Review
Pharmacology & Pharmacy
Konstantin Mechler, Tobias Banaschewski, Sarah Hohmann, Alexander Hage
Summary: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. Treatment options for ADHD include psychoeducation, pharmacological interventions, and non-pharmacological interventions. There is a need for improvement in current pharmacotherapeutic strategies and the development of novel medications.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pediatrics
Li-Fan Pai, Der-Shiun Wang, Wan-Fu Hsu, Shao-Wei Huang, Chi-Hsiang Chung, Shyi-Jou Chen, Wu-Chien Chien, Der-Ming Chu
Summary: This study found that children with ADHD have a higher risk of central precocious puberty. Early referral to a pediatric endocrinologist for evaluation can lead to correct diagnosis. Early intervention treatment with gonadotropin-releasing hormone agonist may improve final height in children with central precocious puberty.
PEDIATRIC RESEARCH
(2022)
Article
Psychiatry
Le Zhang, Tyra Lagerberg, Qi Chen, Laura Ghirardi, Brian M. D'Onofrio, Henrik Larsson, Alexander Viktorin, Zheng Chang
Summary: The study developed and validated an algorithm to predict daily dosage and treatment duration from free-text prescriptions, which was applied to ADHD medication prescriptions. The algorithm showed good performance in external validation, with an accuracy of 96.8% for predicting daily dosage.
EVIDENCE-BASED MENTAL HEALTH
(2021)
Article
Multidisciplinary Sciences
Amy M. Ni, Brittany S. Bowes, Douglas A. Ruff, Marlene R. Cohen
Summary: Most systems neuroscience studies can be categorized into basic science work and translational work. This study combines these two approaches and reveals that orally administered methylphenidate enhances spatially selective visual attention and improves visual performance. Furthermore, it suggests that decreased correlated variability of neurons may be a general mechanism for treating neuropsychiatric disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Eliane S. Sanches, Raquel Boia, Ricardo A. Leitao, Maria H. Madeira, Carlos A. Fontes-Ribeiro, Antonio Francisco Ambrosio, Rosa Fernandes, Ana Paula Silva
Summary: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder that affects children, and it is associated with ophthalmologic abnormalities. The effects of methylphenidate (MPH) on retinal physiology in ADHD are still unclear. This study used animal models to investigate the structural, functional, and cellular alterations in the retina of ADHD, as well as the impact of MPH. The findings revealed deficits in retinal structure, function, and neurons in the ADHD animal model, and MPH had a beneficial effect on reducing inflammation and blood-retinal barrier dysfunction. However, MPH had opposite effects in the control animals, impairing retinal function and promoting inflammation.
Article
Psychiatry
Peter van Ruitenbeek, Luisa Franzen, Natasha Leigh Mason, Peter Stiers, Johannes G. Ramaekers
Summary: Shifting from unique characteristics to quantitative variations in mental disorders allows for overlap and potential treatment approaches. This study explores the overlap between attention-deficit/hyperactivity disorder and substance use disorder, and investigates the use of methylphenidate as a treatment for substance use disorder. Both disorders share common characteristics such as maladaptive behavior, impaired cognitive control, altered brain activity, and reduced brain volume. Methylphenidate has shown promise in improving cognitive control and clinical outcomes in substance use disorder patients, but many unanswered questions remain, including the universality of its effectiveness across different substances.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Developmental
Giorgia Michelini, Agatha Lenartowicz, Joel P. Diaz-Fong, Robert M. Bilder, James J. McGough, James T. McCracken, Sandra K. Loo
Summary: This study found that the combination of d-methylphenidate and guanfacine can reduce midoccipital neural activity and improve symptoms in children with ADHD, while the monotherapy with these two drugs has limited effects and may have detrimental effects on performance. These findings are important for monitoring the treatment of children with ADHD in the future.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Kelsey K. Wiggs, Rosanna Breaux, Joshua M. Langberg, James L. Peugh, Stephen P. Becker
Summary: This study examines the sleep differences in adolescents with ADHD who use stimulant medication. The findings suggest that stimulant treatment does not significantly affect the sleep of adolescents with ADHD.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Sneha M. Vaddadi, Nicholas J. Czelatka, Belsy D. Gutierrez, Bhumika C. Maddineni, Kenneth L. McCall, Brian J. Piper
Summary: In recent years, the use of prescription stimulants in the United States has been increasing, particularly for amphetamine and lisdexamfetamine. The study found that the usage of stimulants in the Western region was lower compared to other regions, and areas with a higher percentage of Hispanic populations also had lower stimulant usage.
Article
Multidisciplinary Sciences
Kristine Kaalund-Brok, Tine Bodil Houmann, Marie Bang Hebsgaard, Maj-Britt Glenn Lauritsen, Louise Hyldborg Lundstrom, Helene Gronning, Lise Darling, Susanna Reinert-Petersen, Morten Aagaard Petersen, Jens Richardt Mollegaard Jepsen, Anne Katrine Pagsberg, Kerstin Jessica Plessen, Henrik Berg Rasmussen, Pia Jeppesen
Summary: Randomized placebo-controlled trials have shown the efficacy of methylphenidate (MPH) for ADHD, but selection biases may limit generalizability. A study on 207 children with ADHD found that 81.2% responded favorably to carefully titrated MPH treatment with minimal adverse effects.
Article
Clinical Neurology
Tien-Wei Hsu, Mu-Hong Chen, Che-Sheng Chu, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Chih-Sung Liang
Summary: This study found that children, adolescents, and young adults with ADHD have a higher risk of migraine, and the risk is not associated with the dosage of ADHD medications.
Review
Clinical Neurology
Sylvain Rheims, Stephane Auvin
Summary: ADHD is a common comorbidity in patients with epilepsy, and diagnosis requires the use of validated rating scales by parents and teachers. Treatment with methylphenidate can improve symptoms in 60-75% of patients. While there is currently no specific treatment for ADHD in epilepsy patients, current treatment options are considered safe in this population.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Lanliu Deng, Ping Zhou, Lin Zhu, Yu Zhang, Ting Yang, Qiuxia Zhao, Jie Chen, Tingyu Li, Qian Cheng, Li Chen
Summary: This study found that the physical growth indexes of school-age children and adolescents with ADHD were negatively affected while taking MPH, but these effects were gradually mitigated with continued treatment. ATX had minor effects on weight and BMI. It is important for clinicians to consider children's diet during treatment.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Psychology, Developmental
Annet Bluschke, Nicolas Zink, Moritz Mueckschel, Veit Roessner, Christian Beste
Summary: Patients with AD(H)D show increased intra-individual variability in behavioral performance, likely reflecting dopaminergic deficiencies. Differences in performance between healthy controls and AD(H)D patients do not persist continuously over longer time periods, alternating with periods of no differences. Medication status and subtype do not affect this performance pattern. The findings suggest phasic deficiencies in the dopaminergic system of AD(H)D patients, not sufficiently ameliorated by first-line pharmacological treatment, with important clinical and scientific implications.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Review
Clinical Neurology
Christoph U. Correll, Brittney R. Starling, Michael Huss
Summary: The study found that transdermal therapies are a useful treatment option for patients with ADHD, showing similar safety and efficacy in children and adults, and high compliance rates. However, there is still a lack of research on transdermal treatments for adults with ADHD, indicating a need for further exploration.
Review
Cell Biology
Alejandro Romero, Eva Ramos, Francisco Lopez-Munoz, Emilio Gil-Martin, Germaine Escames, Russel J. Reiter
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has become a significant global health concern. While the clinical symptoms are well-characterized, the mechanisms of how the virus invades and spreads in the central nervous system, causing brain damage, remain unclear. Recent findings of the virus in neural tissue highlight the need for neurotherapeutic strategies in COVID-19 patients with underlying diseases.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
International Relations
Esther Cuerda-Galindo, Francisco Lopez-Munoz
Summary: The role of medical personnel in torture has evolved significantly throughout history, from being officially required to be present in torture sessions to actively collaborating in the implementation of various torture methods. Efforts are needed to ensure that health professionals comply with international conventions and treaties against torture.
INTERNATIONAL POLITICS
(2022)
Article
Health Care Sciences & Services
Laura de Anta, Miguel Angel Alvarez-Mon, Miguel A. Ortega, Cristina Salazar, Carolina Donat-Vargas, Javier Santoma-Vilaclara, Maria Martin-Martinez, Guillermo Lahera, Luis Gutierrez-Rojas, Roberto Rodriguez-Jimenez, Javier Quintero, Melchor Alvarez-Mon
Summary: Twitter users mainly discuss the effects of antidepressants on health-related areas, particularly sleep and appetite/weight. Patients and their relatives are the most frequent users posting tweets with medical content, while non-medical tweets often involve drug trivialization. Caregivers have a low presence in Twitter conversations about antidepressants.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nutrition & Dietetics
Cielo Garcia-Montero, Miguel A. Ortega, Miguel Angel Alvarez-Mon, Oscar Fraile-Martinez, Adoracion Romero-Bazan, Guillermo Lahera, Jose Manuel Montes-Rodriguez, Rosa M. Molina-Ruiz, Fernando Mora, Roberto Rodriguez-Jimenez, Javier Quintero, Melchor Alvarez-Mon
Summary: This article explores the role of malnutrition in the onset and course of major depressive disorder (MDD) in women. Women are twice as likely to suffer from MDD compared to men, which is related to fluctuations in sexual hormones and dietary habits and nutritional requirements during specific life periods. Nutritional intervention programs with a gender perspective may potentially improve women's mental health and quality of life.
Article
Nutrition & Dietetics
Fernando Mora, Miguel A. Alvarez-Mon, Sonia Fernandez-Rojo, Miguel A. Ortega, Miriam P. Felix-Alcantara, Isabel Morales-Gil, Alberto Rodriguez-Quiroga, Melchor Alvarez-Mon, Javier Quintero
Summary: This study analyzed the relationship between sociodemographic and behavioral factors, as well as self-esteem, in students of the first cycle of middle school and the likelihood of belonging to the risk group of eating disorders (ED). The results suggest that self-esteem is significantly related to belonging to an ED risk group, and variables related to dysfunctional feeding patterns are also associated with ED risk. These findings can help inform the development of effective preventive programs for EDs.
Article
Health Care Sciences & Services
Seiji Hamada, Takuhiro Moromizato, Masashi Narita, Kiyosu Taniguchi, Kenji Shibuya, Yasuharu Tokuda
Summary: The number of hospital physicians in Japan is related to patient admissions, highlighting the importance of increasing the physician workforce to improve healthcare capacity.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Psychiatry
L. de Anta, M. A. Alvarez-Mon, C. Donat-Vargas, F. J. Lara-Abelanda, V. Pereira-Sanchez, C. Gonzalez Rodriguez, F. Mora, M. A. Ortega, J. Quintero, M. Alvarez-Mon
Summary: This study examines public views on electroconvulsive therapy (ECT) by analyzing Twitter posts. Healthcare providers were the main publishers of ECT-related content, but more than half of the tweets had joking or trivializing contents. Personal opinions on ECT were mostly negative.
EUROPEAN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Miguel A. Ortega, Oscar Fraile-Martinez, Cielo Garcia-Montero, Sonia Rodriguez-Martin, Rosa Funes M. Monux, Coral Bravo, Juan A. De Leon-Luis, Jose V. Saz, Miguel A. Saez, Luis G. Guijarro, Guillermo Lahera, Jorge Monserrat, Fernando Mora, Javier Quintero, Julia Bujan, Natalio Garcia-Honduvilla, Melchor Alvarez-Mon, Miguel Angel Alvarez-Mon
Summary: Psychosis is a complex clinical syndrome characterized by a loss of contact with reality and changes in behavior, senses, and motor functions. It can occur during pregnancy and have detrimental effects on maternal and fetal well-being. This study explored the role of oxidative stress in the placenta of women who experienced their first episode of psychosis during pregnancy. The findings suggest that oxidative stress markers may play a significant pathophysiological role in the placental tissue, contributing to the impact of psychosis on pregnancy.
Article
Medicine, General & Internal
Isidoro Raga-Martinez, Francisco J. Povedano-Montero, Jesus Hernandez-Gallego, Francisco Lopez-Munoz
Summary: The purpose of this study is to investigate the changes in retinal thickness in chronic migraine patients using optical coherence tomography (OCT). The study found that the thickness of the retinal nerve fibre layer and ganglion cell layer, as well as macular thickness, were significantly thinner in chronic migraine patients compared to healthy controls. These findings suggest that OCT can be used as a diagnostic tool for detecting retinal thinning in chronic migraines.
Article
Biochemistry & Molecular Biology
Juan J. Fernandez-Miranda, Silvia Diaz-Fernandez, Francisco Lopez-Munoz
Summary: In this 5-year observational study, the impact of route of administration and doses of second-generation antipsychotics (SGAs) on treatment adherence, hospital admissions, and suicidal behavior in patients with severe schizophrenia was assessed. Results showed that patients on oral antipsychotics (Aps) had higher treatment discontinuation rates and more hospitalizations compared to those on long-acting injectables (LAIs). Suicidal behavior was also less common in LAI-treated patients. Overall, LAI treatment was found to be more effective in managing severe schizophrenia.
Review
Pharmacology & Pharmacy
Eva Ramos, Javier Egea, Francisco Lopez-Munoz, Emilio Gil-Martin, Alejandro Romero
Summary: The purpose of this systematic review is to summarize the knowledge on the therapeutic potential of melatonin in counteracting the negative effects of chemotherapy in breast cancer patients. The review analyzed preclinical and clinical evidence, identified gaps in the research, and suggested future studies. The selected randomized clinical trials indicated that combining melatonin with standard chemotherapy could improve the quality of life for breast cancer patients and increase partial response and 1-year survival rates.
Review
Biochemistry & Molecular Biology
Eva Ramos, Emilio Gil-Martin, Cristobal de los Rios, Javier Egea, Francisco Lopez-Munoz, Rene Pita, Antonio Juberias, Juan J. J. Torrado, Dolores R. R. Serrano, Russel J. J. Reiter, Alejandro Romero
Summary: In this review, melatonin is proposed as a therapeutic option to counteract the toxicological mechanisms and pathways activated after exposure to sulfur and nitrogen mustards. Additionally, the metabolites of melatonin are predicted to have a scavenger action and neutralize the damage induced by these blister agents. The anti-inflammatory action and NLRP3 inflammasome modulation of melatonin can also provide protection against sulfur and nitrogen mustard-induced injury.
Article
Biochemistry & Molecular Biology
Beatriz Chamorro, Sara Izquierdo-Bermejo, Maria Dolores Martin-de-Saavedra, Francisco Lopez-Munoz, Mourad Chioua, Jose Marco-Contelles, Maria Jesus Oset-Gasque
Summary: Ischemic stroke is a major cause of disability and death worldwide, and current therapeutic strategies are limited in their efficacy. Nitrones, known for their antioxidant and anti-inflammatory effects, show great promise as an alternative treatment. In this study, the neuroprotective effects of two nitrones were further investigated and compared with three reference compounds, showing significant neuroprotective effects.
Article
Biochemistry & Molecular Biology
Alejandra Palomino-Antolin, Celine Decouty-Perez, Victor Farre-Alins, Paloma Narros-Fernandez, Ana Belen Lopez-Rodriguez, Maria Alvarez-Rubal, Ines Valencia, Francisco Lopez-Munoz, Eva Ramos, Antonio Cuadrado, Ana I. Casas, Alejandro Romero, Javier Egea
Summary: The role of inflammation and immunity in the pathomechanism of neurodegenerative diseases is significant. The NLRP3 inflammasome plays a crucial role in activating inflammatory responses. The interaction between NOX4 and Nrf2 is found to be critical in the activation of NLRP3 inflammasomes.
Article
Psychiatry
Lorena Frances, Antoni Ruiz, C. Virginia Soler, Joan Frances, Jessica Caules, Amaia Hervas, Carolina Carretero, Barbara Cardona, Elizabeth Quezada, Alberto Fernandez, Javier Quintero
Summary: The study found a high prevalence of neurodevelopmental disorders among 6-year-old children, with higher rates in boys than in girls. A significant proportion of cases had not been previously diagnosed, highlighting the importance of early detection programs and policies to support disadvantaged populations.
FRONTIERS IN PSYCHIATRY
(2023)