期刊
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
卷 18, 期 9, 页码 565-573出版社
SPRINGER
DOI: 10.1007/s00787-009-0014-y
关键词
Early adolescence; Externalizing behavior problems; Cortisol; Pre- and perinatal risk factors; General population
资金
- Netherlands Organization [GB-MW 940-38-011]
- ZonMW Brainpower [100-001-004]
- ZonMW Risk Behavior and Dependence [60-60600-97-118]
- ZonMW Culture and Health [261-98-710]
- Social Sciences Council medium-sized investment [GB-MaGW 480-01-006, GB-MaGW 457-03-018, GB-MaGW 452-04-314]
- NOW large-sized investment [175.010.2003.005]
- Sophia Foundation for Medical Research [301, 393]
- Dutch Ministry of Justice (WODC)
To examine whether HPA-axis activity mediates the relationship between obstetric complications (OCs) and externalizing behavior problems, and to investigate whether this model is different for boys and girls. In a population-based cohort of 1,768 10- to 12-year-old early adolescents, we assessed the cortisol awakening response and evening cortisol levels. Externalizing behavior problems were assessed using the Child Behavior Checklist and the Youth Self-Report. OCs were retrospectively assessed in a parent interview. OCs significantly predicted externalizing behavior problems, but OCs did not predict HPA-axis activity. Thus, the mediation model was not supported. In addition to the relationship between HPA-axis activity and externalizing behavior problems, which is specific for girls, there is also a relationship between OCs and externalizing behavior problems. However, these two mechanisms are not related to each other indicating that HPA-axis activity is not a mediator in the relationship between OCs and externalizing behavior problems. Future research should focus on understanding the mechanism through which OCs cause externalizing behavior problems.
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