☆ 4.7 Editorial Material

HDL-cholesterol levels and cardiovascular risk: acCETPing the context

EUROPEAN HEART JOURNAL (2008)

期刊

EUROPEAN HEART JOURNAL

卷 29, 期 22, 页码 2708-2709

出版社

OXFORD UNIV PRESS

DOI: 10.1093/eurheartj/ehn450

关键词

-

类别

Cardiac & Cardiovascular Systems

资金

NHLBI NIH HHS [HL75360, R01 HL075360] Funding Source: Medline

向作者/读者索取更多资源

Protocol

Reagent

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Review Biochemistry & Molecular Biology

Unraveling the Complexity of HDL Remodeling: On the Hunt to Restore HDL Quality

Leonie Schoch, Lina Badimon, Gemma Vilahur

Summary: Increasing doubt has been raised over the HDL-cholesterol hypothesis, with evidence pointing towards the complexity and molecular changes in HDL particles. Chemical modifications, compositional changes, and miRNA cargo have been identified as factors contributing to the ineffectiveness of HDL particles. Overcoming challenges is crucial to bringing hope to HDL-targeted approaches.

BIOMEDICINES (2021)

添加到收藏夹

Review Environmental Sciences

Serum Cholesterol Levels and Risk of Cardiovascular Death: A Systematic Review and a Dose-Response Meta-Analysis of Prospective Cohort Studies

Eujene Jung, So Yeon Kong, Young Sun Ro, Hyun Ho Ryu, Sang Do Shin

Summary: This study conducted a systematic review and meta-analysis to investigate the relationship between serum cholesterol levels and cardiovascular mortality. The results showed that serum total cholesterol and LDL-C levels are associated with increased cardiovascular disease mortality, while HDL-C level is inversely associated with cardiovascular disease mortality.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Hyperuricemia increases the risk of cardiovascular mortality associated with very high HdL-cholesterol level

Paolo Palatini, Agostino Virdis, Stefano Masi, Alessandro Mengozzi, Edoardo Casiglia, Valerie Tikhonoff, Arrigo F. G. Cicero, Andrea Ungar, Gianfranco Parati, Giulia Rivasi, Massimo Salvetti, Carlo M. Barbagallo, Michele Bombelli, Raffaella Dell'Oro, Berardino Bruno, Luciano Lippa, Lanfranco D'Elia, Maria Masulli, Paolo Verdecchia, Gianpaolo Reboldi, Fabio Angeli, Francesca Mallamaci, Massimo Cirillo, Marcello Rattazzi, Pietro Cirillo, Loreto Gesualdo, Alberto Mazza, Cristina Giannattasio, Alessandro Maloberti, Massimo Volpe, Giuliano Tocci, Guido Iaccarino, Pietro Nazzaro, Ferruccio Galletti, Claudio Ferri, Giovambattista Desideri, Francesca Viazzi, Roberto Pontremoli, Maria Lorenza Muiesan, Guido Grassi, Claudio Borghi

Summary: This study investigates the association between very high HDL-cholesterol levels and cardiovascular mortality (CVM), and whether this association is influenced by hyperuricemia. The results show a J-shaped association between high HDL-cholesterol levels and CVM in women, but not in men. Additionally, the risk of CVM related to high HDL-cholesterol is increased in women with hyperuricemia.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2023)

添加到收藏夹

Article Multidisciplinary Sciences

Neutrophil to high-density lipoprotein cholesterol ratio as the risk mark in patients with type 2 diabetes combined with acute coronary syndrome: a cross-sectional study

Hao Ren, Botao Zhu, Zhenyu Zhao, Yuan Li, Guiyuan Deng, Zewei Wang, Boyan Ma, Yuxin Feng, Zaiqiu Zhang, Xiaoxuan Zhao, Md Sayed Ali Sheikh, Ke Xia

Summary: Chronic inflammation and dyslipidemia are important risk factors for atherosclerotic cardiovascular disease. The neutrophil to high-density lipoprotein cholesterol ratio (NHR) is a novel marker reflecting inflammation and lipid metabolic disorder. This study analyzed the NHR level in T2DM patients with ACS and explored its predictive and diagnostic values.

SCIENTIFIC REPORTS (2023)

添加到收藏夹

Article Endocrinology & Metabolism

Circulating Sclerostin Levels Are Positively Related to Coronary Artery Disease Severity and Related Risk Factors

Monika Frysz, Ingrid Gergei, Hubert Scharnagl, George Davey Smith, Jie Zheng, Deborah A. Lawlor, Markus Herrmann, Winfried Maerz, Jon H. Tobias

Summary: The study found that higher levels of sclerostin were associated with increased risk of diabetes and certain cardiovascular risk factors, as well as higher severity of coronary artery disease and cardiac mortality. However, these associations were partially explained by major cardiovascular risk factors.

JOURNAL OF BONE AND MINERAL RESEARCH (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Association Between High-Density Lipoprotein Cholesterol Levels and Adverse Cardiovascular Outcomes in High-risk Populations

Chang Liu, Devinder Dhindsa, Zakaria Almuwaqqat, Yi-An Ko, Anurag Mehta, Ayman A. Alkhoder, Zahran Alras, Shivang Rajan Desai, Krishan Jignesh Patel, Ananya Hooda, Mohamad Wehbe, Laurence S. Sperling, Yan Sun, Arshed A. Quyyumi

Summary: This cohort study examined the association between very high HDL-C levels (>80 mg/dL) and mortality in patients with coronary artery disease (CAD). The results demonstrated a U-shaped association, with higher risk of death in individuals with both low and very high HDL-C levels compared to those with midrange values. Specifically, very high HDL-C levels were associated with increased risk of all-cause death and cardiovascular death. These associations were independent of common genetic polymorphisms associated with high HDL-C levels.

JAMA CARDIOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

HDL cholesterol concentrations and risk of atherosclerotic cardiovascular disease - Insights from randomized clinical trials and human genetics

Emilie Westerlin Kjeldsen, Jesper Qvist Thomassen, Ruth Frikke-Schmidt

Summary: Over the past seven decades, studies have observed an inverse association between HDL cholesterol concentrations and atherosclerotic cardiovascular disease (ASCVD) risk. However, recent evidence from human genetics and randomized clinical trials suggest that targeting HDL cholesterol concentrations may not be a viable approach for preventing ASCVD.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Association of Apolipoprotein B-Containing Lipoproteins and Risk of Myocardial Infarction in Individuals With and Without Atherosclerosis Distinguishing Between Particle Concentration, Type, and Content

Nicholas A. Marston, Robert P. Giugliano, Giorgio E. M. Melloni, Jeong-Gun Park, Valerie Morrill, Michael A. Blazing, Brian Ference, Evan Stein, Erik S. Stroes, Eugene Braunwald, Patrick T. Ellinor, Steven A. Lubitz, Christian T. Ruff, Marc S. Sabatine

Summary: This study found that the number of apoB-containing lipoproteins plays a crucial role in predicting cardiovascular risk independently of cholesterol or TG content. Lowering the concentration of all apoB-containing lipoproteins should be the primary focus of therapeutic strategies.

JAMA CARDIOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Effect of Statins on the Blood Lipid Profile in Patients with Different Cardiovascular Diseases: A Systematic Review with Meta-analysis of Randomized Clinical Trials

Saeed Aslani, Bahman Razi, Danyal Imani, Keyhan Mohammadi, Tannaz Jamialahmadi, Zeljko Reiner, Amirhossein Sahebkar

Summary: A systematic review and meta-analysis showed that statin therapy effectively lowered levels of total cholesterol, LDL-C, and TG, and increased levels of HDL-C in patients with different CVDs.

CURRENT MEDICINAL CHEMISTRY (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

HDL: Fact, fiction, or function? HDL cholesterol and cardiovascular risk

Marc P. Allard-Ratick, Bryan R. Kindya, Jay Khambhati, Marc C. Engels, Pratik B. Sandesara, Robert S. Rosenson, Laurence S. Sperling

Summary: The measurement of high-density lipoprotein cholesterol is commonly used to predict cardiovascular risk, but it is not causally associated with atherosclerotic cardiovascular disease events. Dysfunctional high-density lipoprotein may better predict future cardiovascular events.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

The Potential of ANGPTL8 Antagonism to Simultaneously Reduce Triglyceride and Increase HDL-Cholesterol Plasma Levels

Ren Zhang

Summary: Elevated triglyceride and reduced high-density lipoprotein-cholesterol plasma levels are risk factors for atherosclerosis and cardiovascular disease. By inhibiting lipoprotein lipase and endothelial lipase, Angiopoietin-like 3 (ANGPTL3) plays a role in regulating plasma triglyceride and HDL-C levels. Angiopoietin-like 3 inhibition of LPL requires complex formation with Angiopoietin-like 8, which is not required for its inhibition of EL. By disrupting or precluding the ANGPTL3-8 complex formation, ANGPTL8 antagonism can increase LPL activity while decreasing EL activity, leading to reduced plasma triglyceride and increased HDL-C levels.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

HDL cholesterol and clinical outcomes in diabetes mellitus

Takuma Ishibashi, Hidehiro Kaneko, Satoshi Matsuoka, Yuta Suzuki, Kensuke Ueno, Ryusei Ohno, Akira Okada, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Issei Komuro

Summary: The aim of this study was to investigate the association between fasting plasma glucose, HDL cholesterol levels, and clinical outcomes. The findings suggest that there is a U-shaped association between HDL cholesterol and clinical outcomes, and this association is amplified with worsening glucose tolerance.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2023)

添加到收藏夹

Article Biochemical Research Methods

Preparative Electrophoresis for HDL Particle Size Separation and Intact-Mass Apolipoprotein Proteoform Analysis

Cameron Lloyd-Jones, Henrique dos Santos Seckler, Nicholas DiStefano, Allan Sniderman, Phillip D. Compton, Neil L. Kelleher, John T. Wilkins

Summary: This study investigated the relationship between the types and abundance of proteins in high-density lipoprotein (HDL) and the size of HDL using a new gel electrophoresis technique combined with intact protein mass spectrometry. The results showed that fatty-acylated forms of APOA1 were associated with larger HDL particles and had four times higher abundance in larger particles compared to total serum. The abundance of APOA2 protein forms was similar across different sizes of HDL particles. These findings suggest a connection between acylated APOA1 protein forms and larger HDL particles.

JOURNAL OF PROTEOME RESEARCH (2023)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Cumulative non-high-density lipoprotein cholesterol burden and risk of atherosclerotic cardiovascular disease: a prospective community-based study

Xu-Min Guan, Hong-Po Shi, Shuang Xu, Yue Chen, Rong-Feng Zhang, Ying-Xue Dong, Lian-Jun Gao, Shou-Ling Wu, Yun-Long Xia

Summary: This study aimed to examine the association between cumulative non-HDL-C burden and ASCVD risk in the Kailuan cohort of China. The results showed that long-term and higher cumulative non-HDL-C were significantly associated with an increased risk of ASCVD, independent of non-HDL-C level.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2023)

添加到收藏夹

Article Nutrition & Dietetics

Excessive Consumption of Alcoholic Beverages and Extremely High Levels of High-Density Lipoprotein Cholesterol (HALP) in the ELSA-Brasil Cohort Baseline

Oscar Geovanny Enriquez-Martinez, Taisa Sabrina Silva Pereira, Jose Geraldo Mill, Maria de Jesus Mendes da Fonseca, Maria del Carmen Bisi Molina, Rosane Harter Griep

Summary: According to a cross-sectional analysis, excessive alcohol consumption is positively associated with extremely high HDL-C levels, especially among women and higher-income individuals.

NUTRIENTS (2023)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Reinforcing rigor and reproducibility expectations for use of sex and gender in cardiovascular research

Merry L. Lindsey, Amanda J. LeBlanc, Crystal M. Ripplinger, Jason R. Carter, Jonathan A. Kirk, Kara Hansell Keehan, Keith R. Brunt, Petra Kleinbongard, Zamaneh Kassiri

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

The HEART Camp Exercise Intervention Improves Exercise Adherence, Physical Function, and Patient-Reported Outcomes in Adults With Preserved Ejection Fraction Heart Failure

Windy W. Alonso, Kevin A. Kupzyk, Joseph F. Norman, Scott W. Lundgren, Alfred Fisher, Merry L. Lindsey, Steven J. Keteyian, Bunny J. Pozehl

Summary: The multicomponent behavioral intervention program, HEART Camp, has been found to improve adherence to exercise in individuals with heart failure. Participants with heart failure with preserved ejection fraction (HFpEF) in the intervention group showed significantly higher adherence compared to the enhanced usual care group, and demonstrated improvements in physical function and symptoms. However, in participants with heart failure with reduced ejection fraction (HFrEF), only patient-reported anxiety improved significantly.

JOURNAL OF CARDIAC FAILURE (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

S100A9 is a functional effector of infarct wall thinning after myocardial infarction

Upendra Chalise, Mediha Becirovic-Agic, Michael J. Daseke, Shelby R. Konfrst, Jocelyn R. Rodriguez-Paar, Dan Feng, Jeffrey D. Salomon, Daniel R. Anderson, Leah M. Cook, Merry L. Lindsey

Summary: Neutrophils infiltrate into the left ventricle early after myocardial infarction and launch a proinflammatory response. Along with neutrophil infiltration, LV wall thinning due to cardiomyocyte necrosis also peaks at day 1 in the mouse model of MI. S100A9 is identified as a functional effector of infarct wall thinning.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Faster skin wound healing predicts survival after myocardial infarction

Mediha Becirovic-Agic, Upendra Chalise, Mira Jung, Jocelyn R. Rodriguez-Paar, Shelby R. Konfrst, Elizabeth R. Flynn, Jeffrey D. Salomon, Michael E. Hall, Merry L. Lindsey

Summary: The speed of skin wound healing predicts the healing response of the heart after myocardial infarction. Two plasma proteins, EAF1 and A2M, at day 3 of myocardial infarction can predict the risk of death in 66% of cases. ApoD negatively regulates skin and cardiac wound healing by promoting inflammation. Skin acts as a reflection of the heart, with common pathways linking wound healing across different organs.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2022)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Metabolic transformation of fat in obesity determines the inflammation resolving capacity of splenocardiac and cardiorenal networks in heart failure

Ganesh Halade, Vasundhara Kain, Xavier De La Rosa, Merry L. Lindsey

Summary: The type of fat intake can have varying effects on obesity and cardiovascular health, with DHA showing potential for controlling inflammation and improving resolving mechanisms in the heart and kidneys, leading to better survival rates in chronic heart failure patients post-MI.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2022)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Getting it right

Merry L. Lindsey

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2022)

添加到收藏夹

Editorial Material Physiology

An American Physiological Society cross-journal Call for Papers on The Physiology of Obesity

Sue C. Bodine, Heddwen L. Brooks, Hilary A. Coller, Ana I. Domingos, Mark R. Frey, Barbara E. Goodman, Thomas R. Kleyman, Merry L. Lindsey, Rory E. Morty, Ole H. Petersen, Jan-Marino Ramirez, Liliana Schaefer, Morten B. Thomsen, Gina L. C. Yosten

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2022)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Sex still matters in cardiovascular research

Merry L. Lindsey, Jason R. Carter, Crystal M. Ripplinger, Zamaneh Kassiri, Kara Hansell Keehan, Keith R. Brunt, Jonathan A. Kirk, Petra Kleinbongard, Amanda J. LeBlanc

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2023)

添加到收藏夹

Editorial Material Education, Scientific Disciplines

How to be a GREAT mentor

Jamaine S. Davis, Amos M. Sakwe, Aramandla Ramesh, Merry L. Lindsey, Letha Woods

Summary: We provide a framework for developing mentorship skills using the GREAT model, which includes giving opportunities and opening doors, helping students identify strengths and reach goals, serving as a positive example, advising as individuals, and training for independent thinking.

ADVANCES IN PHYSIOLOGY EDUCATION (2023)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Spring cleaning: freshening up the portfolio

Merry L. Lindsey, Zamaneh Kassiri, Amanda J. LeBlanc, Crystal M. Ripplinger, Jonathan A. Kirk, Jason R. Carter, Petra Kleinbongard, Keith R. Brunt

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2023)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

We asked and you answered

Merry L. Lindsey, Petra Kleinbongard, Zamaneh Kassiri, Jason R. Carter, Kara Hansell Keehan, Crystal M. Ripplinger, Amanda J. LeBlanc, Keith R. Brunt, Jonathan A. Kirk

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2023)

添加到收藏夹

Article Physiology

Skin wound healing as a mirror to cardiac wound healing

Merry L. L. Lindsey, Mediha Becirovic-Agic

Summary: This review focuses on the topic of wound healing, discussing the three phases of inflammation, inflammation resolution, and repair. It compares the wound-healing response of the skin after an injury to the wound-healing response of the heart after a myocardial infarction.

EXPERIMENTAL PHYSIOLOGY (2023)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Improving rigor and reproducibility in cardiovascular research

Merry L. Lindsey, Amanda J. Leblanc, Luc Bertrand, Amy D. Bradshaw, Petra Kleinbongard

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2023)

添加到收藏夹

Review Medicine, Research & Experimental

The cardiac wound healing response to myocardial infarction

Upendra Chalise, Mediha Becirovic-Agic, Merry L. Lindsey

Summary: Myocardial infarction triggers a healing response in the heart, involving inflammation, anti-inflammation, and tissue repair. Leukocytes play a key role in this process, secreting proteases and transitioning cell phenotypes to promote healing. Cardiac fibroblasts are responsible for generating new extracellular matrix.

WIRES MECHANISMS OF DISEASE (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

Macrophages secrete murinoglobulin-1 and galectin-3 to regulate neutrophil degranulation after myocardial infarction

Upendra Chalise, Michael J. Daseke, William J. Kalusche, Shelby R. Konfrst, Jocelyn R. Rodriguez-Paar, Elizabeth R. Flynn, Leah M. Cook, Mediha Becirovic-Agic, Merry L. Lindsey

Summary: The study found that macrophages at MI day 1 secrete MUG1 to limit neutrophil degranulation and Lgals3 to enhance degranulation, thus regulating infarct wall thinning. The ratio of MUG1 to Lgals3 positively correlates with infarct wall thickness, demonstrating their roles in modulating infarct healing.

MOLECULAR OMICS (2022)

添加到收藏夹

暂无数据

© Peeref 2019-2024. All rights reserved.