Review
Cardiac & Cardiovascular Systems
Muzamil Khawaja, Hafeez Ul Hassan Virk, Dhrubajyoti Bandyopadhyay, Mario Rodriguez, Johao Escobar, Mahboob Alam, Hani Jneid, Chayakrit Krittanawong
Summary: For patients with a clinical indication for aortic valve replacement, they can choose surgical aortic valve replacement or Transcatheter Aortic Valve Implantation. The choice depends on factors such as age, life expectancy, comorbidities, frailty, and patient preference. However, there are controversies regarding the outcomes of TAVI, including death, stroke, and major cardiovascular events. We propose that a precision medicine approach should be emphasized in the selection and management of TAVI patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Medicine, General & Internal
Pier Pasquale Leone, Andrea Scotti, Edwin C. Ho, Manaf Assafin, James Doolittle, Mei Chau, Leandro Slipczuk, Matthew Levitus, Damiano Regazzoli, Antonio Mangieri, Azeem Latib
Summary: Transcatheter aortic valve implantation (TAVI) has emerged as a safe and effective alternative to surgical aortic valve replacement for severe aortic stenosis. This review focuses on commercially available TAVI devices and provides a guide for selecting the appropriate prosthesis based on patient-related factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Henning Rud Andersen
Summary: This story highlights the invention and struggles surrounding transcatheter aortic valve implantation (TAVI), showcasing the transformation of innovative technology from conception to commercialization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Daniela Geisler, Piotr Nikodem Rudzinski, Waseem Hasan, Martin Andreas, Ena Hasimbegovic, Christopher Adlbrecht, Bernhard Winkler, Gabriel Weiss, Andreas Strouhal, Georg Delle-Karth, Martin Grabenwoeger, Markus Mach
Summary: The study identified risk factors associated with higher one-year mortality following TF and TA TAVR, including cerebrovascular disease, home oxygen dependency, wheelchair dependency, periinterventional myocardial infarction, and postinterventional renal replacement therapy. It emphasizes the importance of precise preinterventional evaluation and highlights the subtle differences in baseline characteristics between the TF and TA cohorts and their impact on one-year mortality.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Valentino Bianco, Andreas Habertheuer, Arman Kilic, Edgar Aranda-Michel, Derek Serna-Gallegos, John Schindler, Dustin Kliner, Catalin Toma, Adrian Zalewski, Ibrahim Sultan
Summary: Unadjusted survival was significantly worse for the urgent cohort up to 1 year. This trend continued for 5-year survival, however, after risk adjustment there was no significant difference in survival between cohorts. Although urgent TAVR is associated with increased periprocedural risk due to more comorbid disease, outcomes and long-term survival are encouraging and support the consideration of urgent TAVR as a viable alternative for this patient population.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Gabriela Tirado-Conte, Carlos H. Salazar, Angela McInerney, Alejandro Cruz-Utrilla, Pilar Jimenez-Quevedo, Javier Cobiella, Nieves Gonzalo, Manuel Carnero, Pablo Salinas, Fernando Macaya, Luis C. Maroto, Isidre Vilacosta, Antonio Fernandez-Ortiz, Javier Escaned, Carlos Macaya, Luis Nombela-Franco
Summary: Thrombocytopenia is a common complication after TAVR, and its severity can predict clinical outcomes. This study found that a decrease in platelet count of more than 46% and a late nadir were associated with early mortality and higher two-year mortality. These findings highlight the importance of monitoring platelet levels in TAVR patients and may help guide treatment decisions.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Christian Basile, Costantino Mancusi, Anna Franzone, Marisa Avvedimento, Luca Bardi, Domenico Angellotti, Domenico Simone Castiello, Andrea Mariani, Rachele Manzo, Nicola De Luca, Plinio Cirillo, Giovanni De Simone, Giovanni Esposito
Summary: This study selected patients with comorbid arterial hypertension and severe aortic stenosis undergoing TAVI to evaluate the impact of ACEIs or ARBs on cardiovascular mortality. It found that treatment with ACEIs/ARBs was significantly associated with a lower risk of cardiovascular mortality after 2 years.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Vassili Panagides, Dimitri Kalavrouziotis, Eric Dumont, Robert Delarochelliere, Jean-Michel Paradis, Jules Mesnier, Siamak Mohammadi, Josep Rodes-Cabau
Summary: This study evaluated the safety of transcatheter aortic valve replacement (TAVR) via the transcarotid route through pre- and post-procedure carotid artery ultrasound assessment. The results showed that TC-TAVR was associated with a mild but significant increase in carotid flow velocities, without clinical events. Further studies are needed.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Pablo Solla-Suarez, Pablo Avanzas, Isaac Pascual, Manuel Bermudez-menendez de la Granda, Marcel Almendarez, Jose M. Arche-Coto, Daniel Hernandez-Vaquero, Rebeca Lorca, Eva Lopez-Alvarez, Rut Alvarez-Velasco, Carmen Moreno-Planillo, Cesar Moris de la Tassa, Jose Gutierrez-Rodriguez
Summary: The study aimed to determine the prevalence of frailty in patients undergoing aortic valve replacement, with 19.6% of patients identified as frail, associated with factors such as age, functional index, and atrial fibrillation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Markus Mach, Thomas Poschner, Waseem Hasan, Philipp Szalkiewicz, Martin Andreas, Bernhard Winkler, Stephanie Geisler, Daniela Geisler, Piotr N. Rudzinski, Victoria Watzal, Andreas Strouhal, Christopher Adlbrecht, Georg Delle-Karth, Martin Grabenwoeger
Summary: Arterial tortuosity is associated with increased risk of adverse clinical events after TF-TAVR. The IFT score is a valuable tool for predicting access and bleeding complications, providing risk stratification before the procedure.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Vassili Panagides, Dimitri Kalavrouziotis, Eric Dumont, Robert Delarochelliere, Jean-Michel Paradis, Jules Mesnier, Siamak Mohammadi, Josep Rodes-Cabau
Summary: This study found that cranial nerve injury (CNI) is a potential complication of TC-TAVR and it may have clinically important implications for patients' vocal function.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Henri Lu, David Rotzinger, Pierre Monney, Olivier Muller, Michael Egea, Matthieu Grange, Eric Eeckhout, Matthias Kirsch, Salah D. Qanadli
Summary: This study found that patients at high-risk for acute mesenteric ischemia (AMesI) had worse prognosis following transcatheter aortic valve implantation (TAVI). Mesenteric revascularization before TAVI interventions may be beneficial in these high-risk patients. These findings emphasize the clinical importance of identifying high-risk AMesI patients and suggest potential strategies for improving prognosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Christian Nitsche, Paul R. Scully, Kush P. Patel, Andreas A. Kammerlander, Matthias Koschutnik, Carolina Dona, Tim Wollenweber, Nida Ahmed, George D. Thornton, Andrew D. Kelion, Nikant Sabharwal, James D. Newton, Muhiddin Ozkor, Simon Kennon, Michael Mullen, Guy Lloyd, Marianna Fontana, Philip N. Hawkins, Francesca Pugliese, Leon J. Menezes, James C. Moon, Julia Mascherbauer, Thomas A. Treibel
Summary: This study compared clinical characteristics and outcomes of patients with concomitant severe aortic stenosis and cardiac amyloidosis (AS-CA) to those with lone AS. Results showed that AS-CA patients had worse clinical presentation and a trend towards worse prognosis, but transcatheter aortic valve replacement (TAVR) improved survival for both groups. The study also developed a clinical score to predict the presence of AS-CA in older patients with AS, suggesting that TAVR should not be withheld for this population.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kerstin Piayda, Katharina Hellhammer, Verena Veulemans, Shazia Afzal, Kathrin Klein, Nora Berisha, Pia Leuders, Ralf Erkens, Julian Kirchner, Houtan Heidari, Malte Kelm, Gerald Antoch, Tobias Zeus, Christine Quast
Summary: This study aimed to investigate the reliability between routinely used workflows for pre-procedural analysis. There was excellent correlation in the analysis of simple diameters and poor correlation in the assessment of more complex structures with impact on calculated valve size.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Alexander Kille, Kilian Franke, Noe Corpataux, Julia Hromek, Christian M. Valina, Franz-Josef Neumann, Dietmar Trenk, Thomas G. Nuehrenberg, Willibald Hochholzer
Summary: This study aimed to evaluate whether on-treatment platelet reactivity is a predictor for bleeding events after transcatheter aortic valve implantation (TAVI). The study found that low/normal/high on-clopidogrel platelet reactivity and use of oral anticoagulation were the strongest predictors for peri-interventional bleeding events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
G. Michael Deeb, Jeffrey J. Popma, Stanley J. Chetcuti, Steven J. Yakubov, Mubashir Mumtaz, Thomas G. Gleason, Mathew R. Williams, Hemal Gada, Jae K. Oh, Shuzhen Li, Michael J. Boulware, Arie Pieter Kappetein, Michael J. Reardon
ANNALS OF THORACIC SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Philippe Pibarot, Erwan Salaun, Abdellaziz Dahou, Eleonora Avenatti, Ezequiel Guzzetti, Mohamed-Salah Annabi, Oumhani Toubal, Mathieu Bernier, Jonathan Beaudoin, Geraldine Ong, Julien Ternacle, Laura Krapf, Vinod H. Thourani, Raj Makkar, Susheel K. Kodali, Mark Russo, Samir R. Kapadia, S. Chris Malaisrie, David J. Cohen, Jonathon Leipsic, Philipp Blanke, Mathew R. Williams, James M. McCabe, David L. Brown, Vasilis Babaliaros, Scott Goldman, Wilson Y. Szeto, Philippe Genereux, Ashish Pershad, Maria C. Alu, Ke Xu, Erin Rogers, John G. Webb, Craig R. Smith, Michael J. Mack, Martin B. Leon, Rebecca T. Hahn
Letter
Cardiac & Cardiovascular Systems
Ismail El-Hamamsy, Derek R. Brinster, Joseph J. DeRose, Leonard N. Girardi, Kazuhiro Hisamoto, Mohammed N. Imam, Shinobu Itagaki, Paul A. Kurlansky, Christopher Lau, Samantha Nemeth, Mathew Williams, Benjamin A. Youdelman, Hiroo Takayama
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Raj R. Makkar, Philipp Blanke, Jonathon Leipsic, Vinod Thourani, Tarun Chakravarty, David Brown, Alfredo Trento, Robert Guyton, Vasilis Babaliaros, Mathew Williams, Hasan Jilaihawi, Susheel Kodali, Isaac George, Michael Lu, James M. McCabe, John Friedman, Richard Smalling, Shing Chiu Wong, Shahram Yazdani, Deepak L. Bhatt, Jeroen Bax, Samir Kapadia, Howard C. Herrmann, Michael Mack, Martin B. Leon
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Immunology
Homam Ibrahim, Andras Perl, Deane Smith, Tyler Lewis, Zachary Kon, Ronald Goldenberg, Kinan Yarta, Cezar Staniloae, Mathew Williams
CLINICAL IMMUNOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Alan Vainrib, Daniele Massera, Mark Sherrid, Daniel G. Swistel, Daniel Bamira, Homam Ibrahim, Cezar Staniloae, Mathew R. Williams, Muhamed Saric
Summary: The article discusses the novel approach of using three-dimensional echocardiography to observe and treat obstructive heart valve disease, focusing on the visualization value of 3D TEE imaging of SAM. It provides step-by-step instructions for acquiring and optimizing imaging, and describes unique findings such as double-orifice LVOT, dolphin smile phenomenon, and delineation of SAM width.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Article
Cardiac & Cardiovascular Systems
Bahira Shahim, S. Chris Malaisrie, Isaac George, Vinod H. Thourani, Angelo B. Biviano, Mark J. Russo, David L. Brown, Vasilis Babaliaros, Robert A. Guyton, Susheel K. Kodali, Tamim M. Nazif, James M. McCabe, Mathew R. Williams, Philippe Genereux, Michael Lu, Xiao Yu, Maria C. Alu, John G. Webb, Michael J. Mack, Martin B. Leon, Ioanna Kosmidou
Summary: In low-risk patients with severe aortic stenosis treated with transcatheter (TAVR) or surgical aortic valve replacement (SAVR), the presence of preexisting atrial fibrillation or flutter (AF) was associated with a higher risk of composite outcome of death, stroke, or rehospitalization at 2 years, regardless of treatment modality.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Makoto Nakashima, Mathew Williams, Yuxin He, Run Du, Muhamed Saric, Cezar Staniloae, Michael Querijero, Illya Pushkar, Anna Kapitman, Hasan Jilaihawi
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Martin B. Leon, Michael J. Mack, Rebecca T. Hahn, Vinod H. Thourani, Raj Makkar, Susheel K. Kodali, Maria C. Alu, Mahesh V. Madhavan, Katherine H. Chau, Mark Russo, Samir R. Kapadia, S. Chris Malaisrie, David J. Cohen, Philipp Blanke, Jonathon A. Leipsic, Mathew R. Williams, James M. McCabe, David L. Brown, Vasilis Babaliaros, Scott Goldman, Howard C. Herrmann, Wilson Y. Szeto, Philippe Genereux, Ashish Pershad, Michael Lu, John G. Webb, Craig R. Smith, Philippe Pibarot
Summary: In low surgical risk patients with symptomatic severe aortic stenosis, the PARTNER 3 trial showed superiority of transcatheter aortic valve replacement (TAVR) over surgery for the primary endpoint at 1 year. However, at 2 years, differences in death and stroke between TAVR and surgery were no longer significant, and TAVR patients had an increased risk of valve thrombosis.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Daniel J. F. M. Thuijs, Piroze Davierwala, Milan Milojevic, Salil Deo, Thilo Noack, A. Pieter Kappetein, Patrick W. Serruys, Friedrich-Wilhelm Mohr, Marie-Claude Morice, Michael J. Mack, L. Elisabeth G. E. Stahle, Niels J. Verberkmoes, David R. Holmes, Stuart J. Head
Summary: The study found that patients who underwent multiple arterial grafts (MAG) in the SYNTAX study had a significantly lower all-cause death rate at the 12.6-year follow-up compared to those who received single arterial grafts (SAG).
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Patrick W. Serruys, Hideyuki Kawashima, Mattia Lunardi, Rutao Wang, Hironori Hara, Chao Gao, Scot Garg, Neil O'Leary, Joanna J. Wykrzykowska, Jan J. Piek, David R. Holmes, Marie-Claude Morice, Arie Pieter Kappetein, Thilo Noack, Piroze M. Davierwala, John A. Spertus, David J. Cohen, Yoshinobu Onuma
Summary: The aim of this study was to investigate the impact of patient-reported anginal status at 1 year following percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) on 10-year survival in patients with left main coronary artery disease (LMCAD) and/or three-vessel CAD (3VD). The study found that while angina at 1 year was associated with repeat revascularization at 5 years, it did not significantly increase 10-year mortality.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Song Li, Mark S. Slaughter, Shelley Hall, Erin Davis, Arie Pieter Kappetein, Alexandra Dedrick, Christopher T. Salerno, Francis D. Pagani, Claudius Mahr
Summary: Based on the quarterly reports from 2022, there seems to be no increase in mortality, stroke, pump thrombus, or device explant for patients supported by the HVAD system after the market withdrawal and recent device recalls.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Cezar Staniloae, Homam Ibrahim, Jorge Fuentes, Carlos Gonzales, Anna Kapitman, Samantha Vidal, Sonja Paschke, Kazuhiro Hisamoto, Hasan Jilaihawi, Mathew Williams
Summary: This study describes the use of orbital atherectomy to prepare iliofemoral vessels for large-bore access prior to transcatheter aortic valve replacement (TAVR), which is shown to be a safe and effective technique for facilitating TF-TAVR in patients with hostile peripheral anatomy.
JOURNAL OF INVASIVE CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Moritz C. Wyler von Ballmoos, Michael J. Reardon, Mathew R. Williams, Abeel A. Mangi, Neal S. Kleiman, Steven J. Yakubov, Daniel Watson, Susheel Kodali, Isaac George, Peter Tadros, George L. I. I. I. I. I. I. Zorn, John Brown, Robert Kipperman, Jae K. Oh, Hongyan Qiao, John K. Forrest
Summary: The study evaluated the clinical and hemodynamic performance of the Evolut PRO system at 3 years post TAVR, showing favorable outcomes with low mortality rates, excellent hemodynamics, and low prevalence of PVR.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Justyna Rzucidlo, Vita Jaspan, Darien Paone, Hasan Jilaihawi, Yuhe Xia, Anna Kapitman, Makoto Nakashima, Yuxin He, Homam Ibrahim, Illya Pushkar, Peter J. Neuburger, Muhamed Saric, Daniel Bamira, Sonja Paschke, Chloe Kalish, Cezar Staniloae, Binita Shah, Mathew Williams
Summary: This study focused on the long-term outcomes of patients with renal insufficiency after TAVR, showing that despite procedural optimization with transfemoral access and extremely low-contrast approach, these patients remain a challenging population with poor long-term outcomes.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2021)