, Myriam Amsallem, Yukari Kobayashi, Kenneth W. Mahaffey, Svati H. Shah, Gerald S. Bloomfield, Tatiana Kuznetsova, Pamela S. Douglas
Summary: This study aimed to investigate the heterogeneity of clinical and echocardiographic features in the development of heart failure and evaluate their association with exercise capacity. Through surveys and examinations of community-dwelling individuals, diverse clinical and echocardiographic features were observed, which were related to exercise capacity. The presence or absence of heart failure risk factors and echocardiographic abnormalities in different subgroups had varying impacts on physical performance.
JOURNAL OF CARDIAC FAILURE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Donna Mancini, Pamela S. Douglas, Teresa De Marco, Maria Rosa Constanzo, Mary Norine Walsh, Sharon Hunt, Evelyn M. Horn, JoAnn Lindenfeld, Mariell Jessup
JACC-HEART FAILURE
(2023)
Article
Medicine, General & Internal
Marton Kolossvary, Chris deFilippi, Sara McCallum, Kathlee V. Fitch, Marissa R. Diggs, Evelynne S. Fulda, Heather J. Ribaudo, Carl J. Fichtenbaum, Judith A. Aberg, Carlos D. Malvestutto, Judith S. Currier, Jose L. Casado, Felix Gutierrez, Irini Sereti, Pamela S. Douglas, Markella V. Zanni, Steven K. Grinspoon
Summary: This study investigates the mechanisms contributing to COVID-19 severity in people with HIV. The researchers analyzed temporal changes in plasma proteins following SARS-CoV-2 infection and identified pre-infection proteomic markers associated with future COVID-19. The findings suggest that specific proteins and pathways may be linked to COVID-19-related morbidity in HIV patients.
Article
Immunology
Samuel R. Schnittman, Douglas W. Kitch, Talia H. Swartz, Tricia H. Burdo, Kathleen Fitch, Sara McCallum, Jacqueline M. Flynn, Evelynne S. Fulda, Marissa R. Diggs, Jack T. Stapleton, Jose L. Casado, Jana Taron, Judith S. Currier, Markella Zanni, Carlos Malvestutto, Carl J. Fichtenbaum, Judith A. Aberg, Heather J. Ribaudo, Michael T. Lu, Pamela S. Douglas, Steven K. Grinspoon
Summary: Among ART-treated people with HIV at low-moderate traditional cardiovascular disease risk, inflammasome activation markers were associated with Leaman score, a composite index of plaque burden and severity, which has been associated with major cardiovascular events in the general population.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Samuel R. Schnittman, Wonyeong Jung, Kathleen V. Fitch, Markella V. Zanni, Sara McCallum, Jessica Shih-Lu Lee, Sally Shin, Brandon J. Davis, Evelynne S. Fulda, Marissa R. Diggs, Francoise Giguel, Romina Chinchay, Anandi N. Sheth, Carl J. Fichtenbaum, Carlos Malvestutto, Judith A. Aberg, Judith Currier, Douglas A. Lauffenburger, Pamela S. Douglas, Heather J. Ribaudo, Galit Alter, Steven K. Grinspoon
Summary: People with HIV (PWH) have suboptimal pathogen responses and worse COVID-19 outcomes. The effects of host factors and COVID-19 on the humoral repertoire in PWH are unclear. A comprehensive assessment reveals distinct SARS-CoV-2-specific humoral immune profiles among PWH with obesity or lower nadir CD4+ T cell count, highlighting mechanisms associated with worse COVID-19-related outcomes in this population.
Article
Cardiac & Cardiovascular Systems
Mayra E. Guerrero, Mackram F. Eleid, Dee Dee Wang, Amit Pursnani, Susheel K. Kodali, Isaac George, Igor Palacios, Hyde Russell, Raj R. Makkar, Saibal Kar, Lowell F. Satler, Vivek Rajagopal, George Dangas, Gilbert H. L. Tang, James M. Mccabe, Brian K. Whisenant, Kenith Fang, Prakash Balan, Richard Smalling, Tatiana Kaptzan, Bradley Lewis, Pamela S. Douglas, Rebecca T. Hahn, Jeremy Thaden, Jae K. Oh, Martin Leon, William O'Neill, Charanjit Rihal
Summary: The MITRAL trial evaluated the use of balloon-expandable aortic transcatheter heart valves in patients with failed surgical bioprostheses or annuloplasty rings and severe mitral annular calcification. The results showed that patients treated with MViV had excellent survival at 5 years and significant improvement in heart failure symptoms, while the MViR and ViMAC groups had lower survival rates.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Immunology
Kristine M. Erlandson, Triin Umbleja, Michael T. Lu, Jana Taron, Heather J. Ribaudo, Edgar T. Overton, Rachel M. Presti, David W. Haas, Paul E. Sax, Michael T. Yin, Bingxue Kris Zhai, Rochelle Louis, Namrata Upadhyay, Parastou Eslami, Pamela S. Douglas, Markella V. Zanni, Kathleen V. Fitch, Evelynne S. Fulda, Carl J. Fichtenbaum, Carlos D. Malvestutto, Steven K. Grinspoon, Todd T. Brown
Summary: The study aimed to evaluate the association between paraspinal muscle density and area with cardiac or physical function outcomes in people with HIV. The findings showed that greater paraspinal muscle density was associated with a lower prevalence of coronary artery disease, while greater muscle area was associated with better physical performance.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2023)
Article
Cardiac & Cardiovascular Systems
James E. Udelson, Michelle D. Kelsey, Michael G. Nanna, Christopher B. Fordyce, Eric Yow, Robert M. Clare, Daniel B. Mark, Manesh R. Patel, Campbell Rogers, Nick Curzen, Gianluca Pontone, Pal Maurovich-Horvat, Bernard De Bruyne, John P. Greenwood, Victor Marinescu, Jonathon Leipsic, Gregg W. Stone, Ori Ben-Yehuda, Colin Berry, Shea E. Hogan, Bjorn Redfors, Ziad A. Ali, Robert A. Byrne, Christopher M. Kramer, Robert W. Yeh, Beth Martinez, Sarah Mullen, Whitney Huey, Kevin J. Anstrom, Hussein R. Al-Khalidi, Karen Chiswell, Sreekanth Vemulapalli, Pamela S. Douglas
Summary: This study demonstrates that deferring diagnostic testing in low-risk patients with suspected coronary artery disease can be a safe strategy, reducing the number of low-yield diagnostic tests.
Article
Cardiac & Cardiovascular Systems
Pamela S. Douglas, Michael G. Nanna, Michelle D. Kelsey, Eric Yow, Daniel B. Mark, Manesh R. Patel, Campbell Rogers, James E. Udelson, Christopher B. Fordyce, Nick Curzen, Gianluca Pontone, Pal Maurovich-Horvat, Bernard De Bruyne, John P. Greenwood, Victor Marinescu, Jonathon Leipsic, Gregg W. Stone, Ori Ben-Yehuda, Colin Berry, Shea E. Hogan, Bjorn Redfors, Ziad A. Ali, Robert A. Byrne, Christopher M. Kramer, Robert W. Yeh, Beth Martinez, Sarah Mullen, Whitney Huey, Kevin J. Anstrom, Hussein R. Al-Khalidi, Sreekanth Vemulapalli
Summary: This study investigates the optimal initial evaluation pathway for reducing unnecessary testing and referral in patients with suspected coronary artery disease. The precision strategy, which includes the use of PROMISE minimal risk score and selective fractional flow reserve assessment, improved clinical efficiency without significant impact on safety compared to the usual testing approach.
Article
Radiology, Nuclear Medicine & Medical Imaging
Borek Foldyna, Thomas Mayrhofer, Michael T. Lu, Julia Karady, Marton Kolossvary, Maros Ferencik, Svati H. Shah, Neha J. Pagidipati, Pamela S. Douglas, Udo Hoffmann
Summary: The prognostic value of CT-derived coronary artery disease (CAD) characteristics differs across categories of clinical cardiovascular risk. Among patients with low cardiovascular disease risk, CAD >= 50% has the highest prognostic value, while coronary artery calcium (CAC) and high-risk plaque (HRP) have higher prognostic value among patients with high cardiovascular disease risk.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Massimo Mancone, Aldo J. Vazquez Mezquita, Lucia Ilaria Birtolo, Pal Maurovich-Horvat, Klaus F. Kofoed, Theodora Benedek, Patrick Donnelly, Jose Rodriguez-Palomares, Andrejs Erglis, Cyril Stechovsky, Gintare Sakalyte, Nada Cemerlic Adic, Matthias Gutberlet, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kepka, Radosav Vidakovic, Marco Francone, Malgorzata Ilnicka-Suckiel, Fabian Plank, Juhanni Knuuti, Rita Faria, Stephen Schroeder, Colin Berry, Luca Saba, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jaqueline Mueller-Nordhorn, Bela Merkely, Per E. Sigvardsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtech Suchanek, Antanas Jankauskas, Filip Adic, Michael Woinke, Stephen Keane, Ignacio Lecumberri, Erica Thwaite, Mariusz Kruk, Vladimir Jovanovic, Donata Kusmierz, Gudren Feuchtner, Mikko Pietilae, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Vitanio Palmisano, Michael Fisher, Zsofia D. Drobni, Charlotte Kragelund, Rosca Aurelian, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Melinda Boussoussou, Jens D. Hove, Ioana Rodean, Susan Regan, Hug Cuellar Calabria, David Becker, Linnea Larsen, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Mahmoud Mohamed, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Pamela S. Douglas, Melanie Estrella, Maria Bosserdt, Peter Martus, Lina M. Serna-Higuita, Jonathan D. Dodd, Marc Dewey
Summary: The impact of cardiac computed tomography (CT) versus invasive coronary angiography (ICA) on cardiovascular events appears to be consistent across different smoking status groups in patients with stable chest pain. The CT-first strategy resulted in a higher detection rate of non-obstructive coronary artery disease and fewer complications, regardless of smoking status.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Pamela S. Douglas, Michael G. Nanna, Michelle D. Kelsey, Eric Yow, Daniel B. Mark, Manesh R. Patel, Campbell Rogers, James E. Udelson, Christopher B. Fordyce, Nick Curzen, Gianluca Pontone, Pal Maurovich-Horvat, Bernard De Bruyne, John P. Greenwood, Victor Marinescu, Jonathon Leipsic, Gregg W. Stone, Ori Ben-Yehuda, Colin Berry, Shea E. Hogan, Bjorn Redfors, Ziad A. Ali, Robert A. Byrne, Christopher M. Kramer, Robert W. Yeh, Beth Martinez, Sarah Mullen, Whitney Huey, Kevin J. Anstrom, Hussein R. Al-Khalidi, Sreekanth Vemulapalli
Summary: This study tested a modified initial cCTA strategy compared to usual testing in patients with stable chest pain and found that the modified strategy improved clinical efficiency at 1 year. Further randomized clinical trials are needed to confirm these findings.