Article
Geriatrics & Gerontology
Gabriela Cardenas-Fuentes, Camille Lassale, Miguel Angel Martinez-Gonzalez, Maria Grau, Jordi Salas-Salvado, Dolores Corella, Lluis Serra-Majem, Julia Warnberg, Jadwiga Konieczna, Ramon Estruch, Xavier Pinto, J. Alfredo Martinez, Clotilde Vazquez, Josep Vidal, Josep A. Tur, Andres Diaz-Lopez, Hana Lancova, Montserrat Fito, Helmut Schroder
Summary: In older adults at high cardiovascular risk, increasing levels of physical activity and adherence to a Mediterranean diet were associated with a lower inflammatory score, which was partly mediated by a reduction in body fat.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Lu Chen, Jun Zhang, Nan Zhou, Jia-Yi Weng, Zheng-Yang Bao, Li-Da Wu
Summary: The study investigated the association between different obesity patterns and hypertension risk in a large male population in the US. The results showed that overweight and general obesity, abdominal obesity, and compound obesity were all significantly associated with an increased risk of hypertension. Furthermore, waist circumference was positively correlated with the risk of hypertension.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Marta Borges-Canha, Joao Sergio Neves, Maria Manuel Silva, Fernando Mendonca, Telma Moreno, Sara Ribeiro, Joao Correa, Catarina Vale, Juliana Goncalves, Helena Urbano Ferreira, Sara Gil-Santos, Vanessa Guerreiro, Ana Sande, Selma B. Souto, Jorge Pedro, Paula Freitas, Davide Carvalho
Summary: Non-alcoholic fatty liver disease is associated with other metabolic disorders and inflammation. Body fat content, especially abdominal fat, is linked to negative cardiometabolic outcomes.
Article
Nutrition & Dietetics
Xinyu Xiao, Xinyi Yu, Huiping Zhu, Xiaobing Zhai, Shiyang Li, Wenzhi Ma, Meishou Ouyang, Keyang Liu, Ehab S. Eshak, Jinhong Cao
Summary: This study investigated the associations between anthropometric parameters and cardiovascular disease (CVD) and all-cause mortality among diabetic patients. The results showed that arm circumference (AC) and arm-to-waist ratio (AC/WC) were inversely associated with CVD and all-cause mortality among individuals with diabetes. These anthropometric parameters are important for diabetic patients.
Article
Medicine, General & Internal
Juana Carretero-Gomez, Pablo Perez-Martinez, Jose Miguel Segui-Ripoll, Francisco Javier Carrasco-Sanchez, Nagore Lois Martinez, Esther Fernandez Perez, Onan Perez Hernandez, Miguel Angel Garcia Ordonez, Candelaria Martin Gonzalez, Juan Francisco Vigueras-Perez, Francesc Puchades, Maria Cristina Blasco Avaria, Maria Isabel Perez Soto, Javier Ena, Jose Carlos Arevalo-Lorido
Summary: Using cluster analysis, two profiles of subjects with high-risk obesity were identified. Compared to cluster 1, cluster 2 had a worse profile, characterized by older age, more comorbidities, poorer psychological health, and greater inflammation. This study provides important guidance for interventions targeting obese patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Matthew N. Ahmadi, I-Min Lee, Mark Hamer, Borja del Pozo Cruz, Li Jung Chen, Elif Eroglu, Yun-Ju Lai, Po Wen Ku, Emmanuel Stamatakis
Summary: This study found that increasing physical activity and decreasing adiposity can reduce the risk of all-cause mortality, cardiovascular disease mortality, and cancer mortality, regardless of baseline levels. The beneficial associations of joint changes were primarily driven by physical activity, suggesting that lower mortality risk may be more immediate through physical activity improvements compared to adiposity improvements alone.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Cardiac & Cardiovascular Systems
Hidemi Sorimachi, Kazunori Omote, Massar Omar, Dejana Popovic, Frederik H. Verbrugge, Yogesh N. Reddy, Grace Lin, Masaru Obokata, John M. Miles, Michael D. Jensen, Barry A. Borlaug
Summary: Central obesity is more common than general obesity in HFpEF, and there are significant sex differences in its relationships with metabolic abnormalities and hemodynamic perturbations, with greater impact in women.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Review
Cardiac & Cardiovascular Systems
Nathalia Gonzalez-Jaramillo, Matthias Wilhelm, Ana Maria Arango-Rivas, Valentina Gonzalez-Jaramillo, Cristina Mesa-Vieira, Beatrice Minder, Oscar H. Franco, Arjola Bano
Summary: This study found that maintaining or adopting an active lifestyle can reduce all-cause mortality risk in patients with CHD, especially for those who remained active. The results also suggest that the benefits of past activity in reducing CVD mortality risk may be lost if appropriate physical activity is not maintained.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Marah Aqeel, Jiaqi Guo, Luotao Lin, Saul Gelfand, Edward Delp, Anindya Bhadra, Elizabeth A. Richards, Erin Hennessy, Heather A. Eicher-Miller
Summary: The study found that temporal PA patterns with lower activity counts were associated with higher BMI, waist circumference, and obesity prevalence, while patterns with higher activity counts were related to lower BMI and WC. This suggests a meaningful link between temporal PA patterns and health status.
PREVENTIVE MEDICINE
(2021)
Article
Geriatrics & Gerontology
Miao Dai, Quhong Song, Jirong Yue, Taiping Lin, Wei Jie, Xiang Wang, Ning Ge
Summary: This study investigated the association between waist-calf circumference ratio (WCR) and frailty risk in older adults. The study found a positive association between WCR and frailty risk, as well as a negative association between calf circumference (CC) and frailty risk. The results suggest that a combination of high central fat and low lean body mass may increase the risk of developing frailty.
Editorial Material
Oncology
Smith Giri, Grant R. Williams
Summary: This article discusses the importance of quantifying skeletal muscle and adipose tissue compartments using CT images in cancer patients and demonstrates an application of body composition measurement in oncology by identifying the risk of glucose intolerance after transplantation.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Endocrinology & Metabolism
Sangmo Hong, Jung Hwan Park, Kyungdo Han, Chang Beom Lee, Dong Sun Kim, Sung Hoon Yu
Summary: Elderly patients with T2DM and obesity have better clinical outcomes compared to normal-weight patients. Waist circumference (WC) is a suitable indicator for assessing obesity-related risks in these patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Mengyi Liu, Panpan He, Chun Zhou, Zhuxian Zhang, Yuanyuan Zhang, Huan Li, Ziliang Ye, Qimeng Wu, Sisi Yang, Yanjun Zhang, Chengzhang Liu, Xianhui Qin
Summary: This study found that higher waist circumference and lower calf circumference were significantly associated with the incidence of cognitive impairment in older adults. The waist-calf circumference ratio had a relatively stronger association with cognitive impairment. Maintaining higher muscle mass and lower central fat can prevent cognitive impairment.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Miguel A. Sanchez-Lastra, Ding Ding, Knut-Eirik Dalene, Ulf Ekelund, Jakob Tarp
Summary: This study examined the impact of physical activity and adiposity measures on all-cause mortality. Results showed that high physical activity was associated with a lower risk of premature mortality, particularly in all adiposity strata except for BMI >= 35 kg/m(2).
MAYO CLINIC PROCEEDINGS
(2021)
Article
Nutrition & Dietetics
Luotao Lin, Jiaqi Guo, Marah M. Aqeel, Saul B. Gelfand, Edward J. Delp, Anindya Bhadra, Elizabeth A. Richards, Erin Hennessy, Heather A. Eicher-Miller
Summary: This study analyzed the diet and physical activity of US adults and applied the temporal sequence to patterns of health status indicators. The results showed that the joint temporal pattern of diet and physical activity had significant associations with BMI, waist circumference, total cholesterol, and obesity.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Antonio J. Vallejo-Vaz, Sarah Bray, Guillermo Villa, Julia Brandts, Gaia Kiru, Jennifer Murphy, Maciej Banach, Stefano De Servi, Dan Gaita, Ioanna Gouni-Berthold, G. Kees Hovingh, Jacek J. Jozwiak, J. Wouter Jukema, Robert Gabor Kiss, Serge Kownator, Helle K. Iversen, Vincent Maher, Luis Masana, Alexander Parkhomenko, Andre Peeters, Piers Clifford, Katarina Raslova, Peter Siostrzonek, Stefano Romeo, Dimitrios Tousoulis, Charalambos Vlachopoulos, Michal Vrablik, Alberico L. Catapano, Neil R. Poulter, Kausik K. Ray
Summary: In patients with atherosclerotic cardiovascular disease (ASCVD), achieving European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) LDL-C goals may result in an additional 2% absolute risk reduction (ARR) over 10 years compared to the American College of Cardiology/American Heart Association (ACC/AHA) approach.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
M. T. H. M. Henkens, J. F. van Ast, A. S. J. M. te Riele, A. C. Houweling, A. S. Amin, R. Nijveldt, M. L. Antoni, X. Li, S. M. T. Wehrens, J. H. von der Thusen, K. Damman, E. N. ter Horst, O. C. Manintveld, R. Y. Abma-Schouten, H. W. M. Niessen, H. H. W. Sillje, J. W. Jukema, P. A. Doevendans
Summary: The Netherlands Heart Tissue Bank (NHTB) is a non-profit biobank that aims to enhance cardiovascular disease-related research by providing a collection of healthy and diseased human cardiac tissue and clinical data. This initiative addresses the limitations of current animal and in vitro models in understanding the pathophysiological processes underlying cardiac diseases.
NETHERLANDS HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Yannick Kaiser, Jeremy Labrecque, Erik S. G. Stroes, S. Matthijs Boekholdt, Daniel Bos
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Gali Albalak, Marjon Stijntjes, David van Bodegom, J. Wouter Jukema, Douwe E. Atsma, Diana van Heemst, Raymond Noordam
Summary: Morning physical activity is associated with lower risks of incident cardiovascular diseases, irrespective of total physical activity.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Clinical Neurology
L. A. Rinkel, B. J. Bouma, S. M. Boekholdt, C. F. P. Beemsterboer, N. H. J. Lobe, L. F. M. Beenen, H. A. Marquering, C. B. L. M. Majoie, Y. B. W. E. M. Roos, A. van Randen, R. N. Planken, J. M. Coutinho
Summary: This study found that cardiac CT has low sensitivity in screening for PFO (patent foramen ovale) in patients with acute stroke, therefore it is not a suitable method for detecting PFO. For young patients with cryptogenic stroke, additional echocardiography is still needed after cardiac CT as a first-line screening method.
JOURNAL OF NEUROLOGY
(2023)
Article
Genetics & Heredity
Amar D. Levens, Melina C. den Haan, J. Wouter Jukema, Mette Heringa, Wilbert B. van den Hout, Dirk Jan A. R. Moes, Jesse J. Swen
Summary: Tailoring antiplatelet therapy based on CYP2C19 pharmacogenetic testing can improve cardiovascular outcomes and reduce healthcare costs. To evaluate the feasibility of CYP2C19-guided de-escalation of prasugrel/ticagrelor to clopidogrel, a proof-of-concept study was conducted in community pharmacies. The study found that community pharmacies are a suitable location for point-of-care PGx testing and the majority of patients and pharmacists view it as valuable.
Article
Medicine, Research & Experimental
Kin Ki Jim, Joelle J. N. Daems, S. Matthijs Boekholdt, Karin van Dijk
Summary: Candida infective endocarditis is a rare and serious condition that is difficult to treat, especially in patients with drug-resistant fungi and comorbidities. Treatment guidelines for these patients are based on limited clinical data due to their rarity. A case of Nakaseomyces glabrata prosthetic valve endocarditis in a patient with congenital heart disease highlights the therapeutic dilemma and the need for novel antifungal drugs and further clinical studies.
MEDICAL MYCOLOGY CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Tinka J. van Trier, Marjolein Snaterse, S. Matthijs Boekholdt, Wilma J. M. Scholte op Reimer, Steven H. J. Hageman, Frank L. J. Visseren, Jannick A. N. Dorresteijn, Ron J. G. Peters, Harald T. Jorstad
Summary: This study aims to assess the discrimination, calibration, and clinical utility of low-risk SCORE2 and SCORE2-OP models for cardiovascular disease risk evaluation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Shaun G. Goodman, Philippe Gabriel Steg, Yann Poulouin, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Genevieve Garon, Robert A. Harrington, J. Wouter Jukema, Garen Manvelian, Wanda Stipek, Michael Szarek, Harvey D. White, Gregory G. Schwartz
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jordan M. Kraaijenhof, Tycho R. Tromp, Nick S. Nurmohamed, Laurens F. Reeskamp, Marije Langenkamp, Johannes H. M. Levels, S. Matthijs Boekholdt, Nicholas J. Wareham, Menno Hoekstra, Erik S. G. Stroes, G. Kees Hovingh, Aldo Grefhorst
Summary: The study found that while ANGPTL3 predominantly resides on HDL, its activity is highest when bound to LDL particles.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
C. F. P. Beemsterboer, L. A. Rinkel, V. Guglielmi, N. -S. Groeneveld, N. H. J. Lobe, S. M. Boekholdt, B. J. Bouma, F. F. Muller, L. F. M. Beenen, H. A. Marquering, C. B. L. M. Majoie, Y. B. W. E. M. Roos, A. van Randen, R. N. Planken, J. M. Coutinho
Summary: This observational pilot study found that cardiac thrombi can dissolve within days of ischemic stroke occurrence, with or without thrombolysis treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Adrianus J. Bakermans, Merel Kouwenhoven, Judith De Vos, Dylan K. De Vries, Yolan J. Reckman, Emile S. Farag, David R. Koolbergen, Jolanda Kluin, Aart J. Nederveen, Gustav J. Strijkers, S. Matthijs Boekholdt
Summary: This study aimed to validate MRI measurements of extracellular volume fraction (ECV) against ex vivo histology of myocardial tissue samples. The results showed a strong correlation between ECV and myocardial collagen content. However, there was no correlation between native T-1 values of the myocardium and ECV or myocardial collagen content.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2023)
Article
Sport Sciences
Juliette C. van Hattum, Sjoerd M. Verwijs, S. Matthijs Boekholdt, Maarten Groenink, R. Nils Planken, Adrienne van Randen, Aart J. Nederveen, Maarten H. Moen, Cornelis A. C. M. Wijne, Joelle J. N. Daems, Birgitta K. Velthuis, Danny A. J. van de Sande, Ruud Spee, Suzanna T. de Vries, Maurits J. van der Veen, Yigal M. Pinto, Arthur A. M. Wilde, Harald T. Jorstad, ELITE Consortium
Summary: This article introduces the ELITE study, which aims to investigate the cardiovascular effects of elite sports and exercise. The study collects data from elite athletes in the Netherlands and conducts long-term observations and diagnostics to determine the impact of elite sports and exercise on the heart. The study also includes research on cardiac sequelae following infections with myocardial involvement. This is a prospective observational study.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jussi Schultz, Inge J. van den Hoogen, Jurrien H. Kuneman, Michiel A. de Graaf, Vasileios Kamperidis, Alexander Broersen, J. Wouter Jukema, Antonis Sakellarios, Sotirios Nikopoulos, Konstantina Tsarapatsani, Katerina Naka, Lampros Michalis, Dimitrios Fotiadis, Teemu Maaniitty, Antti Saraste, Jeroen J. Bax, Juhani Knuuti
Summary: This study evaluated CCTA-based ESS values in coronary arteries without atherosclerosis and identified factors affecting ESS values. The findings showed that ESS was highest in the left anterior descending artery and lower in men compared to women, even after adjusting for lumen diameter. ESS values were also highest in small segments and had a correlation with the distance from the ostium.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Review
Geriatrics & Gerontology
Michelle H. Zonneveld, Denise Abbel, Saskia le Cessie, J. Wouter Jukema, Raymond Noordam, Stella Trompet
Summary: This systematic review examined the association between cardiac troponin, cognitive function, and dementia. The findings suggest that elevated troponin is associated with cognitive impairment, increased risk of dementia, and higher prevalence of dementia hospitalization, specifically due to vascular dementia.
