期刊
EUROPEAN HEART JOURNAL
卷 32, 期 7, 页码 888-896出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehq479
关键词
Aortic stenosis; Glycophorin A; Intraleaflet haemorrhage; Neovascularization
资金
- Ministry of Health, Labour and Welfare (Tokyo, Japan)
Aims The haemorrhage in the plaque (intraplaque haemorrhage) plays a critical role in the progression of atherosclerosis. The purpose of this study is to clarify whether the haemorrhage in the aortic valve leaflet (intraleaflet haemorrhage) accelerates the progression of aortic valve stenosis (AS). Methods and results We examined specimens of aortic valve leaflets obtained from 36 patients who had undergone aortic valve replacement for degenerative AS and in whom echocardiographic data were available just before the operation and at least 180 days before the last study. The stenotic valves were examined by immunohistochemistry to detect intraleaflet haemorrhage with antibody against glycophorin A, an erythrocyte-specific protein. The progression of AS was assessed by annualized change in the aortic valve area (Delta AVA: cm(2)/year). The patients were divided into two groups, namely the rapid progression group (Delta AVA >= 0.1 cm(2)/year) and the slow progression group (Delta AVA >= 0.1 cm(2)/year), according to the reported average progression rate of AS. Intraleaflet haemorrhage was observed in 78 % of the specimens. Intraleaflet haemorrhage was associated with neovascularization and macrophage infiltration. The areas of intraleaflet haemorrhage and macrophage infiltration were greater in the rapid progression group than in the slow progression group. Multivariate analysis has shown that the area of intraleaflet haemorrhage was the sole independent factor that positively correlated with DAVA. Conclusions Intraleaflet haemorrhage was frequently observed in the valve leaflets of degenerative AS and associated with a rapid progression of Delta AVA.
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