Review
Immunology
Cong Chen, Jie Wang, Chao Liu, Jun Hu
Summary: Acute myocardial infarction (MI) is a common and fatal global disease, and heart failure (HF) remains a significant risk despite standard treatment. Cardiac resident macrophages (cMacs) have emerged as key regulators in the pathophysiology of post-MI progression, regulating aspects such as immune cell recruitment, cell clearance, fibrosis, and energy metabolism. Targeting cMacs presents a promising therapeutic strategy, including using nanocarriers to deliver drugs or introducing exogenous protective cMacs through cell therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sean Coffey, Parul Dixit, Eng Leng Saw, Aram A. Babakr, Isabelle van Hout, Ivor F. Galvin, Pankaj Saxena, Richard W. Bunton, Philip J. Davis, Regis R. Lamberts, Rajesh Katare, Michael J. A. Williams
Summary: The study examined whether thiamine would improve Cardiac Progenitor Cell (CPC) function in humans, but found that it did not improve CPC proliferation ability in patients undergoing coronary artery bypass surgery (CABG). However, thiamine did increase the proportion of CD34(-)/CD105(+) cells in isolated CPCs.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xavier Revelo, Preethy Parthiban, Chen Chen, Fanta Barrow, Gavin Fredrickson, Haiguang Wang, Dogacan Yucel, Adam Herman, Jop H. van Berlo
Summary: This study assessed the role of cardiac immune cells in the early hypertrophy response to cardiac pressure overload and found that cardiac resident macrophages play a key role in stimulating angiogenesis and inhibiting fibrosis in response to cardiac pressure overload.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Xi Lou, Yawen Tang, Lei Ye, Danielle Pretorius, Vladimir G. Fast, Asher M. Kahn-Krell, Jue Zhang, Jianhua Zhang, Aijun Qiao, Gangjian Qin, Timothy Kamp, James A. Thomson, Jianyi Zhang
Summary: The study demonstrates that human cardiac muscle patches containing three types of cardiac cells derived from human pluripotent stem cells significantly improved cardiac function, reduced infarct size, and promoted cardiac maturation in a pig model of myocardial infarction. The inclusion of cardiac fibroblasts in the cardiac patches enhanced the maturity and function of cardiac muscle cells. Transplantation of cardiac patches with cardiac fibroblasts resulted in better cardiac recovery and engraftment compared to patches without fibroblasts.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Elisa Rauseo, Cristian Izquierdo Morcillo, Zahra Raisi-Estabragh, Polyxeni Gkontra, Nay Aung, Karim Lekadir, Steffen E. Petersen
Summary: This study demonstrated the potential value of CMR radiomics in detecting subtle cardiac changes associated with chronic ischemic processes involving the brain and heart. Radiomics features provided significantly better disease discrimination than conventional indices, showing the potential to improve our understanding of complex mechanisms behind brain-heart interactions during ischemia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Engineering, Biomedical
Ian L. Chin, Sebastian E. Amos, Ji Hoon Jeong, Livia Hool, Yongsung Hwang, Yu Suk Choi
Summary: In this study, the authors investigated cardiomyocyte mechanosensation in a three-dimensional (3D) context. They found that cardiomyocytes had limited ability to adapt their volume to increasing substrate stiffness in a stiffness gradient GelMA hydrogel. The expression of mechanomarkers was better correlated with cell and nuclear volume than substrate stiffness. Furthermore, when cultured as spheroids, cardiomyocytes showed sensitivity to stiffness cues and exhibited different morphologies compared to individually cultured cells. These findings suggest that cardiac cell volume adaptation may be enhanced by cell-cell interactions.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
David Schumacher, Adelina Curaj, Sakine Simsekyilmaz, Andreas Schober, Elisa A. Liehn, Sebastian F. Mause
Summary: The study found that genetic depletion of miR155 in a dyslipidemic mouse model of myocardial infarction does not reduce infarction size and consecutive heart failure, but it does decrease myofibroblast density in the post-ischemic scar.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Birgit Rasmussen, Sasja Jul Hakonsen, Bente Toft
Summary: Cardiac rehabilitation is important in the treatment of cardiovascular heart disease, but many patients do not enrol. This scoping review aims to evaluate studies reporting on face-to-face interventions to encourage patients to enrol in cardiac rehabilitation. The findings will be summarized to facilitate the integration of diverse evidence.
Article
Cardiac & Cardiovascular Systems
Andrew R. Kompa, David W. Greening, Anne M. Kong, Paul J. McMillan, Haoyun Fang, Ritika Saxena, Raymond C. B. Wong, Jarmon G. Lees, Priyadharshini Sivakumaran, Andrew E. Newcomb, Bakhos A. Tannous, Cameron Kos, Lina Mariana, Thomas Loudovaris, Derek J. Hausenloy, Shiang Y. Lim
Summary: Subcutaneous implantation of TheraCyte devices containing the secretome of human cardiac stem cells attenuated adverse cardiac remodelling and preserved cardiac function following myocardial infarction. The secretome-based therapy led to reduced fibrosis, increased myocardial vascular density, and improved cardiac function.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jonas Silverdal, Entela Bollano, Josefin Henrysson, Carmen Basic, Michael Fu, Helen Sjoland
Summary: Patients with recent-onset non-ischaemic heart failure (HFrEF) responded better to guideline-directed medical treatment (GDMT) compared to those with ischaemic heart failure (IHF). There is a reported lack of diagnostic work-up for ischaemic heart disease (IHD) in HF patients.
Article
Multidisciplinary Sciences
Al Shaimaa Hasan, Lan Luo, Satoko Baba, Tao-Sheng Li
Summary: This study found that estrogen can increase the yield of cardiac stem cells and reverse the quality impairment caused by estrogen deficiency. The research also showed that estrogen can enhance the proliferative activity of stem cells, improve telomerase activity, and reduce DNA damage.
Article
Multidisciplinary Sciences
Aubin Michalon, Andreas Hagenbuch, Christian Huy, Evita Varela, Benoit Combaluzier, Thibaud Damy, Ole B. Suhr, Maria J. Saraiva, Christoph Hock, Roger M. Nitsch, Jan Grimm
Summary: Through analyzing memory B cell repertoires of healthy elderly, researchers developed a selective human antibody that removes cardiac amyloid by recruiting phagocytic immune cells.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Diogo Santos-Ferreira, Silvia O. Diaz, Joao Pedro Ferreira, Nicolas Girerd, Pierpaolo Pellicori, Beatrice Mariottoni, Franco Cosmi, Mark Hazebroek, Job A. J. Verdonschot, Joe Cuthbert, Johannes Petutschnigg, Stephane Heymans, Jan A. Staessen, Burkert Pieske, Frank Edelmann, Andrew L. Clark, Patrick Rossignol, Ricardo Fontes-Carvalho, John G. F. Cleland, Faiez Zannad
Summary: The aim of this study is to characterize the clinical and proteomic profiles of patients at risk of developing heart failure with coronary artery disease or prior myocardial infarction. The results showed that patients with coronary artery disease or prior myocardial infarction had different proteomic profiles regarding inflammatory, immunological, and collagen catabolic processes.
Article
Cardiac & Cardiovascular Systems
Amil. M. M. Shah, Brian Claggett, Narayana Prasad, Guichu Li, Mayra Volquez, Karola Jering, Maja Cikes, Attila Kovacs, Wilfried Mullens, Jose C. Nicolau, Lars Kober, Peter Van der Meer, Pardeep. S. S. Jhund, Ghionul Ibram, Martin Lefkowitz, Yinong Zhou, Scott. D. D. Solomon, Marc A. Pfeffer
Summary: This study compared the effects of sacubitril/valsartan and ramipril on left ventricular function and adverse remodeling after acute myocardial infarction (AMI). The results showed that patients randomized to sacubitril/valsartan had better improvements in filling pressure, left ventricular volume changes, and other aspects compared to those randomized to ramipril.
Article
Cardiac & Cardiovascular Systems
Elric Zweck, Maximilian Karschnia, Daniel Scheiber, Harald Heidecke, Ralf Dechend, Carmen Barthuber, Sina Kaufmann, Malte Kelm, Michael Roden, Ralf Westenfeld, Julia Szendroedi, Fritz Boege
Summary: GPCR autoantibodies are significantly altered in non-ischaemic heart failure (HF), but they are poorly correlated or even inversely correlated with haemodynamic, metabolic, and functional markers of disease severity, myocardial histology, and myocardial mitochondrial efficiency. These observations do not suggest a specific cardio-pathogenic role of GPCR autoantibodies in non-ischaemic HF, and further investigations are needed before specific therapies targeting GPCR autoantibodies can be clinically tested.
Article
Cardiac & Cardiovascular Systems
Erik Beckmann, Andreas Martens, Tim Kaufeld, Ruslan Natanov, Heike Krueger, Axel Haverich, Malakh Shrestha
Summary: Total aortic arch replacement using the frozen elephant trunk (FET) technique carries significantly higher perioperative morbidity and mortality risks in septuagenarians compared to younger patients. Long-term survival is notably compromised in older patients. Thorough patient selection and optimization of perioperative management are recommended to improve outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Maximilian Pichlmaier, Joscha Buech, Nikolaos Tsilimparis, Thomas G. Fabry, Dominik Joskowiak, Saad Rustum, Andreas Martens, Christian Hagl, Sven Peterss
Summary: The SAVSTEB technique simplifies the reattachment of the supraaortic vessels in aortic arch surgery and has shown to be a safe and effective method in the short and intermediate term. However, vertebral overstenting remains a critical technical issue.
ANNALS OF THORACIC SURGERY
(2022)
Article
Chemistry, Analytical
Michael Pflaum, Julia Dahlmann, Lena Engels, Hossein Naghilouy-Hidaji, Denise Adam, Janina Zoellner, Annette Otto, Sabrina Schmeckebier, Ulrich Martin, Axel Haverich, Ruth Olmer, Bettina Wiegmann
Summary: The study demonstrated the potential therapeutic effect of iPSC-derived endothelial cells (ECs) in forming a continuous, non-thrombogenic, and non-inflammatory monolayer on blood-contacting surfaces of biohybrid lung (BHL). These specific ECs could reduce platelet adhesion and repopulate scratched areas, showing promise for BHL application.
Article
Cardiac & Cardiovascular Systems
Shekhar Saha, Dominik Joskowiak, Mateo Marin-Cuartas, Mahmoud Diab, Benedikt M. Schwaiger, Rodrigo Sandoval-Boburg, Aron-Frederik Popov, Carolyn Weber, Sam Varghese, Andreas Martens, Serghei Cebotari, Maximilian Scherner, Walter Eichinger, David Holzhey, Daniel-Sebastian Dohle, Thorsten Wahlers, Torsten Doenst, Martin Misfeld, Julinda Mehilli, Steffen Massberg, Christian Hagl
Summary: This study retrospectively analyzed 69 patients who underwent cardiac surgery due to TIE at 9 cardiac surgical departments across Germany. The main causative organisms for TIE were Enterococcus faecalis, coagulase-negative Staphylococcus spp., Methicillin-sensitive Staphylococcus aureus, and viridians group streptococci. The survival rates at 6 months and 1 year were found to be 68% and 53%, respectively.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Tomislav Cvitkovic, Dmitry Bobylev, Alexander Horke, Murat Avsar, Philipp Beerbaum, Andreas Martens, Dietmar Boethig, Elena Petena, Marcel Gutberlet, Frerk Hinnerk Beyer, Frank Wacker, Serghei Cebotari, Axel Haverich, Jens Vogel-Claussen, Samir Sarikouch, Christoph Czerner
Summary: This study compares the hemodynamic parameters of long-valved decellularized aortic homografts and patients who underwent valve-sparing aortic root replacement with healthy controls. The results show that the hemodynamic parameters of decellularized long aortic homografts are similar to those of healthy controls and patients who underwent valve-sparing aortic root replacement 2.5 years postoperatively.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Erik Beckmann, Andreas Martens, Tim Kaufeld, Ruslan Natanov, Heike Krueger, Linda Rudolph, Axel Haverich, Malakh Shrestha
Summary: Full root replacement does not increase the perioperative risk in patients who undergo frozen elephant trunk for acute aortic dissection. Careful patient selection is important for such complex procedures. Continuous myocardial perfusion can help reducing the risk for intraoperative complications during such complex operations.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Denisa Bojkova, Rui Costa, Philipp Reus, Marco Bechtel, Mark-Christian Jaboreck, Ruth Olmer, Ulrich Martin, Sandra Ciesek, Martin Michaelis, Jindrich Cinatl
Summary: SARS-CoV-2 infection induces a metabolic shift towards glycolysis in host cells, with the glycolysis inhibitor 2DG being developed for COVID-19 treatment. Enhanced levels of transketolase (TKT) in infected cells suggest a role for the non-oxidative PPP, supported by the TKT inhibitor BOT inhibiting SARS-CoV-2 replication and synergizing with 2DG. Metabolic drugs like BOT and 2DG may improve COVID-19 therapy outcomes by targeting both viral replication and immunopathology.
Article
Cardiac & Cardiovascular Systems
Erik Beckmann, Tim Kaufeld, Andreas Martens, Linda Rudolph, Heike Krueger, Ruslan Natanov, Axel Haverich, Malakh Lal Shrestha
Summary: Despite more concomitant total arch replacements in the redo group, early mortality was comparable in both groups. AVSRR can be performed in redo cardiac surgery without compromising the early postoperative outcome. Careful patient assessment and selection are crucial when considering the David procedure for patients with a history of previous cardiac surgery.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Medicine, Research & Experimental
Stephanie Wunderlich, Alexandra Haase, Sylvia Merkert, Kirsten Jahn, Maximillian Deest, Helge Frieling, Silke Glage, Wilhelm Korte, Andreas Martens, Andreas Kirschning, Andre Zeug, Evgeni Ponimaskin, Gudrun Goehring, Mania Ackermann, Nico Lachmann, Thomas Moritz, Robert Zweigerdt, Ulrich Martin
Summary: Drug-inducible suicide systems can help reduce the risk of drug-resistant subclones in hiPSC therapies, but rare drug-resistant subclones can still appear in monoallelic iCASP9 hiPSCs both in vitro and in vivo.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Article
Oncology
Uwe Bieri, Benedikt Kranzbuehler, Burkhardt Seifert, Birgit Maria Helmchen, Alexander Gu, Basil Kaufmann, Dejan Lavrek, Thomas Scherer, Marian S. Wettstein, Cedric Poyet, Thomas Hermanns
Summary: Patients with non-muscle invasive urothelial bladder cancer are at increased risk for a secondary upper-urinary-tract urothelial carcinoma. Routine upper-tract imaging surveillance during bladder cancer follow-up may not be useful in detecting these secondary cancers. Risk-adjusted follow-up strategies should be explored in the future.
Article
Cell Biology
Laura von Schledorn, David Puertollano Martin, Nicole Cleve, Janina Zoellner, Doris Roth, Ben Ole Staar, Jan Hegermann, Felix C. Ringshausen, Janna Nawroth, Ulrich Martin, Ruth Olmer
Summary: Primary ciliary dyskinesia (PCD) is a rare genetic disorder that affects the function of motile cilia in the respiratory tract, leading to chronic inflammation and lung damage. Current treatment options for PCD are only symptomatic, highlighting the need for curative therapies. In this study, researchers developed an in vitro model using human induced pluripotent stem cells (hiPSC) to recapitulate the diseased phenotype of PCD at the molecular, structural, and functional levels.
Article
Pharmacology & Pharmacy
Joerg Eiringhaus, Anna-Lena de Vries, Stephan Hohmann, Dietmar Boethig, Johanna Mueller-Leisse, Henrike A. K. Hillmann, Andreas Martens, Robert Zweigerdt, Annette Schrod, Ulrich Martin, David Duncker, Ina Gruh, Christian Veltmann
Summary: Computer-based analysis of long-term ECG monitoring in animal models is a time-consuming process due to the need for manual supervision for accurate arrhythmia detection. This study investigated the performance and feasibility of three ECG interval analysis approaches in detecting ventricular arrhythmias. Results showed that the combined attribute and pattern recognition analysis approach had higher accuracy in classifying detected events and accurately depicting arrhythmia burden. Additionally, this approach significantly reduced working time compared to manual supervision. Therefore, it is a valuable method for cost-effective and time-efficient analysis of large preclinical ECG datasets.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2023)
Article
Cell Biology
Ian O. Shum, Sylvia Merkert, Svitlana Malysheva, Kirsten Jahn, Nico Lachmann, Murielle Verboom, Helge Frieling, Michael Hallensleben, Ulrich Martin
Summary: Abnormalities during trophoblast development can lead to pregnancy-related complications, but the underlying mechanisms are established during the first trimester. Human pluripotent stem cell (hPSC) technology provides a renewable source of cells for studying these diseases. By optimizing the treatment protocol, we were able to generate trophoblast cells enriched for HLA-G(pos) EVT-like cells, which will aid in understanding placenta-related disorders and investigation of immune tolerance towards the fetus.
Review
Medicine, General & Internal
Florian Helms, Bastian Schmack, Alexander Weymann, Jasmin Sarah Hanke, Ruslan Natanov, Andreas Martens, Arjang Ruhparwar, Aron-Frederik Popov
Summary: Minimally invasive techniques in cardiovascular surgery have become increasingly important, expanding from coronary and mitral valve surgery to more complex operations such as ascending aorta replacements. Various techniques, including upper hemisternotomy and sternal sparing thoracotomy, have been established and reported. These techniques require high demands on patient selection, preoperative planning, and practical implementation.
MEDICINA-LITHUANIA
(2023)
Review
Oncology
Andreas Trojan, Basil Baettig, Meinrad Mannhart, Burkhardt Seifert, Mathis N. Brauchbar, Marco Egbring
Summary: The study compared the utilization of two versions of a mobile app for electronic monitoring of patient-reported outcomes, finding that the second version showed better results in terms of increased data entries and patient-doctor symptom review. Collaborative review of symptoms between patients and physicians appears to positively impact digital symptom data entries.
