Article
Nutrition & Dietetics
Dahyun Park, Juhee Lee, Clara Yongjoo Park, Min-Jeong Shin
Summary: This study found that low levels of vitamin D (<20 ng/mL) were associated with a higher risk of mortality in Korean adults, especially in men and those with hypertension, suggesting an impact of vitamin D on mortality risk.
Review
Biochemistry & Molecular Biology
Armin Zittermann, Christian Trummer, Verena Theiler-Schwetz, Elisabeth Lerchbaum, Winfried Maerz, Stefan Pilz
Summary: Research on the potential impact of vitamin D on cardiovascular disease risk has yielded contradictory results, with no strong evidence for its beneficial effects. Further studies are needed to determine if specific subgroups may benefit from vitamin D supplementation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Pollyanna Patriota, Idris Guessous, Serge Rezzi, Pedro Marques-Vidal
Summary: This prospective population-based study found that vitamin D levels were inversely associated with cardiovascular disease (CVD) events, but not with CVD or overall mortality.
Review
Urology & Nephrology
Marc G. Vervloet, Simon Hsu, Ian H. de Boer
Summary: The efficacy of vitamin D supplements in patients with chronic kidney disease is controversial. Observational studies have shown that higher circulating concentrations of 25hydroxyvitamin D are associated with improved health outcomes. However, recent large clinical trials have contradicted these findings.
KIDNEY INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Adriana J. van Ballegooijen, Joline W. J. Beulens, Lyanne M. Kieneker, Martin H. de Borst, Ron T. Gansevoort, Ido P. Kema, Leon J. Schurgers, Marc G. Vervloet, Stephan J. L. Bakker
Summary: Combined low vitamin D and K status are associated with increased all-cause mortality risk and possibly with cardiovascular mortality and cardiovascular events compared with adequate vitamin D and K status.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Man Hung, Wendy C. Birmingham, Monica Ocampo, Amir Mohajeri
Summary: Cardiovascular diseases (CVD) are the leading cause of death in the United States. This study aimed to determine the association between reported CVD and serum 25-hydroxyvitamin D [25(OH)D]. Using data from the National Health and Nutrition Examination Survey, the study found that deficiency and insufficiency of 25(OH)D were associated with CVD, while adequacy of 25(OH)D was not. Healthcare professionals may consider vitamin D supplementation to improve cardiovascular health in adults for CVD prevention.
Review
Nutrition & Dietetics
Yi-Yan Pei, Yu Zhang, Xing-Chen Peng, Zhe-Ran Liu, Ping Xu, Fang Fang
Summary: This systematic review and meta-analysis found that vitamin D supplementation was not associated with a lower risk of cardiovascular events or mortality. These findings do not support the routine use of vitamin D supplementation.
Article
Public, Environmental & Occupational Health
Akiko Nanri, Tetsuya Mizoue, Atsushi Goto, Mitsuhiko Noda, Norie Sawada, Shoichiro Tsugane
Summary: This study found inconsistent associations between vitamin D intake and all-cause mortality as well as cause-specific mortality. Among Japanese adults, higher vitamin D intake was associated with a lower risk of all-cause mortality, particularly in individuals with low sunlight exposure. Higher intake of vitamin D was also linked to reduced mortality risk for individuals with hypertension and higher calcium intake.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Lei Dai, Man Liu, Liangkai Chen
Summary: Vitamin D insufficiency or deficiency is common in patients with cardiovascular disease (CVD). Increasing levels of serum 25(OH)D are independently associated with a decreased risk of all-cause and cause-specific mortality among individuals with existing CVD, particularly beneficial for those with vitamin D deficiency.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Filippo Pirrotta, Guido Cavati, Christian Mingiano, Daniela Merlotti, Ranuccio Nuti, Luigi Gennari, Alberto Palazzuoli
Summary: Vitamin D is important for bone metabolism and plays a role in regulating calcium and phosphate levels in the body. It has been found to have an impact on cardiovascular disease, with evidence of vitamin D receptors in the cardiovascular system. This study examined the relationship between vitamin D levels and hospitalization for heart failure, overall mortality, and cardiovascular mortality.
Article
Medicine, General & Internal
Kyoung Jin Kim, Jimi Choi, Kyeong Jin Kim, Nam Hoon Kim, Sin Gon Kim
Summary: This study examined the effects of calcium supplementation with or without vitamin D on all-cause and cause-specific mortalities in a large cohort. The results showed that calcium supplementation alone did not affect all-cause mortality, but the combination of calcium and vitamin D reduced the risk of all-cause mortality, especially cardiovascular disease-associated mortality.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ben Hu, Jian Chen, Yihang Shi, Linlin Hou
Summary: This study aimed to investigate the association between serum 25(OH)D levels and the risk of all-cause mortality in patients with prior cardiovascular disease. The results showed that higher serum 25(OH)D levels were associated with a lower risk of all-cause mortality, but the relationship followed an L-shaped pattern. The findings suggest that increasing serum 25(OH)D levels may not provide further reduction in the risk of all-cause mortality.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Medicine, General & Internal
Wei Luo, Dan Xu, Jin Zhang, Yao Zhou, Qin Yang, Qiuju Lv, Zhen Qu
Summary: This study found that a decreased level of serum 25-hydroxyvitamin D (25-OHD) is associated with an increased risk of cardiovascular disease (CVD).
POSTGRADUATE MEDICINE
(2023)
Article
Nutrition & Dietetics
M. Kyla Shea, Kathryn Barger, Sarah L. Booth, Jifan Wang, Harold Feldman, Raymond R. Townsend, Jing Chen, John Flack, Jiang He, Bernard G. Jaar, Mayank Kansal, Sylvia E. Rosas, Daniel E. Weiner
Summary: The study found that individuals with better vitamin K status in chronic kidney disease have a lower risk of all-cause mortality, but there is no significant difference in the risk of atherosclerotic cardiovascular disease events.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Oktay Tutarel, Lucia Baris, Werner Budts, Mohamad Gamal Abd-El Aziz, Csilla Liptai, David Majdalany, Silvana Jovanova, Alexandra Frogoudaki, Heidi M. Connolly, Mark R. Johnson, Aldo P. Maggioni, Roger Hall, Jolien W. Roos-Hesselink
Summary: The study found that women with an sRV generally tolerated pregnancy well with favorable outcomes for both mother and fetus, with heart failure and arrhythmias being the most common adverse cardiac events. Pre-pregnancy signs of heart failure and sRV ejection fraction <40% were predictors for major adverse cardiac events. There were no significant differences between women with CCTGA and TGA.
Article
Medicine, General & Internal
Peter W. Horby, Guilherme Pessoa-Amorim, Natalie Staplin, Jonathan R. Emberson, Mark Campbell, Enti Spata, Leon Peto, Nigel J. Brunskill, Simon Tiberi, Victor Chew, Thomas Brown, Hasan Tahir, Beate Ebert, David Chadwick, Tony Whitehouse, Rahuldeb Sarkar, Clive Graham, J. Kenneth Baillie, Buddha Basnyat, Maya H. Buch, Lucy C. Chappell, Jeremy Day, Saul N. Faust, Raph L. Hamers, Thomas Jaki, Edmund Juszczak, Katie Jeffery, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Marion Mafham, Richard Haynes, Martin J. Landray
Summary: In patients hospitalized with COVID-19, aspirin was not associated with reductions in 28-day mortality or in the risk of progressing to invasive mechanical ventilation or death, but was associated with a small increase in the rate of being discharged alive within 28 days.
Article
Medicine, General & Internal
Fiona Bragg, Eirini Trichia, Diego Aguilar-Ramirez, Jelena Besevic, Sarah Lewington, Jonathan Emberson
Summary: This study found that metabolic biomarkers were independently associated with the risk of T2D, and further addition of metabolic biomarker principal components improved the prediction of T2D risk.
Article
Cardiac & Cardiovascular Systems
Yohann Bohbot, Gilbert Habib, Cecile Laroche, Elisabeth Stohr, Catherine Chirouze, Marta Hernandez-Meneses, Maria Melissopoulou, Bulent Mutlu, Valentina Scheggi, Luisa Branco, Carmen Olmos, Graciela Reyes, Michal Pazdernik, Bernard Iung, Rouguiatou Sow, Maja Mirocevic, Patrizio Lancellotti, Christophe Tribouilloy
Summary: The study found that patients with left-sided infective endocarditis complicated by congestive heart failure tend to be older, have more comorbidities, and more severe valve damage, leading to significantly higher 30-day and 1-year mortality rates. Early surgery is strongly associated with lower mortality but is only performed on approximately half of these patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Transplantation
William G. Herrington, Christoph Wanner, Jennifer B. Green, Sibylle J. Hauske, Parminder Judge, Kaitlin J. Mayne, Sarah Y. A. Ng, Emily Sammons, Doreen Zhu, Natalie Staplin, David Preiss, Will Stevens, Karl Wallendszus, Rejive Dayanandan, Carol Knott, Michael Hill, Jonathan Emberson, Susanne Brenner, Vladimir Cejka, Alfred K. Cheung, Zhihong Liu, Jing Li, Peiling Chen, Laiseong Hooi, Wen Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Cherney, Roberto Pontremoli, Aldo Pietro Maggioni, Shinya Goto, Aiko Tomita, Rajat Deo, Katherine Tuttle, Jens Eilbracht, Stefan Hantel, Mark Hopley, Martin J. Landray, Colin Baigent, Richard Haynes
Summary: The EMPA-KIDNEY trial aims to evaluate the effects of empagliflozin on the risk of kidney disease progression or cardiovascular death in patients with chronic kidney disease. The trial includes a widely generalizable population of CKD patients and uses a streamlined design with minimal data collection. Results are anticipated in 2022.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Letter
Public, Environmental & Occupational Health
Jesus Alegre-Diaz, Louisa G. Friedrichs, Raul Ramirez-Reyes, Rachel Wade, Fiona Bragg, William G. Herrington, Robert Clarke, Richard Peto, Rory Collins, Pablo Kuri-Morales, Jonathan R. Emberson, Roberto Tapia-Conyer
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Peripheral Vascular Disease
Natalie Staplin, William G. Herrington, Federico Murgia, Maysson Ibrahim, Katherine R. Bull, Parminder K. Judge, Sarah Y. A. Ng, Michael Turner, Doreen Zhu, Jonathan Emberson, Martin J. Landray, Colin Baigent, Richard Haynes, Jemma C. Hopewell
Summary: The study findings provide genetic evidence supporting the causal relationship between blood pressure differences and decreased kidney function, glomerular hyperfiltration, and albuminuria. This conclusion is important for understanding the association between blood pressure and kidney diseases.
Article
Medicine, General & Internal
Alex Pitcher, Enti Spata, Jonathan Emberson, Kelly Davies, Heather Halls, Lisa Holland, Kate Wilson, Christina Reith, Anne H. Child, Tim Clayton, Matthew Dodd, Marcus Flather, Xu Yu Jin, George Sandor, Maarten Groenink, Barbara Mulder, Julie De Backer, Arturo Evangelista, Alberto Forteza, Gisela Teixido-Tura, Catherine Boileau, Guillaume Jondeau, Olivier Milleron, Ronald Lacro, Lynn A. Sleeper, Hsin-Hui Chiu, Mei-Hwan Wu, Stefan Neubauer, Hugh Watkins, Hal Dietz, Colin Baigent
Summary: In patients with Marfan syndrome, ARBs reduce the rate of increase in the aortic root Z score, including among those taking beta blockers. The effects of beta blockers are similar to those of ARBs. Combination therapy with ARBs and beta blockers provides a more significant reduction in the rate of aortic enlargement than either treatment alone.
Article
Cardiac & Cardiovascular Systems
Zachary I. Whinnett, Matthew J. Shun-Shin, Mark Tanner, Paul Foley, Badri Chandrasekaran, Philip Moore, Shaumik Adhya, Norman Qureshi, Amal Muthumala, Rebecca Lane, Aldo Rinaldi, Sharad Agarwal, Francisco Leyva, Jonathan Behar, Sukh Bassi, Andre Ng, Paul Scott, Rachana Prasad, Jon Swinburn, Joseph Tomson, Amarjit Sethi, Jaymin Shah, Phang Boon Lim, Andreas Kyriacou, Dewi Thomas, Jenny Chuen, Ravi Kamdar, Prapa Kanagaratnam, Myril Mariveles, Leah Burden, Katherine March, James P. Howard, Ahran Arnold, Pugazhendhi Vijayaraman, Berthold Stegemann, Nicholas Johnson, Emanuela Falaschetti, Darrel P. Francis, John G. F. Cleland, Daniel Keene
Summary: The study evaluated the effects of optimized His bundle pacing compared to no-pacing in patients with heart failure. It was found that His bundle pacing significantly improved quality of life and was preferred by the majority of patients. However, it did not show any significant changes in peak oxygen uptake or left ventricular ejection fraction.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
William G. Herrington, Natalie Staplin, Christoph Wanner, Jennifer B. Green, Sibylle J. Hauske, Jonathan R. Emberson, David Preiss, Parminder Judge, Kaitlin J. Mayne, Sarah Y. A. Ng, Emily Sammons, Doreen Zhu, Michael Hill, Will Stevens, Karl Wallendszus, Susanne Brenner, Alfred K. Cheung, Zhi-Hong Liu, Jing Li, Lai Seong Hooi, Wen Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Cherney, Aldo P. Maggioni, Roberto Pontremoli, Rajat Deo, Shinya Goto, Xavier Rossello, Katherine R. Tuttle, Dominik Steubl, Michaela Petrini, Dan Massey, Jens Eilbracht, Martina Brueckmann, Martin J. Landray, Colin Baigent, Richard Haynes
Summary: Empagliflozin therapy reduces the risk of disease progression or cardiovascular death in patients with chronic kidney disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Robert A. Byrne, Stephen Fremes, Davide Capodanno, Martin Czerny, Torsten Doenst, Jonathan R. Emberson, Volkmar Falk, Mario Gaudino, John J. Mcmurray, Roxana Mehran, Milan Milojevic, Miguel Sousa Uva
Summary: In October 2021, the ESC and EACTS established a task force to review the 2018 guidelines on myocardial revascularization for patients with LM disease. The task force suggested updated recommendations for revascularization modality, stating that both CABG and PCI are clinically reasonable options for stable patients with LM disease. The task force also acknowledged knowledge gaps and emphasized the need for more data.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Rohan Wijesurendra, Rebecca Sardell, Raja Jayaram, Nathan Samuel, Zhengming Chen, Natalie Staplin, Rory Collins, Zhe Zheng, Richard Haynes, Michael Hill, Jonathan Emberson, Barbara Casadei
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Peter W. Horby, Natalie Staplin, Leon Peto, Jonathan R. Emberson, Mark Campbell, Guilherme Pessoa-Amorim, Buddha Basnyat, Louise Thwaites, Rogier van Doorn, Raph L. Hamers, Jeremy Nel, John Amuasi, Manisha Rawal, Dipansu Ghosh, Jonathan Douse, Fergus Hamilton, Anthony Kerry, Pinky Thu-Ta, John Widdrington, Christopher A. Green, Purav Desai, Richard Stewart, Nguyen Thanh Phong, J. Kenneth Baillie, Maya Buch, Saul N. Faust, Thomas Jaki, Edmund Juszczak, Katie Jeffery, Marian Knight, Wei Shen Lim, Alan Montgomery, Aparna Mukherjee, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Marion Mafham, Richard Haynes, Martin J. Landray
Summary: Empagliflozin is not associated with reduced mortality, hospital stay, or progression to invasive mechanical ventilation or death in hospitalized adults with COVID-19.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Thomas Addey, Jesus Alegre-Diaz, Fiona Bragg, Eirini Trichia, Rachel Wade, Rogelio Santacruz-Benitez, Raul Ramirez-Reyes, Adrian Garcilazo-Avila, Carlos Gonzales-Carballo, Omar Yaxmehen Bello-Chavolla, Neftali Eduardo Antonio-Villa, Diego Aguilar-Ramirez, Louisa Gnatiuc Friedrichs, Sarah Lewington, Richard Peto, Rory Collins, Jaime Berumen, Jonathan R. Emberson, Pablo Kuri-Morales, Roberto Tapia-Conyer
Summary: There are marked educational inequalities in premature adult mortality in this Mexican population, which are largely accounted for by lifestyle and related risk factors. Effective interventions targeting these risk factors could reduce inequalities and have a significant impact on premature mortality.
LANCET PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Peter W. Horby, Marion Mafham, Leon Peto, Mark Campbell, Guilherme Pessoa-Amorim, Enti Spata, Natalie Staplin, Jonathan R. Emberson, Benjamin Prudon, Paul Hine, Thomas Brown, Christopher A. Green, Rahuldeb Sarkar, Purav Desai, Bryan Yates, Tom Bewick, Simon Tiberi, Tim Felton, J. Kenneth Baillie, Maya H. Bitch, Lucy C. Chappell, Saul N. Faust, Thomas Jaki, Katie Jeffery, Edmund Juszczak, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, David M. Weinreich, Richard Haynes, Martin J. Landray
Summary: This study evaluated the efficacy and safety of the combination therapy of casirivimab and imdevimab in patients hospitalized with COVID-19. The results showed that this combination therapy reduced the 28-day mortality rate in patients without detectable antibodies to SARS-CoV-2 infection at baseline, but not in those with detectable antibodies.