Article
Biochemistry & Molecular Biology
Giulia Sbrini, Sabrina I. Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader, Fabio Fumagalli, Natalia Alenina, Judith R. Homberg, Francesca Calabrese
Summary: Peripheral serotonin levels have an influence on brain functions under basal and dynamic situations. The lack of peripheral serotonin can reduce anxiety-like behavior, as well as neuronal activation and the expression of brain plasticity-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Aleksandra Grozic, Keaton Coker, Christopher M. Dussik, Marya S. Sabir, Zhela Sabir, Arianna Bradley, Lin Zhang, Jin Park, Steven Yale, Ichiro Kaneko, Maryam Hockley, Lucinda A. Harris, Tisha N. Lunsford, Todd R. Sandrin, Peter W. Jurutka
Summary: This study aimed to identify potential biomarkers and unique gene expression patterns that define the pathological state of irritable bowel syndrome (IBS). Gene expression profiling of colonic tissue samples from 29 participants, including IBS patients and healthy controls, revealed 858 differentially expressed genes potentially characteristic of IBS. After screening and analysis, seven putative IBS biomarkers, including genes involved in serotonin metabolism, were identified.
Review
Biochemistry & Molecular Biology
Emily Christie M. Fonseca, Lanalice R. Ferreira, Pablo Luis B. Figueiredo, Cristiane do Socorro F. Maia, William N. Setzer, Joyce Kelly R. Da Silva
Summary: This review assesses studies on plants whose essential oils have exhibited antidepressant activity in the past decade and examines the mechanism of action of the major components and models tested. It provides valuable insights for the development of potential antidepressant medications and offers a molecular approach to understanding the antidepressant mechanism of action of the major volatile compounds reported in the past decade.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Nikita Deo, Gregory Redpath
Summary: This article examines the important role of endocytosis in the cellular basis of depression and anxiety. It provides a detailed explanation of the endocytic regulation of 5-HT receptors and SERT, and explores how SSRIs and hallucinogenic compounds modulate serotonin signaling through endocytosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Faiq Amin, Mahmoud A. Ibrahim, Syed Rizwan-ul-Hasan, Saima Khaliq, Gamal A. Gabr, Muhammad, Asra A. Khan, Peter A. Sidhom, Prashant M. Tikmani, Ahmed M. Shawky, Saara Ahmad, Syed Hani Abidi
Summary: This study evaluated the binding affinity of apigenin and safranal with 5HT1AR/5HT2AR and their therapeutic effects on depressive and anxious behavior. The results showed that apigenin had superior interacting capacity with 5HT1A/5HT2A receptors compared to safranal, and both compounds effectively reduced depressive/anxiety symptoms in rodents.
Article
Biochemistry & Molecular Biology
Cynthia Haidee Tran, Cynthia Shannon Weickert, Thomas Wesley Weickert, Duncan Sinclair
Summary: Early life stress has long-lasting impacts on brain regions involved in dopamine neurotransmission, changing the trophic environment and potentially altering responsiveness to subsequent stressful events in a sex-specific pattern.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Minhee Kim, Wonil Choi, Jihyeon Yoon, Byung-kwan Jeong, Suvarna H. Pagire, Haushabhau S. Pagire, Jungsun Park, Jung Eun Nam, Chang Joo Oh, Jae-Han Jeon, Seong Soon Kim, Byung Hoi Lee, Jin Sook Song, Myung Ae Bae, In-Kyu Lee, Hail Kim, Jin Hee Ahn
Summary: Non-alcoholic fatty liver disease (NAFLD) is a prevalent disease worldwide, characterized by excessive fat accumulation in the liver. This study discovered the role of the serotonin receptor subtype 5HT(2A) in regulating hepatic lipid metabolism. Newly synthesized peripheral 5HT(2A) receptor antagonists showed potential for treating NAFLD.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Cong-Yuan Xia, Jun He, Li-Da Du, Yu Yan, Wen-Wen Lian, Jie-Kun Xu, Wei-Ku Zhang
Summary: This review discusses the relationships between glutamate receptor subunits and depressive-like behaviors, summarizing the alterations of these subunits in patients with MDD and animal models of depression, as well as surveying animal behaviors in response to dysfunction of glutamate receptor subunits.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Behavioral Sciences
Ofelia Limon-Morales, Kenia Morales-Quintero, Marcela Arteaga-Silva, Tania Molina-Jimenez, Marco Cerbon, Herlinda Bonilla-Jaime
Summary: Depressive illness is associated with cognitive impairment, reduced levels of neurotrophins, and dysfunctions in the serotonergic system. The study found that neonatal treatment with clomipramine caused molecular changes in brain regions related to learning and memory.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Multidisciplinary Sciences
Trent Davidson, David B. Braudt, Robert Keers, Elham Assary, Kathleen Mullan Harris, Jason D. Boardman
Summary: This study re-evaluated one of the most cited and disputed papers in gene-environment interaction literature, using a genome-wide polygenic indicator to examine the genetic determinants of stress sensitivity. The results supported the stress-diathesis perspective and validated the scientific contributions of the original paper.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Atom J. Lesiak, Kevin Coffey, Joshua H. Cohen, Katharine J. Liang, Charles Chavkin, John F. Neumaier
Summary: Research has found that stress leads to upregulation of Fkbp5 mRNA in male and female mice, and pretreatment with a selective FKBP51 inhibitor can reduce stress-induced anhedonia. This suggests that FKBP51 may play an important role in integrating circulating stress hormones and serotonergic regulation of stress responses.
MOLECULAR PSYCHIATRY
(2021)
Article
Cell Biology
Ian M. Gans, Janelle Grendler, Remy Babich, Nishad Jayasundara, James A. Coffman
Summary: Kruppel-like factor 9 (Klf9) is a feedforward regulator of glucocorticoid receptor (GR) signaling and is expressed in synchrony with fkbp5 in zebrafish. Loss of Klf9 results in elevated levels of fkbp5 transcript and hyperacetylation of the fkbp5 promoter, suggesting that GR regulates fkbp5 via an incoherent feedforward loop with klf9. Klf9(-/-) mutants show decreased oxygen consumption rate and upregulation of glycolytic genes, indicating a role for Klf9 in regulating metabolic rate and gene expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Jelena Bakusic, Manosij Ghosh, Andrea Polli, Bram Bekaert, Wilmar Schaufeli, Stephan Claes, Lode Godderis
Summary: The study revealed that job stress was associated with increased levels of cortisol and cortisone in burnout participants. Changes in DNA methylation of the NR3C1 and SLC6A4 genes were observed in burnout individuals, and some of these methylation changes correlated with burnout symptoms. Increased methylation in a specific CpG in the SLC6A4 gene moderated the association between job stress and burnout, while DNA methylation in this CpG was also associated with increased cortisol levels. Furthermore, average methylation of NR3C1 was negatively associated with cortisone levels.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biology
Gregory Redpath, Nikita Deo
Summary: Serotonin plays a broader role in regulating human physiology beyond mood regulation, with a key involvement in endocytosis through multiple mechanisms. Understanding the role of serotonin in regulating endocytosis is essential for unraveling its impact on mood regulation and the broader understanding of endocytosis and its regulation throughout the body.
Review
Psychiatry
Lina Wang, Yu Chen, Miao Wang, Chaoben Zhao, Dongdong Qiao
Summary: This systematic review investigates the role of gene-environment interaction (G x E) in obsessive-compulsive disorder (OCD). The study examines the relationship between G x E and the susceptibility to OCD occurrence, disease progression, and treatment response. The findings suggest that G x E increases the susceptibility to OCD, plays a crucial role in clinical characteristics, and has an inconsistent impact on treatment response.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
