Article
Physiology
Louise Arno, Jan Quan, Nhan T. Nguyen, Maarten Vanmarcke, Elena G. Tolkacheva, Hans Dierckx
Summary: Our analysis of ventricular tachycardia in rabbit hearts shows that nearly all detected PSs were found on PDLs, but the PDLs had a significantly longer lifespan than the detected PSs. The proposed framework revisits basic building blocks of cardiac activation patterns and can become a useful tool for further theory development and experimental analysis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Mathematics, Interdisciplinary Applications
Ying Xu, Guodong Ren, Jun Ma
Summary: This paper investigates the electric activity in myocardial tissue and the impact of external electromagnetic radiation on its stability and wave propagation. A memristive cardiac tissue model is developed by incorporating magnetic flux variable and induction current. The results show that external electromagnetic radiation can control the wave propagation in cardiac tissue and generate specific spatial patterns.
CHAOS SOLITONS & FRACTALS
(2023)
Article
Biochemistry & Molecular Biology
Naiem T. Issa, Stephen W. Byers, Sivanesan Dakshanamurthy
Summary: ES-Screen is a novel electrostatics-driven virtual screening method that optimizes electrostatic and nonpolar interactions by replacing electrostatic interaction energies, providing a unique approach for finding biologically relevant ligand-protein interactions in drug discovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yayoi Honda, Jun Li, Aya Hino, Shinji Tsujimoto, Jong-Kook Lee
Summary: Evaluation of drug-induced arrhythmia is crucial for drug discovery, and new evaluation systems based on human iPS cell-derived cardiomyocytes have been established. With the increasing incidence of atrial arrhythmias and the lack of established experimental methods, a high-throughput drug evaluation system using atrial-like cardiomyocytes has been developed to detect potential risks for drug-induced atrial arrhythmias.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biology
Naoki Tomii, Masatoshi Yamazaki, Takashi Ashihara, Kazuo Nakazawa, Nitaro Shibata, Haruo Honjo, Ichiro Sakuma
Summary: Through numerical simulations, it was found that conduction blocks induce discontinuous boundaries in spatial phase maps of cardiac spiral waves, providing a more appropriate model of the wave center than phase singularities.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Sebastian Koenig, Thomas Schroeter, Michael A. Borger, Livio Bertagnolli, Sotirios Nedios, Angeliki Darma, Gerhard Hindricks, Arash Arya, Borislav Dinov
Summary: This study retrospectively analyzed patients who underwent cardiac sympathetic denervation (CSD) at the Heart Center Leipzig. The results showed that CSD had a moderate efficacy in suppressing ventricular arrhythmias in patients who had previously unsuccessful catheter ablation. However, there were significant procedure-related complications and a high overall risk of procedure-unrelated adverse events and death.
Article
Biology
Youssef Belhamadia, Zeinab Rammal
Summary: This study introduces three ADI schemes for efficient solution of the nonlinear cardiac monodomain model, aiming to reduce computational time and memory consumption. The proposed methods have second order accuracy and evaluate the ionic model only once per time-step. Large-scale two- and three-dimensional simulations show higher efficiency of the proposed methods.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Nour Raad, Philip Bittihn, Marine Cacheux, Dongtak Jeong, Zeki Ilkan, Delaine Ceholski, Erik Kohlbrenner, Lu Zhang, Chen-Leng Cai, Evangelia G. Kranias, Roger J. Hajjar, Francesca Stillitano, Fadi G. Akar
Summary: This study highlights the crucial role of primary electrical remodeling caused by the hPLN(R14del) mutation in early-stage arrhythmogenic phenotype. The preferential right ventricular action potential prolongation and steep repolarization gradient at the left ventricular/right ventricular interface are key mechanisms underlying the increased arrhythmia susceptibility in R14del hearts. The unique spatiotemporal dynamics of high-frequency rotors pinned to the right ventricle contribute to their increased stability in R14del compared with wildtype hearts.
Article
Cardiac & Cardiovascular Systems
Runzhu Shi, Marius Reichardt, Dominik J. Fiegle, Linda K. Kuepfer, Titus Czajka, Zhengwu Sun, Tim Salditt, Andreas Dendorfer, Thomas Seidel, Tobias Bruegmann
Summary: This study evaluates the use of healthy pig myocardial slices and biomimetic cultivation setups as a new approach for screening cardiotoxicity. The method was able to accurately assess the effects of different drugs on cardiac tissue, including their mode of action on ion channels. The results demonstrate the potential of this approach for improving preclinical cardiotoxicity screening.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Henry Sutanto
Summary: The activation and inactivation of atrial ion channels play a crucial role in maintaining the function of atrium. Disturbances in ion channels can lead to changes in the atrial action potential, but the effects might vary in different computational models.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Physics, Multidisciplinary
Jian Gao, Changgui Gu, Huijie Yang
Summary: This study successfully eliminated spiral waves in cardiac muscle through global pulse disturbance, reducing the frequency of cardiac muscle and returning the medium to normal oscillation state, thereby preventing ventricular tachycardia and ventricular fibrillation.
Article
Pharmacology & Pharmacy
Zhenzhen Yan, Ling Zhong, Wandi Zhu, Sookja Kim Chung, Panpan Hou
Summary: Cardiovascular disease (CVD) is the leading cause of disability and death worldwide, and cardiac ion channels play a crucial role in the formation of cardiac action potentials and the control of heartbeats. Chinese herbal remedies have shown promise in regulating cardiac ion channels and alleviating arrhythmia and CVD. This review discusses the role of cardiac ion channels, the efficacy of Chinese herbal compounds, and the potential for developing new anti-CVD drugs based on Chinese herbal medicines.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Mathematics, Applied
Shahrokh Shahi, Flavio H. Fenton, Elizabeth M. Cherry
Summary: This paper introduces an integrated architecture for predicting complex signals during cardiac arrhythmias using machine learning methods. Results show that the proposed approach outperforms other methods in predicting action potentials, with smaller mean absolute errors and less sensitivity to algorithmic parameter settings.
Article
Mathematics, Applied
Stephanie Dodson, Timothy J. Lewis
Summary: This article investigates the induced reflected waves when propagated action potentials in cardiac tissue interact with local heterogeneities, and their association with cardiac arrhythmias. By conducting direct numerical simulation and using continuation methods, the existence and stability of a one-dimensional spiral wave in a qualitative ionic model is studied to determine the influence of system parameters on reflection behavior. The results confirm and expand upon the hypothesis that the one-dimensional spiral is an unstable periodic orbit resulting from a global rearrangement of heteroclinic orbits, and identifies key parameters and physiological processes affecting reflection behavior.
SIAM JOURNAL ON APPLIED DYNAMICAL SYSTEMS
(2022)
Article
Chemistry, Medicinal
Ju Hee Kim, Hye Ryeong Cha, Eun Kyo Ha, Ji Hee Kwak, Hakjun Kim, Jeewon Shin, Hye Mi Jee, Man Yong Han
Summary: This study aimed to assess the association between first-generation H1-antihistamine use and cardiovascular events in a pediatric population. The findings showed an increased risk of cardiovascular events in children who were administered first-generation H1-antihistamines.
Article
Engineering, Biomedical
Viktor A. Balashov, Vasily S. Gorbunov, Konstantin G. Guria, Konstantin I. Agladze
ANNALS OF BIOMEDICAL ENGINEERING
(2020)
Article
Microscopy
Nobuhiro Morone, Eiji Usukura, Akihiro Narita, Jiro Usukura
Article
Cell Biology
Niall Buckley, Emanuele Panatta, Nobuhiro Morone, Masafumi Noguchi, Luca Scorrano, Richard A. Knight, Ivano Amelio, Gerry Melino
Article
Multidisciplinary Sciences
Ivano Amelio, Emanuele Panatta, Maria Victoria Niklison-Chirou, Joern R. Steinert, Massimiliano Agostini, Nobuhiro Morone, Richard A. Knight, Gerry Melino
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
A. D. Podgurskaya, M. M. Slotvitsky, V. A. Tsvelaya, S. R. Frolova, S. G. Romanova, V. A. Balashov, K. I. Agladze
Summary: Cyclophosphamide (CP), an anticancer drug, can cause cardiotoxicity by affecting the conduction properties and cytoskeleton structure of cardiomyocytes, potentially leading to arrhythmic effects in vivo.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Joanna L. Fox, Michelle A. Hughes, Xin Meng, Nikola A. Sarnowska, Ian R. Powley, Rebekah Jukes-Jones, David Dinsdale, Timothy J. Ragan, Louise Fairall, John W. R. Schwabe, Nobuhiro Morone, Kelvin Cain, Marion MacFarlane
Summary: Regulated cell death is essential in development and cellular homeostasis. The core FADD:Caspase-8 complex and its regulatory partners, such as the cell death inhibitor c-FLIP, play a critical role in coordinating cell fate. The recruitment of c-FLIPS into this complex inhibits Caspase-8 activity by altering its structure.
NATURE COMMUNICATIONS
(2021)
Article
Cell & Tissue Engineering
Shingo Io, Mio Kabata, Yoshiki Iemura, Katsunori Semi, Nobuhiro Morone, Atsutaka Minagawa, Bo Wang, Ikuhiro Okamoto, Tomonori Nakamura, Yoji Kojima, Chizuru Iwatani, Hideaki Tsuchiya, Belinda Kaswandy, Eiji Kondoh, Shin Kaneko, Knut Woltjen, Mitinori Saitou, Takuya Yamamoto, Masaki Mandai, Yasuhiro Takashima
Summary: The study demonstrates that naive human pluripotent stem cells can recapitulate trophoblast development, establishing an authentic paradigm for human trophoblast development. These findings provide valuable insights into the molecular mechanisms underlying trophoblast development and related diseases.
Article
Chemistry, Multidisciplinary
Yasushi Takemoto, Shin Kadota, Itsunari Minami, Shinya Otsuka, Satoshi Okuda, Masahiro Abo, Louvy Lynn Punzalan, Yan Shen, Yuji Shiba, Motonari Uesugi
Summary: The study elucidates the differential effects of KY02111 on Wnt and TGF beta signaling, and demonstrates how it disrupts the interaction between SQS and TMEM43 to recapitulate the molecular mechanism of ARVC.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Stefano Grosso, Alberto Marini, Katarina Gyuraszova, Johan Vande Voorde, Aristeidis Sfakianos, Gavin D. Garland, Angela Rubio Tenor, Ryan Mordue, Tanya Chernova, Nobu Morone, Marco Sereno, Claire P. Smith, Leah Officer, Pooyeh Farahmand, Claire Rooney, David Sumpton, Madhumita Das, Ana Teodosio, Catherine Ficken, Maria Guerra Martin, Ruth V. Spriggs, Xiao-Ming Sun, Martin Bushell, Owen J. Sansom, Daniel Murphy, Marion MacFarlane, John P. C. Le Quesne, Anne E. Willis
Summary: The study identifies mRNA translation dysregulation in malignant pleural mesothelioma (MpM) cell lines through polysome profiling, and highlights mTORC1 and 2 as potential pharmacological targets. This dysregulation leads to accelerated protein biosynthesis, abnormal mitochondrial morphology, increased oxygen consumption, and ultimately drives cell growth and disease progression. Inhibition of mRNA translation, especially through targeting mTORC1 and 2, has been shown to reverse these effects and inhibit malignant cell growth, providing a promising therapeutic option for patients with MpM.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Hideki Kobayashi, Shugo Tohyama, Hideaki Kanazawa, Hajime Ichimura, Shuji Chino, Yuki Tanaka, Yota Suzuki, Jian Zhao, Naoko Shiba, Shin Kadota, Kazumasa Narita, Takafumi Naito, Tatsuichiro Seto, Koichiro Kuwahara, Yuji Shiba, Keiichi Fukuda
Summary: Advancements in stem cell biology have allowed for cardiac regeneration through the use of human pluripotent stem cell-derived cardiomyocytes (PSC-CMs). However, current transplantation methods involving PSC-CMs have limitations such as poor engraftment and the need for invasive procedures. This study investigated the feasibility of intracoronary transplantation of PSC-CMs in cynomolgus monkeys. The results showed low efficacy of this approach, with no coronary embolism or graft survival, and scar formation due to cardiac ischemic injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Aygul Nizamieva, Sheida Frolova, Mihail Slotvitsky, Sandaara Kovalenko, Valeriya Tsvelaya, Anna Nikitina, David Sergeevichev, Konstantin Agladze
Summary: This study reveals that botulinum toxin A not only inhibits the nervous system of the heart, but also has a direct effect on heart tissue, contributing to its antiarrhythmic effect. The combination with chitosan enhances the inhibitory effect of botulinum toxin A and reduces its effective dose.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Mikhail Slotvitsky, Andrey Berezhnoy, Serafima Scherbina, Beatrisa Rimskaya, Valerya Tsvelaya, Victor Balashov, Anton E. Efimov, Igor Agapov, Konstantin Agladze
Summary: This article explores the use of polymer kernels to influence the survival and electrophysiological coupling of induced pluripotent stem cells (iPSCs) after intramyocardial injection. The polymer kernels can adsorb to cells and provide support for cell morphology and cytoskeleton organization. By using optical excitation markers, it was shown that adsorption of polymer kernels can restore the excitability of suspended cardiomyocytes and increase the likelihood of stable electrophysiological coupling in vitro. These findings demonstrate the potential of smart biomaterials in controlling the engraftment process of injected cells.
Article
Cell & Tissue Engineering
Silvia Marchiano, Kenta Nakamura, Hans Reinecke, Lauren Neidig, Michael Lai, Shin Kadota, Filippo Perbellini, Xiulan Yang, Jordan M. Klaiman, Leslie P. Blakely, Elaheh Karbassi, Paul A. Fields, Aidan M. Fenix, Kevin M. Beussman, Anu Jayabalu, Faith A. Kalucki, Jennifer C. Potter, Akiko Futakuchi-Tsuchida, Gerhard J. Weber, Sarah Dupras, Hiroshi Tsuchida, Lil Pabon, Lili Wang, Bjorn C. Knollmann, Steven Kattman, R. Scott Thies, Nathan Sniadecki, W. Robb MacLellan, Alessandro Bertero, Charles E. Murry
Summary: Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show promise as a cell-based therapy for myocardial infarction, but transient ventricular arrhythmias (EA) have limited their clinical applications. Researchers found that the pacemaker-like activity of hPSC-CMs contributes to EA due to their developmental immaturity. By manipulating ion channels and transplanting engineered cell lines into uninjured porcine hearts, they successfully created hPSC-CMs without automaticity that can contract with external stimulation and engraft with host cardiomyocytes without causing sustained EAs.
Article
Mathematics, Applied
A. A. Nizamieva, I. Y. Kalita, M. M. Slotvitsky, A. K. Berezhnoy, N. S. Shubina, S. R. Frolova, V. A. Tsvelaya, K. I. Agladze
Summary: New approaches to suppressing cardiac arrhythmias require an understanding of spiral wave dynamics. Azobenzene derivatives, such as AzoTAB, can noninvasively control cell excitability through light. Experimental and computer modeling studies show that light control can effectively terminate spiral waves and the direction of termination depends on the observation time and intercellular connections.
Article
Cell & Tissue Engineering
Yuki Tanaka, Shin Kadota, Jian Zhao, Hideki Kobayashi, Satomi Okano, Masaki Izumi, Yusuke Honda, Hajime Ichimura, Naoko Shiba, Takeshi Uemura, Yuko Wada, Shinichiro Chuma, Tsutomu Nakada, Shugo Tohyama, Keiichi Fukuda, Mitsuhiko Yamada, Tatsuichiro Seto, Koichiro Kuwahara, Yuji Shiba
Summary: Long-term cultured mature hiPSC-CMs promote engraftment, maturation, and angiogenesis post-transplantation in infarcted rat hearts, enhancing the therapeutic potential of hiPSC-CMs.
STEM CELL RESEARCH & THERAPY
(2023)