Article
Medical Laboratory Technology
Gjin Ndrepepa, Stefan Holdenrieder, Erion Xhepa, Salvatore Cassese, Shqipdona Lahu, Sebastian Kufner, Adnan Kastrati
Summary: Elevated ALP activity is associated with increased risk of 3-year mortality in patients with diabetes mellitus and ischemic heart disease.
CLINICA CHIMICA ACTA
(2022)
Article
Cardiac & Cardiovascular Systems
Hanna Froehlich, Anna Bossmeyer, Syed Kazmi, Kevin M. Goode, Stefan Agewall, Dan Atar, Morten Grundtvig, Norbert Frey, John G. F. Cleland, Lutz Frankenstein, Andrew L. Clark, Tobias Taeger
Summary: A high BMI is associated with better survival in patients with heart failure (HF) or diabetes mellitus (DM), but there is controversy whether this obesity paradox exists in patients with HF and concomitant DM. Furthermore, the impact of glycaemic control and diabetes treatment on the presence or absence of the obesity paradox in patients with HF and DM is unknown.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Victor Bento Oliveira, Fabio Wildson Gurgel Costa, Alex Nogueira Haas, Renan Magalhaes Montenegro Junior, Rodrigo Otavio Rego
Summary: This study aimed to summarize the evidence on the effect of subgingival instrumentation (with or without open flap) on the reduction of glycosylated haemoglobin (HbA1c). The meta-analysis of 12 randomized controlled trials showed that subgingival instrumentation can significantly reduce HbA1c levels and have important clinical value for diabetes control in patients with type 2 diabetes mellitus.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Medicine, General & Internal
Terry C. Simpson, Janet E. Clarkson, Helen Worthington, Laura MacDonald, Jo C. Weldon, Ian Needleman, Zipporah Iheozor-Ejiofor, Sarah H. Wild, Ambrina Qureshi, Andrew Walker, Veena A. Patel, Dwayne Boyers, Joshua Twigg
Summary: Treatment for periodontitis through subgingival instrumentation can significantly improve glycaemic control in patients with diabetes, benefiting their overall health.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Endocrinology & Metabolism
Anca Balintescu, Marcus Lind, Mikael Andersson Franko, Anders Oldner, Maria Cronhjort, Bjorn Eliasson, Christer Svensen, Johan Martensson
Summary: This study found an association between glycated haemoglobin (HbA1c) and sepsis in adults with type 1 diabetes, and explored the relationship between HbA1c and mortality among individuals who developed sepsis. It revealed a J-shaped relationship between HbA1c and sepsis risk, with the lowest risk observed at HbA1c levels about 53 mmol/mol (7.0%). HbA1c was not associated with mortality in individuals affected by sepsis.
DIABETES OBESITY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Sophia Eilat-Tsanani, Avital Margalit, Liran Nevet Golan
Summary: The burden of type 2 diabetes is increasing due to both increased incidence and its comorbidities. This study found that the combination of concordant and discordant comorbidities in persons with diabetes is common and indicates a continuum of morbidity, highlighting the significant contribution of discordant comorbidities to disease outcomes. The high prevalence of these comorbidities before the onset of type 2 diabetes emphasizes the importance of proactive management of both types of comorbidities.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Helene Affres, Marie-Victoire Senat, Alexandra Letourneau, Philippe Deruelle, Magali Coustols-Valat, Hanane Bouchghoul, Jean Bouyer
Summary: In women with gestational diabetes mellitus (GDM), glyburide is effective for reaching glycemic goals during pregnancy, but may increase the risk of maternal hypoglycemia. Switching to insulin therapy after glyburide treatment failure can improve glycemic control.
DIABETES & METABOLISM
(2021)
Article
Medicine, General & Internal
Bertram Pitt, Gerasimos Filippatos, Rajiv Agarwal, Stefan D. Anker, George L. Bakris, Peter Rossing, Amer Joseph, Peter Kolkhof, Christina Nowack, Patrick Schloemer, Luis M. Ruilope
Summary: Finerenone therapy improved cardiovascular outcomes in patients with type 2 diabetes and stage 2 to 4 CKD with moderately elevated albuminuria or stage 1 or 2 CKD with severely elevated albuminuria, compared to placebo. The risk of the primary outcome event was significantly lower in the finerenone group, primarily driven by a reduction in hospitalization for heart failure.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Se Yong Jang, Jieun Jang, Dong Heon Yang, Hyun-Jai Cho, Soo Lim, Eun-Seok Jeon, Sang Eun Lee, Jae-Joong Kim, Seok-Min Kang, Sang Hong Baek, Myeong-Chan Cho, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Sue K. Park, Hae-Young Lee
Summary: Patients with diabetes mellitus and heart failure have a higher risk of mortality. Insulin therapy was found to be associated with increased mortality in acute heart failure patients, especially in those with low levels of glycated hemoglobin.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Multidisciplinary Sciences
Jason Gurney, James Stanley, Andrea Teng, Jeremy Krebs, Jonathan Koea, Chunhuan Lao, Ross Lawrenson, Ineke Meredith, Dianne Sika-Paotonu, Diana Sartati
Summary: The number of new cases of cancer and diabetes mellitus is increasing each year. It is common for an individual to have both conditions simultaneously as they both increase the risk of each other. In this study, the occurrence of cancer among a national prevalent cohort of patients with diabetes in New Zealand was examined. The rate of cancer was found to be highest among those with diabetes for the majority of common cancers, especially those related to the endocrine or gastrointestinal system and obesity. Prevention of cancer among individuals with diabetes could lead to a substantial overall reduction in the burden of cancer in the population. This highlights the importance of prioritizing and allocating resources to diabetes prevention activities as they are also cancer prevention activities.
Review
Cardiac & Cardiovascular Systems
Karishma Mahtani, Brihitejas Patel, Brian Wang, Anthony Barron
Summary: Sacubitril/valsartan, a first-in-class Angiotensin Receptor-Neprilysin inhibitor (ARNi), has been approved for the treatment of heart failure with reduced ejection fraction (HFrEF). It has become a mainstay of treatment in heart failure management due to its inhibition of the neurohumoral system. There is evidence to suggest that sacubitril/valsartan may improve glycaemic control through the enhancement of neprilysin substrates, particularly glucagon-like peptide 1 (GLP-1). However, the role of neprilysin in GLP-1 degradation raises important clinical considerations.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Valtteri Muroke, Mikko Jalanko, Jari Haukka, Juha Sinisalo
Summary: This study aimed to evaluate the long-term mortality and cause-specific mortality of patients with atrial septal defect (ASD) in a nationwide cohort. The results showed that patients with ASD had higher overall mortality, with increased cause-specific mortality in congenital malformations, stroke, and heart diseases.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Hsuan-Chih Tsai, Po-Sheng Hsu, Lung-Fa Pan, Chia-Lien Hung, Deng-Ho Yang, Kuang-Chen Hung, Chun-Cheng Liao
Summary: This is a 10-year retrospective cohort study in the Taiwanese population evaluating hyperglycemia-associated mortality. The study found that the hazard ratios for all-cause, cancer, and heart disease mortality in the diabetes mellitus subgroup were 1.560, 1.381, and 1.828, respectively.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Sohyun Chun, Dong Wook Shin, Kyungdo Han, Jin Hyung Jung, Bongseong Kim, Hee-Won Jung, Ki Young Son, Seung-Pyo Lee, Sang Chol Lee
Summary: The study concluded that slower Timed Up and Go test speed is associated with a higher risk of myocardial infarction, congestive heart failure, and mortality in older adults.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Review
Endocrinology & Metabolism
Harriet Esdaile, Neil Hill, Jamil Mayet, Nick Oliver
Summary: Diabetes is a prevalent disease that poses risks of cardiovascular damage and mortality. Despite improvements in myocardial infarction management, individuals with diabetes still face complications and mortality due to reasons such as increased coronary atherosclerosis, microvascular dysfunction, and diabetic cardiomyopathy. Dysglycaemia leads to endothelial dysfunction and inflammation, which can persist despite efforts to control blood sugar. While clinical guidelines recommend avoiding hyper- and hypoglycemia after a heart attack, the evidence for long-term benefits of glycemic control is lacking. Glycemic variability may have prognostic significance, and continuous glucose monitoring and new medications offer potential interventions for diabetic patients post myocardial infarction.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Ragna Elise Store Govatsmark, Imre Janszky, Stig Arild Slordahl, Marta Ebbing, Rune Wiseth, Bjornar Grenne, Elisabeth Vesterbekkmo, Kaare Harald Bonaa
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2020)
Article
Engineering, Biomedical
Lucas O. Mueller, Fredrik E. Fossan, Anders T. Braten, Arve Jorgensen, Rune Wiseth, Leif R. Hellevik
Summary: Model-based prediction of fractional flow reserve in stable coronary artery disease diagnosis relies on various modelling assumptions, including defining baseline coronary flow. The study investigates methods to estimate and distribute baseline coronary flow and highlights their significant impact on FFR predictions. However, addressing uncertainties related to stenosis geometry and hyperemic inducing drugs is crucial for improving FFR prediction accuracy.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Gert Richardt, Mohammad Abdelghani, Abdelhakim Allali, Ralph Toelg, Mohamed Abdellaoui, Florian Krackhardt, Rune Wiseth, Marie-Claude Morice, Samuel Cope, Hans-Peter Stoll, Philip Urban
Summary: Patients undergoing non-cardiac surgery after PCI with drug-coated stent had a lower likelihood of clinically driven target lesion revascularization compared to those with bare-metal stent. However, there was no significant difference in primary composite safety end point or bleeding complications. Early non-cardiac surgery after bare-metal stent PCI was associated with increased risk, while timing of surgery did not have such an impact after drug-coated stent implantation.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Gregg W. Stone, Akiko Maehara, Ziad A. Ali, Claes Held, Mitsuaki Matsumura, Lars Kjoller-Hansen, Hans Erik Botker, Michael Maeng, Thomas Engstrom, Rune Wiseth, Jonas Persson, Thor Trovik, Ulf Jensen, Stefan K. James, Gary S. Mintz, Ovidiu Dressler, Aaron Crowley, Ori Ben-Yehuda, David Erlinge
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Kaspar Broch, Anne Kristine Anstensrud, Sindre Woxholt, Kapil Sharma, Ingvild Maria Tollefsen, Bjorn Bendz, Svend Aakhus, Thor Ueland, Brage Hoyem Amundsen, Jan Kristian Damas, Erlend Sturle Berg, Elisabeth Bjorkelund, Christina Bendz, Einar Hopp, Ola Kleveland, Knut Haakon Stensaeth, Anders Opdahl, Nils-Einar Klow, Ingebjorg Seljeflot, Geir Oystein Andersen, Rune Wiseth, Pal Aukrust, Lars Gullestad
Summary: The study showed that tocilizumab, an interleukin-6 receptor inhibitor, increased myocardial salvage in patients with acute STEMI, reduced microvascular obstruction, but did not significantly decrease final infarct size.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Per Morten Molstad, Jan Erik Nordrehaug, Terje K. Steigen, Tom Wilsgaard, Rune Wiseth, Svein Rotevatn, Jan Mannsverk, Tommy Larsen, Kristina Elisabet Larsby, Sigrun Adnegard Skarstad, Eivind Oygard Fosse, Oystein Dahl-Eriksen, Kaare Harald Bonaa
Summary: This study compared drug-eluting stents (DES) with bare-metal stents (BMS) in terms of target lesion revascularization (TLR) rate in native vessels and saphenous vein grafts (SVG). The results showed that DES had a persistent benefit in reducing TLR rate in native vessels after 5 years, but there was no difference between DES and BMS in SVG. The high rate of TLR and myocardial infarction (MI) in SVG suggests that treating native vessels should be preferred whenever possible.
Article
Cell Biology
Maria Dalen Taraldsen, Rune Wiseth, Vibeke Videm, Anja Bye, Erik Madssen
Summary: This study found that specific miRs were associated with coronary plaque components in patients with coronary artery disease. After aerobic exercise intervention, changes in miR levels were associated with a regression of coronary plaque burden. These findings may contribute to the development of biomarkers for coronary artery disease and coronary plaque composition.
PHYSIOLOGICAL GENOMICS
(2022)
Article
Cardiac & Cardiovascular Systems
Elisabeth Kleivhaug Vesterbekkmo, Erik Madssen, Inger-Lise Aamot Aksetoy, Turid Follestad, Hans Olav Nilsen, Knut Hegbom, Ulrik Wisloff, Rune Wiseth
Summary: The effect of high intensity interval training (HIIT) on lipid content in coronary plaques is inconclusive. However, there may be a correlation between increased fitness and reduced lipid content in coronary atheromatous plaques.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Elisabeth Kleivhaug Vesterbekkmo, Inger-Lise Aamot Aksetoy, Turid Follestad, Hans Olav Nilsen, Knut Hegbom, Ulrik Wisloff, Rune Wiseth, Erik Madssen
Summary: This study investigated the changes in coronary plaque geometry in stable coronary artery disease patients after 6 months of supervised high-intensity interval training (HIIT). The results showed a reduction in plaque volume and number after HIIT. Therefore, it can be concluded that HIIT can inhibit the progression of coronary plaques and is of significant importance in the prevention of coronary artery disease.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Per Molstad, Jan Erik Nordrehaug, Terje Steigen, Tom Wilsgaard, Rune Wiseth, Kaare H. Bonaa
Summary: Patients with known diabetes had significantly increased all-cause, cardiac, and noncardiac mortality during the 5-year follow-up, while patients with new diabetes only had an association with increased noncardiac mortality. Diabetic and nondiabetic patients had similar responses to treatment with BMS or DES.
Article
Medicine, General & Internal
David Erlinge, Akiko Maehara, Ori Ben-Yehuda, Hans Erik Botker, Michael Maeng, Lars Kjoller-Hansen, Thomas Engstrom, Mitsuaki Matsumura, Aaron Crowley, Ovidiu Dressler, Gary S. Mintz, Ole Frobert, Jonas Persson, Rune Wiseth, Alf Inge Larsen, Lisette Okkels Jensen, Jan Erik Nordrehaug, Oyvind Bleie, Elmir Omerovic, Claes Held, Stefan K. James, Ziad A. Ali, James E. Muller, Gregg W. Stone
Summary: The study conducted a prospective natural history research in Denmark, Norway, and Sweden, confirming that combined NIRS and intravascular ultrasound can identify high-risk plaques and predict future adverse cardiac events. Non-obstructive plaques with high lipid content and large plaque burden are more likely to lead to cardiovascular adverse events.
Article
Cardiac & Cardiovascular Systems
Maria Dalen Taraldsen, Vibeke Videm, Knut Hegbom, Rune Wiseth, Erik Madssen
Summary: This study showed that 3 months of aerobic exercise training in patients treated with DES implantation resulted in a significant decrease in plaque burden and necrotic core content at the distal stent edges, with larger reductions seen in the AIT group.
CARDIOVASCULAR INTERVENTION AND THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Havard Dalen, Espen Holte, Anna Ulstein Guldal, Johan-Arnt Hegvik, Knut Haakon Stensaeth, Anders Tjellaug Braaten, Ole Christian Mjolstad, Ole Rossvoll, Rune Wiseth
Article
Cardiac & Cardiovascular Systems
Oystein Pettersen, Elzbieta Pociask, Krzysztof P. Malinowski, Magdalena Slezak, Knut Hegbom, Rune Wiseth, Dag Ole Nordhaug
CARDIOLOGY JOURNAL
(2020)
Meeting Abstract
Cardiac & Cardiovascular Systems
Ragnhild Helseth, Ola Kleveland, Thor Ueland, Rune Wiseth, Jan Kristian Damaas, Kaspar Broch, Annika Elisabet Michelsen, Bjorn Bendz, Lars Gullestad, Paal Aukrust, Ingebjoerg Seljeflot
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)