Article
Medicine, General & Internal
Gregory Y. H. Lip, Allison Keshishian, Yan Zhang, Amiee Kang, Amol D. Dhamane, Xuemei Luo, Christian Klem, Mauricio Ferri, Jenny Jiang, Huseyin Yuce, Steven Deitelzweig
Summary: In this study of patients with NVAF and high risk of GI bleed, NOACs were associated with lower rates of stroke and/or SE, but NOACs had varying risks of MB compared with warfarin. These results may help inform treatment options in this patient population.
Article
Cardiac & Cardiovascular Systems
Malik Elharram, Michelle Samuel, Ahmed AlTurki, Michael Quon, Hassan Behlouli, Amal Bessissow, Louise Pilote
Summary: This study aimed to investigate the association between oral anticoagulation (OAC) use and thromboembolic events and major bleeding in patients with new postoperative atrial fibrillation (POAF) after noncardiac surgery. The results showed that OAC was not associated with a reduction in long-term thromboembolic events in these patients, but it did increase the risk for major bleeding. Future prospective clinical studies are needed to better understand the efficacy and safety of anticoagulation therapy in the setting of POAF after noncardiac surgery.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jakub Z. Qazi, Mireille E. Schnitzer, Robert Cote, Marie-Josee Martel, Marc Dorais, Sylvie Perreault
Summary: The study aimed to develop a predictive model for major bleeding in new users of oral anticoagulants with atrial fibrillation, finding similar predictors among different types of anticoagulant users. The final model accurately predicted the risk of bleeding, providing a useful tool for future pharmacoepidemiologic studies.
Article
Medicine, General & Internal
Vicente Bertomeu-Gonzalez, Jose Moreno-Arribas, Maria Asuncion Esteve-Pastor, Inmaculada Roldan-Rabadan, Javier Muniz, Deborah Otero Garcia, Martin Ruiz-Ortiz, Angel Cequier, Vicente Bertomeu-Martinez, Lina Badimon, Manuel Anguita, Gregory Y. H. Lip, Francisco Marin
Summary: Atrial fibrillation (AF) patients with peripheral artery disease (PAD) have higher cardiovascular risks compared to those without PAD, leading to significantly higher rates of mortality, stroke, bleeding, and major adverse cardiovascular events (MACE) after 3 years of follow-up. However, the exact contribution of PAD to these events, independently of other cardiovascular diseases or risk factors, requires further investigation.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Gregory F. Michaud, William G. Stevenson
Summary: A 63-year-old healthy male with atrial fibrillation presents with symptoms of dyspnea and irregular heartbeat. Physical examination reveals high blood pressure, irregular pulse, and ECG confirms atrial fibrillation. Further evaluation and treatment plan are needed.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jeffrey S. Berger, Francois Laliberte, Akshay Kharat, Dominique Lejeune, Kenneth Todd Moore, Young Jung, Patrick Lefebvre, Veronica Ashton
Summary: Rivaroxaban may be a safe and effective alternative to warfarin for obese NVAF patients, with a lower risk of stroke or systemic embolism compared to warfarin. There was no significant difference in major bleeding risk between rivaroxaban and warfarin-treated patients. Subgroup analyses yielded consistent results with the overall polypharmacy analysis.
ADVANCES IN THERAPY
(2021)
Review
Medicine, Research & Experimental
Stefano Ballestri, Elisa Romagnoli, Dimitriy Arioli, Valeria Coluccio, Alessandra Marrazzo, Afroditi Athanasiou, Maria Di Girolamo, Cinzia Cappi, Marco Marietta, Mariano Capitelli
Summary: This article systematically evaluates the risk of bleeding complications of direct oral anticoagulants (DOACs) compared to vitamin K antagonists (VKAs) in patients with atrial fibrillation and venous thromboembolism. It also discusses the management of bleeding complications and the possibility of resuming anticoagulation for special patient populations. Recommendations for choosing the optimal DOAC to minimize adverse events according to individual patient characteristics and bleeding risk are provided.
ADVANCES IN THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Paul L. Hess, Kensey L. Gosch, Sandeep M. Jani, Paul D. Varosy, Steven M. Bradley, Thomas M. Maddox, P. Michael Ho, Salim S. Virani
Summary: This study analyzed the use of oral anticoagulants among patients with valvular atrial fibrillation from 2013 to 2019 using the PINNACLE Registry. The results showed variations in the use of direct oral anticoagulants and warfarin, but consistent trends in their usage over time.
AMERICAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Qiuyu Meng, Zhifu Cen
Summary: The study indicates that NOACs are effective and safe for preventing stroke/SE in patients with both NVAF and PAD.
Article
Clinical Neurology
Oh Young Bang, Siin Kim, Young Keun On, Myung-Yong Lee, Sung-Won Jang, Seongwook Han, Jaeyun Ryu, Seongsik Kang, Hae Sun Suh, Young-Hoon Kim
Summary: NOACs have been proven to be alternative medications for preventing stroke in patients with non-valvular atrial fibrillation. However, the use of antiplatelet agents, warfarin, and NOACs in clinical practice is influenced by patient factors.
FRONTIERS IN NEUROLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Xiaojun Zhuo, Jian Wang, Lihui Shao
Summary: Rivaroxaban appears to be a better option than warfarin for obese patients with non-valvular AF, as it is associated with significantly lower risks of stroke and bleeding outcomes.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Clinical Neurology
Brian Mac Grory, Sean R. Landman, Paul D. Ziegler, Chantal J. Boisvert, Shane P. Flood, Christoph Stretz, Tracy E. Madsen, Michael E. Reznik, Shawna Cutting, Elizabeth E. Moore, Hunter Hewitt, James B. Closser, Jose Torres, Patrick J. Lavin, Karen L. Furie, Ying Xian, Wayne Feng, Valerie Biousse, Matthew Schrag, Shadi Yaghi
Summary: The study found that the cumulative incidence of new atrial fibrillation (AF) after central retinal artery occlusion (CRAO) was approximately 49.6% at 2 years. Patients with CRAO had a higher risk of developing AF compared to controls and a similar risk to patients with stroke. CRAO was also associated with an increased incidence of new stroke.
Article
Cardiac & Cardiovascular Systems
Jae-Sun Uhm, Jun Kim, Hee Tae Yu, Tae-Hoon Kim, So-Ryoung Lee, Myung-Jin Cha, Eue-Keun Choi, Jung Myung Lee, Jin-Bae Kim, Junbeom Park, Jin-Kyu Park, Ki-Woon Kang, Jaemin Shim, Hyung Wook Park, Young Soo Lee, Chang-Soo Kim, Ji Eun Mun, Nak-Hoon Son, Boyoung Joung
Summary: The study aimed to investigate the risk of stroke and systemic embolism in patients with atrial fibrillation and heart failure according to different types of heart failure. The highest risk was observed in the HFpEF group, while the risk was comparable between the HFmrEF and HFrEF groups.
Article
Hematology
Jean-Pierre Bassand, Saverio Virdone, Marc Badoz, Freek W. A. Verheugt, A. John Camm, Frank Cools, Keith A. A. Fox, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Gloria Kayani, Frank Misselwitz, Karen S. Pieper, Alexander G. G. Turpie, Martin van Eickels, Ajay K. Kakkar
Summary: In patients with atrial fibrillation, NOACs show lower risks of bleeding and all-cause mortality compared to VKAs, with major bleeding associated with the highest risk of death. Minor bleeding and CRNM bleeding are also linked to a higher risk of death compared to no bleeding. A significant percentage of deaths within 30 days after a major bleed are due to intracranial/intraspinal hemorrhage.
Article
Cardiac & Cardiovascular Systems
Hsin-Fu Lee, Lai-Chu See, Pei-Ru Li, Jia-Rou Liu, Tze-Fan Chao, Shang-Hung Chang, Lung-Sheng Wu, Yung-Hsin Yeh, Chi-Tai Kuo, Yi-Hsin Chan, Gregory Y. H. Lip
Summary: A study comparing the effectiveness and safety of non-vitamin K antagonist oral anticoagulants (NOACs) vs. warfarin in atrial fibrillation (AF) patients with peripheral artery disease (PAD) found that NOACs were associated with comparable risk of stroke but significantly lower risk of major adverse limb events and bleeding compared to warfarin, suggesting that NOACs may be a better option for these patients.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Clinical Neurology
Andrew Smyth, Martin O'Donnell, Sumathy Rangarajan, Graeme J. Hankey, Shahram Oveisgharan, Michelle Canavan, Clodagh McDermott, Denis Xavier, Hongye Zhang, Albertino Damasceno, Alvaro Avezum, Nana Pogosova, Aytekin Oguz, Danuta Ryglewicz, Helle Klingenberg Iversen, Fernando Lanas, Annika Rosengren, Salim Yusuf, Peter Langhorne
Summary: This study examined the association between alcohol consumption and stroke in a large international population. It found that high and moderate alcohol intake increased the odds of stroke, while low intake was not associated with stroke. However, there were regional variations in the relationship.
Article
Cardiac & Cardiovascular Systems
Josephine Harrington, Anthony P. Carnicelli, Kaiyuan Hua, Lars Wallentin, Manesh R. Patel, Stefan H. Hohnloser, Robert P. Giugliano, Keith A. A. Fox, Ziad Hijazi, Renato D. Lopes, Sean D. Pokorney, Hwanhee Hong, Christopher B. Granger
Summary: Through meta-analysis of multiple research databases, it was found that standard-dose DOACs are safer and more effective than warfarin in patients with kidney dysfunction. While lower-dose DOACs do not significantly lower the incidence of bleeding or intracranial hemorrhage compared to standard-dose DOACs, they are associated with a higher incidence of stroke and systemic embolism as well as death. Therefore, these findings support the use of standard-dose DOACs over warfarin in patients with kidney dysfunction.
Article
Endocrinology & Metabolism
Xiaoying Liu, Kaye E. Brock, Tara C. Brennan-Speranza, Leon Flicker, Jonathan Golledge, Graeme J. Hankey, Christian M. Girgis, Bu B. Yeap
Summary: Older people are more prone to vitamin D deficiency, and individual lifestyle factors have an impact on vitamin D levels. This study focused on older men and found that engaging in multiple healthy lifestyle behaviors, including physical activity, was associated with better vitamin D status. Further research is needed to determine the effects of promoting healthy lifestyle behaviors on vitamin D sufficiency.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ross J. Marriott, Kevin Murray, Charley A. Budgeon, Veryan Codd, Jennie Hui, Gillian M. Arscott, John P. Beilby, Graeme J. Hankey, Gary A. Wittert, Frederick C. W. Wu, Bu B. Yeap
Summary: Lower testosterone concentrations in middle-aged and older men are associated with shorter telomeres, suggesting that testosterone may contribute to biological aging in men.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Yongjun Wang, Jiejie Li, S. Claiborne Johnston, Graeme J. Hankey, J. Donald Easton, Xia Meng, Fu-Dong Shi, Yilong Wang, Xingquan Zhao, Zixiao Li, Liping Liu, Hongqiu Gu, Yong Jiang, Anxin Wang, Yuesong Pan, Jing Jing, Siying Niu, Hao Li
Summary: The CHANCE-3 study is a randomized, double-blind, placebo-controlled multicenter trial that aims to investigate the efficacy of colchicine therapy in patients with acute minor-to-moderate ischemic stroke or transient ischemic attack. The study will randomly assign 8,238 patients with high-sensitivity CRP level of >= 2 mg/L to receive colchicine or placebo, in addition to optimal medical therapy. The primary outcome is the occurrence of any stroke within 3 months of randomization, with a goal of detecting a 25% reduction in the colchicine group.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Neuroimaging
Arosha S. Dissanayake, Emalee Burrows, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: In a retrospective analysis of patients with aneurysmal subarachnoid hemorrhage (aSAH) treated with ultra-early intervention, the World Federation of Neurosurgical Societies (WFNS) grade was found to be superior to three published models for predicting re-bleeding.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Geriatrics & Gerontology
Jack Paterson, Michelle Trevenen, Keith Hill, Osvaldo P. Almeida, Bu B. Yeap, Jonathan Golledge, Graeme J. Hankey, Leon Flicker
Summary: This study found that poorer balance and strength performance are associated with future all-cause and cardiovascular mortality, and balance is equal to strength as a modifiable risk factor for cause-specific mortality.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Clinical Neurology
Karly Zacharia, Emily Ramage, Margaret Galloway, Meredith Burke, Graeme J. Hankey, Elizabeth Lynch, Catherine M. Said, Coralie English, Amanda Patterson, Lesley Macdonald-Wicks
Summary: This study examined the dietary intake and quality of Australian stroke survivors. The findings indicate that the diet quality of stroke survivors is poor, with inadequate intake of nutrients important for reducing recurrent stroke risk. Further research is needed to develop effective interventions to improve diet quality.
CEREBROVASCULAR DISEASES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Florian A. Wenzl, Keith A. A. Fox, Thomas F. Luescher
EUROPEAN HEART JOURNAL
(2023)
Article
Clinical Neurology
Coralie English, Emily R. Ramage, John Attia, Julie Bernhardt, Billie Bonevski, Meredith Burke, Margaret Galloway, Graeme J. Hankey, Heidi Janssen, Richard Lindley, Elizabeth Lynch, Chris Oldmeadow, Catherine M. Said, Neil J. Spratt, Karly Zacharia, Lesley MacDonald-Wicks, Amanda Patterson
Summary: This study tested the feasibility and safety of a 6-month telehealth intervention to increase physical activity and improve diet quality. The results showed that the intervention was safe and feasible and may have led to significant behavior change.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Valery L. Feigin, Rita Krishnamurthi, Oleg Medvedev, Alexander Merkin, Balakrishnan Nair, Michael Kravchenko, Shabnam Jalili-Moghaddam, Suzanne Barker-Collo, Yogini Ratnasabapathy, Luke Skinner, Mayowa Owolabi, Bo Norrving, Perminder S. Sachdev, Bruce Arroll, Michael Brainin, Amanda Thrift, Graeme J. Hankey
Summary: The PreventS-MD web app showed high usability, feasibility, and satisfaction among healthcare professionals (HCPs) and individuals at risk of stroke/CVD. Patients at risk of stroke/CVD also demonstrated strong confidence and motivation in following and adhering to the preventive recommendations generated by PreventS-MD.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Environmental Sciences
Joshua S. Jones, Lee Nedkoff, Jane S. Heyworth, Osvaldo P. Almeida, Leon Flicker, Jonathan Golledge, Graeme J. Hankey, Elizabeth H. Lim, Mark Nieuwenhuijsen, Bu B. Yeap, Michelle L. Trevenen
Summary: This study aimed to determine the dose-response relationship between long-term exposure to low-concentration PM2.5 air pollution and incident ischemic heart disease (IHD), heart failure (HF), and atrial fibrillation (AF) in older men. The results showed a trend of increased incidence of IHD, HF, and AF, but none were statistically significant under low-concentration PM2.5 air pollution exposure.
ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Review
Medicine, General & Internal
A. Cochrane, C. Chen, J. Stephen, O. M. Ronning, C. S. Anderson, G. J. Hankey, Al-Shahi R. Salman
Summary: This study aimed to determine the overall effectiveness and safety of antithrombotic drugs in reducing major adverse cardiovascular events (MACE) for stroke survivors with intracerebral hemorrhage (ICH). The results showed that long-term therapeutic dose oral anticoagulation may reduce MACE and major occlusive vascular events, while short-term prophylactic dose anticoagulation and long-term antiplatelet therapy did not show significant effects. However, the certainty of the evidence was moderate, and further large-scale randomized controlled trials are needed to address the ongoing dilemmas of antithrombotic treatment after ICH.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Endocrinology & Metabolism
Stephanie Y. Tan, S. A. Paul Chubb, Leon Flicker, Osvaldo P. Almeida, Jonathan Golledge, Graeme J. Hankey, Bu B. Yeap
Summary: The study aimed to assess the prevalence and incidence of subclinical thyroid dysfunction in older men. The results showed that one-fifth of initially euthyroid men developed subclinical or overt hypothyroidism, and age and higher baseline thyroid stimulating hormone (TSH) levels predicted this outcome.
CLINICAL ENDOCRINOLOGY
(2023)
